Latent Modulation of Neuropathic Pain Intensity via Hypothalamus-pituitary-thyroid Axis of Psychogenic Stress

Background: In patients with complex regional pain syndrome (CRPS) delayed pain flares consistently occur ten days following salient psychogenic stress episodes. Timing of latent flares suggests pain modulation via hypothalamus-pituitary-thyroid (HPT) axis hormones. Objective: To determine if thyroxine (T4) may modulate latent stress-related neuropathic pain flare intensity, temporal relationships between daily stress, serum T4 levels, and perceived pain intensity in patients with CRPS were investigated. Patients and Methods: Daily, for ten weeks, three patients with type I CRPS and no thyroid pathology Hx provided blood samples for T4 assay and ratings of stress and pain. Measures included visual analog pain scale, McGill pain questionnaire, and Daily Stress Scale. Blood draws yielded bound T4 and free thyroxine index (FTI) values using microplate enzyme immunoassay. Each sample was split for blind assay from two independent labs. Results: Across patients, 14 peak stress episodes and 26 significant pain flares were reported. Each stress episode was followed ten days by a significant pain flare and free T4 values exceeding normal adult range (2.4ng/dL). Serial lag correlations were strongest between stress and pain for pain experienced ten days after peak stress episodes (r=+0.381, p\u3c 0.05). FTI correlated strongest with stress ten days following a stressful episode (r =+0.454, p\u3c 0.001). Same-day pain and FTI correlated at r=+0.643, p\u3c 0.001. Conclusions: Increased pain ten days following stressful events is related to psychogenic HPT activity in CRPS patients. Pain modulation by thyroxine may assist understanding pain fluctuation etiology and suggest new treatment avenues for managing neuropathic pain

Using GLM Flash Density, Flash Area, and Flash Energy to Diagnose Tropical Cyclone Structure and Intensification

Increased lightning in tropical cyclones (TCs) is typically associated with intensification, but significant lightning outbreaks are also observed in weakening storms. The total number of lightning flashes in a TC is not always a reliable indicator of TC intensity evolution. Issues with the range and detection efficiency of ground-based networks, particularly for intracloud lightning. Physical processes such as vertical wind shear can intensify asymmetric convection while also weakening the TC. The commissioning of the Geostationary Lightning Mapper (GLM) aboard GOES-16 and GOES-17 marked, for the first time, the presence of an operational lightning detector in geostationary orbit. In addition to flash density (the number of flashes per unit area per unit time), GLM also provides continuous observations of flash area and total optical energy

There and back again: detecting regularity in human encounter communities

Detecting communities that recur over time is a challenging problem due to the potential sparsity of encounter events at an individual scale and inherent uncertainty in human behavior. Existing methods for community detection in mobile human encounter networks ignore the presence of temporal patterns that lead to periodic components in the network. Daily and weekly routine are prevalent in human behavior and can serve as rich context for applications that rely on person-to-person encounters, such as mobile routing protocols and intelligent digital personal assistants. In this article, we present the design, implementation, and evaluation of an approach to decentralized periodic community detection that is robust to uncertainty and computationally efficient. This alternative approach has a novel periodicity detection method inspired by a neural synchrony measure used in the field of neurophysiology. We evaluate our approach and investigate human periodic encounter patterns using empirical datasets of inferred and direct-sensed encounters

Atlas of common bean (Phaseolus vulgaris L.) production in Africa

The Bean atlas is a comprehensive map of the bean growing areas in Africa. The first version was first published in 1998 and in paper format. For the last four years, PABRA has been developing the second edition, which shows dramatic changes in bean production areas across Africa, where some have expanded and others have shifted. The new atlas will be digital and available online soon. The new edition contains information from bean producing areas in Eastern, Southern and Western Africa and represents a total of 22 countries. It overlays bean producing areas with information on: bean varieties grown in those regions; ongoing seed production and dissemination work; local, national and international bean markets; market routes; information on end users, farmers and bean consumption; bean constraints, both Biotic and abiotic; and more

The Effectiveness of Desensitization Therapy for Individuals with Complex Regional Pain Syndrome: A Systematic Review

