The Tectonic Evolution of the Tibetan Plateau: Insights from the Deformation and Erosion History of Northern Tibet and the Surrounding Region.

The Tibetan Plateau-Himalaya system is the archetype of a continental collision thus, defining its tectonic and topographic evolution is of great importance to our understanding of continental tectonics. Ongoing India-Eurasia convergence since ~55 Ma is the widely accepted cause of great crustal thickness (>60 km) and high elevation (>5 km) within this region; however, the manner in which this convergence is accommodated is controversial. In this dissertation, I employ a multidisciplinary approach to constrain the structural and topographic evolution of the Tibetan Plateau at two spatial scales: a detailed study along the northeastern plateau margin and a broader-scope study across the width of the plateau interior. Results from geologic mapping, low-temperature thermochronometry, and 40Ar/39Ar geochronology indicate that pre-Miocene deformation within northern Tibet occurred primarily along contractional structures oriented favorably to accommodate NNE-SSW Indo-Eurasian plate convergence. Deformation patterns appear to have changed beginning in the post middle-Miocene, as both thrusting and strike-slip fault motion of variable orientation is observed in a zone of transpression bounded by the Kunlun and Haiyuan left-lateral faults. Results from the broad-scale, detrital low-temperature thermochronometry erosion study suggest that erosion rates increase by at least an order of magnitude between 11-4 Ma following a period of slow erosion across the entire east-central Tibetan Plateau. Taken together, the finding of an early to mid-Cenozoic deformation history in northern Tibet and the synchroneity of accelerated erosion across the entire eastern plateau challenges the widely accepted view that the orogen grew northward through time. Instead, widespread accelerated river incision during the mid-to-late Miocene is consistent with regional scale uplift that occurred in concert with eastern expansion of the orogen by lower crustal flow. Timing of proposed eastward crustal flow overlaps with the shift to a predominantly left-lateral strike-slip fault regime documented in northern Tibet and with the timing of onset of other major intracontinental strike-slip faults in southern and central Tibet. Here I propose that these crustal processes occur as a consequence of long-term plate convergence rather than resulting from a specific event, such as mantle delamination, or abrupt change in plate kinematics.Ph.D.GeologyUniversity of Michigan, Horace H. Rackham School of Graduate Studieshttp://deepblue.lib.umich.edu/bitstream/2027.42/89636/1/duvall_1.pd

Widespread late Cenozoic increase in erosion rates across the interior of eastern Tibet constrained by detrital low-temperature thermochronometry

New detrital low-temperature thermochronometry provides estimates of long-term erosion rates and the timing of initiation of river incision from across the interior of the Tibetan Plateau. We use the erosion history of this region to evaluate proposed models of orogenic development as well as regional climatic events. Erosion histories of the externally drained portion of the east-central Tibetan Plateau are recorded in modern river sands from major rivers across a transect that spans >750 km and covers a region with no published thermochronometric ages. Individual grains from eight catchments were analyzed for apatite (U-Th)/He and fission track thermochronometry. A wide distribution in ages that, in most cases, spans the entire Cenozoic and Late Mesozoic eras requires a long period of slow or no erosion with a relative increase in erosion rate toward the present. We apply a recently developed methodology for inversion of detrital thermochronometric data for three specified erosion scenarios: constant erosion rate, two-stage erosion history, and three-stage erosion history. Modeling results suggest that rates increase by at least an order of magnitude between 11 and 4 Ma following a period of slow erosion across the studied catchments. Synchroneity in accelerated erosion across the whole of the Tibetan Plateau rather than a spatial or temporal progression challenges the widely held notion that the plateau evolved as a steep, northward-propagating topographic front, or that south to north precipitation gradients exert a primary control on erosion rates. Instead, we suggest that accelerated river incision late in the orogen's history relates to regional-scale uplift that occurred in concert with eastern expansion of the plateau

