A signature-based data security and authentication framework for internet of things applications

Internet of things (IoT) is the next big revolution in modernized network technologies connecting a massive number of heterogeneous smart appliances and physical objects. Owing to these technologies' novelty, various issues are characterized by security concerns are the most prioritized issue. A review of existing security approaches highlights that they are very particular about the solution towards a specific attack and cannot resist any unknown attacker. Therefore, this manuscript presents a novel computational model that introduces a unique authentication process using a simplified encryption strategy. The simulated study outcome shows that the proposed system offers efficient security and efficient data transmission performance in the presence of an unknown adversary. Hence, the study outcome exhibits better effects than frequently used security solutions when implemented in a vulnerable IoT environment

Serum Visfatin: A Novel Marker in Chronic Kidney Disease

BACKGROUND: Chronic Kidney Disease (CKD) is defined as Glomerular Filteration Rate < 60ml/min/1.73m2 for a minimum of 3 months irrespective of the cause. Accelerated atherosclerosis is the main cause of morbidity and mortality in CKD patients. Visfatin is a 52KDa protein predominantly secreted by the visceral adipose tissue which has anti-inflammatory, Insulin-mimetic and antiapoptotic activities. AIMS AND OBJECTIVE: To estimate the levels of serum Visfatin in patients with CKD and to compare it with serum hsCRP (high sensitive C reactive protein), Ccr(Creatinine clearance) and lipid profile. MATERIALS AND METHODS: The study was conducted at Thanjavur Medical College Hospital. 50 patients of CKD as cases and 50 age and gender matched healthy individuals were selected as cases and controls respectively.Serum Visfatin and Serum hsCRP were estimated by Enzyme Immune Assay and Immunoturbidimetric method respectively. Serum Total Cholesterol (TC), Triglycerides (TGL), Very Low Density Lipoprotein(VLDL-C), High Density Lipoprotein (HDL-C) were estimated by enzymatic method. Creatinine Clearance (Ccr)and Low Density Lipoprotein (LDL-C) were calculated using formula. RESULTS: The mean value of Visfatin in cases and controls were 27.42±8.92 and 10.62±1.57 ng/ml (t=13.11; p<0.05 significant) respectively. The level of serum visfatin is inversely correlated with Ccr (r= -0.898; p< 0.01). Serum hsCRP, TGL and VLDL-C were significantly increased and HDL-C was significantly decreased in cases when compared to controls (p < 0.05). There is no significant difference of TC between cases and controls. CONCLUSION: 1. The present study demonstrated that serum Visfatin levels are significantly increased in patients with CKD. This increase in serum Visfatin level is progressive from the early stages to the late stages of CKD . 2. Visfatin may be considered as the novel marker of mortality predictor in CKD patients. Higher the visfatin level, higher the mortality of CKD patients

ADVENT OF AUGMENTED REALITY EXPERIENCE IN RETAIL AND ONLINE SHOPPING AND ITS INFLUENCING SIGNIFICANCE IN FUTURE

Augmented Reality (AR) is a trending technology that augments or superimposes an image generated by a computer system virtually into the real world environment for the user’s viewpoint using a smart phone or other hand held devices. AR shows recent advancements in the shopping domain with various implementation trails and refinement. The simplicity and flexibility in online shopping where people stay in their own place and do shopping brought a great challenge to retail shopping environment today. Retail stores are now struggling a lot to bring in the customers and the foot traffic has been greatly reduced due to which online sales are boosting and retail sales are stalling. This necessitates to bring new technological innovations to offline shopping to attract people. With the use of AR, it is possible to merge digital component to physical products in the store to stimulate the engagement of the shopping experience with more fun and joy. On the other hand, in the online shopping, though user reviews and product showcase aids the customers to analyze the quality, look and feel of diverse products, the buyer still cannot see how exactly the product fits in a real environment or how it works. Here plays AR a vital role in online shopping where it uses animations and visualization techniques to offer more value to their shoppers virtually aiding to see exactly the look of the product in user environment. This paper explains the advancement of AR in both retail and online shopping of various product domains with an implementation model of ShopAR for Online shopping and AR significance in near future

Blackcurrants: A Nutrient-Rich Source for the Development of Functional Foods for Improved Athletic Performance

Blackcurrants are nutrient-rich fruits with a significant amount of bioactive compounds including vitamin C and polyphenols, especially anthocyanins. The high phytochemical content of blackcurrants promotes this fruit to become a valuable functional food ingredient with varying health-promoting activities targeting different consumers including athletes. Athletes experience oxidative stress during intense exercise, which can result in inflammation and reduced exercise performance. Antioxidants such as vitamin C and polyphenols can restore the regular oxidative status of the body. Blackcurrant supplementation has shown potential ergogenic activity to improve athlete performance during high-intensity training. Clinical trials have evaluated the effectiveness of blackcurrant supplementation on exercise performance, fat oxidation, blood lactate levels, muscle fatigue, and cardiac output. Due to the rich nutritional value of blackcurrants, they can be a potential candidate for the development of functional foods targeted at the improved performance of athletes. Blackcurrants can be used as ingredients to develop functional beverages and snacks for athletes as well as gluten-free products for celiac athletes.Blackcurrant is rich in bioactive compounds that can help improve athletic performance. It can be considered a potential bioactive ingredient to develop functional foods for athletes

Facile and Novel Strategy for Methods of Extraction of Biofuel Grade Lipids from Microalgae- an Experimental Report

