A QSAR classification model of skin sensitization potential based on improving binary crow search algorithm

Classifying of skin sensitization using the quantitative structure-activityrelationship (QSAR) model is important. Applying descriptor selection isessential to improve the performance of the classification task. Recently, abinary crow search algorithm (BCSA) was proposed, which has been successfully applied to solve variable selection. In this work, a new time-varyingtransfer function is proposed to improve the exploration and exploitation capability of the BCSA in selecting the most relevant descriptors in QSAR classification model with high classification accuracy and short computing time.The results demonstrated that the proposed method is reliable and can reasonably separate the compounds according to sensitizers or non-sensitizerswith high classification accuracy

Methods of Preparation of Aromatic Anils

The aim of this study is to to prepare and identify and characterize the aromatic anils (Schiff.s bases or benzylidene aniline) then used for kinetic study that is cooxidation in presence of oxalic acid by chromic acid in acetic acid medium

Cooxidation of Chalcones and Oxalic acid using Chromium (VI)

Chalcones can be easily oxidized in presence of oxalic acid, by Cr(VI) in acetic acid medium, the rate of cooxidation was found to be a fractional order with respect to the chalcones and its substituents. The order with respect to the chromic acid is unity whereas order with respect to oxalic acid is also a fractional order. The effect of various parameters such as [H+], [NaCl], [NaNO3] and dielectric constant of the medium by changing the (v/v) ratio of acetic acid and water content were studied .The intermediate is formed between chalcones and a chromic aci

Improved Refractory Aluminosilicate Bricks Through Nano Zirconia Additions

The physico-mechanical and refractory properties of refractory bricks, prepared from 50 wt.% kaolin and 50 wt.% alumina, were improved through the addition of different contents (2, 4, 6, 8 and 10 wt. %) of nano zirconia powder. The densification parameters (bulk density and apparent porosity), mechanical properties (cold crushing strength) and refractory properties (thermal shock resistance) were tested for the prepared refractory bricks fired at 1500 oC. The mineralogical composition of the prepared zirconia and the refractory bricks were followed by X-ray diffraction analysis (XRD) whereas while their microstructure and chemical constituents were depicted using scanning electron microscope attached with energy dispersive x-ray unit (SEM + EDAX). The refractory brick samples containing 8 wt. % of nano zirconia was considered as the optimum among the investigated samples as it shows the best sintering, mechanical and refractory properties, these were correlated with their recognized assemblage of minerals; mullite-cristobalite-zirconia

Treatment of Sewer Water Using Alum Salt

This investigation was carried out to study the effect of addition o

Statistical assessment of physicomechanical properties of refractory ceramics based on petroleum waste sludge -bauxite compositions

The aim of this work is to apply the analysis of variance (ANOVA) statistical program to the experimental data of high-quality refractory ceramics prepared from various compositions of petroleum waste sludge (PWS) and raw bauxite mineral to reach a precise and conclusive decision on a statistical basis to the optimum mix that is thought to be more suitable for use in refractory applications. Seven ceramic mixes were prepared from various proportions of PWS and bauxite varying between 0 and 100 wt. % via solid state technique with heat treatment at different degrees of firing reached 1600 oC. The physicomechanical properties namely, linear change, mechanical strength, bulk density, as well as apparent porosity were tested according to the international standards. The One-way ANOVA proves that there is statistically difference regarding linear shrinkage (p = 0.01) and mechanical strength (p \u3c 0.001) for six groups of firing temperature [F (5, 24) = 15.87, p \u3c 0.001]. There was also a statistically significant difference in both bulk density of the ceramic bodies for the six groups [F (5, 24) = 12.5, p = 000] and the apparent porosity in mean apparent porosity [F (5, 24) = 21.538, p = 0.000]. Thus, the One- way ANOVA results are compatible with the results shown in our previous published data. Moreover, the test added a good value by showing CM4 almost like CM3 and economically it is much better to utilize it instead of CM3 in industrial applications

Synthesis, crystal structure and cholinesterase enzymes inhibitory activities of new pyridine alkaloid derivative

A new pyridine alkaloid derivative named as 2-(6-benzyl-4-oxo-5-phenyl-1,4-dihydro pyridine-3-yl)-benzoic acid ethylester (3) has been prepared by the reaction of ninhydrin with 1,3-diphenylacetonep-tosylhydrazone and the structure has been established with the help of spectral analysis and X-ray analysis. The title compound demonstrated potent inhibitory activity against butyrylcholinesterase (BChE; IC50 = 4.91 µM) comparable to physostigmine (IC50 = 4.72 x 10-1 µM). However it showed moderate inhibitory activity against acetylcholinesterase (AChE; IC50 = 82.00 µM)). It was BChE selective over AChE, in contrast to physostigmine, which was more AChE selective. Being a potent and selective BChE inhibitor, it may serve as a new class of drug for prevention of the progression of neurodegeneration as well for symptomatic treatment of Alzheimer patient