CAKE: Compact and Accurate K-dimensional representation of Emotion

Numerous models describing the human emotional states have been built by the psychology community. Alongside, Deep Neural Networks (DNN) are reaching excellent performances and are becoming interesting features extraction tools in many computer vision tasks.Inspired by works from the psychology community, we first study the link between the compact two-dimensional representation of the emotion known as arousal-valence, and discrete emotion classes (e.g. anger, happiness, sadness, etc.) used in the computer vision community. It enables to assess the benefits -- in terms of discrete emotion inference -- of adding an extra dimension to arousal-valence (usually named dominance). Building on these observations, we propose CAKE, a 3-dimensional representation of emotion learned in a multi-domain fashion, achieving accurate emotion recognition on several public datasets. Moreover, we visualize how emotions boundaries are organized inside DNN representations and show that DNNs are implicitly learning arousal-valence-like descriptions of emotions. Finally, we use the CAKE representation to compare the quality of the annotations of different public datasets

Dark matter and leptogenesis linked by classical scale invariance

In this work we study a classically scale invariant extension of the Standard Model that can explain simultaneously dark matter and the baryon asymmetry in the universe. In our set-up we introduce a dark sector, namely a non-Abelian SU(2) hidden sector coupled to the SM via the Higgs portal, and a singlet sector responsible for generating Majorana masses for three right-handed sterile neutrinos. The gauge bosons of the dark sector are mass-degenerate and stable, and this makes them suitable as dark matter candidates. Our model also accounts for the matter-anti-matter asymmetry. The lepton flavour asymmetry is produced during CP-violating oscillations of the GeV-scale right-handed neutrinos, and converted to the baryon asymmetry by the electroweak sphalerons. All the characteristic scales in the model: the electro-weak, dark matter and the leptogenesis/neutrino mass scales, are generated radiatively, have a common origin and related to each other via scalar field couplings in perturbation theory

Electrochemical impedance spectroscopy to study physiological changes affecting the red blood cell after invasion by malaria parasites

The malaria parasite, Plasmodium falciparum, invades human erythrocytes and induces dramatic changes in the host cell. The idea of this work was to use RBC modified electrode to perform electrochemical impedance spectroscopy (EIS) with the aim of monitoring physiological changes affecting the erythrocyte after invasion by the malaria parasite. Impedance cell-based devices are potentially useful to give insight into cellular behavior and to detect morphological changes. The modelling of impedance plots (Nyquist diagram) in equivalent circuit taking into account the presence of the cellular layer, allowed us pointing out specific events associated with the development of the parasite such as (i) strong changes in the host cell cytoplasm illustrated by changes in the film capacity, (ii) perturbation of the ionic composition of the host cell illustrated by changes in the film resistance, (iii) releasing of reducer (lactic acid or heme) and an enhanced oxygen consumption characterized by changes in the charge transfer resistance and in the Warburg coefficient characteristic of the redox species diffusion. These results show that the RBC-based device may help to analyze strategic events in the malaria parasite development constituting a new tool in antimalarial research

Towards a General Model of Knowledge for Facial Analysis by Multi-Source Transfer Learning

This paper proposes a step toward obtaining general models of knowledge for facial analysis, by addressing the question of multi-source transfer learning. More precisely, the proposed approach consists in two successive training steps: the first one consists in applying a combination operator to define a common embedding for the multiple sources materialized by different existing trained models. The proposed operator relies on an auto-encoder, trained on a large dataset, efficient both in terms of compression ratio and transfer learning performance. In a second step we exploit a distillation approach to obtain a lightweight student model mimicking the collection of the fused existing models. This model outperforms its teacher on novel tasks, achieving results on par with state-of-the-art methods on 15 facial analysis tasks (and domains), at an affordable training cost. Moreover, this student has 75 times less parameters than the original teacher and can be applied to a variety of novel face-related tasks

In vitro antiplasmodial activity of1,1 0-phenanthroline derivatives and its quantitative structure-activity relationship

ABSTRACT Mustofa, Ange Desire Yapi, Alexis Valentin, lqmal Tahir - In vitro antiplasmodial activity of 1,10- phenanthroline derivatives and its quantitative structure-activity relationship Background: Previous study showed that 1,10-phenanthroline skeleton were active in vitro on both Plasmodium falciparum chloroquine-resistant and -sensitive strains. Based on the skeleton, a series of 1,10-phenanthroline derivatives have been synthesized. However the antiplasmodial activity of those molecules has not been reported. Objective: To know the in vitro antiplasmodial activity of thirteen 1,10-phenantroline derivatives and its quantitative structure-activity relationship. Methods: The in vitro antiplasmodial activity was tested on two strains of Plasmodium falciparum, FcB1Columbia (chloroquine-resistant strain) and a Nigerian (chloroquine-sensitive strain) using a radioactive micromethod. The parasite growth was estimated by [3H1-hipoxanthine incorporation after 24 and 48 hours incubation with each molecule tested. The control parasite free from any molecules was referred to as 100% growth. For this radioactive method IC5o value showing concentration inhibiting 50% of the parasite was determined graphically in concentration versus percent inhibition curves. The quantitative structure-activity relationships (QSAR) of 1,10-phenanthroline derivatives were investigated using atomic net charges as predictors of their activity. Data of predictors were obtained using semi-empirical Austin Model 1 (AM1) calculation method. The possible linear relationships of in vitro antiplasmodial activity with atomic net charge parameters of those compounds were studied. The best model QSAR was evaluated by multiple linear regression method. Results: The results showed that the IC5o values of 1,10-phenanthroline derivatives range from 0.02 to 11.05 uM for the FcB1 strain and from 0.14 to 19.84 pM for the Nigerian strain. The molecure (4), 2,10- methy1-3-12-chloroethyl)-4-chloropirydo [2,3-i] quinolineium iodide exhibited the best in vitro antiplasmodial activity with an IC50 value ranging 0.02 to 0.16 1.1M. The best model QSAR was expressed by log IC5o = -3.4398 - 14.9050 qN1 - 8.5589 qC10 - 14.7565 qC7 + 5.0457 qC11 (n = 13r = 0.96275r2 = 0.92689SE = 0.61578 and F (4,8) = 25.3556). Conclusion: The molecule (4) yield the best in vitro antiplasmodial activity on both P. falciparum strains. In addition, there is correlation between antiplasmodial activity and atomic net charges of atoms on the 1,10-phenanthroline skeleton. Key words : 1,10-phenanthroline, antiplasmodial activity, quantitative structure-activity relationship

