Mobilization of ionophore antibiotics and glyphosate after a rainfall simulation on agricultural soils amended with poultry litter

Poultry litter (PL) is a majority waste of the intensive avian production, commonly used as an organic amendment in agricultural soils. We studied the input of pollutants from the PL, as inorganic P and ionophore antibiotics (IPA), and the influence on soil pollutants (GLP and AMPA) in real systems, after a rainfall simulation on an agronomic amended soil with PL at two residence times. Physicochemical parameters were altered in the runoff after the amendment. PL from commercial farms present a preliminary load of monensin and salinomycin. The mobility of IPA by surface runoff (0.8–31%) and leaching (0.4–38%) was determined, with monensin showing the maximum losses in both processes at both residence times. PL amendments act as a pollution diffuse source of IPA. Moreover, the amendment enhanced the mobility of GLP and AMPA in soils. Maximum losses of GLP in runoff increased from 0.56% to 9.84% in soil with PL treatment. The results were related to the amounts of P released in the surface runoff. Strategies for reducing the animal wastes and their antibiotic content must be investigated regarding the productive practice involving these residues, as water and soil conservation are proven to be a key asset in the sustainability and success of circular economy processes. This is the first study to demonstrate the combined release of pollutants from multiple origins, after the amendment with poultry litter on real agricultural soils.Fil: Navarro, Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Química. Centro de Investigaciones del Medio Ambiente; ArgentinaFil: Alonso, Lucas Leonel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Química. Centro de Investigaciones del Medio Ambiente; ArgentinaFil: Capparelli, Alberto Luis. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas; ArgentinaFil: Marino, Damian Jose Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Química. Centro de Investigaciones del Medio Ambiente; Argentin

Behavior of ionophore antibiotics in aquatic environments in Argentina: The distribution on different scales in water courses and the role of wetlands in depuration

We studied for the first time three ionophore anticoccidial drugs: monensin (MON), lasalocid (LAS), and salinomycin (SAL) as emerging pollutants originating from animal and plant husbandry in surface waters (n = 89) in one of the most extensive hydrological basins in South América (Del Plata basin). The soluble fraction of ionophores was pretreated by solid-phase extraction and analyzed by LC-MS/MS at a limit of detection of 1.7 ng·L−1. A statistical approach noted the need to report parameters calculated by methods based on the number of observations and the censorship percentage over substitution methods for more precise estimations of environmental data with a high percentage of left-censored data. Water collectors adjacent to intensive-husbandry facilities, placed in direct runoffs from animal excreta, or in wastewater emissions contained median concentrations of MON and SAL approximately 70 times higher than those found in regional tributaries and main courses of 5 sub-basins of the pampas and mesopotamic regions, thus exhibiting a relevance to other similar agricultural pollutants widely reported as pesticides. Chemical speciation of these compounds in surface water was characterized especially for MON and SAL, where the pH and chemical oxygen demand of the natural water body was associated with the concentration of the soluble fraction. The concentrations in abundant rivers such as the Gualeguay deliver a contribution to a natural wetland such as the Paraná-River delta, which registered only one sample with a [MON] ≤ the limit of quantification. Since wetlands possess a limited removal capability, these affluent contributions recorded strongly indicate that attention must be paid to the development of guidelines involving quality criteria for assessing the impact of ionophore antibiotics on such ecosystems.Fil: Alonso, Lucas Leonel. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Química. Centro de Investigaciones del Medio Ambiente; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Demetrio, Pablo Martin. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Química. Centro de Investigaciones del Medio Ambiente; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Capparelli, Alberto Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata; ArgentinaFil: Marino, Damian Jose Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata; Argentin

Lineamientos y estrategias de integración regional para la vereda Colombia (kilómetro 41), municipio de Manizales, Caldas. Aportes para una propuesta de desarrollo regional sostenible

