Progesterone fate in rabbit cornea

1. 1. Excised cornea from adult New Zealand rabbits were incubated with progesterone-4-14C in Eagle's media for 96 hr. Samples were inactivated at intervals of 24 hr incubation periods. The following metabolites of progesterone were isolated: 2. 2. 20?-Hydroxy-4-pregnen-3-one, 20-hydroxy-4-pregnen-3-one, 5?-pregnane-3,20-dione; 5?-pregnane-3,20-dione and 6?-hydroxy-4-pregnen-3,20-dione. 3. 3. 20?-Hydroxy-pregnen-3-one was the predominant metabolite of progesterone-4-14C. A linear increase was observed throughout 96 hr. The opposite was found for 5? and 5? pregnane-3,20-dione. 4. 4. Compounds remaining at the origin of the paper chromatograms contained 6?-hydroxy-4-pregnen-3,20-dione and other still unidentified metabolites of progesterone-4-14C. 5. 5. Presence of 20? and 20?-reductase; 5? and 5?-reductase and 6?-hydroxylase enzyme systems are involved in corneal progesterone metabolism. 6. 6. No fungal neither bacterial enzymatic biotransformation occurred in the culture media. � 1987

Synthesis of 1-benzyl-3-[4-(aryl-1-piperazinyl) carbonyl]-1H-indoles. Novel ligands with potential D4 dopaminergic activity

Artículo de publicación ISIThe synthesis of a series of functionalized 1-Benzyl-3-[4-Aryl-1-piperazingl]carbonyl-1H-Indoles 6(a-f), as a potential new class of bioactive ligands at D4 receptors is reported. The synthetic strategy took place through a five steps sequence to provide indole amides 6(a-f) in 75-92% yield.PROYECTO FONDECYT 109016