Low-temperature thermochronometry along the Kunlun and Haiyuan Faults, NE Tibetan Plateau: Evidence for kinematic change during late-stage orogenesis

The Tibetan Plateau is a prime example of a collisional orogen with widespread strike-slip faults whose age and tectonic significance remain controversial. We present new low-temperature thermochronometry to date periods of exhumation associated with Kunlun and Haiyuan faulting, two major strike-slip faults within the northeastern margin of Tibet. Apatite and zircon (U-Th)/He and apatite fission-track ages, which record exhumation from ~2 to 6 km crustal depths, provide minimum bounds on fault timing. Results from Kunlun samples show increased exhumation rates along the western fault segment at circa 12–8 Ma with a possible earlier phase of motion from ~30–20 Ma, along the central fault segment at circa 20–15 Ma, and along the eastern fault segment at circa 8–5 Ma. Combined with previous studies, our results suggest that motion along the Haiyuan fault may have occurred as early as ~15 Ma along the western/central fault segment before initiating at least by 10–8 Ma along the eastern fault tip. We relate an ~250 km wide zone of transpressional shear to synchronous Kunlun and Haiyuan fault motion and suggest that the present-day configuration of active faults along the northeastern margin of Tibet was likely established since middle Miocene time. We interpret the onset of transpression to relate to the progressive confinement of Tibet against rigid crustal blocks to the north and expansion of crustal thickening to the east during the later stages of orogen development

River patterns reveal two stages of landscape evolution at an oblique convergent margin, Marlborough Fault System, New Zealand

Here we examine the landscape of New Zealand's Marlborough Fault System (MFS), where the Australian and Pacific plates obliquely collide, in order to study landscape evolution and the controls on fluvial patterns at a long-lived plate boundary. We present maps of drainage anomalies and channel steepness, as well as an analysis of the plan-view orientations of rivers and faults, and we find abundant evidence of structurally controlled drainage that we relate to a history of drainage capture and rearrangement in response to mountain-building and strike-slip faulting. Despite clear evidence of recent rearrangement of the western MFS drainage network, rivers in this region still flow parallel to older faults, rather than along orthogonal traces of younger, active strike-slip faults. Such drainage patterns emphasize the importance of river entrenchment, showing that once rivers establish themselves along a structural grain, their capture or avulsion becomes difficult, even when exposed to new weakening and tectonic strain. Continued flow along older faults may also indicate that the younger faults have not yet generated a fault damage zone with the material weakening needed to focus erosion and reorient rivers. Channel steepness is highest in the eastern MFS, in a zone centered on the Kaikōura ranges, including within the low-elevation valleys of main stem rivers and at tributaries near the coast. This pattern is consistent with an increase in rock uplift rate toward a subduction front that is locked on its southern end. Based on these results and a wealth of previous geologic studies, we propose two broad stages of landscape evolution over the last 25 million years of orogenesis. In the eastern MFS, Miocene folding above blind thrust faults generated prominent mountain peaks and formed major transverse rivers early in the plate collision history. A transition to Pliocene dextral strike-slip faulting and widespread uplift led to cycles of river channel offset, deflection and capture of tributaries draining across active faults, and headward erosion and captures by major transverse rivers within the western MFS. We predict a similar landscape will evolve south of the Hope Fault, as the locus of plate boundary deformation migrates southward into this region with time.</p

Off-fault deformation rate along the southern San Andreas Fault at Mecca Hills inferred from landscape modeling of curved drainages