El Corregimiento 1 denominado Colombia, está ubicado al Nor-Occidente del Municipio de Manizales y ocupa un área aproximada de 4.332 hectáreas. El principal asentamiento humano se encuentra en Puente Colombia y cuenta con una temperatura promedio de 25°C, su topografía es plana y ondulada. De acuerdo a diferentes estudios que se han realizado, como el de Corpocaldas en su Agenda Ambiental (2002), se considera el corregimiento como alternativa de polo agroindustrial y núcleo Industrial de Manizales. Su ubicación geográfica y características ambientales dentro del llamado Triangulo de Oro: Cali–Medellín–Bogotá, así como el avance alcanzado en el desarrollo de infraestructura vial, la implementación de la vía férrea con el Tren de Occidente, la conexión con el proyecto del puerto de Tribugá y la construcción del aeropuerto Aerocafé, hacen que este territorio sea visto como estratégico para la articulación con los municipios y departamentos vecinos desde una perspectiva de desarrollo regional sostenible. Durante varias décadas se han formulado propuestas para impulsar la región que hasta hoy no han sido concretadas, a pesar de que diferentes actores, gremiales, políticos, comunitarios, sociedad civil y academia, reconocen la importancia y conveniencia que tiene la zona de estudio. Lo que busca esta investigación de tesis de maestría, a partir de la implementación de una metodología descriptiva-explicativa, es analizar si la vereda Colombia, centro poblado “Kilómetro 41”, por su ubicación estratégica, su topografía, los proyectos viales, ferroviario y aéreo, que se están concretando a su alrededor, así como su vocación agropecuaria y la clasificación de los diferentes usos de suelo que se le han dado en los Planes de Ordenamiento Territorial, le permiten convertirse en un centro de desarrollo sub-regional, donde se puedan ubicar diferentes actividades además de las de vivienda, la industria, agroindustria, o como se ha planteado en los estudios realizados, permiten la ubicación de un puerto seco, una plataforma logística o una zona franca. No obstante y pese a los numerosos intentos fallidos por consolidar la zona como polo de desarrollo regional, este estudio aporta en conclusiones de tiempo y oportunidad existentes para formular y poner en marcha un ambicioso proyecto de desarrollo socioeconómico, aprovechando las ventajas comparativas y competitivas existentes, las relacionadas con su ubicación geoestratégica, la movilidad y conectividad con el resto del país y la normatividad en desarrollo territorial existente.Corregimiento 1 called Colombia, is located to the North-West of the Municipality of Manizales and occupies an area of approximately 4,332 hectares. The main human settlement is in Puente Colombia and has an average temperature of 25 ° C, its topography is flat and undulating. According to different studies that have been carried out, such as that of Corpocaldas in its Environmental Agenda (2002), the township is considered as an alternative to the agroindustrial pole and Industrial nucleus of Manizales. Its geographical location and environmental characteristics within the so-called Golden Triangle: Cali – Medellín – Bogotá, as well as the progress made in the development of road infrastructure, the implementation of the railroad with the Tren de Occidente, the connection with the port project of Tribugá and the construction of the Aerocafé airport, make this territory is seen as strategic for the articulation with neighboring municipalities and departments from a perspective of sustainable regional development. For several decades, proposals have been formulated to promote the region that until today have not been specified, despite the fact that different actors, unions, politicians, community, civil society and academia, recognize the importance and convenience of the study area. What this master's thesis research seeks, based on the implementation of a descriptive-explanatory methodology, is to analyze whether the village of Colombia, a populated center "Kilometer 41", due to its strategic location, its topography, road, railway and air, which are taking shape around it, as well as its agricultural vocation and the classification of the different land uses that have been given in the Land Use Plans, allow it to become a sub-regional development center, where can locate different activities in addition to housing, industry, agribusiness, or as has been raised in the studies carried out, allow the location of a dry port, a logistics platform or a free zone. However, and despite numerous unsuccessful attempts to consolidate the area as a regional development pole, this study provides conclusions of the time and existing opportunity to formulate and implement an ambitious socioeconomic development project, taking advantage of the existing comparative and competitive advantages, those related to its geostrategic location, mobility and connectivity with the rest of the country and existing regulations on territorial development

Parsimonious Argument Annotations for Hate Speech Counter-narratives

We present an enrichment of the Hateval corpus of hate speech tweets (Basile et. al 2019) aimed to facilitate automated counter-narrative generation. Comparably to previous work (Chung et. al. 2019), manually written counter-narratives are associated to tweets. However, this information alone seems insufficient to obtain satisfactory language models for counter-narrative generation. That is why we have also annotated tweets with argumentative information based on Wagemanns (2016), that we believe can help in building convincing and effective counter-narratives for hate speech against particular groups. We discuss adequacies and difficulties of this annotation process and present several baselines for automatic detection of the annotated elements. Preliminary results show that automatic annotators perform close to human annotators to detect some aspects of argumentation, while others only reach low or moderate level of inter-annotator agreement

