Ceftriaxone-induced toxic epidermal necrolysis mimicking burn injury: a case report

<p>Abstract</p> <p>Introduction</p> <p>Toxic epidermal necrolysis is a rare exfoliative disorder with a high mortality rate.</p> <p>Case presentation</p> <p>We present a 70-year-old woman of Iranian descent who presented with toxic epidermal necrolysis that was initially diagnosed as a scald burn. Further anamnesis prompted by spread of the lesions during hospitalization revealed that the patient had been receiving ceftriaxone for several days. To the best of our knowledge, this is the first case of ceftriaxone-induced toxic epidermal necrolysis in the English literature.</p> <p>Conclusion</p> <p>Toxic epidermal necrolysis is an acute, life-threatening, exfoliative disorder with a high mortality rate. High clinical suspicion, prompt recognition, and initiation of supportive care is mandatory. Thorough investigation of the pathogenetic mechanisms is fundamental. Optimal treatment guidelines are still unavailable.</p

The cicadas (Hemiptera: Cicadidae) of India, Bangladesh, Bhutan, Myanmar, Nepal and Sri Lanka: an annotated provisional catalogue, regional checklist and bibliography

This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The attached file is the published version of the article.NHM Repositor

Old-new ERP effects and remote memories : the late parietal effect is absent as recollection fails whereas the early mid-frontal effect persists as familiarity is retained

Acknowledgments Wael El-Deredy acknowledges the support from CONICYT Basal project FB0008, Chile.The authors would like to thank the two reviewers for their very useful suggestions and comments.Peer reviewedPublisher PD

Assessing additive and subtractive manufacturing technologies for the production of tools in the automotive industry

Tooling is an integral component to the traditional manufacturing cycle, despite the fact that it’s both costly and time-consuming to produce. Additive manufacturing (AM) is currently considered viable in certain instances, often competing against subtractive manufacturing in the delivery of tools, on time, with the required quality. This paper considers the use of AM and computer numerical control (CNC) machining to manufacture an insert for the tooling of a vehicle headlight adjuster clip. The proposed methodology for manufacturing the insert is composed of two manufacturing techniques: AM using selective laser melting (SLM) technology and CNC milling. The tool material used to manufacture the inserts in both cases is Stainless Steel 316L, whilst the injected parts are manufactured in polypropylene. Performance tests were applied to each of the two inserts in the context of material chemical composition, microstructure, hardness, surface roughness, and dimensional accuracy. Furthermore, the injected parts produced were tested to determine dimensional accuracy, quality and functionality. Finally, it was concluded that both the SLM insert and CNC machined insert successfully produced functional parts. Moreover, the products from the SLM tool insert were more accurate dimensionally, but in terms of surface finish, the CNC product was perceived to be better quality

Maintaining real-time precise point positioning during outages of orbit and clock corrections

The precise point positioning (PPP) is a popular positioning technique that is dependent on the use of precise orbits and clock corrections. One serious problem for real-time PPP applications such as natural hazard early warning systems and hydrographic surveying is when a sudden communication break takes place resulting in a discontinuity in receiving these orbit and clock corrections for a period that may extend from a few minutes to hours. A method is presented to maintain real-time PPP with 3D accuracy less than a decimeter when such a break takes place. We focus on the open-access International GNSS Service (IGS) real-time service (RTS) products and propose predicting the precise orbit and clock corrections as time series. For a short corrections outage of a few minutes, we predict the IGS-RTS orbits using a high-order polynomial, and for longer outages up to 3 h, the most recent IGS ultra-rapid orbits are used. The IGS-RTS clock corrections are predicted using a second-order polynomial and sinusoidal terms. The model parameters are estimated sequentially using a sliding time window such that they are available when needed. The prediction model of the clock correction is built based on the analysis of their properties, including their temporal behavior and stability. Evaluation of the proposed method in static and kinematic testing shows that positioning precision of less than 10 cm can be maintained for up to 2 h after the break. When PPP re-initialization is needed during the break, the solution convergence time increases; however, positioning precision remains less than a decimeter after convergence

Selective Laser Melting for improving quality characteristics of a prism shaped topology injection mould tool insert for the automotive industry

Manufacturing process constraints and design complexities are the main challenges that face the aftermarket automotive industry. For that reason, recently, selective laser melting (SLM) is being recognised as a viable approach in the fabrication of injection moulding tool inserts. Due to its versatility, SLM technology is capable of producing freeform designs. For the first reported time, in this study SLM is recognized for its novel application in overcoming fabrication complexities for prism shaped topology of a vehicle headlamp’s reflector injection moulding tool insert. Henceforth, performance measures of the SLM-fabricated injection mould tool insert is assessed in comparison to a CNC-milled counterpart to improve quality characteristics. Tests executed and detailed in this paper are divided into two stages; the first stage assesses both fabricated tool inserts in terms of manufacturability; the second stage assesses the functionality of the end-products by measuring the surface roughness, dimensional accuracy and light reflectivity from the vehicle reflectors. The results obtained show that employing SLM technology can offer an effective and efficient alternative to subtractive manufacturing, successfully producing tool inserts with complex surface topology. Significant benefits in terms of surface roughness, dimensional accuracy and product functionality were achieved through the use of SLM technology. it was concluded that the SLM-fabricated inserts products proved to have relatively lower values of surface roughness in comparison to their CNC counterparts

Bounded and unitary elements in pro-C^*-algebras

A pro-C^*-algebra is a (projective) limit of C^*-algebras in the category of topological *-algebras. From the perspective of non-commutative geometry, pro-C^*-algebras can be seen as non-commutative k-spaces. An element of a pro-C^*-algebra is bounded if there is a uniform bound for the norm of its images under any continuous *-homomorphism into a C^*-algebra. The *-subalgebra consisting of the bounded elements turns out to be a C^*-algebra. In this paper, we investigate pro-C^*-algebras from a categorical point of view. We study the functor (-)_b that assigns to a pro-C^*-algebra the C^*-algebra of its bounded elements, which is the dual of the Stone-\v{C}ech-compactification. We show that (-)_b is a coreflector, and it preserves exact sequences. A generalization of the Gelfand-duality for commutative unital pro-C^*-algebras is also presented.Comment: v2 (accepted

Evaluation of alternative solvents in common amide coupling reactions : replacement of dichloromethane and N,N-dimethylformamide

A range of alternative solvents have been evaluated within amidation reactions employing common coupling reagents with a view to identifying suitable replacements for dichloromethane and N,N-dimethylformamid