Synthesis, crystal structure and spectroscopic studies of a new silver complex derived from [1-(3-pyridinyl) ethanone]

In this work, a new silver (I) complex, [Ag(3-pye)2(H2O)](NO3) where 3-pye=1-(3-pyridinyl) ethanone, has been synthesized and characterized by elemental analyses, FT-IR, fluorescence spectroscopy, and single X-ray crystallography. The X-ray diffraction analysis revealed that the Ag(I) complex crystallized in the monoclinic system with the C2/c space group. Computational studies were performed using DFT approache on the present complex to get insight into the structural parameters, spectral characteristics and electronic properties. The characterization results were found to be consistent with the proposed structure of the complex, and the DFT approach supported the experimental results. Also, Hirshfeld surface analysis was used to identify the non-covalent interactions within the crystal structure as well as to visualize the conformity of the crystal structure

Do We Have to Obtain Rebound Bilirubin Levels and What is the Optimal Time?

Aim:We aimed to determine the frequency of rebound hyperbilirubinemia (RHB) needing treatment and therefrom, to clarify the clinical importance of routinely checking serum total bilirubin (STB) levels after the cessation of phototherapy and to define an optimal time to check STB levels for the detection of RHB.Materials and Methods:Term and late preterm babies who received phototherapy were included in this study. The demographic and clinical features, time of onset of jaundice, phototherapy time and results to determine the etiology of jaundice were recorded for all babies. Serum “rebound” bilirubin measurements were performed two times at 12 and at 24 hours after the cessation of phototherapy. The re-initiation of phototherapy according to the 12th and 24th hour STB levels was accepted as “early rebound” and “late rebound”, respectively. IBM SPSS 22 was used for statistical analyses.Results:Data was available for 110 infants. The rebound rate requiring phototherapy was 9.1% (n=10) and all had a risk factor. Most of the babies (9/10) rebounded at the 12th hour after the termination of phototherapy. Hemolysis and prematurity were found to be statistically significant for RHB (p=0.008; p=0.048).Conclusion:Post-phototherapy bilirubin follow-up may be incorporated using a combined approach of individualization, evaluation of risk factors, and application of common sense before discharge. Our study showed that STB levels could be measured after the cessation of phototherapy, especially in patients with a risk factor, at the 12th hour before discharge. Randomized controlled studies with larger sample sizes are still needed for definitive recommendations

International nosocomial infection control consortium (INICC) report, data summary of 36 countries, for 2004-2009

The results of a surveillance study conducted by the International Nosocomial Infection Control Consortium (INICC) from January 2004 through December 2009 in 422 intensive care units (ICUs) of 36 countries in Latin America, Asia, Africa, and Europe are reported. During the 6-year study period, using Centers for Disease Control and Prevention (CDC) National Healthcare Safety Network (NHSN; formerly the National Nosocomial Infection Surveillance system [NNIS]) definitions for device-associated health care-associated infections, we gathered prospective data from 313,008 patients hospitalized in the consortium's ICUs for an aggregate of 2,194,897 ICU bed-days. Despite the fact that the use of devices in the developing countries' ICUs was remarkably similar to that reported in US ICUs in the CDC's NHSN, rates of device-associated nosocomial infection were significantly higher in the ICUs of the INICC hospitals; the pooled rate of central line-associated bloodstream infection in the INICC ICUs of 6.8 per 1,000 central line-days was more than 3-fold higher than the 2.0 per 1,000 central line-days reported in comparable US ICUs. The overall rate of ventilator-associated pneumonia also was far higher (15.8 vs 3.3 per 1,000 ventilator-days), as was the rate of catheter-associated urinary tract infection (6.3 vs. 3.3 per 1,000 catheter-days). Notably, the frequencies of resistance of Pseudomonas aeruginosa isolates to imipenem (47.2% vs 23.0%), Klebsiella pneumoniae isolates to ceftazidime (76.3% vs 27.1%), Escherichia coli isolates to ceftazidime (66.7% vs 8.1%), Staphylococcus aureus isolates to methicillin (84.4% vs 56.8%), were also higher in the consortium's ICUs, and the crude unadjusted excess mortalities of device-related infections ranged from 7.3% (for catheter-associated urinary tract infection) to 15.2% (for ventilator-associated pneumonia). Copyright © 2012 by the Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved

Degradace lepených spojů na konstrukčních ocelích

Cílem této disertační práce je nalezení vztahu mezi pevností lepených spojů a materiálových vlastností adherendu a lepidla. Pro dosažení tohoto cíle byly studovány čtyři základní vlastnosti důležité pro lepené spoje. Pro dosažené dobrých výsledků byla zjištěna důležitost povrchové předúpravy, kdy byl pozorován pozitivní vliv vyšší drsnosti. Zlepšení smáčivosti bylo zjišťováno pomocí měření kontaktního úhlu. Hodnota kontaktního úhlu je přímo úměrná povrchové energii, která má značný vliv na pevnost lepeného spoje. Nejlepších výsledků statické pevnosti bylo dosaženo při předúpravě pomocí moření v kyselině a následným tryskáním. V tomto případě bylo dosaženo pro jednoduše přeplátovaný spoj pevnosti až 14,4 MPa. Z hlediska životnosti připravených spojů byla zjištěna také nejvyšší trvanlivost spojů a nebyla zjištěna žádná degradace povrchu během testů životnosti v korozním prostředí. Bylo zjištěno. že zkoušky stárnutí pro pro jednoduše přeplátované spoje jsou zdlouhavá a není možné jednoznačně stanovit dobu stárnutí. Naproti tomu při využití ?scratch testu? byly získány velmi rychle výsledky , které je možno využít pro stanovování životnosti lepidel.The aim of this dissertation is to find a relationship between the strength of adhesive joints and the material properties of adherend and adhesive. In order to achieve this, the current study is motivated by four main objectives for adhesively bonded joints. According to the results, the surface treatments were enhanced with positive influences or greater adhesion by means of roughening of the surface. The improved wettability of the surface is displayed by measured contact angles, and these values are equated with surface energy values to calculate adhesion strength. As a consequence of static tensile test results for single lap joints, acid etched plus sanded treatment joints are observed to have the highest shear strength of single lap joints (14.4 MPa). However, in the case of the durability of prepared joint samples, sanded treated joints are shown to have the best performance and do not indicate any visual signs of failure in the interfacial zone due to ageing. As a result of an ageing test, it seems difficult to determine an exact time period for the ageing mechanism of single lap joints, whereas a scratch test may acquire failure results over the short term, compared to the ageing of single lap joints.Dopravní fakulta Jana Perner

Comparıson Of Protectıve Effects Of A-Tocopherol And A-Tocotrıenol Forms Of Vıtamın E Agaınst Beta Amyloıd Plaque Accumulatıon In The Braın

