36 research outputs found

    Preparation and physicochemical characterization of meloxicam orally fast disintegration tablet using its solid dispersion

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    Meloxicam (MLX) is a non-steroidal, anti-inflammatory drug that is prescribed in the treatment of rheumatoid arthritis and osteoarthritis. MLX is practically insoluble in water and exhibits a slow onset of action. In this study, MLX solid dispersions (MLX SDs) were prepared to improve the water solubility of this poorly water-soluble drug. Then orally disintegrating tablets (ODT) of MLX were developed using MLX SD to decrease the onset of action of this drug. MLX, poloxamer 188, and crospovidone of different ratios were melted in molten poloxamer 188 as a hydrophilic carrier. The optimum SD with the highest saturation solubility in water (13.09±0.34 microgram/mL) consisting of MLX: poloxamer 188: crospovidone in the ratio of 1:2:0 was used for the preparation of MLX ODTs. MLX ODTs were prepared by the direct compression method and optimized by the 23 factorial design. The effect of the superdisintegrant concentration, the mannitol-avicel ratio, and the level of compression force on the disintegration time, hardness, and percent of dissolved MLX from MLX ODTs after 30 min was evaluated. DSC and XRD analysis approved an amorphous form of MLX in SDs. The optimized ODT formulation containing 10% of superdisintegrant, and mannitol and avicel in the ratio of 4:1 respectively was compressed using a high level of compression force. The optimized ODT showed hardness (34.37±2.1 N) and friability (1.26±0.04%). This formulation showed a rapid disintegration in 12.66±2.5 seconds, which 82.66±5.1% of the MLX released within 30 min. MLX ODTs, prepared from MLX SD, could be introduced as a suitable dosage form of MLX with improved solubility and the onset of action

    Treatment with platelet lysate induces endothelial differentiation of bone marrow mesenchymal stem cells under fluid shear stress

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    By considering stem cell-based therapies as a new hope for the treatment of some tragic diseases, marrow stromal cells or marrow mesenchymal stem cells (MSCs) were considered as a suitable and safe multipotential cell source for this new therapeutic approach. For this purpose, many investigations have been performed on differentiation of MSCs toward specific cell lines to overcome the demand for providing the organ specific cells for cell therapy or preparation of engineered tissues. In the present study, differentiation of MSCs to endothelial cells (ECs) by mechanical and chemical stimulation was evaluated. Fluid shear stress (FSS) was used as mechanical inducer, while platelet lysate (PL) and estradiol (E) were used as chemical induction factors. MSCs were placed under FSS with different forces (2, 5 and 10 dyn/cm²) for different periods (6, 12 and 24 hours). In some groups, PL and E were added to the culture media to evaluate their effect on expression of EC specific markers. This investigation revealed that FSS with low tension (2.5-5 dyn/cm²) for a long time (24 hours) or high tension (10 dyn/cm²) in short time (6 hours) in the presence of PL could differentiate MSCs toward ECs. The presence of PL was necessary for initiation of endothelial differentiation, and in the absence of PL, there was not any expression of CD34 and Cadherin5 (Cdh5) among cells. Adding E to the culture medium did not change the rate of endothelial differentiation under FSS. Generated endothelial progenitors could produce von Willebrand factor (vWF) after two weeks culture and also they formed tubular structures after culture on matrigel

    Collaborative development of the Arrowsmith two node search interface designed for laboratory investigators.