Self-subduction of the Pangaean global plate

One of the most striking and rare occurrences in the Earth's history is the amalgamation of most of the continental lithosphere into one supercontinent. The most recent supercontinent, Pangaea, lasted from 320 to 200 million years ago. Here, we show that after the continental collisions that led to the formation of Pangaea, plate convergence continued in a large, wedge-shaped oceanic tract. We súggest that plate strain at the periphery of the supercontinent eventually resulted in self-subduction of the Pangaean global plate, when the ocean margin of the continent subducted beneath the continental edge at the other end of the same plate. Our scenario results in a stress regime within Pangaea that explains the development of a large fold structure near the apex of the Palaeotethys Ocean, extensive lower crustal heating and continental magmatism at the core of the continent as well as the development of radially arranged continental rifts in more peripheral regions of the plate

Constraints on the structure and seasonal variations of Triton’s atmosphere from the 5 October 2017 stellar occultation and previous observations

J.M.O. acknowledges financial support from the Portuguese Foundation for Science and Technology (FCT) and the European Social Fund (ESF) through the PhD grant SFRH/BD/131700/2017. The work leading to these results has received funding from the European Research Council under the European Community's H2020 2014-2021 ERC grant Agreement nffi 669416 "Lucky Star". We thank S. Para who supported some travels to observe the 5 October 2017 occultation. T.B. was supported for this research by an appointment to the National Aeronautics and Space Administration (NASA) Post-Doctoral Program at the Ames Research Center administered by Universities Space Research Association (USRA) through a contract with NASA. We acknowledge useful exchanges with Mark Gurwell on the ALMA CO observations. This work has made use of data from the European Space Agency (ESA) mission Gaia (https://www.cosmos.esa.int/gaia), processed by the Gaia Data Processing and Analysis Consortium (DPAC, https://www.cosmos.esa.int/web/gaia/dpac/consortium).Funding for the DPAC has been provided by national institutions, in particular the institutions participating in the Gaia Multilateral Agreement. J.L.O., P.S.-S., N.M. and R.D. acknowledge financial support from the State Agency for Research of the Spanish MCIU through the "Center of Excellence Severo Ochoa" award to the Instituto de Astrofisica de Andalucia (SEV-2017-0709), they also acknowledge the financial support by the Spanish grant AYA-2017-84637-R and the Proyecto de Excelencia de la Junta de Andalucia J.A. 2012-FQM1776. The research leading to these results has received funding from the European Union's Horizon 2020 Research and Innovation Programme, under Grant Agreement no. 687378, as part of the project "Small Bodies Near and Far" (SBNAF). P.S.-S. acknowledges financial support by the Spanish grant AYA-RTI2018-098657-J-I00 "LEO-SBNAF". The work was partially based on observations made at the Laboratorio Nacional de Astrofisica (LNA), Itajuba-MG, Brazil. The following authors acknowledge the respective CNPq grants: F.B.-R. 309578/2017-5; R.V.-M. 304544/2017-5, 401903/2016-8; J.I.B.C. 308150/2016-3 and 305917/2019-6; M.A. 427700/20183, 310683/2017-3, 473002/2013-2. This study was financed in part by the Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior -Brasil (CAPES) -Finance Code 001 and the National Institute of Science and Technology of the e-Universe project (INCT do e-Universo, CNPq grant 465376/2014-2). G.B.R. acknowledges CAPES-FAPERJ/PAPDRJ grant E26/203.173/2016 and CAPES-PRINT/UNESP grant 88887.571156/2020-00, M.A. FAPERJ grant E26/111.488/2013 and A.R.G.Jr. FAPESP grant 2018/11239-8. B.E.M. thanks CNPq 150612/2020-6 and CAPES/Cofecub-394/2016-05 grants. Part of the photometric data used in this study were collected in the frame of the photometric observations with the robotic and remotely controlled telescope at the University of Athens Observatory (UOAO; Gazeas 2016). The 2.3 m Aristarchos telescope is operated on Helmos Observatory by the Institute for Astronomy, Astrophysics, Space Applications and Remote Sensing of the National Observatory of Athens. Observations with the 2.3 m Aristarchos telescope were carried out under OPTICON programme. This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 730890. This material reflects only the authors views and the Commission is not liable for any use that may be made of the information contained therein. The 1. 2m Kryoneri telescope is operated by the Institute for Astronomy, Astrophysics, Space Applications and Remote Sensing of the National Observatory of Athens. The Astronomical Observatory of the Autonomous Region of the Aosta Valley (OAVdA) is managed by the Fondazione Clement Fillietroz-ONLUS, which is supported by the Regional Government of the Aosta Valley, the Town Municipality of Nus and the "Unite des Communes valdotaines Mont-Emilius". The 0.81 m Main Telescope at the OAVdA was upgraded thanks to a Shoemaker NEO Grant 2013 from The Planetary Society. D.C. and J.M.C. acknowledge funds from a 2017 'Research and Education' grant from Fondazione CRT-Cassa di Risparmio di Torino. P.M. acknowledges support from the Portuguese Fundacao para a Ciencia e a Tecnologia ref. PTDC/FISAST/29942/2017 through national funds and by FEDER through COMPETE 2020 (ref. POCI010145 FEDER007672). F.J. acknowledges Jean Luc Plouvier for his help. S.J.F. and