Convergence of the Crank-Nicolson-Galerkin finite element method for a class of nonlocal parabolic systems with moving boundaries

The aim of this paper is to establish the convergence and error bounds to the fully discrete solution for a class of nonlinear systems of reaction-diffusion nonlocal type with moving boundaries, using a linearized Crank-Nicolson-Galerkin finite element method with polynomial approximations of any degree. A coordinate transformation which fixes the boundaries is used. Some numerical tests to compare our Matlab code with some existing moving finite elements methods are investigated

NMR studies of transiente protein complexes

Dissertação apresentada para obtenção do Grau de Doutor em Bioquímica,especialidade Bioquímica Física,pela Universidade Nova de Lisboa,Faculdade de Ciências e TecnologiaFundação para a Ciência e Tecnologia - Bolsa de Doutoramento (SFRH/BD/25342/2005)no âmbito do Programa Operacional Potencial Humano, da União Europeia (Fundo Social Europeu

On a nonlocal degenerate parabolic problem

Conditions for the existence and uniqueness of weak solutions for a class of nonlinear nonlocal degenerate parabolic equations are established. The asymptotic behaviour of the solutions as time tends to infinity are also studied. In particular, the finite time extinction and polynomial decay properties are proved

Bluetooth hotspots for smart spaces interaction

We may find in the market many smart space applications and projects which are using Bluetooth services as mechanism for user-interaction. However, their ad-hoc implementation come as a limitation to their deployment in a global interactive model. This survey focuses on the requirements of such applications, systematizing their interaction models and presents the main key design of a middleware component for Bluetooth interaction-based pervasive applications, running on Linux routers

Project management guide for student project teams

Project based learning is a methodology based on students’ teams developing interdisciplinary work to deliver an outcome as a result of a project. The engineering students’ teams when performing project work have to adopt project management methodologies. Assuming that the quality of the results on project work is also dependent on the project management methodology applied and that project management is one of the competencies to be developed during engineering degrees, this paper presents a project management guide to be followed by students’ teams involved in large projects. This project management methodology is the result of the experience of students and teachers involved in project based learning practices in the last 6 years in the engineering school at the University of Minho

Transthyretin mutagenesis: impact on amyloidogenesis and disease

Funding This work was supported by COMPETE and CENTRO-202010. 13039/501100011929 and by Fundação para a Ciência e a Tecnologia (FCT) through grants UIDB/00313/2020 and UIDP/00313/2020 (to Coimbra Chemistry Center, University of Coimbra) and doctoral fellowship SFRH/BD/137991/2018 (to Z.L.A.).Transthyretin (TTR), a homotetrameric protein found in plasma, cerebrospinal fluid, and the eye, plays a pivotal role in the onset of several amyloid diseases with high morbidity and mortality. Protein aggregation and fibril formation by wild-type TTR and its natural more amyloidogenic variants are hallmarks of ATTRwt and ATTRv amyloidosis, respectively. The formation of soluble amyloid aggregates and the accumulation of insoluble amyloid fibrils and deposits in multiple tissues can lead to organ dysfunction and cell death. The most frequent manifestations of ATTR are polyneuropathies and cardiomyopathies. However, clinical manifestations such as carpal tunnel syndrome, leptomeningeal, and ocular amyloidosis, among several others may also occur. This review provides an up-to-date listing of all single amino-acid mutations in TTR known to date. Of approximately 220 single-point mutations, 93% are considered pathogenic. Aspartic acid is the residue mutated with the highest frequency, whereas tryptophan is highly conserved. “Hot spot” mutation regions are mainly assigned to β-strands B, C, and D. This manuscript also reviews the protein aggregation models that have been proposed for TTR amyloid fibril formation and the transient conformational states that convert native TTR into aggregation-prone molecular species. Finally, it compiles the various in vitro TTR aggregation protocols currently in use for research and drug development purposes. In short, this article reviews and discusses TTR mutagenesis and amyloidogenesis, and their implications in disease onset.info:eu-repo/semantics/publishedVersio