Meesmann Corneal Dystrophy; a Clinico-Pathologic, Ultrastructural and Confocal Scan Report

Purpose: To report the microstructural features of Meesmann corneal dystrophy (MCD) in two patients. Case Report: The first patient was a 10-year-old boy who presented with bilateral visual loss, diffuse corneal epithelial microcystic changes, high myopia and amblyopia. With a clinical impression of MCD, automated lamellar therapeutic keratoplasty was performed in his left eye. Histopathologic examination of the corneal button disclosed epithelial cell swelling and cyst-like intracytoplasmic inclusions. The cells contained moderate amounts of periodic acid-Schiff-positive and diastase-sensitive material (glycogen). Transmission electron microscopy revealed numerous vacuoles and moderate numbers of electron-dense membrane-bound bodies in the cytoplasm, similar to lysosomes, some engulfed by the vacuoles. The second patient was a 17-year-old female with a clinical diagnosis of MCD and episodes of recurrent corneal erosion. On confocal scan examination of both corneas, hyporeflective round-shaped areas measuring 6.8 to 41.4 μm were seen within the superficial epithelium together with irregular and ill-defined high-contrast areas in the sub-basal epithelial region. The subepithelial nervous plexus was not visible due to regional hyperreflectivity. Conclusion: This case report further adds to the microstructural features of Meesmann corneal dystrophy and suggests confocal scan as a non-invasive method for delineating the microstructural appearance of this rare dystrophy

Dry Eye Syndrome

Our understanding of keratoconjunctivitis sicca (KCS), also known as dry eye syndrome, has been changed over recent years. Until lately, the condition was thought to be merely due to aqueous tear insufficiency. Today, it is understood that KCS is a multifactorial disorder due to inflammation of the ocular surface and lacrimal gland, neurotrophic deficiency and meibomian gland dysfunction. This change in paradigm has led to the development of new and more effective medications

CRITICIZING THE EPISTEMOLOGICAL PLURALISM BASICS WITH AN EMPHASIS ON THE HOLY QURAN’S AYAT

Abstract. Understanding of the religious texts and the emergence process of various interpretations areamongst the challenging topics in the present era. Epistemological pluralism is amongst the notions proposed in the rea of Holy Quran understanding and interpretation. The theory is a form of epistemological relativism that realizes the cognizance or verity as relative based on time, place, society, culture, inheritance and belief in such a way that the thing that is considered as cognizance depends on the value or the importance of one or several of the abovementioned variables. The necessity of epistemological pluralism is the closing of the perception and conversation while the canonical ruler intends a special purpose of offering a text and pours his intention within the cast of words. The most important basics of the theory are: human cognizance relativity, originality of senses and human’s materialism, non- specification of a text’s meaning. The present writing aims at investigation of the foundations of epistemological pluralism and it has been carried out based on an analytical-descriptive method from n intra-religion standpoint and takes advantage of the holy Quran’s AYAT to criticize and challenge the issue.Keywords: epistemological pluralism, relativity of cognizance, originality of sense, semantic specification

The Impact of Electronic Advertising on the Cereal Importers' Decision to Buy

The purpose of this study was to investigate the effect of electronic advertising on the cereal importers' decision to buy. The present research is a causal descriptive-survey study and an applied study regarding the purpose. The statistical population of the present study is comprised of cereals importers in the first six months of the year 2016, which consist of 202 companies. Sample size was obtained through Cochran formula as 132, and then the questionnaire is distributed through random and classical sampling. The data was collected using two questionnaires: the pre-designed questionnaires was for evaluating electronic advertisement including 4 components and 20 questions, and a researcher-made questionnaire based on Philip Cutler's purchase decision theory to assess purchasing decision and consisted of 4 components, with 47 items. Both of the questionnaires were based on the five-degree Likert spectrum and their reliability was measured using the Cronbach's Alpha coefficient. The data collected through the questionnaire was entered into the spss19 software system. For the inferential statistics of variables to statistically analyze the data, different statistical tests including Kolmogorov-Smirnov test and Pearson correlation test and linear regression were used. The results of the research indicated that electronic advertising has a positive and significant effect on the decision making of cereal importers' purchase. Also, the dimensions of electronic advertising including banner, e-mail, web site, and search engines have a positive and significant effect on shoppers' e-shopping decision. Keywords: electronic advertising, banner, e-mail, web site, search engine

Do FOMC Actions Speak Loudly? Evidence from Corporate Bond Credit Spreads

We find that Federal Open Market Committee (FOMC) actions (especially rate cuts) narrowed corporate credit spreads during the pre-crisis period of 2002-2007. During the 2008 crisis period, we find that both conventional cuts and quantitative easing decreased spreads. But FOMC inactions caused significant widening of spreads. The effects are especially large for speculative-grade and short-maturity bonds. Overall, the policy uncertainty during the crisis and macroeconomic theories during the pre-crisis period help to explain why FOMC announcements impacted credit spreads. The Fed’s actions targeted at promoting growth and/or providing systemic liquidity were especially noted by the corporate bond market. Keywords

Noise-Adaptive Compiler Mappings for Noisy Intermediate-Scale Quantum Computers

A massive gap exists between current quantum computing (QC) prototypes, and the size and scale required for many proposed QC algorithms. Current QC implementations are prone to noise and variability which affect their reliability, and yet with less than 80 quantum bits (qubits) total, they are too resource-constrained to implement error correction. The term Noisy Intermediate-Scale Quantum (NISQ) refers to these current and near-term systems of 1000 qubits or less. Given NISQ's severe resource constraints, low reliability, and high variability in physical characteristics such as coherence time or error rates, it is of pressing importance to map computations onto them in ways that use resources efficiently and maximize the likelihood of successful runs. This paper proposes and evaluates backend compiler approaches to map and optimize high-level QC programs to execute with high reliability on NISQ systems with diverse hardware characteristics. Our techniques all start from an LLVM intermediate representation of the quantum program (such as would be generated from high-level QC languages like Scaffold) and generate QC executables runnable on the IBM Q public QC machine. We then use this framework to implement and evaluate several optimal and heuristic mapping methods. These methods vary in how they account for the availability of dynamic machine calibration data, the relative importance of various noise parameters, the different possible routing strategies, and the relative importance of compile-time scalability versus runtime success. Using real-system measurements, we show that fine grained spatial and temporal variations in hardware parameters can be exploited to obtain an average $2.9$x (and up to $18$x) improvement in program success rate over the industry standard IBM Qiskit compiler.Comment: To appear in ASPLOS'1

Multi-objective, multi-year dynamic generation and transmission expansion planning- renewable energy sources integration for Iran's National Power Grid

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Protective properties of Rydingia persica in reproductive complications induced by diabetes in male rats: An experimental study

Background: In Iranian traditional medicine, Rydingia persica (R.P) is commonly used to treat diabetes mellitus (DM). Objective: We assessed the protective effects of R.P against testis and epididymis oxidative stress and the hormonal changes induced by DM. Materials and Methods: Forty male Wistar rats (12 wk old) weighing 230-270 gr were divided into five groups (n = 8/each): 1. Control (C); 2. diabetic (D); 3. diabetic + R.P200 (D+R200); 4. diabetic + R.P400 (D+R400); and 5. diabetic + R.P600 (D+R600). Groups C and D received 2 ml of normal saline orally daily for two wk and groups D+R200, D+R400, and D+R600 received 200, 400, and 600 mg/kg body weight of R.P powder, respectively, orally daily for two wk. DM was induced by a single intraperitoneal injection of streptozotocin at 60 mg/kg body weight. We assessed malondialdehyde, glutathione peroxidase, glutathione reductase, superoxide dismutase, catalase, hydrogen peroxide, and glutathione in both the testis and epididymis and also the histological changes of the testis. Results: Diabetic rats showed a significantly increased and decreased level of oxidant and antioxidant factors, respectively, and a significantly lower level of serum testosterone and luteinizing hormone than the control group. In the histological study of the testis, deteriorations were observed. Treatment with R.P reversed these changes toward the state of the control group with the highest effectiveness shown by group D+R600. Conclusion: The data obtained suggest that R.P powder has antioxidant effects on testis and epididymis tissues in diabetic rats and that it improves histological testicular structure in diabetics. It can also correct testosterone and luteinizing hormone changes induced by DM. Key words: Diabetes mellitus, Rydingia persica, Oxidative stress, Reproductive, Testosterone

Magic-State Functional Units: Mapping and Scheduling Multi-Level Distillation Circuits for Fault-Tolerant Quantum Architectures

Quantum computers have recently made great strides and are on a long-term path towards useful fault-tolerant computation. A dominant overhead in fault-tolerant quantum computation is the production of high-fidelity encoded qubits, called magic states, which enable reliable error-corrected computation. We present the first detailed designs of hardware functional units that implement space-time optimized magic-state factories for surface code error-corrected machines. Interactions among distant qubits require surface code braids (physical pathways on chip) which must be routed. Magic-state factories are circuits comprised of a complex set of braids that is more difficult to route than quantum circuits considered in previous work [1]. This paper explores the impact of scheduling techniques, such as gate reordering and qubit renaming, and we propose two novel mapping techniques: braid repulsion and dipole moment braid rotation. We combine these techniques with graph partitioning and community detection algorithms, and further introduce a stitching algorithm for mapping subgraphs onto a physical machine. Our results show a factor of 5.64 reduction in space-time volume compared to the best-known previous designs for magic-state factories.Comment: 13 pages, 10 figure

Resource Optimized Quantum Architectures for Surface Code Implementations of Magic-State Distillation

Quantum computers capable of solving classically intractable problems are under construction, and intermediate-scale devices are approaching completion. Current efforts to design large-scale devices require allocating immense resources to error correction, with the majority dedicated to the production of high-fidelity ancillary states known as magic-states. Leading techniques focus on dedicating a large, contiguous region of the processor as a single "magic-state distillation factory" responsible for meeting the magic-state demands of applications. In this work we design and analyze a set of optimized factory architectural layouts that divide a single factory into spatially distributed factories located throughout the processor. We find that distributed factory architectures minimize the space-time volume overhead imposed by distillation. Additionally, we find that the number of distributed components in each optimal configuration is sensitive to application characteristics and underlying physical device error rates. More specifically, we find that the rate at which T-gates are demanded by an application has a significant impact on the optimal distillation architecture. We develop an optimization procedure that discovers the optimal number of factory distillation rounds and number of output magic states per factory, as well as an overall system architecture that interacts with the factories. This yields between a 10x and 20x resource reduction compared to commonly accepted single factory designs. Performance is analyzed across representative application classes such as quantum simulation and quantum chemistry.Comment: 16 pages, 14 figure