Distinguishing the effect of diapir growth on magnetic fabrics of syn-diapiric overburden rocks: Basque-Cantabrian basin, Northern Spain

An analysis of Anisotropy of Magnetic Susceptibility was done on Aptian–Albian sediments from the Basque–Cantabrian basin. Samples were collected from 39 sites in the halokinetic sequences of the Bakio, Bermeo, Guernica and Mungia diapirs; 28 sites were sampled close to diapirs, and 11 sites were far from the diapir edges. The magnetic foliation is parallel to bedding, suggesting it reflects depositional and compaction processes, whereas the orientation of magnetic lineation varies. Far from the diapir edges, the magnetic lineation is interpreted as being related to the regional Pyrenean compression. Close to diapir edges, the observed behaviour shows that diapirs, predominantly formed by rigid ophites, have acted as buttresses, with shadow areas at their northern faces being protected from the Pyrenean compression. The high sensitivity of AMS makes it a very useful tool to distinguish deformation in halokinetic sequences related to diapir growth from that related to subsequent compression.Funding came from projects CGL2014-54118-C2-1-R and CGL2014-54118-C2-2-R (Spanish Ministry).Peer reviewe

Datos paleomagnéticos en materiales sin-diapíricos Aptienses-Albienses (cuenca Vasco-Cantábrica, N Iberia)

In order to obtain a kinematic model linking the diapir formation and the geometry of the syn-diapir sediments, a paleomagnetic study has been conducted in selected syn-diapiric sequences of the Basque-Cantabrian Basin. The studied diapirs (Bakio, Bermeo, Guernika and Mungia) developed during the Early Cretaceous in relation to the North Iberian extensional margin which was subsequently reactivated during the Pyrenean contractional deformation (Late Cretaceous-Miocene). They are cored by Triassic red clays and evaporites and they are flanked by synkinematic Albian shelf and slope carbonates and Upper Albian to Cenomanian siliciclastics. The paleomagnetic study has focused on the synkinematic overburden to detect and quantify vertical axis rotations related to the growth of the diapirs. 29 paleomagnetic sites have been analyzed. After obtaining the site mean directions it can be concluded that most of the sites are remagnetized, hindering the kinematics of the diapirs growth to be deduced. The age of this remagnetization is difficult to assess, it could be either an earlier Albian-Maastrichtian remagnetization or a remagnetization linked to the Pyrenean compression.Trabajo financiado gracias a los proyectos coordinados CGL2014-54118-C2-1-R y CGL2014-54118-C2-2-R y al GGAC 2014SGR467Peer Reviewe

Barred-beach morphological control on infragravity motion

A conceptual analysis of the coupling between bars and infragravity waves is performed combining laboratory experiments and numerical modeling. Experiments are carried out in a wave flume with a barred profile. The Boussinesq fully-nonlinear model SERR1D is validated with the laboratory data and a sensitivity analysis is performed next to study the influence on the infragravity wave dynamics of bar amplitude and location, and swash zone slope. A novel technique of incident and reflected motions separation that conserves temporal characteristics is applied. We observe that changing bar characteristics induces substantial variations in trapped energy. Interestingly, a modification of swash zone slope has a large influence on the reflected component, controlling amplitude and phase time-lag, and consequently on the resonant pattern. Variations of trapped infragravity energy induced by changes of swash zone slope reach 25 %. These changes in infragravity pattern consequently affect short-wave dynamics by modifying the breakpoint location and the breaking intensity. Our conceptual investigation suggests the existence of a morphological feedback through the action of evolving morphology on infragravity structures which modulates the action of short-waves on the morphology itself

Modelling Cross-Shore Shoreline Change on Multiple Timescales and Their Interactions

In this paper, a new approach to model wave-driven, cross-shore shoreline change incorporating multiple timescales is introduced. As a base, we use the equilibrium shoreline prediction model ShoreFor that accounts for a single timescale only. High-resolution shoreline data collected at three distinctly different study sites is used to train the new data-driven model. In addition to the direct forcing approach used in most models, here two additional terms are introduced: a time-upscaling and a time-downscaling term. The upscaling term accounts for the persistent effect of short-term events, such as storms, on the shoreline position. The downscaling term accounts for the effect of long-term shoreline modulations, caused by, for example, climate variability, on shorter event impacts. The multi-timescale model shows improvement compared to the original ShoreFor model (a normalized mean square error improvement during validation of 18 to 59%) at the three contrasted sandy beaches. Moreover, it gains insight in the various timescales (storms to inter-annual) and reveals their interactions that cause shoreline change. We find that extreme forcing events have a persistent shoreline impact and cause 57–73% of the shoreline variability at the three sites. Moreover, long-term shoreline trends affect short-term forcing event impacts and determine 20–27% of the shoreline variability.</jats:p

