9,929 research outputs found

    Stress Tensors of Multiparticle Collision Dynamics Fluids

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    Stress tensors are derived for the multiparticle collision dynamics algorithm, a particle-based mesoscale simulation method for fluctuating fluids, resembling those of atomistic or molecular systems. Systems with periodic boundary conditions as well as fluids confined in a slit are considered. For every case, two equivalent expressions for the tensor are provided, the internal stress tensor, which involves all degrees of freedom of a system, and the external stress, which only includes the interactions with the confining surfaces. In addition, stress tensors for a system with embedded particles are determined. Based on the derived stress tensors, analytical expressions are calculated for the shear viscosity. Simulations illustrate the difference in fluctuations between the various derived expressions and yield very good agreement between the numerical results and the analytically derived expression for the viscosity

    Tumbling of polymers in semidilute solution under shear flow

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    The tumbling dynamics of individual polymers in semidilute solution is studied by large-scale non-equilibrium mesoscale hydrodynamic simulations. We find that the tumbling time is equal to the non-equilibrium relaxation time of the polymer end-to-end distance along the flow direction and strongly depends on concentration. In addition, the normalized tumbling frequency as well as the widths of the alignment distribution functions for a given concentration-dependent Weissenberg number exhibit a weak concentration dependence in the cross-over regime from a dilute to a semidilute solution. For semidilute solutions a universal behavior is obtained. This is a consequence of screening of hydrodynamic interactions at polymer concentrations exceeding the overlap concentration

    A Parsec-Scale Study of the 5/15 GHz Spectral Indices of the Compact Radio Sources in M82

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    Observations of the starburst galaxy, M82, have been made with the VLA in its A-configuration at 15 GHz and MERLIN at 5 GHz enabling a spectral analysis of the compact radio structure on a scale of < 0.1'' (1.6 pc). Crucial to these observations was the inclusion of the Pie Town VLBA antenna, which increased the resolution of the VLA observations by a factor of ~2. A number of the weaker sources are shown to have thermal spectra and are identified as HII regions with emission measures ~10^7 cm^-6 pc. Some of the sources appear to be optically thick at 5 GHz implying even higher emission measures of ~10^8 cm^-6 pc. The number of compact radio sources in M82 whose origin has been determined is now 46, of which 30 are supernova related and the remaining 16 are HII regions. An additional 15 sources are noted, but have yet to be identified, meaning that the total number of compact sources in M82 is at least 61. Also, it is shown that the distribution of HII regions is correlated with the large-scale ionised gas distribution, but is different from the distribution of supernova remnants. In addition, the brightest HII region at (B1950) 09h 51m 42.21s +69 54' 59.2'' shows a spectral index gradient across its resolved structure which we attribute to the source becoming optically thick towards its centre.Comment: Accepted for publication in MNRAS. 15 pages, 9 figure

    The effect of multiple sclerosis on carotid baroreflex control of heart rate and blood pressure

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    Multiple sclerosis (MS) is marked by conduction abnormalities within the central nervous system that can lead to impaired blood pressure regulation. However, the impact of this disease on dynamic neural control—responsiveness and timing (i.e., latency)—of blood pressure has not been examined. Utilizing a variable neck chamber system, we tested the hypothesis that patients with MS (MS: n=4) exhibit an altered response following baroreflex perturbation compared to sex and age matched healthy controls (CON: n=4). At rest, 5-sec pulses of neck suction (NS; -60 Torr) and neck pressure (NP; +40 Torr) were applied to simulate carotid hypertension and hypotension, respectively. Mean arterial pressure (MAP; Finometer) and heart rate (HR) were continuously measured in response to the perturbations. Carotid baroreflex (CBR) latencies (i.e., time-to-peak responses) were examined using carotid-cardiac (peak HR responses), carotid-vasomotor (peak MAP responses), and change in MAP at the peak HR response of the corresponding stimuli (MAP@HRpeak), all of which were not significant for both NP and NS. Following NS, responses in MAP (MS: -12±5, CON: -10±3 mmHg; p=0.43) and HR (MS: -9±3, CON: -8±4 BPM; p=0.58) were similar between groups. Following administration of NP, HR responses (MS: 4±2, CON: 5±4 BPM; p=0.47) were no different. However, the differences found in MAP were significant (MS: 5±2, CON: 8±2 mmHg; p=0.05), providing some evidence that baroreceptor responsiveness may be compromised when faced with a hypotensive challenge