In this thesis study, the protective effects of α-tocopherol and α-tocotrienol forms of vitamin E, a powerful antioxidant, against beta amyloid-induced neurodegeneration were experimentally investigated and compared on a two-dimensional in vitro neurodegeneration model using cell culture methods. The focus of the study was to examine the protective effect of α-tocopherol and α-tocotrienol derivatives of vitamin E against cell death caused by beta amyloid accumulation and to compare the protective effects of these two vitamin E derivatives with each other. In this context, primary neuron isolation was performed and beta amyloid was applied on the obtained primary neurons in order to establish a two-dimensional neurodegeneration model. Afterwards, cell viability was determined by analysis of 3- (4,5-dimethylthiazol-2-yl) -2,5-diphenyl tetrazolium bromide, cytotoxicity was determined by neutral red analysis, beta amyloid accumulation amount was determined by Congo Red analysis and percent apoptosis, and necrosis were determined by Acridine Orange / Propidium Iodide analysis. In addition, the expression amounts of voltage-dependent l-type calcium channel and Beta-Secretase 1 genes whose expression increased in beta amyloid-induced neurodegeneration mechanism were measured by Real Time Polymerase Chain Reaction. Experimental studies were carried out using 17-18 day old rat pups obtained from mating six female and one male rats. According to the findings, α-tocopherol and α-tocotrienol derivatives of vitamin E showed a protective effect against beta amyloid-induced neurodegeneration at 48 and 72 hours of application. As a result of the Real Time Polymerase Chain Reaction analysis, it was revealed that α-tocopherol and α-tocotrienol were effective on Voltage-gated L-type calcium channel and Beta secretase 1 mechanism. These two components of vitamin E have been observed to significantly reduce the expression of the Voltage-gated L-type calcium channel gene. On the other hand, the decrease observed on Beta secretase 1 expression was not statistically significant. The protective effect of α-tocopherol and α-tocotrienol against beta amyloid-induced neurodegeneration was observed at different levels in terms of cell viability and cytotoxicity in 48 and 72 hours applications. In this context, more detailed studies are required in the future in order to better understand the difference between the protective effects of α-tocopherol and α-tocotrienol against beta amyloid-induced neurodegeneration and the effect of vitamin E on beta secretase 1 gene expression.Bu tez çalışmasında, güçlü bir antioksidan olan E vitamininin α-tokoferol ve α-tokotrienol formlarının beta amiloid kaynaklı nörodejenerasyona karşı koruyucu etkileri hücre kültürü yöntemleri kullanılarak iki boyutlu in vitro nörodejenerasyon modeli üzerinde deneysel olarak incelenmiş ve karşılaştırılmıştır. Çalışmada E vitamininin α-tokoferol ve α-tokotrienol türevlerinin beta amiloid birikimi sonucu oluşan hücre ölümüne karşı koruyucu etkisinin incelenmesine ve bu iki E vitamini türevinin ortaya çıkardığı koruyucu etkilerin birbirleri ile karşılaştırılmasına odaklanılmıştır. Bu kapsamda iki boyutlu bir nörodejenerasyon modeli kurulabilmesi için primer nöron izolasyonu yapılmış ve elde edilen primer nöronlar üzerine beta amiloid uygulanmıştır. Ardından 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide analizi ile hücre canlılığı, nötral kırmızısı analizi ile sitotoksisite, Kongo Kırmızısı analizi ile beta amiloid birikim miktarı ve Akridin Orange / Propidium Iodide analizi ile yüzde apoptoz ve yüzde nekroz tespit edilmiştir. Gerçek Zamanlı Polimeraz Zincir Reaksiyonu ile beta amiloid kaynaklı nörodejenerasyon mekanizmasında ifadesi artış gösteren Voltaj kapılı L-tip kalsiyum kanalı ve Beta sekretaz 1 genlerinin ifade edilme miktarları ölçülmüştür. Deneysel çalışmalar altı adet dişi ve bir adet erkek sıçanın çiftleştirilmesi sonucu elde edilen 17-18 günlük sıçan yavruları kullanılarak gerçekleştirilmiştir. Elde edilen bulgulara göre E vitamininin α-tokoferol ve α-tokotrienol türevleri 48 ve 72 saatlik uygulamalarda beta amiloid kaynaklı nörodejenerasyona karşı koruyucu etki göstermiştir. Yapılan Gerçek Zamanlı Polimeraz Zincir Reaksiyonu analizi sonucu α-tokoferol ve α-tokotrienolün Voltaj kapılı L-tip kalsiyum kanalı ve Beta sekretaz 1 mekanizması üzerinde etkili olduğu ortaya çıkmıştır. E vitaminin bu iki türevinin Voltaj kapılı L-tip kalsiyum kanalı geninin ifadesini anlamlı bir şekilde azalttığı gözlemlenmiştir. Buna karşın Beta sekretaz 1 ifadesi üzerinde gözlemlenen düşüş istatistiksel olarak anlamlı değildir. α-tokoferol ve α-tokotrienolün beta amiloid kaynaklı nörodejenerasyona karşı gösterdiği koruyucu etki, hücre canlılığı ve sitotoksisite bakımından 48 ve 72 saatlik uygulamalarda farklı seviyelerde gözlemlenmiştir. Bu kapsamda α-tokoferol ile α-tokotrienolün beta amiloid kaynaklı nörodejenerasyona karşı gösterdiği koruyucu etkiler arasındaki fark ve E vitamininin Beta sekretaz 1 geni ifadesi üzerindeki etkisinin daha iyi anlaşılabilmesi için gelecekte daha detaylı çalışmalar yapılması gerekmektedir

A note on numerical solution of a parabolic-Schrodinger equation

3rd International Conference on Analysis and Applied Mathematics (ICAAM) -- SEP 07-10, 2016 -- Almaty, KAZAKHSTANWOS: 000383223000132In the present study, a nonlocal boundary value problem for a parabolic-Schrodinger equation is considered. The stability estimates for the solution of the given problem is established. The first and second order of difference schemes are presented for approximately solving a specific nonlocal boundary problem. The theoretical statements for the solution of these difference schemes are supported by the result of numerical examples.Inst Math & Math Modeling, Al Farabi Kazakh Natl Univ, L N Gumilyov Eurasian Natl Uni

The characterization of zinc plated surface after aged adhesives

The use of adhesive bonding rather than mechanical fasteners offers the potential for reduced weight and cost.This paper aims to make characterization of zinc plated surface and aged adhesives (in water at 50 °C. Surface analysis related to zinc plated surface and adhesives were carried out by using analytical scanning electron microscopy (SEM) with energy dispersive X-ray (EDX). Acoording to SEM results related to corrosion resistance which are adhesive types, Polyurethane was good, Sikasil SG20 was medium level compared to others, Sikaflex®-552 was very low corrosion resistance. As seen that in the peeling test, Polyurethane was the worst whereas SikasilSG-20 was the best. However, Sikasil® SG20 adhesive would be good choose compared to others, in case of this type of adhesion should improve the feature of corrosion resistant on zinc plated steel surfaces