Authors: Kira L, Donnelly, SPT; Lauryn M. Helmers, SPT; Olivia M. Verberne, SPT; Roger J. Allen, PT, PhD Title: The Effectiveness of Desensitization Therapy for Individuals with Complex Regional Pain Syndrome: A Systematic Review Purpose: Systematically review evidence supporting the use of desensitization therapy to treat Complex Regional Pain Syndrome (CRPS). Subjects: This systematic review evaluated 10 studies from peer-reviewed journals fitting research criteria. Materials/Methods: Databases were searched between Mar and Aug of 2014 with the following search terms: complex regional pain syndrome, CRPS, allodynia, desensitization, neuropathic pain, physical therapy, tactile desensitization, pressure desensitization, hydrotherapy, physiotherapy, capsaicin and somatosensory. Results: Initial search yielded 42 articles with 10 fitting inclusion/exclusion criteria. Articles were evaluated with the STROBE scale and organized by desensitization type: chemical, tactile, thermal and pressure desensitization. Outcome measures varied, including assessing functional use, pressure tolerance and pain tolerance. Conclusions: Despite lacking a standard desensitization protocol, research suggests implementing desensitization by selecting the proper somatosensory modality and using a graded protocol in order to reduce allodynia. Clinical Relevance: Desensitization is often a component of a multifaceted treatment approach for patients with CRPS, which is difficult to isolate within research. To make solid conclusions about desensitization efficacy, studies need to isolate desensitization as a treatment using larger numbers of subjects with CRPS with clear, controlled and replicable protocols. Given current research limitations, existing evidence is promising for continued utilization of graded desensitization therapy for individuals with CRPS. Keywords: desensitization, complex regional pain syndrome, allodynia, tactile desensitization, pressure desensitization, hydrotherapy, capsaicin, physical therap

Quantification of cuttlefish (Sepia officinalis) camouflage : a study of color and luminance using in situ spectrometry

Author Posting. © The Author(s), 2012. This is the author's version of the work. It is posted here by permission of Springer for personal use, not for redistribution. The definitive version was published in Journal of Comparative Physiology A 199 (2013): 211-225, doi:10.1007/s00359-012-0785-3.Cephalopods are renowned for their ability to adaptively camouflage on diverse backgrounds. Sepia officinalis camouflage body patterns have been characterized spectrally in the laboratory but not in the field due to the challenges of dynamic natural light fields and the difficulty of using spectrophotometric instruments underwater. To assess cuttlefish color match in their natural habitats, we studied the spectral properties of S. officinalis and their backgrounds on the Aegean coast of Turkey using point-by-point in situ spectrometry. Fifteen spectrometry datasets were collected from seven cuttlefish; radiance spectra from animal body components and surrounding substrates were measured at depths shallower than 5m. We quantified luminance and color contrast of cuttlefish components and background substrates in the eyes of hypothetical di- and trichromatic fish predators. Additionally, we converted radiance spectra to sRGB color space to simulate their in situ appearance to a human observer. Within the range of natural colors at our study site, cuttlefish closely matched the substrate spectra in a variety of body patterns. Theoretical calculations showed that this effect might be more pronounced at greater depths. We also showed that a non-biological method (“Spectral Angle Mapper”), commonly used for spectral shape similarity assessment in the field of remote sensing, shows moderate correlation to biological measures of color contrast. This performance is comparable to that of a traditional measure of spectral shape similarity, hue and chroma. This study is among the first to quantify color matching of camouflaged cuttlefish in the wild.This study was funded by ONR grant N000140610202 to RTH.2013-12-2

Quantized Response and Topology of Insulators with Inversion Symmetry

We study three dimensional insulators with inversion symmetry, in which other point group symmetries, such as time reversal, are generically absent. Their band topology is found to be classified by the parities of occupied states at time reversal invariant momenta (TRIM parities), and by three Chern numbers. The TRIM parities of any insulator must satisfy a constraint: their product must be +1. The TRIM parities also constrain the Chern numbers modulo two. When the Chern numbers vanish, a magneto-electric response parameterized by "theta" is defined and is quantized to theta= 0, 2pi. Its value is entirely determined by the TRIM parities. These results may be useful in the search for magnetic topological insulators with large theta. A classification of inversion symmetric insulators is also given for general dimensions. An alternate geometrical derivation of our results is obtained by using the entanglement spectrum of the ground state wave-function.Comment: 12 pages main text; 12 pages appendices; 11 figures. Added new refs. in 2nd versio

Systematic Renormalization in Hamiltonian Light-Front Field Theory: The Massive Generalization

Hamiltonian light-front field theory can be used to solve for hadron states in QCD. To this end, a method has been developed for systematic renormalization of Hamiltonian light-front field theories, with the hope of applying the method to QCD. It assumed massless particles, so its immediate application to QCD is limited to gluon states or states where quark masses can be neglected. This paper builds on the previous work by including particle masses non-perturbatively, which is necessary for a full treatment of QCD. We show that several subtle new issues are encountered when including masses non-perturbatively. The method with masses is algebraically and conceptually more difficult; however, we focus on how the methods differ. We demonstrate the method using massive phi^3 theory in 5+1 dimensions, which has important similarities to QCD.Comment: 7 pages, 2 figures. Corrected error in Eq. (11), v3: Added extra disclaimer after Eq. (2), and some clarification at end of Sec. 3.3. Final published versio