C.A. would like to thank the UCL student support observers: Helen Dai, Elise Darragh-Ford, Ross Dobson, Max Hipperson, Edward Kerr-Dineen, Isaac Langley, Emese Meder, Roman Gerasimov, Javier Sanjuan, and Manasvee Saraf. We are grateful to the CAHA, OSN and La Hita Observatory staffs. This research is partially based on observations collected at Centro Astronomico HispanoAleman (CAHA) at Calar Alto, operated jointly by Junta de Andalucia and Consejo Superior de Investigaciones Cientificas (IAA-CSIC). This research was also partially based on observation carried out at the Observatorio de Sierra Nevada (OSN) operated by Instituto de Astrofisica de Andalucia (CSIC). This article is also based on observations made with the Liverpool Telescope operated on the island of La Palma by Liverpool John Moores University in the Spanish Observatorio del Roque de los Muchachos of the Instituto de Astrofisica de Canarias with financial support from the UK Science and Technology Facilities Council. Partially based on observations made with the Tx40 and Excalibur telescopes at the Observatorio Astrofisico de Javalambre in Teruel, a Spanish Infraestructura Cientifico-Tecnica Singular (ICTS) owned, managed and operated by the Centro de Estudios de Fisica del Cosmos de Aragon (CEFCA). Tx40 and Excalibur are funded with the Fondos de Inversiones de Teruel (FITE). A.R.R. would like to thank Gustavo Roman for the mechanical adaptation of the camera to the telescope to allow for the observation to be recorded. R.H., J.F.R., S.P.H. and A.S.L. have been supported by the Spanish projects AYA2015-65041P and PID2019-109467GB-100 (MINECO/FEDER, UE) and Grupos Gobierno Vasco IT1366-19. Our great thanks to Omar Hila and their collaborators in Atlas Golf Marrakech Observatory for providing access to the T60cm telescope. TRAPPIST is a project funded by the Belgian Fonds (National) de la Recherche Scientifique (F.R.S.-FNRS) under grant PDR T.0120.21. TRAPPIST-North is a project funded by the University of Liege, and performed in collaboration with Cadi Ayyad University of Marrakesh. E.J. is a FNRS Senior Research Associate.Context. A stellar occultation by Neptune's main satellite, Triton, was observed on 5 October 2017 from Europe, North Africa, and the USA. We derived 90 light curves from this event, 42 of which yielded a central flash detection. Aims. We aimed at constraining Triton's atmospheric structure and the seasonal variations of its atmospheric pressure since the Voyager 2 epoch (1989). We also derived the shape of the lower atmosphere from central flash analysis. Methods. We used Abel inversions and direct ray-tracing code to provide the density, pressure, and temperature profiles in the altitude range similar to 8 km to similar to 190 km, corresponding to pressure levels from 9 mu bar down to a few nanobars. Results. (i) A pressure of 1.18 +/- 0.03 mu bar is found at a reference radius of 1400 km (47 km altitude). (ii) A new analysis of the Voyager 2 radio science occultation shows that this is consistent with an extrapolation of pressure down to the surface pressure obtained in 1989. (iii) A survey of occultations obtained between 1989 and 2017 suggests that an enhancement in surface pressure as reported during the 1990s might be real, but debatable, due to very few high S/N light curves and data accessible for reanalysis. The volatile transport model analysed supports a moderate increase in surface pressure, with a maximum value around 2005-2015 no higher than 23 mu bar. The pressures observed in 1995-1997 and 2017 appear mutually inconsistent with the volatile transport model presented here. (iv) The central flash structure does not show evidence of an atmospheric distortion. We find an upper limit of 0.0011 for the apparent oblateness of the atmosphere near the 8 km altitude.Portuguese Foundation for Science and Technology SFRH/BD/131700/2017European Social Fund (ESF) SFRH/BD/131700/2017European Research Council under the European Community's H2020 2014-2021 ERC grant 669416Spanish Government SEV-2017-0709 AYA-2017-84637-R AYA-RTI2018-098657-J-I00Junta de Andalucia 2012-FQM1776European Union's Horizon 2020 Research and Innovation Programme, as part of the project "Small Bodies Near and Far" (SBNAF) 687378Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ)Fundacao de Apoio a Pesquisa do Distrito Federal (FAPDF) 309578/2017-5 304544/2017-5 401903/2016-8 308150/2016-3 305917/2019-6 427700/2018-3 310683/2017-3 473002/2013-2Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) 001Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ) 465376/2014-2 CAPES-FAPERJ/PAPDRJ grant E26/203.173/2016 CAPES-PRINT/UNESP grant 88887.571156/2020-00Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio De Janeiro (FAPERJ) E26/111.488/2013Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) 2018/11239-8Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ) 150612/2020-6European Union's Horizon 2020 research and innovation programme 730890Regional Government of the Aosta ValleyTown Municipality of NusUnite des Communes valdotaines Mont-EmiliusPlanetary SocietyFondazione CRT-Cassa di Risparmio di TorinoPortuguese Foundation for Science and Technology PTDC/FISAST/29942/2017FEDER through COMPETE 2020 POCI010145 FEDER007672UK Research & Innovation (UKRI)Science & Technology Facilities Council (STFC)Fondos de Inversiones de Teruel (FITE)Spanish Government AYA2015-65041P PID2019-109467GB-100Grupos Gobierno Vasco IT1366-19Fonds de la Recherche Scientifique - FNRS PDR T.0120.21University of LiegeCAPES/Cofecub-394/2016-0