Changes in the use of anti-asthmatic medication in an international cohort

To access publisher full text version of this article. Please click on the hyperlink in Additional Links fieldThe aim of this study was to describe changes in pharmacotherapy for asthma since the early 1990s in an international cohort of young and middle-aged adults. A total of 28 centres from 14 countries participated in a longitudinal study. The study included 8,829 subjects with a mean follow-up time of 8.7 yrs. Change in the prevalence of use for medication was expressed as absolute net change (95% confidence interval) standardised to a 10-yr period. The use of anti-asthmatics was found to have increased by 3.1% (2.4-3.7%) and the prevalence of symptomatic asthma by 4.0% (3.5-4.5%). In the sample with asthma in both surveys (n=423), the use of inhaled corticosteroids increased by 12.2% (6.6-17.8%). Despite this, only 17.2% were using inhaled corticosteroids on a daily basis at follow-up. Females with continuous asthma were more likely, compared with males, and smokers with asthma, to have started using inhaled corticosteroids since the first survey. The use of anti-asthmatics has increased in a pattern consistent with current consensus on treatment. However, despite increased use of inhaled corticosteroids, a large majority of subjects with symptomatic asthma do not use this treatment on a daily basis, particularly males and smokers with asthma

Treatment challenges in and outside a network setting: Head and neck cancers

Head and neck cancer (HNC) is a rare disease that can affect different sites and is characterized by variable incidence and 5-year survival rates across Europe. Multiple factors need to be considered when choosing the most appropriate treatment for HNC patients, such as age, comorbidities, social issues, and especially whether to prefer surgery or radiation-based protocols. Given the complexity of this scenario, the creation of a highly specialized multidisciplinary team is recommended to guarantee the best oncological outcome and prevent or adequately treat any adverse effect. Data from literature suggest that the multidisciplinary team-based approach is beneficial for HNC patients and lead to improved survival rates. This result is likely due to improved diagnostic and staging accuracy, a more efficacious therapeutic approach and enhanced communication across disciplines. Despite the benefit of MTD, it must be noted that this approach requires considerable time, effort and financial resources and is usually more frequent in highly organized and high-volume centers. Literature data on clinical research suggest that patients treated in high-accrual centers report better treatment outcomes compared to patients treated in low-volume centers, where a lower radiotherapy-compliance and worst overall survival have been reported. There is general agreement that treatment of rare cancers such as HNC should be concentrated in high volume, specialized and multidisciplinary centers. In order to achieve this goal, the creation of international collaboration network is fundamental. The European Reference Networks for example aim to create an international virtual advisory board, whose objectives are the exchange of expertise, training, clinical collaboration and the reduction of disparities and enhancement of rationalize migration across Europe. The purpose of our work is to review all aspects and challenges in and outside this network setting planned for the management of HNC patients

Treatment challenges in and outside a specialist network setting: Pancreatic neuroendocrine tumours

Pancreatic Neuroendocrine Neoplasms comprise a group of rare tumours with special biology, an often indolent behaviour and particular diagnostic and therapeutic requirements. The specialized biochemical tests and radiological investigations, the complexity of surgical options and the variety of medical treatments that require individual tailoring, mandate a multidisciplinary approach that can be optimally achieved through an organized network. The present study describes currents concepts in the management of these tumours as well as an insight into the challenges of delivering the pathway in and outside a Network

Testicular germ-cell tumours and penile squamous cell carcinoma: Appropriate management makes the difference

Germ-cell tumours (GCT) of the testis and penile squamous cell carcinoma (PeSCC) are a rare and a very rare uro-genital cancers, respectively. Both tumours are well defined entities in terms of management, where specific recommendations - in the form of continuously up-to-dated guide lines-are provided. Impact of these tumour is relevant. Testicular GCT affects young, healthy men at the beginning of their adult life. PeSCC affects older men, but a proportion of these patients are young and the personal consequences of the disease may be devastating. Deviation from recommended management may be a reason of a significant prognostic worsening, as proper treatment favourably impacts on these tumours, dramatically on GCT and significantly on PeSCC. RARECAREnet data may permit to analyse how survivals may vary according to geographical areas, histology and age, leading to assume that non-homogeneous health-care resources may impact the cure and definitive outcomes. In support of this hypothesis, some epidemiologic datasets and clinical findings would indicate that survival may improve when appropriate treatments are delivered, linked to a different accessibility to the best health institutions, as a consequence of geographical, cultural and economic barriers. Finally, strong clues based on epidemiological and clinical data support the hypothesis that treatment delivered at reference centres or under the aegis of a qualified multi-institutional network is associated with a better prognosis of patients with these malignancies. The ERN EURACAN represents the best current European effort to answer this clinical need