Development of quality control parameters for the standardization of Leaves and bark of Sida acuta Burm.f

Sidha acuta Burm. f belonging to family Malvaceae is a terrestrial, erect shrub which is up to 155 cm tall. The plant is native to Mexico, Central America and Himalayan region of India but has spread throughout the tropics and subtropics. Sida acuta Burm. f is widely distributed in pantropical areas and is widely used as traditional medicine in many cases. Among illnesses the plant is may be used alone or in combinations with other plants to cure fever, skin diseases, snake bites, Hemorrhoids, impotency and for boils and eye cataracts. Although the plant has been screened and suggested for various therapeutic activities its photocomposition remained unrevealed because of very restricted amount of research work carried out. Thus it was thought worthwhile to explore this endangered plant on the basis of various standardization parameters. The present research work deals with the collection, identification, extraction, pharmacognosical and phytochemical investigation of Leaves of Sidha acuta Burm. f

Optimization Of Herbal Drug Formulations For Syzygium Cumini (Linn) Extracts: Enhancing Antidiabetic And Antioxidant Properties.

The prevalence of diabetes and its associated complications continues to rise globally, creating a pressing need for effective and safe therapeutic approaches. Herbal remedies have gained significant attention as potential adjuncts or alternatives to conventional diabetes management. Syzygium cumini (Linn), commonly known as Jamun or Indian blackberry, possesses established antidiabetic and antioxidant properties. This research paper aims to optimize herbal drug formulations using Syzygium cumini extracts to enhance their antidiabetic and antioxidant effects. The study will involve extraction optimization, formulation development, and evaluation of the final products for potential therapeutic application

Synergistic Enzyme Cocktail to Enhance Hydrolysis of Steam Exploded Wheat Straw at Pilot Scale

Multiple enzymes are required for efficient hydrolysis of lignocellulosic biomass and no wild type organism is capable of producing all enzymes in desired levels. In this study, steam explosion of wheat straw was carried out at pilot scale and a synthetic enzyme mixture (EnzMix) was developed by partially replacing the cellulase with critical dosages of commercially available accessory enzymes (β-glucosidase, xylanase and laccase) through central composite design. Highest degree of synergism (DS) was observed with β-glucosidase (1.68) followed by xylanase (1.36). Finally, benchmarking of EnzMix (Celluclast, β-glucosidase and xylanase in a protein ratio of 20.40: 38.43: 41.16, respectively) and other leading commercial enzymes was carried out. Interestingly, hydrolysis improved by 75% at 6 h and 30% at 24 h, respectively in comparison of control. By this approach, 25% reduction in enzyme dosage was observed for obtaining the same hydrolysis yield with opitimized enzyme cocktail. Thus, development of enzyme cocktail is an effective and sustainable approach for high hydrolysis efficiency

TRANSDERMAL DRUG DELIVERY AS A BOON

Majority of the drugs are taken by the oral route but it is not effective. To improve the effectiveness a route emerged known as Transdermal route. This give rise to Transdermal drug delivery system. Transdermal drug delivery systems (TDDS) are dosage forms that involves drug transport to viable epidermal or dermal tissues of the skin for therapeutic effect while a major fraction of drug is transported into the systemic blood circulation. Transdermal drug delivery can be improved by the use of involves the use of penetration enhancers which penetrate into skin to reversibly reduce the barrier resistance. Transdermal delivery have various advantages such as avoidance of presystemic and systemic first pass metabolism ,controlled release, provides non-invasive and easily terminable means for systemic as well as topical drug delivery. This article provides an overview of TDDS, its advantages over conventional dosage forms, drug delivery routes across skin, penetration enhancers, various components of Transdermal patches, types of Transdermal patches, methods of preparation, methods of evaluation, marketed preparations