917 research outputs found
Accelerating electric vehicle uptake: Modelling public policy options on prices and infrastructure
Transitioning to passenger battery electric vehicles (BEV) can mitigate climate change impacts of road transportation. We develop a novel BEV policy model, nesting it within a national-scale macroeconomic system dynamics model (iSDG-Australia) to simulate a suite of policy pathways. We model combinations of infrastructure support and subsidies, which bring forward the price-parity tipping point, thus rapidly accelerating BEVs’ share of new car sales. However, ongoing complementary charging infrastructure investment is critical to reach 100% new BEV car sales by 2050 in Australia. Even with a rapid transition, the modelled fleet would not achieve net-zero greenhouse gas emissions by 2050 due to vehicle longevity; and suddenly ceasing financial incentives could retard BEV sales by a decade. Based on our assumptions, results suggest emissions reductions are maximised by the fastest transition of the passenger vehicle fleet to BEVs, entailing government policy support from 2020 to 2050, for both adequate infrastructure deployment (AUD17.9b) and vehicle rebates (AUD19.5b), which achieves earlier BEV price-parity with fossil-fuelled vehicles
Macroscopic effects of the spectral structure in turbulent flows
Two aspects of turbulent flows have been the subject of extensive, split
research efforts: macroscopic properties, such as the frictional drag
experienced by a flow past a wall, and the turbulent spectrum. The turbulent
spectrum may be said to represent the fabric of a turbulent state; in practice
it is a power law of exponent \alpha (the "spectral exponent") that gives the
revolving velocity of a turbulent fluctuation (or "eddy") of size s as a
function of s. The link, if any, between macroscopic properties and the
turbulent spectrum remains missing. Might it be found by contrasting the
frictional drag in flows with differing types of spectra? Here we perform
unprecedented measurements of the frictional drag in soap-film flows, where the
spectral exponent \alpha = 3 and compare the results with the frictional drag
in pipe flows, where the spectral exponent \alpha = 5/3. For moderate values of
the Reynolds number Re (a measure of the strength of the turbulence), we find
that in soap-film flows the frictional drag scales as Re^{-1/2}, whereas in
pipe flows the frictional drag scales as Re^{-1/4} . Each of these scalings may
be predicted from the attendant value of \alpha by using a new theory, in which
the frictional drag is explicitly linked to the turbulent spectrum. Our work
indicates that in turbulence, as in continuous phase transitions, macroscopic
properties are governed by the spectral structure of the fluctuations.Comment: 6 pages, 3 figure
Maternal care boosted by paternal imprinting in mammals.
In mammals, mothers are the primary caregiver, programmed, in part, by hormones produced during pregnancy. High-quality maternal care is essential for the survival and lifelong health of offspring. We previously showed that the paternally silenced imprinted gene pleckstrin homology-like domain family A member 2 (Phlda2) functions to negatively regulate a single lineage in the mouse placenta called the spongiotrophoblast, a major source of hormones in pregnancy. Consequently, the offspring's Phlda2 gene dosage may influence the quality of care provided by the mother. Here, we show that wild-type (WT) female mice exposed to offspring with three different doses of the maternally expressed Phlda2 gene-two active alleles, one active allele (the extant state), and loss of function-show changes in the maternal hypothalamus and hippocampus during pregnancy, regions important for maternal-care behaviour. After birth, WT dams exposed in utero to offspring with the highest Phlda2 dose exhibit decreased nursing and grooming of pups and increased focus on nest building. Conversely, 'paternalised' dams, exposed to the lowest Phlda2 dose, showed increased nurturing of their pups, increased self-directed behaviour, and a decreased focus on nest building, behaviour that was robustly maintained in the absence of genetically modified pups. This work raises the intriguing possibility that imprinting of Phlda2 contributed to increased maternal care during the evolution of mammals
Large-scale Nonlinear Variable Selection via Kernel Random Features
We propose a new method for input variable selection in nonlinear regression.
