An alternative origin for nanobacteria in kidney stones

Small (50e200 nm), calcium phosphate (apatite)-covered organic particles called nanobacteria or calcifying nanoparticles (CNP) seem to be ubiquitous in kidney stones and are thought to be involved in stone formation. Although initial claims that these particles are the smallest known life forms have been somewhat softened, much controversy remains as to their involvement in kidney stone formation as well as in other pathological calcifications. I suggest that such particles are non-living and may be formed during the normal living activities of bona-fide bacteria which inhabit the kidneys. This hypothesis is based on previous observations that bacteria immersed in a supersaturated fluid produce organic globules which calcify when released to the surrounding fluid, forming CNP-like particles. The possibility that this process is responsible for the formation of CNP associated with pathological calcifications deserves greater scrutiny

The theoretical and practical value of the OECD policy advice for education

This research seeks to evaluate the policy advice on educational matters provided by the Organisation for Economic Co-operation and Development (OECD), particularly through its Programme for International Student Assessment (PISA). The thesis assesses the “value” of the OECD education policy advice (EPA), that is, whether the EPA is advice worth following because there is evidence that it could help or has helped countries to achieve the goals of greater quality and equity in education. Firstly, a multi-agent practical reasoning model and political discourse analysis are applied to OECD publications to extract education policy recommendations. The EPA is thus comprehensively reconstructed, summarised and organised. The EPA is analysed in terms of its internal coherence, its consistency over time and over publications, as well as its soundness: whether there is empirical evidence that what the OECD suggests that countries should do could work in principle. In the second part of the thesis, evidence of effective EPA-aligned country policies is sought using national and cross-national level data and a mixed-methods approach. From a cross-national perspective, country alignment with the EPA is analysed by collecting 61 expert judgements from 30 PISA countries using a specifically-developed online questionnaire. The plausible impact of EPA-aligned policies is inferred by applying multilevel growth models to PISA trends in performance and equity. The cross-country analysis is complemented by two case studies: The Republic of Ireland and the French Community of Belgium. Data on 50 policies is collected from more than 800 policy documents and through 25 semi-structured expert interviews carried out over two study visits. Policy alignment is analysed with a visual adaptation of the delta-convergence method to account for qualitative data. The effectiveness of EPA-aligned policies is evaluated using a framework developed by Prof J. Douglas Willms and adopted by the OECD, as well as national evaluation reports

Reference charts for fetal cerebellar vermis height: A prospective cross-sectional study of 10605 fetuses

A prospective cross-sectional study between September 2009 and December 2014 was carried out at ALTAMEDICA Fetal–Maternal Medical Centre, Rome, Italy. Of 25203 fetal biometric measurements, 12167 (48%) measurements of the cerebellar vermis were available. After excluding 1562 (12.8%) measurements, a total of 10605 (87.2%) fetuses were considered and analyzed once only. Parametric and nonparametric quantile regression models were used for the statistical analysis. In order to evaluate the robustness of the proposed reference charts regarding various distributional assumptions on the ultrasound measurements at hand, we compared the gestational age-specific reference curves we produced through the statistical methods used. Normal mean height based on parametric and nonparametric methods were defined for each week of gestation and the regression equation expressing the height of the cerebellar vermis as a function of gestational age was calculated. Finally the correlation between dimension/gestation was measured

Multi-Epoch HST Observations of IZw18: Characterization of Variable Stars at Ultra-Low Metallicities

Variable stars have been identified for the first time in the very metal-poor Blue Compact dwarf galaxy IZw18, using deep multi-band (F606W, F814W)time-series photometry obtained with the Advanced Camera for Surveys (ACS) on board the Hubble Space Telescope (HST). We detected 34 candidate variable stars in the galaxy. We classify three of them as Classical Cepheids, with periods of 8.71, 125.0 and 130.3 days, respectively, and other two as long period variables with periodicities longer than a hundred days. These are the lowest metallicity Classical Cepheids known so far, thus providing the opportunity to explore and fit models of stellar pulsation fo Classical Cepheids at previously inaccessible metallicities. The period distribution of the confirmed Cepheids is markedly different from what is seen in other nearby galaxies, which is likely related to the star bursting nature of IZw18. By applying to the 8.71 days Cepheid theoretical Wesenheit (V,I) relations based on new pulsation models of Classical Cepheids specifically computed for the extremely low metallicity of this galaxy (Z=0.0004, Y=0.24), we estimate the distance modulus of IZw18 to be mu_0= 31.4pm0.2 D=19.0^{+1.8}_{-1.7}Mpc) for canonical models of Classical Cepheids, and of 31.2pm0.2 mag (D=17.4^{+1.6}_{-1.6}Mpc) using over luminous models. The theoretical modeling of the star's light curves provides mu_0=31.4pm0.1 mag, D=19.0^{+0.9}_{-0.9} Mpc, in good agreement with the results from the theoretical Wesenheit relations. These pulsation distances bracket the distance of 18.2pm1.5Mpc inferred by Aloisi et al. (2007) using the galaxy's Red Giant Branch Tip.Comment: 13 Pages, 6 Figures, accepted, Ap

Chemical abundances and properties of the ionized gas in NGC 1705

We obtained [O III] narrow-band imaging and multi-slit MXU spectroscopy of the blue compact dwarf (BCD) galaxy NGC 1705 with FORS2@VLT to derive chemical abundances of PNe and H II regions and, more in general, to characterize the properties of the ionized gas. The auroral [O III]\lambda4363 line was detected in all but one of the eleven analyzed regions, allowing for a direct estimate of their electron temperature. The only object for which the [O III]\lambda4363 line was not detected is a possible low-ionization PN, the only one detected in our data. For all the other regions, we derived the abundances of Nitrogen, Oxygen, Neon, Sulfur and Argon out to ~ 1 kpc from the galaxy center. We detect for the first time in NGC 1705 a negative radial gradient in the oxygen metallicity of -0.24 \pm 0.08 dex kpc^{-1}. The element abundances are all consistent with values reported in the literature for other samples of dwarf irregular and blue compact dwarf galaxies. However, the average (central) oxygen abundance, 12 + log(O/H)=7.96 \pm 0.04, is ~0.26 dex lower than previous literature estimates for NGC 1705 based on the [O III]\lambda4363 line. From classical emission-line diagnostic diagrams, we exclude a major contribution from shock excitation. On the other hand, the radial behavior of the emission line ratios is consistent with the progressive dilution of radiation with increasing distance from the center of NGC 1705. This suggests that the strongest starburst located within the central $\sim$150 pc is responsible for the ionization of the gas out to at least $\sim$1 kpc. The gradual dilution of the radiation with increasing distance from the center reflects the gradual and continuous transition from the highly ionized H II regions in the proximity of the major starburst into the diffuse ionized gas.Comment: Accepted for publication on A