BSA-capped gold nanoclusters as potential theragnostic for skin diseases: Photoactivation, skin penetration, in vitro, and in vivo toxicity

BSA-capped gold nanoclusters are promising theragnostic systems that can be excited to render both fluorescence emission and reactive oxygen species. Although their synthesis and photoluminescence properties are already well described, more accurate information about their use as photosensitizers is required in order to advance towards health applications. In this work, we have obtained BSA-capped gold nanoclusters and characterized their photophysics by different techniques. Singlet oxygen production was detected upon irradiation, which was enough to produce toxicity on two cell lines. Remarkably, an internal energy transfer, probably due to the presence of smaller nanoclusters and the contribution of oxidized residues of BSA in the system, caused fluorescence emission near 640 nm after excitation in the UV range. Additionally, the system was capable of penetrating human skin beyond the stratum corneum, which enhances the potential of these nanoclusters as bifunctional photodynamic therapy effectors and biomarkers with application in a diversity of skin diseases. In the absence of radiation, BSA-capped gold nanoclusters did not cause toxicity in vitro, while their toxic effect on an in vivo model as zebrafish was determined.Fil: Lillo, Rolando Cristian Rodrigo. Universidad Nacional de San Martin. Instituto de Nanosistemas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; ArgentinaFil: Calienni, Maria Natalia. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología - Universidad Nacional de Quilmes - GBEyB | Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología - Universidad Nacional de Quilmes - GBEyB | Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología - Universidad Nacional de Quilmes - GBEyB; ArgentinaFil: Rivas Aiello, Maria Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; ArgentinaFil: Prieto, Maria Jimena. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología - Universidad Nacional de Quilmes - GBEyB | Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología - Universidad Nacional de Quilmes - GBEyB | Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología - Universidad Nacional de Quilmes - GBEyB; ArgentinaFil: Rodriguez, Damian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; ArgentinaFil: Tuninetti, Jimena Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; ArgentinaFil: Toledo, Pamela Ludmila. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología - Universidad Nacional de Quilmes - GBEyB | Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología - Universidad Nacional de Quilmes - GBEyB | Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología - Universidad Nacional de Quilmes - GBEyB; ArgentinaFil: Alonso, Silvia del Valle. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología - Universidad Nacional de Quilmes - GBEyB | Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología - Universidad Nacional de Quilmes - GBEyB | Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología - Universidad Nacional de Quilmes - GBEyB; ArgentinaFil: Moya, Sergio Enrique. Centro de Investigación Cooperativa en Biomateriales; España. Centro de Investigación Cooperativa en Biomateriales; EspañaFil: Gonzalez, Monica Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; ArgentinaFil: Martinetti Montanari, Jorge Anibal. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología - Universidad Nacional de Quilmes - GBEyB | Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología - Universidad Nacional de Quilmes - GBEyB | Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología - Universidad Nacional de Quilmes - GBEyB; ArgentinaFil: Soler Illia, Galo Juan de Avila Arturo. Universidad Nacional de San Martin. Instituto de Nanosistemas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin

Health care seeking for Childhood Diarrhea in Developing Countries: Evidence from Seven Sites in Africa and Asia

We performed serial Health Care Utilization and Attitudes Surveys (HUASs) among caretakers of children ages 0–59 months randomly selected from demographically defined populations participating in the Global Enteric Multicenter Study (GEMS), a case-control study of moderate-to-severe diarrhea (MSD) in seven developing countries. The surveys aimed to estimate the proportion of children with MSD who would present to sentinel health centers (SHCs) where GEMS case recruitment would occur and provide a basis for adjusting disease incidence rates to include cases not seen at the SHCs. The proportion of children at each site reported to have had an incident episode of MSD during the 7 days preceding the survey ranged from 0.7% to 4.4% for infants (0–11 months of age), from 0.4% to 4.7% for toddlers (12–23 months of age), and from 0.3% to 2.4% for preschoolers (24–59 months of age). The proportion of MSD episodes at each site taken to an SHC within 7 days of diarrhea onset was 15–56%, 17–64%, and 7–33% in the three age strata, respectively. High cost of care and insufficient knowledge about danger signs were associated with lack of any care-seeking outside the home. Most children were not offered recommended fluids and continuing feeds at home. We have shown the utility of serial HUASs as a tool for optimizing operational and methodological issues related to the performance of a large case-control study and deriving population-based incidence rates of MSD. Moreover, the surveys suggest key targets for educational interventions that might improve the outcome of diarrheal diseases in low-resource settings

Tectonic Plates Come Apart at the Seams

Around the time that the first birds evolved from their reptilian ancestors, between 100 million and 200 million years ago, the Atlantic Ocean was being born. Its creation marked the destruction of the supercontinent Pangea, in which all the land on Earth formed a gigantic, unbroken island surrounded by a worldwide sea

Origin of the Rheic Ocean: Rifting along a Neoproterozoic suture?

The Rheic Ocean is widely believed to have formed in the Late Cambrian–Early Ordovician as a result of the drift of peri-Gondwanan terranes, such as Avalonia and Carolina, from the northern margin of Gondwana, and to have been consumed in the Devonian Carboniferous by continent-continent collision during the formation of Pangea. Other peri-Gondwanan terranes (e.g., Armorica, Ossa-Morena, northwest Iberia, Saxo-Thuringia, Moldanubia) remained along the Gondwanan margin at the time of Rheic Ocean formation. Differences in the Neoproterozoic histories of these peri-Gondwanan terranes suggest the location of the Rheic Ocean rift may have been inherited from Neoproterozoic lithospheric structures formed by the accretion and dispersal of peri-Gondwanan terranes along the northern Gondwanan margin prior to Rheic Ocean opening. Avalonia and Carolina have Sm-Nd isotopic characteristics indicative of recycling of a juvenile ca. 1 Ga source, and they were accreted to the northern Gondwanan margin prior to voluminous late Neoproterozoic arc magmatism. In contrast, Sm-Nd isotopic characteristics of most other peri-Gondwanan terranes closely match those of Eburnian basement, suggesting they reflect recycling of ancient (2 Ga) West African crust. The basements of terranes initially rifted from Gondwana to form the Rheic Ocean were those that had previously accreted during Neoproterozoic orogenesis, suggesting the rift was located near the suture between the accreted terranes and cratonic northern Gondwana. Opening of the Rheic Ocean coincided with the onset of subduction beneath the Laurentian margin in its predecessor, the Iapetus Ocean, suggesting geodynamic linkages between the destruction of the Iapetus Ocean and the creation of the Rheic Ocean