The Importance of Developmental Science for Studies in Bullying and Victimization

Research on bullying and victimization, especially in school settings, has become an important area of developmental research, with strong practical implications. In this article we overview some considerations from neuropsychology, quantitative genetics, developmental neuroscience, we discuss CU traits and conduct problems, individual, group, class and school levels of analysis, developmental changes by age and context, and cross-cultural aspects. Together we argue that these can help bring about a developmental science perspective on to this area of research

Residential neighbourhood greenspace is associated with reduced risk of cardiovascular disease: A prospective cohort study

Background: Living in a greener neighbourhood may reduce the risk of developing incident cardiovascular disease, but evidence is limited by reliance on cross-sectional comparisons. We use data from a longitudinal study with a time-independent measure of risk to explore the association between exposure to greenspace and cardiovascular disease. Methods: Data was from the European Prospective Investigation of Cancer Norfolk UK cohort, baseline 1993–1997 (n = 24,420). Neighbourhoods were defined as 800m radius zones around participants’ home, according to their home postcode (zip code) in the year 2000. Greenspace exposure was identified using classified satellite imagery. Adjusted Cox proportional hazards regression examined associations between greenspace and incident cardiovascular disease. Mediation analysis assessed if physical activity mediated associations, whilst modification by rurality, socio-economic status and age was explored. Results: The mean age of participants was 59.2 years at baseline, 54.7% were female, and mean follow-up time was 14.5 years. Individuals living in the greenest neighbourhood quartile had a 7% lower relative hazard of developing cardiovascular disease than other neighbourhoods (HR 0.93; 95% CI 0.88, 0.97; p = 0.003) after adjusting for age, sex, BMI, prevalent diabetes and socio-economic status (SES). Physical activity did not mediate the relationship (greenest compared to the least green quartile HR 0.99; 95% CI 0.97, 1.01; p = 0.416). Models predicted incidence of cardiovascular disease in the least green neighbourhoods (19.4% greenspace on average) would fall by 4.8% (95% CI 1.6%, 8.2% p = 0.003) if they were as green as the average neighbourhood (59.0% greenspace). Occupation moderated the relationship, whereby exposure to greenspace was not associated with incident CVD for participants engaged in manual occupations. Conclusions: Greener home neighbourhoods may protect against risk of cardiovascular disease even after accounting for SES, whilst the mechanism does not appear to be strongly associated with physical activity. Putative causal mechanisms require investigation

Are GIS-modelled routes a useful proxy for the actual routes followed by commuters?

Active commuting offers the potential to increase physical activity among adults by being built into daily routines. Characteristics of the route to work may influence propensity to walk or cycle. Geographic information system (GIS) software is often used to explore this by modelling routes between home and work. However, if the validity of modelled routes depends on the mode of travel used, studies of environmental determinants of travel may be biased. We aimed to understand how well modelled routes reflect those actually taken, and what characteristics explain these differences. We compared modelled GIS shortest path routes with actual routes measured using QStarz BT-Q1000X Global Positioning System (GPS) devices in a free-living sample of adults working in Cambridge and using varying travel modes. Predictors of differences, according to length and percentage overlap, between the two route sets were assessed using multilevel regression models and concordance coefficients. The 276 trips, made by 51 participants, were on average 27% further than modelled routes, with an average geographical overlap of 39%. However, predictability of the route depended on travel mode. For route length, there was moderate-to-substantial agreement for journeys made on foot and by bicycle. Route overlap was lowest for trips made by car plus walk (22%). The magnitude of difference depended on other journey characteristics, including travelling via intermediate destinations, distance, and use of busy roads. In conclusion, GIS routes may be acceptable for distance estimation and to explore potential routes, particularly active commuting. However, GPS should be used to obtain accurate estimates of environmental contexts in which commuting behaviour actually occurs. Public health researchers should bear these considerations in mind when studying the geographical determinants and health implications of commuting behaviour, and when recommending policy changes to encourage active travel.The Commuting and Health in Cambridge study was developed by David Ogilvie, Simon Griffin, Andy Jones and Roger Mackett and initially funded under the auspices of the Centre for Diet and Activity Research (CEDAR), a UKCRC Public Health Research Centre of Excellence (087636/Z/08/Z and ES/G007462/1). Funding from the British Heart Foundation, Economic and Social Research Council, Medical Research Council, National Institute for Health Research and the Wellcome Trust, under the auspices of the UK Clinical Research Collaboration, is gratefully acknowledged. The study is now funded by the National Institute for Health Research Public Health Research programme (project number 09/3001/06: see http://www.phr.nihr.ac.uk/funded_projects). David Ogilvie is supported by the Medical Research Council (Unit Programme number MC_UU_12015/6). Jenna Panter is supported by an NIHR post-doctoral fellowship (NIHR-PDF-2012-05-157). The views and opinions expressed herein are those of the authors and do not necessarily reflect those of the NIHR PHR programme or the Department of Health. The funders had no role in study design, data collection and analysis, the decision to publish, or the preparation of the manuscript. We thank all staff from the MRC Epidemiology Unit Functional Group Team, in particular for study coordination and data collection (led by Cheryl Chapman), physical activity data processing and data management.This is the final version of the article. It first appeared from Elsevier via http://dx.doi.org/10.1016/j.jth.2014.10.00

