99,310 research outputs found

    Asymptotics of Nonlinear LSE Precoders with Applications to Transmit Antenna Selection

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    This paper studies the large-system performance of Least Square Error (LSE) precoders which~minimize~the~input-output distortion over an arbitrary support subject to a general penalty function. The asymptotics are determined via the replica method in a general form which encloses the Replica Symmetric (RS) and Replica Symmetry Breaking (RSB) ans\"atze. As a result, the "marginal decoupling property" of LSE precoders for bb-steps of RSB is derived. The generality of the studied setup enables us to address special cases in which the number of active transmit antennas are constrained. Our numerical investigations depict that the computationally efficient forms of LSE precoders based on "1\ell_1-norm" minimization perform close to the cases with "zero-norm" penalty function which have a considerable improvements compared to the random antenna selection. For the case with BPSK signals and restricted number of active antennas, the results show that RS fails to predict the performance while the RSB ansatz is consistent with theoretical bounds.Comment: 5 pages; 2 figures; to be presented at ISIT 201

    Genome-driven evolutionary game theory helps understand the rise of metabolic interdependencies in microbial communities

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    Metabolite exchanges in microbial communities give rise to ecological interactions that govern ecosystem diversity and stability. It is unclear, however, how the rise of these interactions varies across metabolites and organisms. Here we address this question by integrating genome-scale models of metabolism with evolutionary game theory. Specifically, we use microbial fitness values estimated by metabolic models to infer evolutionarily stable interactions in multi-species microbial “games”. We first validate our approach using a well-characterized yeast cheater-cooperator system. We next perform over 80,000 in silico experiments to infer how metabolic interdependencies mediated by amino acid leakage in Escherichia coli vary across 189 amino acid pairs. While most pairs display shared patterns of inter-species interactions, multiple deviations are caused by pleiotropy and epistasis in metabolism. Furthermore, simulated invasion experiments reveal possible paths to obligate cross-feeding. Our study provides genomically driven insight into the rise of ecological interactions, with implications for microbiome research and synthetic ecology.We gratefully acknowledge funding from the Defense Advanced Research Projects Agency (Purchase Request No. HR0011515303, Contract No. HR0011-15-C-0091), the U.S. Department of Energy (Grants DE-SC0004962 and DE-SC0012627), the NIH (Grants 5R01DE024468 and R01GM121950), the national Science Foundation (Grants 1457695 and NSFOCE-BSF 1635070), MURI Grant W911NF-12-1-0390, the Human Frontiers Science Program (grant RGP0020/2016), and the Boston University Interdisciplinary Biomedical Research Office ARC grant on Systems Biology Approaches to Microbiome Research. We also thank Dr Kirill Korolev and members of the Segre Lab for their invaluable feedback on this work. (HR0011515303 - Defense Advanced Research Projects Agency; HR0011-15-C-0091 - Defense Advanced Research Projects Agency; DE-SC0004962 - U.S. Department of Energy; DE-SC0012627 - U.S. Department of Energy; 5R01DE024468 - NIH; R01GM121950 - NIH; 1457695 - national Science Foundation; NSFOCE-BSF 1635070 - national Science Foundation; W911NF-12-1-0390 - MURI; RGP0020/2016 - Human Frontiers Science Program; Boston University Interdisciplinary Biomedical Research Office ARC)Published versio

    Nucleation of second-phase near elastic defects in crystalline solids

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    The problem of heterogeneous nucleation of second-phase in alloys in the vicinity of elastic defects is considered. The defect can be a dislocation line or a crack tip residing in a crystalline solid. We use the Ginzburg-Landau equation to describe the spatiotemporal evolution of the order parameter in the environs of the defect. The model accounts for the elasticity of the solid and the interaction of order parameter field with the elastic field of the defect. A finite volume numerical method is used to solve the governing partial differential equation for the order parameter. We examine the nature of the phase transition in the vicinity of the defects.Comment: Prepared for Materials Science & Technology 2011 (MS&T'11), Columbus, Ohio, 16-20 Oct, 201
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