In vitro Antiplasmodial Activity and Cytotoxicity of Vincadifformine and Its Semisynthetic Derivatives

An indole alkaloid with aspidospemane structure possessing a potential antiplasmodial activity, vincadifformine, has been isolated from Aspidosperma pyrifolium Mart. Moreover, 10 derivatives were prepared from the vincadifformine. The study was conducted to evaluate the in vitro antiplasmodial and cytotoxic activity of the vincadifformine and their semisynthetic derivatives. The in vitro antiplasmodial activity was evaluated on Plasmodium falciparum chloroquine-resistant (FcM29) and –sensitive (Nigerian) strains after 24-h and 72-h incubation, while cytotoxic activity was estimated on Hela cells and Cytotoxicity Index (CI = IC50  on HeLa cells/IC50 on FcM29  strain) was calculated to evaluate the safety of tested compounds. Experiment results showed that two compounds (4 and 8) exhibited good antiplasmodial activities in comparison with parent compound, vincadifformine and other tested compounds with IC50   ranging from 5.3 to 12.8 µM on FcM29   strain and 11.4 to 24.0 µM on Nigerian strain. In addition, the CI of two compounds were also lower after 24-h incubation (CI, 2.0 and 4.8) than that of after 72-h incubation (CI, 9.5 and 11.5). Further study will be conducted to evaluate quantitative structure-activity relationship (QSAR) in order to design new antimalarial drugs

Potencial acuífero mediante el sondeo eléctrico vertical (SEV) en las unidades litoestratigráficas en la zona de Agocucho 2019

RESUMEN El centro poblado de Agocucho, localizado en la cuenca de Cajamarca cuenta con un limitado suministro de agua potable. Por lo que la extracción de agua subterránea ha sido identificada como la mejor fuente de suministración de agua en zonas rurales. Este estudio se llevó a cabo con el objetivo de investigar el potencial acuífero en las unidades litoestratigráficas en Agocucho usando el método de sondeos eléctricos verticales (SEV); el diseño de la investigación es experimental, aplicada, de sección transversal y nivel correlacional, y enfoque cuantitativo. El SEV se aplicó utilizando la configuración Schlumberger para determinar la resistividad y delinear el acuífero que permitirá realizar pozos de agua. Se realizó 7 SEV en el área de estudio, la data obtenida fue analizada utilizando el software IPI2WIN en donde se identificó 3 capas geoeléctricas. La primera formación son areniscas arcillosas con una resistividad de 66,14 Ω.m a 84,11 Ω.m y un espesor de 15 metros. La segunda formación son sedimentos medianos con finos con una resistividad de 216 Ω.m a 302,83 Ω.m y un espesor de 25 m a 85m. La tercera formación conformada por calizas con resistividades de 513 Ω.m a 895,30 Ω.m y un espesor con rango entre los 25m a 95m. Los resultados del estudio muestran que el potencial acuífero se encuentra en la capa geoeléctrica 2 a profundidades superficiales entre los 25m a 85m, correlacionándolo con la geología local como depósitos aluviales. PALABRAS CLAVE: Acuífero, sondeos eléctricos verticales.ABSTRACT Agocucho Area, located in Cajamarca Basin has a limited supply of potable water. Groundwater has been identified as the best supply source for water supply in rural zones. This study was carried out with the aim of investigating the aquifer potential in lithostratigraphic units in Agocucho área using resistivity method. Vertical electrical sounding (VES) method was applied using Schlumberger configuration to determinate the resistivity and delineate the aquifer that help to develop wells. A total of 7 VES points were probed in the research area, The collected data was analysed using IPI2SIN software which were identified 3 geoelectric layers. The first formation is clay-sandstones with resistivity ranging from 66,15 Ω.m to 84,11 Ω.m and thickness of 15m. The second formation are sediments with resistivity ranging from 216 Ω.m to 302,83 Ω.m and thickness ranging from 25m to 85m. The third formation is characterized by fresh rock (limestone) with resistivity ranging from 513 Ω.m to 895,30 Ω.m and thickness ranging from 25m to 95m. The results of this study shows aquifer potential is located in the second geoelectric layer at shallow depths ranging between 25m to 85m, based on the geological setting this layer is aluviall deposit. KEYWORDS: Aquifer, vertical electrical sounding