Zero Bias Power Detector Circuits based on MoS2_2 Field Effect Transistors on Wafer-Scale Flexible Substrates

We demonstrate the design, fabrication, and characterization of wafer-scale, zero-bias power detectors based on two-dimensional MoS$_2$ field effect transistors (FETs). The MoS$_2$ FETs are fabricated using a wafer-scale process on 8 $\mu$m thick polyimide film, which in principle serves as flexible substrate. The performances of two CVD-MoS$_2$ sheets, grown with different processes and showing different thicknesses, are analyzed and compared from the single device fabrication and characterization steps to the circuit level. The power detector prototypes exploit the nonlinearity of the transistors above the cut-off frequency of the devices. The proposed detectors are designed employing a transistor model based on measurement results. The fabricated circuits operate in Ku-band between 12 and 18 GHz, with a demonstrated voltage responsivity of 45 V/W at 18 GHz in the case of monolayer MoS2 and 104 V/W at 16 GHz in the case of multilayer MoS$_2$, both achieved without applied DC bias. They are the best performing power detectors fabricated on flexible substrate reported to date. The measured dynamic range exceeds 30 dB outperforming other semiconductor technologies like silicon complementary metal oxide semiconductor (CMOS) circuits and GaAs Schottky diodes.Comment: 28 page

Középkori magyar uralkodók archeogenetikai vizsgálata

Középkori uralkodóink sírjai a történelem viharaiban elvesztek, maradványaik ismeretlen helyen, azonosítatlanul nyugszanak. Máig egyedül III. Béla maradványai kerültek elő, valamint szent királyaink ereklyéi maradtak meg az utókornak, melyek eredetiségét azonban sokan kétségbe vonják. Munkánk során a legtöbb királyunk temetkezési helyéül szolgált székesfehérvári királyi bazilika területén feltárt maradványok archeogenetikai vizsgálatát végezzük el, és azonosítjuk uralkodóink csontvázait. Emellett a Szent László-herma koponyaereklyéjét is megvizsgáltuk, hogy valódiságát igazoljuk. Míg a székesfehérvári vizsgálatokból csak részeredményeket közlünk, lévén a munka még nem fejeződött be, addig a Herma vizsgálata lezajlott, bemutatjuk, hogy eredetisége igazolást nyert, valóban Szent László koponyáját rejti. Mi több, azt is ismertetjük, hogyan járult hozzá Szent László genomvizsgálata az Árpád-házi maradványok személyazonosításához, és kimutatjuk a honfoglalók genetikai örökségét a Szent Király örökítőanyagában

A novel ACE2 decoy for both neutralization of SARS-CoV-2 variants and killing of infected cells

The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to millions of infections and deaths worldwide. As this virus evolves rapidly, there is a high need for treatment options that can win the race against new emerging variants of concern. Here, we describe a novel immunotherapeutic drug based on the SARS-CoV-2 entry receptor ACE2 and provide experimental evidence that it cannot only be used for (i) neutralization of SARS-CoV-2 in vitro and in SARS-CoV-2-infected animal models but also for (ii) clearance of virus-infected cells. For the latter purpose, we equipped the ACE2 decoy with an epitope tag. Thereby, we converted it to an adapter molecule, which we successfully applied in the modular platforms UniMAB and UniCAR for retargeting of either unmodified or universal chimeric antigen receptor-modified immune effector cells. Our results pave the way for a clinical application of this novel ACE2 decoy, which will clearly improve COVID-19 treatment

Temporal and spatial analysis of the 2014-2015 Ebola virus outbreak in West Africa

West Africa is currently witnessing the most extensive Ebola virus (EBOV) outbreak so far recorded. Until now, there have been 27,013 reported cases and 11,134 deaths. The origin of the virus is thought to have been a zoonotic transmission from a bat to a two-year-old boy in December 2013 (ref. 2). From this index case the virus was spread by human-to-human contact throughout Guinea, Sierra Leone and Liberia. However, the origin of the particular virus in each country and time of transmission is not known and currently relies on epidemiological analysis, which may be unreliable owing to the difficulties of obtaining patient information. Here we trace the genetic evolution of EBOV in the current outbreak that has resulted in multiple lineages. Deep sequencing of 179 patient samples processed by the European Mobile Laboratory, the first diagnostics unit to be deployed to the epicentre of the outbreak in Guinea, reveals an epidemiological and evolutionary history of the epidemic from March 2014 to January 2015. Analysis of EBOV genome evolution has also benefited from a similar sequencing effort of patient samples from Sierra Leone. Our results confirm that the EBOV from Guinea moved into Sierra Leone, most likely in April or early May. The viruses of the Guinea/Sierra Leone lineage mixed around June/July 2014. Viral sequences covering August, September and October 2014 indicate that this lineage evolved independently within Guinea. These data can be used in conjunction with epidemiological information to test retrospectively the effectiveness of control measures, and provides an unprecedented window into the evolution of an ongoing viral haemorrhagic fever outbreak.status: publishe