    HD 69686: A Mysterious High Velocity B Star

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    We report on the discovery of a high velocity B star, HD 69686. We estimate its space velocity, distance, surface temperature, gravity, and age. With these data, we are able to reconstruct the trajectory of the star and to trace it back to its birthplace. We use evolutionary tracks for single stars to estimate that HD 69686 was born 73 Myr ago in the outer part of our Galaxy (r∼12r \sim 12 kpc) at a position well below the Galactic plane (z∼−1.8z \sim -1.8 kpc), a very unusual birthplace for a B star. Along the star's projected path in the sky, we also find about 12 other stars having similar proper motions, and their photometry data suggest that they are located at the same distance as HD 69686 and probably have the same age. We speculate on the origin of this group by star formation in a high velocity cloud or as a Galactic merger fragment.Comment: 28 pages, 6 figures, accepted for publication in Ap

    Segmentation and Recent rupture history of the Xianshuihe Fault, Southwestern China

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    Tibetan Plateau in western Sichuan Province, China, is one of the world's most active faults, having produced at least 8 earthquakes of M ≥ 7 since 1725 on a 350-km-long segment of the fault. In the more limited 150-km long northern segment including Luhuo and Daofu, 5 earthquakes of M ≥ 6.9 have occurred during the past 100 years alone, with well documented overlapping surface ruptures. Some of these events were remarkably similar in magnitude and location to earlier historic events, suggesting that the characteristic earthquake model may apply here. No obvious geometric segmentation characterizes the smoothly curving Luhuo-Daofu sector, although its ends are marked by major left-stepping en echelon offsets that have also been the terminating points of individual earthquake ruptures. Minor en echelon offsets and bends within this segment are associated with local vertical relief, and one 9° bend is located close to the epicenter of the 1973 Luhuo earthquake (M = 7.6). In the southern sector of the Xianshuihe fault, south of Qianning, the faults splits into several branches, one of which broke over its entire 27-km length during the 1955 Kangding earthquake (M = 7.5). The main fault near Kangding is characterized by a series of restraining and releasing bends, associated with corresponding topography, and these bends may be related to the fact that this southern segment of the fault seems to be characterized by infrequent great earthquakes (e.g., M = 7-3/4 in 1786) rather than by more frequent moderate earthquakes (M = ± 7) such as those that characterize the straighter and more continuous Luhuo-Daofu sector to the north. Continuing creep has been documented along some segments of the fault, and this, together with its high degree of activity, superb high-altitude exposures, and other unique attributes, make the Xianshuihe fault one of the most promising sites in the world for earthquake-prediction, hazard-evaluation, and segmentation studies

    Electronic collection system for spacelab mission timeline requirements

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    This paper describes the Functional Objective Requirements Collection System (FORCS) software tool that has been developed for use by Principal Investigators (PI's) and Payload Element Developers (PED's) on their own personal computers to develop on-orbit timelining requirements for their payloads. The FORCS tool can be used either in a totally stand-alone mode, storing the information in a local file on the user's personal computer hard disk or in a remote mode where the user's computer is linked to a host computer containing the integrated database of the timeline requirements for all of the payloads on a mission. There are a number of features incorporated in the FORCS software to assist the user. The user may move freely back and forth between the various forms for inputting the data. Several methods are used to input the information, depending on the type of the information. These methods range from filling in text boxes, using check boxes and radio buttons, to inputting information into a spreadsheet format. There are automated features provided to assist in developing the proper format for the data, ranging from limit checking on some of the parameters to automatic conversion of different formats of time data inputs to the one standard format used for the timeline scheduling software