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    Arrowsmith is a unique computer-assisted strategy designed to assist investigators in detecting biologically-relevant connections between two disparate sets of articles in Medline. This paper describes how an inter-institutional consortium of neuroscientists used the UIC Arrowsmith web interface http://arrowsmith.psych.uic.edu in their daily work and guided the development, refinement and expansion of the system into a suite of tools intended for use by the wider scientific community

    Preparation and physicochemical characterization of meloxicam orally fast disintegration tablet using its solid dispersion

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    ABSTRACT Meloxicam (MLX) is a non-steroidal, anti-inflammatory drug that is prescribed in the treatment of rheumatoid arthritis and osteoarthritis. MLX is practically insoluble in water and exhibits a slow onset of action. In this study, MLX solid dispersions (MLX SDs) were prepared to improve the water solubility of this poorly water-soluble drug. Then orally disintegrating tablets (ODT) of MLX were developed using MLX SD to decrease the onset of action of this drug. MLX, poloxamer 188, and crospovidone of different ratios were melted in molten poloxamer 188 as a hydrophilic carrier. The optimum SD with the highest saturation solubility in water (13.09±0.34 microgram/mL) consisting of MLX: poloxamer 188: crospovidone in the ratio of 1:2:0 was used for the preparation of MLX ODTs. MLX ODTs were prepared by the direct compression method and optimized by the 23 factorial design. The effect of the superdisintegrant concentration, the mannitol-avicel ratio, and the level of compression force on the disintegration time, hardness, and percent of dissolved MLX from MLX ODTs after 30 min was evaluated. DSC and XRD analysis approved an amorphous form of MLX in SDs. The optimized ODT formulation containing 10% of superdisintegrant, and mannitol and avicel in the ratio of 4:1 respectively was compressed using a high level of compression force. The optimized ODT showed hardness (34.37±2.1 N) and friability (1.26±0.04%). This formulation showed a rapid disintegration in 12.66±2.5 seconds, which 82.66±5.1% of the MLX released within 30 min. MLX ODTs, prepared from MLX SD, could be introduced as a suitable dosage form of MLX with improved solubility and the onset of action

    Structural Relationships between Mathematical Academic Beliefs and Mathematical Anxiety Mediated by Academic Hardiness in Male High School Students in District 4 of Tehran

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    The aim of this study was to investigate the mediating role of academic rigidity in the relationship between mathematical academic beliefs and mathematical anxiety in students. The research method was descriptive-correlation based on structural equations. The statistical population of the present study consisted of all 2710 male students of the first year of the ninth grade of public schools in Tehran's 4th district in the academic year 1399-1400. In this study, 300 people were selected as a sample size by a two-stage cluster sampling method. To collect data, Plick and Parker (1982) Mathematical Anxiety Questionnaire, Leder and Forges (2002) Mathematical Academic Beliefs Questionnaire, Academic Hardness Questionnaire were collected. Benshik et al. (2005) were used. Structural regression equations with SPSS18 and AMOS23 software were used to analyze the data. Findings showed that academic math beliefs and academic toughness have a direct effect on math anxiety in students. Also, mathematical academic beliefs have a significant effect on mathematical anxiety through the mediation of academic hardiness in students. In general, the research model was approved. The present study shows the importance of cognitive factors in explaining mathematical anxiety

    The Relationship Between Psychological Well-being with Creativity and Performance in Male Coaches of Iran’s Football League

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    Objective: This paper attempts to investigate the relationship between psychological well-being with creativity and performance of male coaches of Iran’s football league. Methods: This descriptive type study is carried out through field study. The statistical population includes all 925 coaches present in Iran’s football league in 1394. 200 coaches were selected as sample of the study by Morgan sampling table. The sampling was conducted through random sampling method. 3 questionnaires of Ryff psychological well-being (1980), Torrence creativity (1974), and performance researcher-prepared questionnaire were used for gathering the required data. Results: For data analysis, Kolmogorov Smirnov (K-S) Tests were used for data distribution test, one-sample T-test for comparing mean variables and hypothetical means of the intended society, Pearson correlation for investigating the relationship between variables and their related components. All statistical works were carried out with SPSS, version 22. Results suggest that all psychological well-being variable and its components except for purposeful life, creativity variable, and its components, and performance variable of male coaches of Iran’s football league are significantly in a proper condition. Conclusion: Also, there is a positive and significant relationship between psychological well-being and all of its components with creativity and all of its components, between psychological well-being and all of its components with the performance, and between creativity and all of its components with performance
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