The rapid invasion of spotted wing drosophila, Drosophila suzukii (Matsumura) (Diptera: Drosophilidae), in Hungary

The invasive spotted wing drosophila, Drosophila suzuk i i (Matsumura) (Diptera: Drosophilidae), native to South-East Asia, is a recent threat for fruit production of temperate zones worldwide. The fly was detected in 2008 for the first time in Europe (Italy and Spain) and four years later, in 2012, it was found in Hungary at a highway rest area. In this study, the results of a countrywide survey of D. suzukii in Hungarian highway rest areas in 2012–2014 are summarized and supplementary trapping results are also represented for three cities. In 2012 and 2013 the species was found only in low numbers and in a few sites in the western part of the country, while in 2014 an outbreak of D. suzukii populations was detected. Adult flies were found at most of the trapping sites all over the country. Additionally, they were also present in the three monitored cities. Our results show that D. suzukii has practically settled in the whole country in 2014

Az amerikai lepkekabóca (Metcalfa pruinosa) és a tujakabóca (Liguropia juniperi) előfordulása hazai autópálya pihenőhelyeken

Az autópálya pihenôhelyek jó lehetôséget nyújtanak egyes inváziós fajok terjedésének nyomon követésére. A hazai autópályák mentén 2009 és 2013 között összesen 41 helyszínen vizsgáltuk az amerikai lepkekabóca elôfordulását. 2013-ig a fajt a vizsgált helyszínek több mint felén találtuk meg. Az M0-ás és az M7-es autópálya bizonyult a legfertôzöttebbnek, míg az M1-es és az M3-as autópályák Budapesttôl távolabbi szakaszain nem sikerült a fajt kimutatni. Eredményeink alapján az amerikai lepkekabóca mára Magyarország nagy részén elôfordul, de elterjedése erôsen mozaikos. A hazánkban elôször 2009-ben észlelt tujakabócát négy budapesti, illetve Budapest közeli helyrôl mutattuk ki, ami arra utal, hogy a faj stabilan megtelepedett az országban

Identifying CO2 Seeps in a Long-Dormant Volcanic Area Using Uncrewed Aerial Vehicle-Based Infrared Thermometry: A Qualitative Study

Ciomadul is a long-dormant volcanic area in the Eastern Carpathians of Romania. The study site, the Stinky Cave, and the surrounding areas are well-known for CO2, and H2S seeps. The gases from these seeps come with high flux and are of magmatic origin, associated with the volcanic activity of Ciomadul. In this study, an Uncrewed Aerial Vehicle coupled with a thermal infrared sensor is used to identify new seeps. In order to achieve this, we carried out several field campaigns, coupling image acquisition with the creation of digital outcrop models and orthomosaics. The study was carried out at low ambient temperatures to identify strong thermal anomalies from the gasses. Using this qualitative study method, we identified several new seeps. The total emission of the greenhouse gas CO2 in the Ciomadul area and other similar sites is highly underestimated. The practical application of this method will serve as a guide for a future regional rollout of the thermal infrared mapping and identification of CO2 seeps in the area

Interaction of clozapine with metformin in a schizophrenia rat model

Abstract The low efficacy of antipsychotic drugs (e.g., clozapine) for negative symptoms and cognitive impairment has led to the introduction of adjuvant therapies. Because previous data suggest the procognitive potential of the antidiabetic drug metformin, this study aimed to assess the effects of chronic clozapine and metformin oral administration (alone and in combination) on locomotor and exploratory activities and cognitive function in a reward-based test in control and a schizophrenia-like animal model (Wisket rats). As impaired dopamine D1 receptor (D1R) function might play a role in the cognitive dysfunctions observed in patients with schizophrenia, the second goal of this study was to determine the brain-region-specific D1R-mediated signaling, ligand binding, and mRNA expression. None of the treatments affected the behavior of the control animals significantly; however, the combination treatment enhanced D1R binding and activation in the cerebral cortex. The Wisket rats exhibited impaired motivation, attention, and cognitive function, as well as a lower level of cortical D1R binding, signaling, and gene expression. Clozapine caused further deterioration of the behavioral parameters, without a significant effect on the D1R system. Metformin blunted the clozapine-induced impairments, and, similarly to that observed in the control animals, increased the functional activity of D1R. This study highlights the beneficial effects of metformin (at the behavioral and cellular levels) in blunting clozapine-induced adverse effects