The method is embedded into a kernel regression machine that can model general
nonlinear functions, not being a priori limited to additive models. This is the
first kernel-based variable selection method applicable to large datasets. It
sidesteps the typical poor scaling properties of kernel methods by mapping the
inputs into a relatively low-dimensional space of random features. The
algorithm discovers the variables relevant for the regression task together
with learning the prediction model through learning the appropriate nonlinear
random feature maps. We demonstrate the outstanding performance of our method
on a set of large-scale synthetic and real datasets.Comment: Final version for proceedings of ECML/PKDD 201
Reticular formation responses to magnetic brain stimulation of primary motor cortex
Transcranial magnetic stimulation (TMS) of cerebral cortex is a popular technique for the non-invasive investigation of motor function. TMS is often assumed to influence spinal circuits solely via the corticospinal tract. We were interested in possible trans-synaptic effects of cortical TMS on the ponto-medullary reticular formation in the brainstem, which is the source of the reticulospinal tract and could also generate spinal motor output. We recorded from 210 single units in the reticular formation of three anaesthetized macaque monkeys whilst TMS was performed over primary motor cortex. Short latency responses were observed consistent with activation of a cortico-reticular pathway. However, we also demonstrated surprisingly powerful responses at longer latency, which often appeared at lower threshold than the earlier effects. These late responses seemed to be generated partly as a consequence of the sound click made by coil discharge, and changed little with coil location. This novel finding has implications for the design of future studies using TMS, as well as suggesting a means of non-invasively probing an otherwise inaccessible important motor centre
TADPOLE Challenge: Accurate Alzheimer's disease prediction through crowdsourced forecasting of future data
The TADPOLE Challenge compares the performance of algorithms at predicting
the future evolution of individuals at risk of Alzheimer's disease. TADPOLE
Challenge participants train their models and algorithms on historical data
from the Alzheimer's Disease Neuroimaging Initiative (ADNI) study. Participants
are then required to make forecasts of three key outcomes for ADNI-3 rollover
participants: clinical diagnosis, ADAS-Cog 13, and total volume of the
ventricles -- which are then compared with future measurements. Strong points
of the challenge are that the test data did not exist at the time of
forecasting (it was acquired afterwards), and that it focuses on the
challenging problem of cohort selection for clinical trials by identifying fast
progressors. The submission phase of TADPOLE was open until 15 November 2017;
since then data has been acquired until April 2019 from 219 subjects with 223
clinical visits and 150 Magnetic Resonance Imaging (MRI) scans, which was used
for the evaluation of the participants' predictions. Thirty-three teams
participated with a total of 92 submissions. No single submission was best at
predicting all three outcomes. For diagnosis prediction, the best forecast
(team Frog), which was based on gradient boosting, obtained a multiclass area
under the receiver-operating curve (MAUC) of 0.931, while for ventricle
prediction the best forecast (team EMC1), which was based on disease
progression modelling and spline regression, obtained mean absolute error of
0.41% of total intracranial volume (ICV). For ADAS-Cog 13, no forecast was
considerably better than the benchmark mixed effects model (BenchmarkME),
provided to participants before the submission deadline. Further analysis can
help understand which input features and algorithms are most suitable for
Alzheimer's disease prediction and for aiding patient stratification in
clinical trials.Comment: 10 pages, 1 figure, 4 tables. arXiv admin note: substantial text
overlap with arXiv:1805.0390
Dibenzoatobis[3-(pyrrol-1-ylmethyl)pyridine]zinc(II)
In the title compound, [Zn(C7H5O2)2(C10H10N2)2], the ZnII ion, located on a twofold axis, is coordinated by two N atoms from two 3-(pyrrol-1-ylmethyl)pyridine ligands and two O atoms from two benzoate ligands in a distorted tetrahedral geometry. The pyridine and the pyrrole rings are nearly perpendicular to each other, making a dihedral angle of 84.83 (7)°
Metal-insulator transition in vanadium dioxide nanobeams: probing sub-domain properties of strongly correlated materials
Many strongly correlated electronic materials, including high-temperature
superconductors, colossal magnetoresistance and metal-insulator-transition
(MIT) materials, are inhomogeneous on a microscopic scale as a result of domain
structure or compositional variations. An important potential advantage of
nanoscale samples is that they exhibit the homogeneous properties, which can
differ greatly from those of the bulk. We demonstrate this principle using
vanadium dioxide, which has domain structure associated with its dramatic MIT
at 68 degrees C. Our studies of single-domain vanadium dioxide nanobeams reveal
new aspects of this famous MIT, including supercooling of the metallic phase by
50 degrees C; an activation energy in the insulating phase consistent with the
optical gap; and a connection between the transition and the equilibrium
carrier density in the insulating phase. Our devices also provide a
nanomechanical method of determining the transition temperature, enable
measurements on individual metal-insulator interphase walls, and allow general
investigations of a phase transition in quasi-one-dimensional geometry.Comment: 9 pages, 3 figures, original submitted in June 200
Proton Driven Plasma Wakefield Acceleration
Plasma wakefield acceleration, either laser driven or electron-bunch driven,
has been demonstrated to hold great potential. However, it is not obvious how
to scale these approaches to bring particles up to the TeV regime. In this
paper, we discuss the possibility of proton-bunch driven plasma wakefield
acceleration, and show that high energy electron beams could potentially be
produced in a single accelerating stage.Comment: 13 pages, 4 figure
A preliminary study of the effect of closed incision management with negative pressure wound therapy over high-risk incisions
Background
Certain postoperative wounds are recognised to be associated with more complications than others and may be termed high-risk. Wound healing can be particularly challenging following high-energy trauma where wound necrosis and infection rates are high. Surgical incision for joint arthrodesis can also be considered high-risk as it requires extensive and invasive surgery and postoperative distal limb swelling and wound dehiscence are common. Recent human literature has investigated the use of negative pressure wound therapy (NPWT) over high-risk closed surgical incisions and beneficial effects have been noted including decreased drainage, decreased dehiscence and decreased infection rates. In a randomised, controlled study twenty cases undergoing distal limb high-energy fracture stabilisation or arthrodesis were randomised to NPWT or control groups. All cases had a modified Robert-Jones dressing applied for 72 h postoperatively and NPWT was applied for 24 h in the NPWT group. Morphometric assessment of limb circumference was performed at six sites preoperatively, 24 and 72 h postoperatively. Wound discharge was assessed at 24 and 72 h. Postoperative analgesia protocol was standardised and a Glasgow Composite Measure Pain Score (GCPS) carried out at 24, 48 and 72 h. Complications were noted and differences between groups were assessed.
Results
Percentage change in limb circumference between preoperative and 24 and 72 h postoperative measurements was significantly less at all sites for the NPWT group with exception of the joint proximal to the surgical site and the centre of the operated bone at 72 h. Median discharge score was lower in the NPWT group than the control group at 24 h. No significant differences in GCPS or complication rates were noted.
Conclusions
Digital swelling and wound discharge were reduced when NPWT was employed for closed incision management. Larger studies are required to evaluate whether this will result in reduced discomfort and complication rates postoperatively
- …