49 research outputs found
Non-linear Simulations of MHD Instabilities in Tokamaks Including Eddy Current Effects and Perspectives for the Extension to Halo Currents
The dynamics of large scale plasma instabilities can strongly be influenced
by the mutual interaction with currents flowing in conducting vessel
structures. Especially eddy currents caused by time-varying magnetic
perturbations and halo currents flowing directly from the plasma into the walls
are important. The relevance of a resistive wall model is directly evident for
Resistive Wall Modes (RWMs) or Vertical Displacement Events (VDEs). However,
also the linear and non-linear properties of most other large-scale
instabilities may be influenced significantly by the interaction with currents
in conducting structures near the plasma. The understanding of halo currents
arising during disruptions and VDEs, which are a serious concern for ITER as
they may lead to strong asymmetric forces on vessel structures, could also
benefit strongly from these non-linear modeling capabilities. Modeling the
plasma dynamics and its interaction with wall currents requires solving the
magneto-hydrodynamic (MHD) equations in realistic toroidal X-point geometry
consistently coupled with a model for the vacuum region and the resistive
conducting structures. With this in mind, the non-linear finite element MHD
code JOREK has been coupled with the resistive wall code STARWALL, which allows
to include the effects of eddy currents in 3D conducting structures in
non-linear MHD simulations. This article summarizes the capabilities of the
coupled JOREK-STARWALL system and presents benchmark results as well as first
applications to non-linear simulations of RWMs, VDEs, disruptions triggered by
massive gas injection, and Quiescent H-Mode. As an outlook, the perspectives
for extending the model to halo currents are described.Comment: Proceeding paper for Theory of Fusion Plasmas (Joint Varenna-Lausanne
International Workshop), Varenna, Italy (September 1-5, 2014); accepted for
publication in: to Journal of Physics: Conference Serie
Enhanced transport at high plasma and sub-threshold kinetic ballooning modes in Wendelstein 7-X
The effect of plasma pressure on ion-temperature-gradient-driven
(ITG) turbulence is studied in the Wendelstein 7-X (W7-X) stellarator, showing
that subdominant kinetic ballooning modes (KBMs) are unstable well below the
ideal MHD threshold and get strongly excited in the quasi-stationary state. By
zonal-flow erosion, these highly non-ideal KBMs affect ITG saturation and
thereby enable higher heat fluxes. Controlling these KBMs will be essential in
order to allow W7-X and future stellarators to achieve maximum performance.Comment: 16 pages, 5 figure
Investigating the causal role of MRE11A p.E506* in breast and ovarian cancer
The nuclease MRE11A is often included in genetic test panels for hereditary breast and ovarian cancer (HBOC) due to its BRCA1-related molecular function in the DNA repair pathway. However, whether MRE11A is a true predisposition gene for HBOC is still questionable. We determined to investigate this notion by dissecting the molecular genetics of the c.1516G > T;p.E506* truncating MRE11A variant, that we pinpointed in two unrelated French-Canadian (FC) HBOC patients. We performed a case-control study for the variant in ~ 2500 breast, ovarian, and endometrial cancer patients from the founder FC population of Quebec. Furthermore, we looked for the presence of second somatic alterations in the MRE11A gene in the tumors of the carriers. In summary, these investigations suggested that the identified variant is not associated with an increased risk of developing breast or ovarian cancer. We finally performed a systematic review for all the previously reported MRE11A variants in breast and ovarian cancer. We found that MRE11A germline variants annotated as pathogenic on ClinVar often lacked evidence for such classification, hence misleading the clinical management for affected patients. In summary, our report suggests the lack of clinical utility of MRE11A testing in HBOC, at least in the White/Caucasian populations
A novel path to runaway electron mitigation via deuterium injection and current-driven MHD instability