Tillage Systems for Row Crop Production

Selecting the tillage system best suited to a particular farming situation is an important management decision. Formerly, the traditional system was a moldboard plow operation followed by several secondary tillage operations before planting. This system can be appropriate for poorly drained soils having little or no slope and low erosion potential. However, plowing has several disadvantages . The potential for soil erosion is high on sloping lands, and labor and fuel requirements can be substantially higher than with other tillage and planting systems. Today, conservation tillage systems are used to reduce preplant tillage operations, thus reducing soil erosion and moisture loss while saving labor and fuel. The label conservation tillage represents a broad spectrum of farming methods, and is most often defined by the amount of residue cover remaining on the soil surface. The minimum amount recommended is 20 to 30 percent after planting. Research in Nebraska and other Midwestern states has shown that leaving at least this much residue will reduce erosion by more than 50 percent of that occurring from a cleanly tilled field. To achieve effective erosion control, this minimum residue cover should be maintained during the critical soil erosion period between spring seedbed preparation and crop canopy establishment. Conservation tillage does not necessarily require new equipment. Most conventional farm implements can be used. For corn, grain sorghum, or wheat residue, one or two passes with a field cultivator, disk, or chisel plow will usually leave more than the 20 percent minimum cover. Additional operations reduce the amount of residue, and thus reduce erosion control. Other tillage and planting systems such as ridge-plant (till-plant) and no till leave even more residue, and thus offer greater erosion control. However, no-till planting is the only method that consistently leaves the minimum surface cover in the more fragile and less abundant soybean residue. No single tillage system is best for all situations at all times. Selecting the best tillage system for a particular soil and cropping situation requires matching the operation to the crop sequence, topography, and soil type. Rotating systems to coincide with crop rotations often provides an excellent combination. For example, a no till system could follow soybeans while a chisel or disk system might follow corn. This tillage rotation provides the best erosion control following soybeans, and provides an opportunity for some tillage in the less fragile and more abundant corn residue

Tillage Systems for Row Crop Production

Selecting the tillage system best suited to a particular farming situation is an important management decision. Formerly, the traditional system was a moldboard plow operation followed by several secondary tillage operations before planting. This system can be appropriate for poorly drained soils having little or no slope and low erosion potential. However, plowing has several disadvantages . The potential for soil erosion is high on sloping lands, and labor and fuel requirements can be substantially higher than with other tillage and planting systems. Today, conservation tillage systems are used to reduce preplant tillage operations, thus reducing soil erosion and moisture loss while saving labor and fuel. The label conservation tillage represents a broad spectrum of farming methods, and is most often defined by the amount of residue cover remaining on the soil surface. The minimum amount recommended is 20 to 30 percent after planting. Research in Nebraska and other Midwestern states has shown that leaving at least this much residue will reduce erosion by more than 50 percent of that occurring from a cleanly tilled field. To achieve effective erosion control, this minimum residue cover should be maintained during the critical soil erosion period between spring seedbed preparation and crop canopy establishment. Conservation tillage does not necessarily require new equipment. Most conventional farm implements can be used. For corn, grain sorghum, or wheat residue, one or two passes with a field cultivator, disk, or chisel plow will usually leave more than the 20 percent minimum cover. Additional operations reduce the amount of residue, and thus reduce erosion control. Other tillage and planting systems such as ridge-plant (till-plant) and no till leave even more residue, and thus offer greater erosion control. However, no-till planting is the only method that consistently leaves the minimum surface cover in the more fragile and less abundant soybean residue. No single tillage system is best for all situations at all times. Selecting the best tillage system for a particular soil and cropping situation requires matching the operation to the crop sequence, topography, and soil type. Rotating systems to coincide with crop rotations often provides an excellent combination. For example, a no till system could follow soybeans while a chisel or disk system might follow corn. This tillage rotation provides the best erosion control following soybeans, and provides an opportunity for some tillage in the less fragile and more abundant corn residue

G91-1046 Conservation Tillage and Planting Systems

Tillage system descriptions and comparisons are included here. Moldboard plowing, followed by such secondary tillage operations as disking and harrowing, was once the most common, or traditional, tillage system before planting. Soil erosion potential from rainfall on sloping lands was great and requirements for labor and fuel were high compared to other tillage and planting systems. One of the most commonly used tillage systems in Nebraska today is two diskings followed by field cultivation. Unfortunately, the potential for soil erosion may be great because the number of tillage operations involved may not leave adequate residue cover for erosion control. Today conservation tillage systems reduce soil erosion and moisture losses while saving labor and fuel. Conservation tillage can represent a broad spectrum of farming methods, provided at least 30 percent of the soil surface remains covered with crop residue following planting. Research in Nebraska and other midwestern states has shown that leaving at least 30 percent residue cover reduces erosion from water by more than 50 percent, as compared to a cleanly tilled field

¹⁵N-amino sugar stable isotope probing (¹⁵N-SIP) to trace the assimilation of fertiliser-N by soil bacterial and fungal communities

Although amino sugars represent a major component of soil organic nitrogen (ON), the assimilation of nitrate (NO3−) and ammonium (NH4+) into amino sugars (AS) by soil bacteria and fungi represents a neglected aspect of the global N cycle. A deeper knowledge of AS responses to N fertiliser addition may help enhance N use efficiency (NUE) within agricultural systems. Our aim was to extend a sensitive compound-specific 15N-stable isotope probing (SIP) approach developed for amino acids (AAs) to investigate the immobilization of inorganic N into a range of amino sugars (muramic acid, glucosamine, galactosamine, mannosamine). Laboratory incubations using 15N-ammonium and 15N-nitrate applied at agriculturally relevant rates (190 and 100 kg N ha−1 for 15NH4+ and 15NO3−, respectively) were carried out to obtain quantitative measures of N-assimilation into the AS pool of a grassland soil over a 32-d period. Using gas chromatography-combustion-isotope ratio mass spectrometry (GC-C-IRMS) we found that δ15N values for individual AS reflected differences in routing of the applied ammonium and nitrate. The contrasting N-assimilation dynamics of bacterial and fungal communities were demonstrated through determinations of percentage 15N incorporation into diagnostic AS. N-assimilation dynamics of the bacterial community were altered with the applied substrate whilst fungal N-assimilation dynamics were unaffected. Rates and fluxes of the applied N-substrates into the bacterial AS pool reflected known biosynthetic pathways for AS, with fungal glucosamine appearing to be biosynthetically further from the applied substrates than bacterial glucosamine due to different turnover rates. This sensitive and specific compound specific 15N-SIP approach using AS, building on existing approaches with AAs, enables differentiation of N assimilation dynamics within the microbial community and assessment of microbial NUE with agriculturally relevant fertilisation rates

G91-1046 Conservation Tillage and Planting Systems

Tillage system descriptions and comparisons are included here. Moldboard plowing, followed by such secondary tillage operations as disking and harrowing, was once the most common, or traditional, tillage system before planting. Soil erosion potential from rainfall on sloping lands was great and requirements for labor and fuel were high compared to other tillage and planting systems. One of the most commonly used tillage systems in Nebraska today is two diskings followed by field cultivation. Unfortunately, the potential for soil erosion may be great because the number of tillage operations involved may not leave adequate residue cover for erosion control. Today conservation tillage systems reduce soil erosion and moisture losses while saving labor and fuel. Conservation tillage can represent a broad spectrum of farming methods, provided at least 30 percent of the soil surface remains covered with crop residue following planting. Research in Nebraska and other midwestern states has shown that leaving at least 30 percent residue cover reduces erosion from water by more than 50 percent, as compared to a cleanly tilled field

Acu-TENS and Postexercise Expiratory Flow Volume in Healthy Subjects

Transcutaneous Electrical Nerve Stimulation over acupoints (Acu-TENS) facilitates recovery of resting heart rate after treadmill exercise in healthy subjects. Its effect on postexercise respiratory indices has not been reported. This study investigates the effect of Acu-TENS on forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) in healthy subjects after a submaximal exercise. Eleven male subjects were invited to the laboratory twice, two weeks apart, to receive in random order either Acu-TENS or Placebo-TENS (no electrical output from the TENS unit) over bilateral Lieque (LU7) and Dingchuan (EX-B1) for 45 minutes, before undergoing exercise following the Bruce protocol. Exercise duration, rate of perceived exertion (RPE), and peak heart rate (PHR) were recorded. Between-group FEV1 and FVC, before, immediately after, at 15, 30, and 45minutes postexercise, were compared. While no between-group differences in PHR, RPE, and FVC were found, Acu-TENS was associated with a longer exercise duration (0.9 min (P = .026)) and a higher percentage increase in FEV1 at 15 and 45 minutes postexercise (3.3 ± 3.7% (P = .013) and 5.1 ± 7.5% (P = .047), resp.) compared to Placebo-TENS. We concluded that Acu-TENS was associated with a higher postexercise FEV1 and a prolongation of submaximal exercise

Delineating the activity of the potent nicotinic acetylcholine receptor agonists (+)-anatoxin-a and (−)-hosieine-A

The affinity and thermodynamic parameters for the interactions of two naturally occurring neurotoxins, (+)-anatoxin-a and (−)-hosieine-A, with acetylcholine-binding protein were investigated using a fluorescence-quenching assay and isothermal titration calorimetry. The crystal structures of their complexes with acetylcholine-binding protein from Aplysia californica (AcAChBP) were determined and reveal details of molecular recognition in the orthosteric binding site. Comparisons treating AcAChBP as a surrogate for human α4β2 and α7 nicotinic acetylcholine receptors (nAChRs) suggest that the molecular features involved in ligand recognition and affinity for the protein targets are conserved. The ligands exploit interactions with similar residues as the archetypal nAChR agonist nicotine, but with greater affinity. (−)-Hosieine-A in particular has a high affinity for AcAChBP driven by a favorable entropic contribution to binding. The ligand affinities help to rationalize the potent biological activity of these alkaloids. The structural data, together with comparisons with related molecules, suggest that there may be opportunities to extend the hosieine-A scaffold to incorporate new interactions with the complementary side of the orthosteric binding site. Such a strategy may guide the design of new entities to target human α4β2 nAChR that may have therapeutic benefit