Quantifying off-fault deformation (OFD) rates on geomorphic timescales (10^2-10^5 yr) along strike-slip faults is critical for resolving discrepancies between geologic and geodetic slip-rate estimates, improving knowledge of seismic hazard, and understanding the influence of tectonic motion on landscapes. Quantifying OFD over these timescales is challenging without displacement markers such as offset terraces or geologic contacts. We present a landscape evolution model coupled with distributed lateral tectonic shear to show how drainage basins sheared by lateral tectonic motion can reveal OFD rates. The model shows that OFD rate can control the orientation of drainage basin topography: the faster the OFD rate, the greater the deflection of drainage basins towards a fault-parallel orientation. We apply the model to the southern San Andreas Fault near the Mecca Hills, where drainages basins change in orientation with proximity to the fault. Comparison of observed and modeled topography suggests that the OFD rate in the Mecca Hills follows an exponential-like spatial pattern with a maximum rate nearest the fault of 3.5 ± 1.5 mm/yr, which decays to approximately zero at ~600 m distance from the fault. This rate is applicable since the initiation of differential rock uplift in the Mecca Hills at approximately 760 ka. Our results suggest that OFD in this 800 m study area may be as high as 10% of total plate motion. This example demonstrates that curved drainage basins may be used to estimate OFD rates along strike slip faults

The growth of northeastern Tibet and its relevance to large-scale continental geodynamics: A review of recent studies

Recent studies of the northeastern part of the Tibetan Plateau have called attention to two emerging views of how the Tibetan Plateau has grown. First, deformation in northern Tibet began essentially at the time of collision with India, not 10–20 Myr later as might be expected if the locus of activity migrated northward as India penetrated the rest of Eurasia. Thus, the north-south dimensions of the Tibetan Plateau were set mainly by differences in lithospheric strength, with strong lithosphere beneath India and the Tarim and Qaidam basins steadily encroaching on one another as the region between them, the present-day Tibetan Plateau, deformed, and its north-south dimension became narrower. Second, abundant evidence calls for acceleration of deformation, including the formation of new faults, in northeastern Tibet since ~15 Ma and a less precisely dated change in orientation of crustal shortening since ~20 Ma. This reorientation of crustal shortening and roughly concurrent outward growth of high terrain, which swings from NNE-SSW in northern Tibet to more NE-SW and even ENE-WSW in the easternmost part of northeastern Tibet, are likely to be, in part, a consequence of crustal thickening within the high Tibetan Plateau reaching a limit, and the locus of continued shortening then migrating to the northeastern and eastern flanks. These changes in rates and orientation also could result from removal of some or all mantle lithosphere and increased gravitational potential energy per unit area and from a weakening of crustal material so that it could flow in response to pressure gradients set by evolving differences in elevation

Adjuvant Chemotherapy for Brain Tumors Delivered via a Novel Intra-Cavity Moldable Polymer Matrix

Introduction Polymer-based delivery systems offer innovative intra-cavity administration of drugs, with the potential to better target micro-deposits of cancer cells in brain parenchyma beyond the resected cavity. Here we evaluate clinical utility, toxicity and sustained drug release capability of a novel formulation of poly(lactic-co-glycolic acid) (PLGA)/poly(ethylene glycol) (PEG) microparticles. Methods PLGA/PEG microparticle-based matrices were molded around an ex vivo brain pseudo-resection cavity and analyzed using magnetic resonance imaging and computerized tomography. In vitro toxicity of the polymer was assessed using tumor and endothelial cells and drug release from trichostatin A-, etoposide- and methotrexate-loaded matrices was determined. To verify activity of released agents, tumor cells were seeded onto drug-loaded matrices and viability assessed. Results PLGA/PEG matrices can be molded around a pseudo-resection cavity wall with no polymer-related artifact on clinical scans. The polymer withstands fractionated radiotherapy, with no disruption of microparticle structure. No toxicity was evident when tumor or endothelial cells were grown on control matrices in vitro. Trichostatin A, etoposide and methotrexate were released from the matrices over a 3-4 week period in vitro and etoposide released over 3 days in vivo, with released agents retaining cytotoxic capabilities. PLGA/PEG microparticle-based matrices molded around a resection cavity wall are distinguishable in clinical scanning modalities. Matrices are non-toxic in vitro suggesting good biocompatibility in vivo. Active trichostatin A, etoposide and methotrexate can be incorporated and released gradually from matrices, with radiotherapy unlikely to interfere with release. Conclusion The PLGA/PEG delivery system offers an innovative intra-cavity approach to administer chemotherapeutics for improved local control of malignant brain tumors

