The use of a complexity model to facilitate in the selection of a fuel cell assembly sequence

Various tools and methods exists for arriving at an optimised assembly sequence with most using a soft computing approach. However, these methods have issues including susceptibly to early convergence and high computational time. The typical objectives for these methods are to minimise the number of assembly change directions, orientation changes or the number of tool changes. This research proposes an alternative approach whereby an assembly sequence is measured based on its complexity. The complexity value is generated using design for assembly metrics and coupled with considerations for product performance, component precedence and material handling challenges to arrive at a sequence solution which is likely to be closest to the optimum for cost and product quality. The case presented in this study is of the assembly of a single proton exchange membrane fuel cell. This research demonstrates a practical approach for determining assembly sequence using data and tools that are used and available in the wider industry. Further work includes automating the sequence generation process and extending the work by considering additional factors such as ergonomi

Hydrogen fuel cell pick and place assembly systems : heuristic evaluation of reconfigurability and suitability

Proton Exchange Membrane Fuel Cells (PEMFCs) offer numerous advantages over combustion technology but they remain economically uncompetitive except for in niche applications. A portion of this cost is attributed to a lack of assembly expertise and the associated risks. To solve this problem, this research investigates the assembly systems that do exist for this product and systematically decomposes them into their constituent components to evaluate reconfigurability and suitability to product. A novel method and set of criteria are used for evaluation taking inspiration from heuristic approaches for evaluating manufacturing system complexity. It is proposed that this can be used as a support tool at the design stage to meet the needs of the product while having the capability to accept potential design changes and variants for products beyond the case study presented in this work. It is hoped this work develops a new means to support in the design of reconfigurable systems and form the foundation for fuel cell assembly best practice, allowing this technology to reduce in cost and find its way into a commercial space

Early postzygotic mutations contribute to de novo variation in a healthy monozygotic twin pair

Cataloged from PDF version of article.Background: Human de novo single-nucleotide variation (SNV) rate is estimated to range between 0.82-1.70×10-8 mutations per base per generation. However, contribution of early postzygotic mutations to the overall human de novo SNV rate is unknown. Methods: We performed deep whole-genome sequencing (more than 30-fold coverage per individual) of the whole-blood-derived DNA samples of a healthy monozygotic twin pair and their parents. We examined the genotypes of each individual simultaneously for each of the SNVs and discovered de novo SNVs regarding the timing of mutagenesis. Putative de novo SNVs were validated using Sanger-based capillary sequencing. Results: We conservatively characterised 23 de novo SNVs shared by the twin pair, 8 de novo SNVs specific to twin I and 1 de novo SNV specific to twin II. Based on the number of de novo SNVs validated by Sanger sequencing and the number of callable bases of each twin, we calculated the overall de novo SNV rate of 1.31×10-8 and 1.01×10-8 for twin I and twin II, respectively. Of these, rates of the early postzygotic de novo SNVs were estimated to be 0.34×10-8 for twin I and 0.04×10-8 for twin II. Conclusions: Early postzygotic mutations constitute a substantial proportion of de novo mutations in humans. Therefore, genome mosaicism resulting from early mitotic events during embryogenesis is common and could substantially contribute to the development of diseases

Perspective of turkish medicine students on cancer, cancer treatments, palliative care, and oncologists (ares study): A study of the palliative care working committee of the turkish oncology group (TOG)

Cancer is one of the most common causes of death all over the World (Rahib et al. in Cancer Res 74(11):2913–2921, 2014; Silbermann et al. in Ann Oncol 23(Suppl 3):iii15–iii28, 2012). It is crucial to diagnose this disease early by effective screening methods and also it is very important to acknowledge the community on various aspects of this disease such as the treatment methods and palliative care. Not only the oncologists but every medical doctor should be educated well in dealing with cancer patients. Previous studies suggested various opinions on the level of oncology education in medical schools (Pavlidis et al. in Ann Oncol 16(5):840–841, 2005). In this study, the perspectives of medical students on cancer, its treatment, palliative care, and the oncologists were analyzed in relation to their educational status. A multicenter survey analysis was performed on a total of 4224 medical school students that accepted to enter this study in Turkey. After the questions about the demographical characteristics of the students, their perspectives on the definition, diagnosis, screening, and treatment methods of cancer and their way of understanding metastatic disease as well as palliative care were analyzed. The questionnaire includes questions with answers and a scoring system of Likert type 5 (absolutely disagree = 1, completely agree = 5). In the last part of the questionnaire, there were some words to detect what the words “cancer” and “oncologist” meant for the students. The participant students were analyzed in two study groups; “group 1” (n = 1.255) were phases I and II students that had never attended an oncology lesson, and “group 2” (n = 2.969) were phases III to VI students that had attended oncology lessons in the medical school. SPSS v17 was used for the database and statistical analyses. A value of p < 0.05 was noted as statistically significant. Group 1 defined cancer as a contagious disease (p = 0.00025), they believed that early diagnosis was never possible (p = 0.042), all people with a diagnosis of cancer would certainly die (p = 0.044), and chemotherapy was not successful in a metastatic disease (p = 0.003) as compared to group 2. The rate of the students that believed gastric cancer screening was a part of the national screening policy was significantly more in group 1 than in group 2 (p = 0.00014). Group 2 had a higher anxiety level for themselves or their family members to become a cancer patient. Most of the students in both groups defined medical oncologists as warriors (57% in group 1 and 40% in group 2; p = 0.097), and cancer was reminding them of “death” (54% in group 1 and 48% in group 2; p = 0.102). This study suggested that oncology education was useful for the students’ understanding of cancer and related issues; however, the level of oncology education should be improved in medical schools in Turkey. This would be helpful for medical doctors to cope with many aspects of cancer as a major health care problem in this country. © 2018, American Association for Cancer Education

