Serving the barriers of Convergence between Iran and Turkey and their effect on politic security of country

Turkey because of geo politic situation, population texture and historical position is one of the most important neighbors of Iran. That what happens there is too important in area. Regarding to the role of two countries and rate of their effects, these two countries are complement in the Middle East that want to develop their power. Their close relationship can make a politics’ security and economic in the Middle East. After that justice party reached to power the relations of Iran and Turkey changed too. But it’s seems what happened in the Middle East to their relationship: The main problem is including: Relationship to Israel Regime and establish defense missile of NATO in Turkey and also Syria’s evolutions. The 3rd one is the most effect one relation between two countries it’s a barrier for Convergence. That even can make a negative effect on politic security of country. Key words: Iran, Turkey, Foreign politic, politic security, Convergenc

Value of Admission HbA1c Level in Non-diabetic Patients With Unstable Angina

Introduction: There have been incompatible evidences about the prognostic value of HbA1c on the adverse outcomes in acute coronary syndrome. Also, these data are so limited in nondiabetic patients with unstable angina.Methods: In this cross-sectional study, HbA1c level of 231 nondiabetic patients admitted with unstable angina, was measured using high performance liquid affinity chromatography (HPLC) at admission. Then transthoracic echocardiography (TTE) was performed for evaluation of ejection fraction (EF) using Simpson method.Results: Our data revealed that HbA1c was significantly higher in patients with EF≤ 50% in comparison with EF>50% group (P value=0.01).Conclusions: HbA1c may be a helpful prognostic marker in nondiabetic patients admitted in emergency department with diagnosis of unstable angina

Optogenetic Stimulation of Primary Cardiomyocytes Expressing ChR2

Introduction: Non-clinical cardiovascular drug safety assessment is the main step in the progress of new pharmaceutical products. Cardiac drug safety testing focuses on a delayed rectifier potassium channel block and QT interval prolongation, whereas optogenetics is a powerful technology for modulating the electrophysiological properties of excitable cells.Methods: For this purpose, the blue light-gated ion channel, channelrhodopsin-2 (ChR2), has been introduced into isolated primary neonatal cardiomyocytes via a lentiviral vector. After being subjected to optical stimulation, transmembrane potential and intracellular calcium were assessed.Results: Here, we generated cardiomyocytes expressing ChR2 (light-sensitive protein), that upon optical stimulation, the cardiomyocytes depolarized result from alterations of membrane voltage and intracellular calcium.Conclusion: This cell model was easily adapted to a cell culture system in a laboratory, making this method very attractive for therapeutic research on cardiac optogenetics. DOI: 10.34172/jlms.2021.3

Designing an InGaP/InAlGaP Double Junction Solar Cell without an Anti-Reflection Coating by Adding a New Window Layer in the Upper Junction and Optimizing the Back Surface Field Layer

Abstract: The present study proposes a novel indium gallium phosphide/aluminum gallium indium phosphide (InGaP/InAlGaP) double junction solar cell without an anti-reflection coating that includes an upper InGaP cell, a lower InAlGaP cell, and a gallium arsenide (GaAs) tunnel junction. To increase the efficiency of the cell, a new window layer was used at the upper junction. To achieve higher efficiency, the researchers also optimized the back surface field layer of the lower cell. The results were analyzed via numerical modeling with Silvaco/Atlas software under the AM1.5 radiation spectrum. Findings suggested that using the sun=1 parameter, the obtained maximum values of short-circuit current, open-circuit voltage, fill factor, and efficiency parameters for the proposed solar cell structure were Jsc = 24.078 mA/cm2, Voc = 3.41886, FF = 91.1836, and Eff = 71.721%, respectively