    Kalirin Decreases Bone Mass Through Effects in Both Osteoclasts and Osteoblasts

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    poster abstractBone homeostasis is maintained by the balance between osteoclasts which degrade bone and osteoblasts, which form new bone. When the activity of either of these cells is dysregulated, bone loss can ensue, leading to osteoporosis, a disease characterized by low bone mass and an increase in bone fragility and risk of fracture. The activity of osteoclasts and osteoblasts is regulated by local and systemic factors, as well as by key signaling proteins expressed in these cells. Kalirin is a novel GTP-exchange factor protein that plays a role in signaling pathways leading to cytoskeletal remodeling and dendritic spine formation in neurons, but its function in other cells is unknown. Western blotting and real time PCR confirmed that Kalirin is expressed in osteoclasts and osteoblasts, suggesting it may play a role in regulating bone cell function and bone mass. We used micro-CT to examine the bone phenotype of 14 week old female mice lacking Kalirin in all tissues (Kal-KO). Kal-KO mice exhibited a 40% lower trabecular bone volume in the distal femur compared to wild-type (WT) mice (n=9/group, p<0.05). We next quantified osteoclasts in histological sections by counting multinucleated cells expressing tartrate-resistant acid phosphatase (TRAP), a marker of mature osteoclasts. We found 48% higher osteoclast surface/bone surface in trabecular bone of Kal-KO mice, compared to WT mice (n=6/group, p<0.05). Osteoclast differentiation is controlled by osteoblasts, which secrete receptor activator of NF-kB ligand (RANKL), macrophage colony stimulating factor (MCSF) and osteoprotegerin (OPG), a decoy receptor for RANKL. We examined if Kalirin could regulate osteoclast differentiation in vitro. Osteoclasts were generated from the bone marrow of WT or Kal-KO mice by incubation with RANKL and MCSF for 7 days, and TRAP+ multinucleated cells were counted. Consistent with our in vivo studies, osteoclast number was significantly higher in cultures from Kal-KO mice, compared to WT mice. We next examined if Kalirin altered the ratio of secreted RANKL and OPG secreted by osteoblasts. Osteoblasts were generated from the calvaria of 2 day old neonates and the level of secreted RANKL and OPG in conditioned media was quantified by ELISA. Consistent with increased osteoclast differentiation, we found a higher RANKL/OPG ratio in conditioned media from Kal-KO osteoblasts, compared to WT cells. These data confirm a role for Kalirin in the regulation of trabecular bone mass through effects in both osteoclasts and osteoblasts

    Segmentation, Geometric Features, and their Seismotectonic Implications for the Holocene Xianshuihe Fault Zone

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    The Holocene Xianshuihe fault zone, which consists of five main branches with left-lateral strike-slip, can be divided into two segments of different structural styles, jointing at the pull-apart area of Huiyuan Monastery. The northwestern segment has a relatively simple structure. While the southeastern segment exhibits a complex structure composed of several branches. The segmentation of fault structure is the main cause of the different historic strong-earthquake activity, and perhaps, the spatial variation of recent fault slip-rates in different segments. The "multiple-order en echelon" pattern is one of the important geometric characteristics of the fault zone. Based on sizes of stepovers, orders of en echelon discontinuities have been relatively classified. Of which, a left-stepping discontinuity in the order A en echelon, which is apparently accompanied with topographic effect of pull-apart structure, has been taken as the dividing point of the segmentation of the fault zone. This discontinuity is also reflected in stopping surficial ruptures during historic earthquakes with approximate magnitude 7. Stepping discontinuities in en echelon faults of the order B and C also have topographic effects to a certain degree, but do not appear to have been significant in stopping large-earthquake ruptures. The earthquake ground-fissures developed within the Quaternary cover are mainly in forms of even lower order of en echelons. Bending is another important geometric characteristics of the fault zone. Along-strike bends at different degrees occur along the entire fault zone and some parts of faults. Local bends along a fault is the main geometric causes for unsymmetrical rupture-spreading and intensity-attenuating during large earthquakes, and perhaps, one of the tectonic backgrounds for recurrences of large or strong earthquakes at the same localities. Finally, three-dimensional models for the source faults of two large historic earthquakes have been analysed and discussed
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