Influence of Beams Distribution on the Dynamic and Seismic Linear Response of RC Frame Buildings

The present study compares the dynamic properties and seismic performances offered by reinforced concrete frame structures characterized by different beams distribution. The understanding of the influence of beams distribution on spatial frames is not only useful when dealing with the seismic vulnerability assessment of existing buildings that may show unusual layouts of beams, such as alternating beams at each storey, but also when facing the design of new buildings with fluid viscous dampers for which some structural flexibility is required. A systematic study is described in this paper. Four (2-, 3-, 6-, and 10-storey) regular frame buildings with rectangular plan are considered as reference structures. Different models are developed according to various layouts of the primary beams, exploring alternatives to the full three-dimensional organisation of beams and frames. For instance: beams placed along the longitudinal direction at the odd storeys and placed along the transversal direction at the even storeys, and vice versa; alternating beams every one and two storeys; beams just placed along one direction. Modal analysis has been conducted to evaluate the influence of beams distribution on the dynamic properties (periods of vibration and modal participating mass ratios). Response spectrum analysis and linear time-history dynamic analysis have been carried out to assess the effects of beams distribution on the fundamental seismic response parameters (shear forces, bending moments, top-storey displacements, interstorey drifts, and floor accelerations). On the contrary of what could be expected, the results indicate that structures with beams alternating every storey may show interesting advantages in terms of reduced total base shear, almost comparable bending moments and accelerations, within a still balanced overall behaviour along the two directions, with respect to the complete three-dimensional frame. Two effects are recognized: the period effect and the static scheme effect. The former acting basically on the storey shear forces; the latter acting mainly on the bending moments

The performance of serological tests for Leishmania infantum infection screening in dogs depends on the prevalence of the disease

Dogs are considered the main reservoir of Leishmania infantum. This protozoan causes visceral leishmaniasis (VL), an uncontrolled urban zoonosis in Brazil. Serological tests and polymerase chain reaction (PCR) on peripheral blood were performed to identify infected dogs in scenarios of higher and lower prevalence of the disease (Teresina and Vitória). One-hundred infected and 57 non-infected animals from Teresina and 100 non-infected animals from Vitória were studied. Animal selection was not dependent on previous serology. The sensitivity (Teresina) and specificity (Teresina and Vitória) were as follows: indirect antibody fluorescence (IFAT) cut-off of 1:40 (IFAT 1:40): 96%, 18%, and 76%; IFAT 1:80: 90%, 33%, and 93%; direct agglutination test (DAT): 96%, 33%, and 98%; fast agglutination screening test (FAST): 93%, 68%, and 100%; immunochromatographic assay with a recombinant rK39 antigen (rK39): 88%, 74%, and 98%; enzyme linked immunosorbent assay (ELISA): 91%, 79%, and 98%; rapid dual-path platform test (TR DPP®): 98%, 60%, and 98%; and blood PCR: 29%, 93%, and 97%, respectively. In the high transmission area, none of the tests adequately discriminated L. infantum-infected from non-infected dogs. However, in the high transmission city, the area under the receiver operating characteristic (ROC) curve of FAST, DAT, ICrK39, ELISA and TR DPP® was hig

4-[3-(Benzylamino)-2-hydroxypropyl]-2,6-di-tert-butylphenol

In the title compound, C24H35NO2, the planes of the two aromatic rings form a dihedral angle of 72.76 (4)°. In the crystal, molecules are linked by O—H...O and O—H...N hydrogen-bond interactions, forming an extended two-dimensional framework parallel to the ab plane

The use of platensimycin and platencin to fight antibiotic resistance

Infectious diseases are known as one of the most life-threatening disabilities worldwide. Approximately 13 million deaths related to infectious diseases are reported each year. The only way to combat infectious diseases is by chemotherapy using antimicrobial agents and antibiotics. However, due to uncontrolled and unnecessary use of antibiotics in particular, surviving bacteria have evolved resistance against several antibiotics. Emergence of multidrug resistance in bacteria over the past several decades has resulted in one of the most important clinical health problems in modern medicine. For instance, approximately 440,000 new cases of multidrug-resistant tuberculosis are reported every year leading to the deaths of 150,000 people worldwide. Management of multidrug resistance requires understanding its molecular basis and the evolution and dissemination of resistance; development of new antibiotic compounds in place of traditional antibiotics; and innovative strategies for extending the life of antibiotic molecules. Researchers have begun to develop new antimicrobials for overcoming this important problem. Recently, platensimycin - isolated from extracts of Streptomyces platensis - and its analog platencin have been defined as promising agents for fighting multidrug resistance. In vitro and in vivo studies have shown that these new antimicrobials have great potential to inhibit methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, and penicillin-resistant Streptococcus pneumoniae by targeting type II fatty acid synthesis in bacteria. Showing strong efficacy without any observed in vivo toxicity increases the significance of these antimicrobial agents for their use in humans. However, at the present time, clinical trials are insufficient and require more research. The strong antibacterial efficacies of platensimycin and platencin may be established in clinical trials and their use in humans for coping with multidrug resistance may be allowed in the foreseeable future. © 2013 Allahverdiyev et al, publisher and licensee Dove Medical Press Ltd

rac-2-tert-Butyl-2,4,5,6,6-pentachlorocyclohex-3-en-1-one

The title compound, C10H11Cl5O, is a chiral molecule with two stereogenic centres. However, it crystallizes as a racemate. One of enantiomers reveals the relative configuration (2S*,5R*). The cyclohexene ring adopts a half-chair conformation