Screening for Depression In Hospitalized Pediatric Patients

How to Cite This Article: Esmaeeli M, Erfani Sayar R, Saghebi A, Elmi Saghi, Rahmani Sh, Elmi S, Rabbani Javadi A. Screening for Depression in Hospitalized Pediatric Patients. Iran J Child Neurol. 2014 Winter; 8(1):47-51. ObjectiveIn chronically ill children who are hospitalized, many mood changes occur. For example, in children with cancer or renal failure, prolonged hospitalization and chemotherapy can lead to depression. With the improved survival of childhoodmalignancies, the effect of treatment on child’s psychosocial well-being becomes increasingly relevant. In this study, we examined the prevalence of depression in hospitalized children with chronic and acute conditions in Dr Sheikh Pediatrics Hospital in Mashhad.Materials & MethodsAfter receiving the approval from the Ethics Committee of Mashhad University of Medical Sciences, we did this cross-sectional descriptive study, from April to June 2012 in Dr Sheikh Pediatric Hospital in Mashhad. Ninety children, aged between 8 to 16 years, were screened for depression. The sampling method was census. Children with a history of depressive or other mental disorders were excluded.Three groups of children (children with chronic renal disease, malignancy, and acute disease) were evaluated for depression using standard Children Depression Inventory Questionnaire (CDI). Two specifically trained nurses with the supervisionof a psychiatrist filled out the questionnaires at patients’ bedside. Depression scores were then analyzed by SPSS software.ResultsOf 90 children, 43(47.7%) were male and 47(52.2%) were female. The Children’s mean age was 11±2.3 years, and the mean length of hospitalization was 8±5.3 days.Depression was detected in various degrees in 63% of patients (N=57), and 36.6% of children (N=32) had no symptoms of depression. Severe depression was not seenin any of the patients with acute illness. More than half of patients with cancer and chronic kidney disease had moderate to severe depression.There was a significant statistical relationship between the duration of illness and severity of depression. There was also a significant correlation between severity of depression and frequency of hospitalization. Children who had been hospitalized more than 3 times in the last year, experienced more severe levels of depression. We also found a significant correlation between pubertal age and severity of depressionin patients with cancers and chronic renal failure.ConclusionChildren who are hospitalized due to chronic conditions are at a higher risk for mood disorders in comparison with the ones with acute conditions. It is therefore advisable to consider more practical plans to improve the care for hospitalizedchildren’s mental health.ReferencesKessler RC, Berglund P, Demler O, Jin R, Merikangas KR, Walters EE. Lifetime prevalence and age-ofonset distributions of dsm-iv disorders in the national comorbidity survey replication. Arch Gen Psychiatry 2005;62(6):593-602.Rutter M. Relationship between mental disorders in children and adulthood. Acta Psychiatr Scand 1995;91(2):73-85.Naerde A, Tambs K, Mathiesen KS Dalgard OS. Symptoms of anxiety and depression among mothers of pre-school children: effect of chronic strain related to children and child care-taking. J affect Discord 2000;58(3):181-99Ernest J, Weissflog G, Brahler E, Romer G, Götze H. Depression in children of cancer patients over time and dependence of parental distress. Prax Kinderpsychol Kinderpsychiatr 2012;61(6):432-46.Gordijn MS, van Listenburg RR, Gemke RJ, Huisman J. Sleep, fatigue, depression, and quality of life in survivors of childhood acute lymphoblastic leukemia. Pediatr Blood Cancer 2013;60(3):479-85.De Sousa A. Psychiatric issues in renal failure and dialysis. Indian J Nephrol 2008;18(2):47-50Bakr A, Amr M, Sarhan A, Hammad A. Psychiatric disorders in children with chronic renal failure. Pediatr Nephrol 2007;22(1):128-31.Goldstein SL, Rosburg NM, Warady BA, Seikaly M, McDonald R, Limbers C, et al. Pediatric end stage renal disease health-related quality of life differs by modality: a PedsQL ESRD analysis. Pediatr Nephrol 2009;24(8):1553-60.Thomalla G, Barkmann C, Romer G. Psychosocial symptoms in children of hemodialysis patients. Prax Kinderpsychol Kinderpsychiatr 2005;54(5):399-416.Laffond C, Dellatolas G, Alapetite C, Puget S, Grill J, Habrand JL, et al. Quality of life, mood and executive functioning after childhood craniopharyngioma treated with surgery and proton beam therapy. Brain Inj 2012;26(3):270-81.Chung TK, Lynch ER, Fiser CJ, Nelson DA, Agricola K, Tudor C, et al. Psychiatric coomorbidity and treatment response in patients with tuberous sclerosis complex. Ann Clin Psychiatry 2011;23(4):263-9.Kinahan KE, Sharp LK, Seidel K, Leisenring W, Didwania A, Lacouture ME, et al. Scarring, disfigurement, and quality of life in long-term survivors of childhood cancer: a report from the Childhood Cancer Survivor study. J Clin Oncol 2012;30(20):2466-74.Adduci A, Jankovic M, Strazzer S, Massimino M, Clerici C, Poggi G. Parent-child communication and psychological adjustment in children with a brain tumor. Pediatr Blood Cancer 2012;59(2):290-4Szabo A, Mezei G, Kovari E, Cserhati E. Depressive symptoms amongst asthmatic children caregivers. Peditr Allergy Immunol 2012;21(4 Pt 2):e667-73.Arabiat DH, Elliot B, Draper P. The prevalence of depression in pediatric oncology patients undergoing chemotherapy treatment in Jordan. Pediatr Oncol Nurs 2012;29(5):283-8.Li HC, Williams PD, Lopez V, Chung JO. Relationships among therapy-related symptoms, depressive symptoms, and quality of life in Chinese children hospitalized with cancer: an exploratory study. Cancer Nurs 2013;36(5):346-54