Relativistic electron (RE) beams at high current density (low safety factor, q ( a )) yet very low free-electron density accessed with D-2 secondary injection in the DIII-D and JET tokamak are found to exhibit large-scale MHD instabilities that benignly terminate the RE beam. In JET, this technique has enabled termination of MA-level RE currents without measurable first-wall heating. This scenario thus offers an unexpected alternate pathway to achieve RE mitigation without collisional dissipation. Benign termination is explained by two synergistic effects. First, during the MHD-driven RE loss events both experiment and MHD orbit-loss modeling supports a significant increase in the wetted area of the RE loss. Second, as previously identified at JET and DIII-D, the fast kink loss timescale precludes RE beam regeneration and the resulting dangerous conversion of magnetic to RE kinetic energy. During the termination, the RE kinetic energy is lost to the wall, but the current fully transfers to the cold bulk thus enabling benign Ohmic dissipation of the magnetic energy on longer timescales via a conventional current quench. Hydrogenic (D-2) secondary injection is found to be the only injected species that enables access to the benign termination. D-2 injection: (1) facilitates access to low q ( a ) in existing devices (via reduced collisionality & resistivity), (2) minimizes the RE avalanche by 'purging' the high-Z atoms from the RE beam, (3) drives recombination of the background plasma, reducing the density and Alfven time, thus accelerating the MHD growth. This phenomenon is found to be accessible when crossing the low q ( a ) stability boundary with rising current, falling toroidal field, or contracting minor radius-the latter being the expected scenario for vertically unstable RE beams in ITER. While unexpected, this path scales favorably to fusion-grade tokamaks and offers a novel RE mitigation scenario in principle accessible with the day-one disruption mitigation system of ITER
The role of nelarabine in the treatment of T-cell acute lymphoblastic leukemia: literature review and own experience
Aim. The analysis of experience of nelarabine use in refractory/relapsed T-cell acute lymphoblastic leukemia (T-ALL) depending on the immunophenotype and the line of therapy. Materials and methods. All the patients with relapsed or refractory T-ALL aged from 0 to 18 years who received treatment with nelarabine as a part of the therapeutic element R6 were included in the study. For all patients a detailed immunological analysis of leukemia cells with discrimination of immunological variants TI, TII, TIII or TIV was performed. Patients administered with nelarabine as a first therapeutic element were referred to the first-line therapy group, other patients were referred to the second-line therapy group. Nelarabine was administered as intravenous infusion at a dose of 650 mg/m2, on days 1-5. Allogeneic hematopoietic stem cells transplantation (allo-HSCT) was considered for all patients. Results. From 2009 to 2017, 54 patients with refractory/relapsed T-ALL were treated with nelarabine. Five-year event-free survival (EFS) and overall survival (OS) was 28% for all patients, cumulative risk of relapse (CIR) was 27%. EFS was significantly higher in nelarabine first-line therapy group in comparison with second-line therapy group (34±8% vs 8±8%, p=0,05). In patients after allo-HSCT EFS, OS and CIR were 51±10%, 50±10% and 39,1±9,5% accordingly. The best results were achieved in patients with TI immunophenotype. No toxicity-related mortality as well as severe neurologic complications or discontinuation of therapy associated with use of nelarabine were reported. Conclusion. The use of nelarabine is an effective strategy for the treatment of relapsed and refractory T-ALL. The best treatment outcomes were obtained in patients with TI immunophenotype and in the first-line therapy group. Optimal dosage regimens can be established during controlled clinical trials
Experimental confirmation of efficient island divertor operation and successful neoclassical transport optimization in Wendelstein 7-X
Publisher Correction: Demonstration of reduced neoclassical energy transport in Wendelstein 7-X
Towards a new image processing system at Wendelstein 7-X: From spatial calibration to characterization of thermal events
Wendelstein 7-X (W7-X) is the most advanced fusion experiment in the stellarator line and is aimed at proving that the stellarator concept is suitable for a fusion reactor. One of the most important issues for fusion reactors is the monitoring of plasma facing components when exposed to very high heat loads, through the use of visible and infrared (IR) cameras. In this paper, a new image processing system for the analysis of the strike lines on the inboard limiters from the first W7-X experimental campaign is presented. This system builds a model of the IR cameras through the use of spatial calibration techniques, helping to characterize the strike lines by using the information given by real spatial coordinates of each pixel. The characterization of the strike lines is made in terms of position, size, and shape, after projecting the camera image in a 2D grid which tries to preserve the curvilinear surface distances between points. The description of the strike-line shape is made by means of the Fourier Descriptors