Tensiones políticas y regionales en la definición de la dirigencia política santafesina, 1852-1868

Este trabajo propone una indagación sobre el origen de esa tácita frontera interna que diferenció al Norte y al Sur de Santa Fe; sobre los obstáculos más tempranos que se interpusieron en la efectiva integración política del territorio provincial y las tensiones que presidieron las relaciones entre autoridades provinciales y la dirigencia rosarina que, aunque resignificadas y moderadas, aún perduran. Para ello, se enfoca en los actores que condujeron la política santafesina entre 1852 y 1868, explorando varias cuestiones y prescindiendo deliberadamente de otras. Por un lado, los ritmos y la distribución de las transformaciones económicas y sociales y las características que adquirieron las sociedades capitalina y rosarina en los primeros años de la segunda mitad del siglo XIX. Por otro lado, los esfuerzos realizados por esos actores para sostenerse en la cumbre del poder político en el marco de un acelerado proceso de modernización; el modo en que entendieron y practicaron la política; las modificaciones operadas en sus matrices de organización —de las tradicionales redes de parentesco a los más modernos clubes políticos- y las discrepancias en sus alineamientos respecto de las fuerzas políticas nacionales. Por último, los vínculos que establecieron entre sí, con el Estado de la Confederación y con el Nacional, considerando que por esas vías es posible explicar tanto la diferenciación como las tensiones. Desde esa perspectiva, pretende aportar al conocimiento del origen de la cuestión Norte/Sur en la provincia y al mismo tiempo, a la comprensión del proceso de consolidación de la dirigencia política nacional al que Santa Fe contribuyó con empeño.Fil: Megías, Alicia. Universidad de Buenos Aires. Facultad de Filosofía y Letras

Degeneración macular exudativa asociada a la edad. Riesgo inducido por facoemulsificación e impacto en los genes e impacto de los genes "CFH" y "ARMS2" sobre la incidencia, desarrrollo y respuesta al tratamiento con ranibizumab intravítreo

Tesis inédita de la Universidad Complutense de Madrid, Facultad de Medicina, Departamento de Oftalmología, leída el 16/04/2013Depto. de Inmunología, Oftalmología y ORLFac. de MedicinaTRUEunpu

Systemic effects of repeated intraocular dexamethasone Intravitreal implant in diabetic patients: a retrospective study

Introduction: The objective of this study is to evaluate the influence of repeated intraocular dexamethasone implant (Ozurdex) injections on metabolic control in type 2 diabetic patients. Methods: Retrospective study of 165 type 2 diabetic patients starting Ozurdex treatment who received no less than three consecutive injections. Glycated hemoglobin (HbA1c), serum creatinine, total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, and triglycerides (TGs) were evaluated during 15 months of follow-up after Ozurdex treatment onset. Results: Fifty-seven patients met inclusion criteria. Mean baseline values for HbA1c, creatinine, total cholesterol, HDL cholesterol, and TGs before treatment (7.1%, 1.3, 176.7, 51.1, and 125.6 mg/ dl, respectively) were similar to mean values after Ozurdex onset (Wilcoxon test p values were 0.68, 0.41, 0.06, 0.87, and 0.33, respectively) and remained stable during the follow-up period. Mean LDL cholesterol levels increased slightly after Ozurdex treatment onset (90.1 vs 88.2 mg/ dl, p = 0.04) but after 15 months of follow-up they had returned to baseline values. Transient increase in LDL cholesterol was remarkable in the group of 24 bilaterally treated patients (96.8 vs 88.4 mg/dl, p = 0.03). A third of these patients increased their baseline LDL values by more than 20%. Even with continuous injections of Ozurdex, LDL cholesterol levels also declined back to baseline by month 15. Conclusion: Ozurdex injections had no influence on HbA1c or renal function. Lipid profile changes were mild and transient. However, a significant temporary increase has been found in LDL cholesterol levels in patients receiving simultaneous bilateral injections. Lipid levels should be monitored in patients starting with bilateral Ozurdex injections especially in those with recent history of acute myocardial infarction