Relationship between the Patients’ Setup Errors with Dosimetric and Radiobiologic Parameters in Whole Breast Radiotherapy

parameters for left-sided Whole-Breast Irradiation (WBI) in three different radiotherapy techniques, including Intensity-Modulated Radiation Therapy (IMRT), Field-In-Field (FIF), and Conventional Wedge (CW). Materials and Methods: Computed Tomography (CT) images of 10 female patients with early-stage left-sided breast cancer were used to simulate different radiotherapy techniques (IMRT, FIF, and CW). The dosimetric parameters; Conformity Index (CI), Homogeneity Index (HI), the dose received by at least 95% (D95%) of Planning Tumor Volume (PTV), the volume of lung and heart that respectively received at least 20% (V20%) and 40% (V40%) of the prescribed dose, as well as, the radiobiologic parameters, including Tumor Control Probability (TCP) and Normal Tissue Complication Probability (NTCP) were assessed for setup errors in patients. The setup errors were assessed by shifting the isocenters and gantry angles of the treatment plans. Results: The D95% of the PTV for an isocenter misplacement plan in the posterior direction decreased by 66.99 (IMRT), 71.86 (CW), and 68.25% (FIF). The TCP of the PTV was reduced by 26.66, 39.16, and 36.97% for IMRT, CW, and FIF techniques, respectively. Increasing gantry angle by a ±10 degree caused a 43%, 41%, and 41% decrease in the D95% of IMRT, FIF, and CW techniques, respectively. The TCP values decreased about 18% in all three techniques with a ±10 degree gantry angle shift; however, the NTCP values of the heart and lungs increased for all three methods. The CI and HI values had significantly more changes with increasing setup errors in the IMRT than in the two techniques. Conclusion: The radiobiologic parameters in IMRT were less sensitive to setup errors compared to FIF and CW techniques. The radiobiological parameters can help estimate the setup errors along with physical parameters during breast radiotherapy

Effective factors on the recurrence of Bipolar mood disorder i in an Iranian population sample using the frailty model with bayesian approach

Objective: Bipolar I disorder is one of the most frequent mental disorders characterized by manic or mixed +/- depressive episodes. Drug treatment has been proved to diminish next episodes, but many other factors are important for exacerbating the conditions. This study aimed to investigate the effective factors on the time and number of episodes in these patients by applying the shared frailty model. Method: In this retrospective longitudinal study, the information of 606 patients with bipolar I disorder, admitted for the first time in Ibn-e-Sina psychiatric hospital in Mashhad from the beginning of 2007 until the end of 2009 were used. These patients were followed up until the end of 2018 for readmission. The Cox model with gamma frailty and Bayesian approach were used to determine the effective factors of frequent recurrences. Results: History of head trauma, substance abuse, and legal conflict had a positive impact on recurrences, while age had a negative effect on recurrences and the risk of recurrence was higher in younger people (P < 0.05). The variance estimation of frailty effect was 0.97 that indicates a correlation between the recurrence intervals of bipolar I patients, owing to a heterogeneity among patients. Conclusion: Based on the results, a higher risk of recurrence of bipolar I disorder was found in younger patients and those with a history of head trauma, substance abuse, and legal conflicts. Further investigations are required to account for the genetic factor and psychosocial exposure during critical periods applying this model

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

Improving Efficacy of Support Groups in Online Environments

In this research I evaluated two strategies for improving performance of online support groups. The first strategy was to use a buddy system in online support groups. This system involves pairing demographically similar members of a group to serve as each other’s buddies. Analyses of real online support groups indicated that members whose only difference with other members is in having a buddy who is more active rather than less active in the group are more engaged in the group and have a higher chance of attaining their goal for which they joined the group. Analysis also showed that members help their buddies more than they help other group members. Results are robust across four measures of tie strength, including contact frequency, reciprocity, and two measures of contact length. Overall, results suggest that managers can use the buddy system in online support groups as an effective method to drive group engagement and increase the support provided and goal attainment.The second strategy was to add a chatbot to the online support groups to provide members with additional informational and motivational support. The design of the chatbot which can respond to members’ messages based on their content is presented here. The chatbot has a natural language understanding component which can identify intent of messages out of 26 possible intents related to smoking cessation which is the main context of the online support groups studied here. The chatbot is supposed to respond to messages with 25 intents called triggering intents and ignore 1 intent which is non-triggering intent. Triggering intents account for less than half of the total messages. The bot is intentionally designed to have higher precision than recall for triggering intents. Precision for triggering intents is the probability of identifying the intent correctly if the message is identified as a triggering intent. Recall for triggering intents is the percentage of triggering messages which are identified with correct intent. The chatbot has the precision of 81% and the recall of 44% for triggering intents. Separate randomized control trial experiments are required to evaluate the overall performance of the chatbot in online support groups