A framework for automatically realizing assembly sequence changes in a virtual manufacturing environment

Global market pressures and the rapid evolution of technologies and materials force manufacturers to constantly design, develop and produce new and varied products to maintain a competitive edge. Although virtual design and engineering tools have been key to supporting this fast rate of change, there remains a lack of seamless integration between and within tools across the domains of product, process, and resource design - especially to accommodate change. This research examines how changes to designs within these three domains can be captured and evaluated within a component based engineering tool (vueOne, developed by the Automation Systems Group at the University of Warwick). This paper describes how and where data within these tools can be mapped to quickly evaluate change (where typically a tedious process of data entry is required) decreasing lead times and cost and increasing productivity. The approach is tested on a sub-assembly of a hydrogen fuel cell, where an assembly system is modelled and changes are made to the sequence which is translated through to control logic. Although full implementation has not yet been realized, the concept has the potential to radically change the way changes are made and the approach can be extended to supporting other change types provided the appropriate rules and mapping

Strong strain path dependence of strain localizations and fracture in magnesium AZ31 sheet

This study compares the deformation and fracture behavior of a basal-textured Mg AZ31 alloy sheet under uniaxial tension and biaxial stretching by using an in-plane biaxial test setup capable of observing and measuring the deformation at both meso (millimeter) and microstructure scales. Strain distributions at the mesoscale and accompanying fracture surfaces indicate a significant dependence on strain path. At the microscale, limited slip activity in biaxial case promotes contraction twins, where severe strain localizations (epsilon(max)/epsilon(mean) approximate to 20) to the twins and their boundaries cause mainly transgranular fracture. This leads to a brittle, and a more pronounced shear-type fracture under biaxial stretching. In uniaxial case, considerable tensile twinning activity reorients the initial texture for slip activity. Strain localizations (epsilon(max)/epsilon(mean) approximate to 2) to the grain interiors and boundaries initiate mainly intergranular fracture. Samples fail by displaying both brittle and ductile fracture structures, with smaller shear lips compared to the biaxial case.Publisher's Versio

Molekularna epizootiologija jednodnevne groznice goveda u Turskoj

In this study, the molecular epidemiology of bovine ephemeral fever in Turkey was investigated, on the basis of a comparison of the nucleotide sequences of the virus that caused the last outbreak, between early August and late November 2012, with those of the strains from the 1985 and 2008 outbreaks in Turkey, as well as BEF virus (BEFV) strains from Far Eastern countries, Israel and Australia. In the NJ analysis, the BEF viruses from the 1985 and 2008 outbreaks in Turkey were placed in the same cluster as the Israel isolates, while the 2012-outbreak BEFVs were placed in a different cluster, with the East Asian strains.Istražena je molekularna epizootiologija jednodnevne groznice goveda u Turskoj. Nukleotidni slijed genoma virusa koji je uzrokovao posljednju epizootiju bolesti koja je u Turskoj harala od početka kolovoza do kraja studenoga 2012. godine bio je uspoređen s nukleotidnim sljedovima sojeva izdvojenih od 1985. do 2008. kao i sojeva iz dalekoistočnih zemalja, Izraela i Australije. Primjenom metode susjednog sparivanja, sojevi dokazani u Turskoj između 1985. i 2008. svrstani su u istu skupinu s izraelskim sojevima, dok su sojevi iz 2012. pripadali istočnoazijskoj skupini