Effect of COVID-19 lockdown in Spain on structural and functional outcomes of Neovascular AMD patients

This is a retrospective single-center study of patients with neovascular age-related macular degeneration whose follow-up was delayed due to COVID-19 pandemic with at least three months between visits in Madrid, Spain. The purpose of the study was to evaluate best corrected visual acuity (BCVA) changes and try to identify features in optical coherence tomography (OCT) that could be related to more profound visual loss. It included 270 eyes. The two last visits before lockdown were used for comparison with the visit after lockdown. BCVA changed from 60.2 ± 18.2 to 55.9 ± 20.5 ETDRS letters. 29% of the eyes lost more than 5 letters. OCT was active in 67% of eyes before lockdown and in 80.4% after lockdown. Multiple lineal analysis showed that patients whose OCT before lockdown presented with a combination of intra and subretinal fluid were more likely to suffer a greater visual loss (p = 0.002). These patients should be encouraged to not miss any visits in case a new lockdown is imposed

Nomads of Knowledge: Analysis of Disruptive Pedagogical Practices in Secondary Education

Ministerio de Ciencia e Innovación, proyecto RTI2018-097144-B-I00 de la secretaría de estado de investigaciónThis paper presents an exploratory study and a critical analysis of experiences of emerging pedagogies and disruptive practices in secondary education, developed in 4 universities, in Spain (Extremadura, Valladolid, Granada and Málaga). This study intends to transform these schools into an open space for educational experimentation through the production of shared designs, prototypes of experiences and cultural productsUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Herramientas de comunicación en el aprendizaje de la Bioquímica

Sección Deptal. de Bioquímica y Biología Molecular (Biológicas)Depto. de Bioquímica y Biología MolecularFac. de Ciencias BiológicasFac. de Ciencias QuímicasFALSEsubmitte

Diseño y utilización de unas prácticas de Regulación del Metabolismo como herramienta integradora de conocimientos multidisciplinares en el Grado en Biología (II)

Se pretende la creación de espacios multidisdiplinares en el Grado en Biología,con prácticas integradas de asignaturas que se cursan simultáneamente, que pudieran servir de base a propuestas de Trabajos de Fin de Grado

CHL1 hypermethylation as a potential biomarker of poor prognosis in breast cancer

The CHL1 gene encodes a cell-adhesion molecule proposed as being a putative tumour-suppressor gene in breast cancer (BC). However, neither the underlying molecular mechanisms nor the clinical value of CHL1 downregulation in BC has been explored. The methylation status of three CpG sites in the CHL1 promoter was analysed by pyrosequencing in neoplastic biopsies from 142 patients with invasive BC and compared with that of non-neoplastic tissues. We found higher CHL1 methylation levels in breast tumours than in non-neoplastic tissues, either from mammoplasties or adjacent-to-tumour, which correlated with lower levels of protein expression in tumours measured by immunohistochemistry. A panel of five BC cell lines was treated with two epigenetic drugs, and restoration of CHL1 expression was observed, indicating in vitro dynamic epigenetic regulation. CHL1 was silenced by shRNA in immortalized but non-neoplastic mammary cells, and enhanced cell proliferation and migration, but not invasion, were found by real-time cell analysis. The prognostic value of CHL1 hypermethylation was assessed by the log-rank test and fitted in a Cox regression model. Importantly, CHL1 hypermethylation was very significantly associated with shorter progression-free survival in our BC patient series, independent of age and stage (p = 0.001). In conclusion, our results indicate that CHL1 is downregulated by hypermethylation and that this epigenetic alteration is an independent prognostic factor in BC

Creación de material audiovisual para el Campus Virtual y plataformas educativas en aras de que los estudiantes de grado, posgrado y profesionales de la visión dominen el análisis ocular con biomicroscopio

Edición y publicación de videos explicando los fundamentos y técnicas del biomicroscopio ocular con el análisis de la salud superficial del polo anterior ocular y las imágenes biomicroscópicas y fluoroscópicas para la correcta adaptación de lentes de contacto