Rainfall Triggers More Deep-Seated Landslides than Cascadia Earthquakes in the Oregon Coast Range, USA

The coastal Pacific Northwest USA hosts thousands of deep-seated landslides. Historic landslides have primarily been triggered by rainfall, but the region is also prone to large earthquakes on the 1100-km-long Cascadia Subduction Zone megathrust. Little is known about the number of landslides triggered by these earthquakes because the last magnitude 9 rupture occurred in 1700 CE. Here, we map 9938 deep-seated bedrock landslides in the Oregon Coast Range and use surface roughness dating to estimate that past earthquakes triggered fewer than half of the landslides in the past 1000 years. We find landslide frequency increases with mean annual precipitation but not with modeled peak ground acceleration or proximity to the megathrust. Our results agree with findings about other recent subduction zone earthquakes where relatively few deep-seated landslides were mapped and suggest that despite proximity to the megathrust, most deep-seated landslides in the Oregon Coast Range were triggered by rainfall

Early Cenozoic faulting of the northern Tibetan Plateau margin from apatite (U–Th)/He ages

Models to explain the distributed nature of continental deformation predict the propagation of strain and high topography away from the plate boundary. Yet a growing body of evidence in the Tibetan orogen suggests that deformation occurred at the far northern extent of the modern plateau early in the orogen's history and thus our current mechanical understanding of orogenic plateau development is incomplete. New apatite (U–Th)/He ages from four elevation transects document periods of rapid exhumation related to erosion pulses in hanging wall rocks of major thrust structures. Accelerated erosion is used as a proxy of fault timing, and is interpreted in a larger context of structural data and sediment accumulation in adjacent foreland basins. Helium results are synthesized with published geologic, thermochronometric, and sedimentologic data from which a growing picture of regional compressional deformation in Middle to Late Eocene time in northern Tibet emerges. We relate the early Cenozoic period of deformation to the initiation of collision between India and Eurasia, despite the fact that the plate boundary was located > 3000 km to the south. Regardless of whether or not high topography was built simultaneously as a result of this deformation, early Cenozoic strain signifies that the modern limit of the orogen has been relatively stationary since continental collision began and that deformation has not significantly propagated farther away from the plate boundary in time

Sex and Race Differences in Cardiac Sarcoidosis Presentation, Treatment and Outcomes.

BACKGROUND: Although sex- and race-based patterns have been described in the extracardiac organ involvement of sarcoidosis, cardiac sarcoidosis (CS)-specific studies are lacking. METHODS: We studied CS presentation, treatment and outcomes based on sex and race in a tertiary-center cohort. Multivariable adjusted Cox proportional hazards and survival analyses were performed for primary composite outcomes (left ventricular assist device, heart transplantation, all-cause death) and for secondary outcomes (ventricular arrhythmia and all-cause death. RESULTS: We identified 252 patients with CS (108 female, 109 Black). At presentation with CS, females vs males (P = 0.001) and Black vs White individuals (P = 0.001) more commonly had symptomatic heart failure (HF), with HF most common in Black females (ANOVA P \u3c 0.001). Treatment differences included more corticosteroid use (90% vs 79%; P = 0.020), higher 1-year prednisone dosage (13 vs 10 mg; P = 0.003) and less frequent early steroid-sparing agent use in males (29% vs 40%; P = 0.05). Black participants more frequently received a steroid-sparing agent (75% vs 60%; P = 0.023). Composite outcome-free survival did not differ by sex or race. Male sex had an adjusted hazard ratio of 2.34 (95% CI 1.13, 4.80; P = 0.021) for ventricular arrhythmia. CONCLUSION: CS course may differ by sex and race and may contribute to distinct clinical CS phenotypes