Synthesis and reactions of 1-amino-1,5,6,10b-tetrahydroimidazo[2,1-a]isoquinolin-2(3H)-ones

1-Amino-1,5,6,10b-tetrahydroimidazo[2,1-a]isoquinolin-2(3H)-ones, as previously unknown ring-annelated isoquinolines with a 3-aminoimidazolidin-4-one scaffold, were selectively prepared upon reacting 2-carbamoylmethyl- or 2-ethoxycarbonylmethyl-3,4-dihydroisoquinolinium salts with hydrazine hydrate. Acylation of the primary amino group with benzoyl chlorides, followed by reductive ring cleavage of the annelated 4-imidazolidinone ring and final cyclodehydration of the N,N'-diacylhydrazines resulted in the synthesis of 1-methyl-2(5-aryl-[1,3,4]oxadiazol-2-ylmethyl)-1,2,3,4-tetrahydroisoquinolines which are of interest due to their potential use as bioisosteres of biologically active N-aryl-2-(1-methyl-3,4-dihydro-1H-isoquinolin-2-yl) acetamides

Synthesis and reactions of 1-hydroxy-9,9a-dihydro-1H-imidazo[1,2-a]indol-2(3H)-ones

In Session: Next Generation Networks: NXG-05: Switching and Routing-I: article no. NXG05-6A hybrid electronic/optical packet switch consists of electronically buffered line-cards interconnected by an optical switch fabric. It provides a scalable switch architecture for next generation high-speed routers. Due to the non-negligible switch reconfiguration overhead, many packet scheduling algorithms are invented to ensure performance guaranteed switching (i.e. 100% throughput with bounded packet delay), at the cost of speedup. In particular, minimum delay performance can be achieved if an algorithm can always find a schedule of no more than N configurations for any input traffic matrix, where N is the switch size. Various minimum delay scheduling algorithms (MIN, α i-SCALE and QLEF) are proposed. Among them, QLEF requires the lowest speedup bound. In this paper, we show that the existing speedup bound for QLEF is not tight enough. A new bound which is 10% lower than the existing one is derived. © 2006 IEEE.published_or_final_versionProceedings of the Global Telecommunications Conference, 2006 (GLOBECOM 2006), San Francisco, CA, USA, 27 November - 1 December 200

Facile synthesis of novel functionalized 1,3-selenazoles

The reaction of selenourea with diethyl 2,4-dibromo-3-oxoglutarate afforded ethyl 2-(2-amino-5-ethoxycarbonyl-1,3-selenazol-4-yl)-2-bromoethanoate. Treatment of the latter with acylating agents and various nucleophiles gave a series of new 4,5-disubstituted 2-amino-1,3-selenazoles. All compounds were characterized spectroscopically. The crystal structure determination of ethyl 2-(2-amino-5-ethoxycarbonyl-1,3-selenazol-4-yl)-2-bromoethanoate is reportedKauno technologijos universiteta

Piridinų kvaternizacija 2-metil- ir 2-amino-4-(chlormetil)tiazolais

Alkilinant piridinus ir pikolinus 2-metil- ir 2-amino-4-(chlormetil) tiazolais, gaunamos naujos funkcionalizuotos piridinio druskos. Trijų komponentų reakcija, kai reakcijos mišinyje vienu metu reaguoja 2-amino-4-(chlormetil)tiazolas, acto rūgšties anhidridas ir piridinas arba pikolinai, įgalina lengvai gauti 1-[2- (acetilamino)tiazol-4-il]metilpiridinio chloridusQuaternisation of pyridines and picolines with 2-methyl- and 2-amino-4-(chloromethyl) thiazoles furnished new highly functionalised pyridinium salts. Threecomponent reaction of 2-amino-4-(chloromethyl)thiazole, acetic anhydride and pyridine afforded 1-[2-(acetylamino)thiazol-4-yl]methylpyridinium chlorideKauno technologijos universiteta

(2E)-3-(3-Methoxy-1-phenyl-1H-pyrazol-4-yl)-2-propenal

The palladium-catalyzed reaction of 4-bromo-3-methoxy-1-phenyl-1H-pyrazole with acrolein diethyl acetal gives the title compound in good yield. Detailed spectroscopic data (1H NMR, 13C NMR, 15N NMR, IR, MS) are presented

Dipyrazolo[1,5-a:4',3'-c]pyridines – a new heterocyclic system accessed via multicomponent reaction

The synthesis of dipyrazolo[1,5-a:4',3'-c]pyridines is described. Easily obtainable 5-alkynylpyrazole-4-carbaldehydes, p-toluenesulfonyl hydrazide, and an aldehyde or ketone containing an α-hydrogen atom were reacted in a silver triflate catalyzed multicomponent reaction affording new tricyclic compounds with a dipyrazolo[1,5-a:4',3'-c]pyridine core. Detailed NMR spectroscopic investigations (1H, 13C and 15N) were undertaken with all obtained compounds

10a,11,11-Trimethyl-10a,11-dihydro-8H-benzo[e]imidazo[1,2-a]indol-9(10H)-one

The alkylation of 1,1,2-trimethyl-1H-benzo[e]indole with 2-chloroacetamide, followed by work-up of the reaction mixture with a base and the subsequent treatment of a crude product with acetic acid gives 10a,11,11-trimethyl-10a,11-dihydro-8H-benzo[e]imidazo[1,2-a]indol-9(10H)-one. The structure assignments were based on data from 1H, 13C, and 15N-NMR spectroscopy. The optical properties of the obtained compound were studied by UV–Vis and fluorescence spectroscopy

(2E)-3-(3-Methoxy-1-phenyl-1H-pyrazol-4-yl)-2-propenal

The palladium-catalyzed reaction of 4-bromo-3-methoxy-1-phenyl-1H-pyrazole with acrolein diethyl acetal gives the title compound in good yield. Detailed spectroscopic data (1H NMR, 13C NMR, 15N NMR, IR, MS) are presented

5-Chloro-4-iodo-1,3-dimethyl-1H-pyrazole

Reaction of 5-chloro-1,3-dimethyl-1H-pyrazole with I2/HIO3 in refluxing acetic acid gives the title compound in good yield. Detailed spectroscopic data (1H NMR, 13C NMR, 15N NMR, IR, MS) are presented