The structural features of microalgal cell make it too difficult to extract the total lipid content of the cell as such. Thus, the cell disruption before lipid extraction becomes mandatory and has to be cost-effective. In the present study various methods and combination of few methods were adopted for effective extraction in order to choose the most effective cell disruption method for the complete extraction of lipids from a selected indigenous freshwater isolate, Scenedesmus sp. NTEB03. Interestingly, we found that grinding and bead-beating method showed two fold increased lipid productivity (23.2%) than the other methods tested. Biomass and lipid productivity of Scenedesmus sp., was found to be 0.0418 g L-1 d-1 and 4.3 mg L-1 d-1 respectively. Fatty acid profiles revealed that oleic (C18:1) and linoleic acid (C18:2) content being higher in the lipids, which are most appropriate for the biodiesel production. A novel strategy for most effective, simple method for cell disruption in Scenedesmus sp., was grinding/bead-beating, which is the most suitable method for complete extraction of biofuel grade lipids

Blackcurrants: A Nutrient-Rich Source for the Development of Functional Foods for Improved Athletic Performance

Blackcurrants are nutrient-rich fruits with a significant amount of bioactive compounds including vitamin C and polyphenols, especially anthocyanins. The high phytochemical content of blackcurrants promotes this fruit to become a valuable functional food ingredient with varying health-promoting activities targeting different consumers including athletes. Athletes experience oxidative stress during intense exercise, which can result in inflammation and reduced exercise performance. Antioxidants such as vitamin C and polyphenols can restore the regular oxidative status of the body. Blackcurrant supplementation has shown potential ergogenic activity to improve athlete performance during high-intensity training. Clinical trials have evaluated the effectiveness of blackcurrant supplementation on exercise performance, fat oxidation, blood lactate levels, muscle fatigue, and cardiac output. Due to the rich nutritional value of blackcurrants, they can be a potential candidate for the development of functional foods targeted at the improved performance of athletes. Blackcurrants can be used as ingredients to develop functional beverages and snacks for athletes as well as gluten-free products for celiac athletes.Blackcurrant is rich in bioactive compounds that can help improve athletic performance. It can be considered a potential bioactive ingredient to develop functional foods for athletes

Biochemical and Functional Characterization of Mouse Mammary Tumor Virus Full-Length Pr77Gag Expressed in Prokaryotic and Eukaryotic Cells

The mouse mammary tumor virus (MMTV) Pr77Gag polypeptide is an essential retroviral structural protein without which infectious viral particles cannot be formed. This process requires specific recognition and packaging of dimerized genomic RNA (gRNA) by Gag during virus assembly. Most of the previous work on retroviral assembly has used either the nucleocapsid portion of Gag, or other truncated Gag derivatives&mdash;not the natural substrate for virus assembly. In order to understand the molecular mechanism of MMTV gRNA packaging process, we expressed and purified full-length recombinant Pr77Gag-His6-tag fusion protein from soluble fractions of bacterial cultures. We show that the purified Pr77Gag-His6-tag protein retained the ability to assemble virus-like particles (VLPs) in vitro with morphologically similar immature intracellular particles. The recombinant proteins (with and without His6-tag) could both be expressed in prokaryotic and eukaryotic cells and had the ability to form VLPs in vivo. Most importantly, the recombinant Pr77Gag-His6-tag fusion proteins capable of making VLPs in eukaryotic cells were competent for packaging sub-genomic MMTV RNAs. The successful expression and purification of a biologically active, full-length MMTV Pr77Gag should lay down the foundation towards performing RNA&ndash;protein interaction(s), especially for structure-function studies and towards understanding molecular intricacies during MMTV gRNA packaging and assembly processes

Detection of Antinuclear Antibodies Targeting Intracellular Signal Transduction, Metabolism, Apoptotic Processes and Cell Death in Critical COVID-19 Patients

Background and Objectives: The heterogeneity of the coronavirus disease of 2019 (COVID-19) lies within its diverse symptoms and severity, ranging from mild to lethal. Acute respiratory distress syndrome (ARDS) is a leading cause of mortality in COVID-19 patients, characterized by a hyper cytokine storm. Autoimmunity is proposed to occur as a result of COVID-19, given the high similarity of the immune responses observed in COVID-19 and autoimmune diseases. Here, we investigate the level of autoimmune antibodies in COVID-19 patients with different severities. Results: Initial screening for antinuclear antibodies (ANA) IgG using ELISA revealed that 1.58% (2/126) and 4% (5/126) of intensive care unit (ICU) COVID-19 cases expressed strong and moderate ANA levels, respectively. An additional sample was positive with immunofluorescence assays (IFA) screening. However, all the non-ICU cases (n=273) were ANA negative using both assays. Samples positive for ANA were further confirmed with large-scale autoantibody screening by phage immunoprecipitation-sequencing (PhIP-Seq). The majority of the ANA-positive samples showed "speckled" ANA pattern by microscopy and revealed autoantibody specificities that targeted proteins involved in intracellular signal transduction, metabolism, apoptotic processes, and cell death by PhIP-Seq; further denoting reactivity to nuclear and cytoplasmic antigens. Conclusion: Our results further support the notion of routine screening for autoimmune responses in COVID-19 patients, which might help improve disease prognosis and patient management. Further, results provide compelling evidence that ANA-positive individuals should be excluded from being donors for convalescent plasma therapy in the context of COVID-19.This study was supported by funds from QNRF, grant # NPRP11S-1212-170092

Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

Background Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy