Epigenetic activation of the FLT3 gene by ZNF384 fusion confers a therapeutic susceptibility in acute lymphoblastic leukemia.

FLT3 is an attractive therapeutic target in acute lymphoblastic leukemia (ALL) but the mechanism for its activation in this cancer is incompletely understood. Profiling global gene expression in large ALL cohorts, we identify over-expression of FLT3 in ZNF384-rearranged ALL, consistently across cases harboring different fusion partners with ZNF384. Mechanistically, we discover an intergenic enhancer element at the FLT3 locus that is exclusively activated in ZNF384-rearranged ALL, with the enhancer-promoter looping directly mediated by the fusion protein. There is also a global enrichment of active enhancers within ZNF384 binding sites across the genome in ZNF384-rearranged ALL cells. Downregulation of ZNF384 blunts FLT3 activation and decreases ALL cell sensitivity to FLT3 inhibitor gilteritinib in vitro. In patient-derived xenograft models of ZNF384-rearranged ALL, gilteritinib exhibits significant anti-leukemia efficacy as a monotherapy in vivo. Collectively, our results provide insights into FLT3 regulation in ALL and point to potential genomics-guided targeted therapy for this patient population

Biological Vestiges in American Psycho

In proposing that the use of violence as allegory in Bret Easton Ellis’s American Psycho is warranted, this essay challenges a popular reading of the text, one found in many critical articles, that proposes otherwise. Specifically, this essay will break the novel’s cast into three factions, with each faction having a biologically definable origin: representations of the past, representations of the present, and representation of an ambiguous territory in between. Jean serves to depict a time when people communicated on a level beyond that which is comprehensible to most Generation Xrs. She has been transplanted into the novel’s present from the past, to serve as a scientific control. Patrick’s colleagues and Wall Street competitors depict the novel’s present. They are fully evolved, fully invested in their contemporary capitalistic endeavors. Patrick exists as a mutant, stuck between generations. He retains vestiges of the past, alongside his otherwise insatiable desire for capitalistic success. It is his uncomfortable position that causes Patrick’s angst, and his murderous tendencies

USM Service-Learning Classes 2014-2022

A list of service-learning classes at The University of Southern Mississippi from 2014-2022, as reported to the Center for Community Engagement

A language-sensitive text editor for Dutch

Modern word processors begin to offer a range of facilities for spelling, grammar and style checking in English. For the Dutch language hardly anything is available as yet. Many commercial word processing packages do include a hyphenation routine and a lexicon-based spelling checker but the practical usefulness of these tools is limited due to certain properties of Dutch orthography, as we will explain below. In this chapter we describe a text editor which incorporates a great deal of lexical, morphological and syntactic knowledge of Dutch and monitors the orthographical quality of Dutch texts. Section 1 deals with those aspects of Dutch orthography which pose problems to human authors as well as to computational language sensitive text editing tools. In section 2 we describe the design and the implementation of the text editor we have built. Section 3 is mainly devoted to a provisional evaluation of the system

Summer Commencement: August 2, 1991

UND Summer Commencement program from August 2, 1991

Eastern Washington College of Education, Cheney, Washington, annual catalog, 1937-1938

The Eastern Washington College of Education catalog for the 1937-1938 academic year.https://dc.ewu.edu/catalogs/1040/thumbnail.jp

Gender Notes Fall 2011

An annual newsletter produced by the Women and Gender Studies program. It features the scholarly activities of the WMS faculty, staff, students and alumni. Conferences, scholarship awards, study opportunities, and other news of interest round out the newsletter\u27s content.https://digitalcommons.brockport.edu/gendernotes/1001/thumbnail.jp

Washington State Normal School, Cheney, Washington, annual catalog, 1934-1935

The State Normal School\u27s (Cheney) catalog for the 1934-1935 academic year.https://dc.ewu.edu/catalogs/1022/thumbnail.jp