Constraints on late-forming exploding black holes

Black holes can be produced in collapse of small-scale dark matter structures, which can happen at any time from the early to present-day universe. Microstructure black holes (MSBHs) can have a wide range of masses. Small MSBHs evaporate via Hawking radiation with lifetimes shorter than the age of the universe, but they are not subject to the usual early-universe bounds on the abundance of small primordial black holes. We investigate the possible signal of such a population of exploding, late-forming black holes, constraining their abundance with observations from diffuse extragalactic gamma- and x-ray sources, the galactic center, and dwarf spheroidal galaxies.Comment: 7 pages, 5 figure

Explaining the GeV excess with exploding black holes

Black holes may form in present-day collapse of microscopic structures of dark matter. We show that, if microstructure black holes (MSBH) with mass $m\sim 10^{13}~g$ are produced, the spectrum of gamma rays from their evaporation agrees remarkably well with the GeV excess observed by Fermi Gamma-ray Space Telescope, while still avoiding all observational constraints. We also discuss the generic requirements for MSBHs to explain the GeV excess.Comment: letter---4 pages 1 figur

Influence of cemented carbide composition on cutting temperatures and corresponding hot hardnesses

During metal cutting, high temperatures of several hundred-degree Celsius occur locally at the cutting edge, which greatly impacts tool wear and life. Not only the cutting parameters, but also the tool material’s properties influence the arising cutting temperature which in turn alters the mechanical properties of the tool. In this study, the hardness and thermal conductivity of cemented tungsten carbides were investigated in the range between room temperature and 1000 °C. The occurring temperatures close to the cutting edge were measured with two color pyrometry. The interactions between cemented carbide tool properties and cutting process parameters, including cutting edge rounding, are discussed. The results show that cemented carbides with higher thermal conductivities lead to lower temperatures during cutting. As a result, the effective hardness at the cutting edge can be strongly influenced by the thermal conductivity. The differences in hardness measured at room temperature can be equalized or evened out depending on the combination of hardness and thermal conductivity. This in turn has a direct influence on tool wear. Wear is also influenced by the softening of the workpiece, so that higher cutting temperatures can lead to less wear despite the same effective hardness

Transcranial Magnetic Stimulation Provides Means to Assess Cortical Plasticity and Excitability in Humans with Fragile X Syndrome and Autism Spectrum Disorder

Fragile X Syndrome (FXS) is the most common heritable cause of intellectual disability. In vitro electrophysiologic data from mouse models of FXS suggest that loss of fragile X mental retardation protein affects intracortical excitability and synaptic plasticity. Specifically, the cortex appears hyperexcitable, and use-dependent long-term potentiation (LTP) and long-term depression (LTD) of synaptic strength are abnormal. Though animal models provide important information, FXS and other neurodevelopmental disorders are human diseases and as such translational research to evaluate cortical excitability and plasticity must be applied in the human. Transcranial magnetic stimulation paradigms have recently been developed to non-invasively investigate cortical excitability using paired pulse stimulation, as well as LTP- and LTD-like synaptic plasticity in response to theta burst stimulation (TBS) in vivo in the human. TBS applied on consecutive days can be used to measure metaplasticity (the ability of the synapse to undergo a second plastic change following a recent induction of plasticity). The current study investigated intracortical inhibition, plasticity and metaplasticity in full mutation females with FXS, participants with autism spectrum disorders (ASD), and neurotypical controls. Results suggest that intracortical inhibition is normal in participants with FXS, while plasticity and metaplasticity appear abnormal. ASD participants showed abnormalities in plasticity and metaplasticity, as well as heterogeneity in intracortical inhibition. Our findings highlight the utility of non-invasive neurophysiological measures to translate insights from animal models to humans with neurodevelopmental disorders, and thus provide direct confirmation of cortical dysfunction in patients with FXS and ASD

Suitability of natural rocks as materials for cutting tools

This study presents an investigation of the usability and suitability of natural rocks as cutting tool materials. Therefore, indexable inserts are manufactured from eight different rocks and two mono minerals in this study and are used for turning of an aluminium alloy. Besides that, a characterization of the rock properties is performed. The wear of the rock tools and the surface roughness of the workpiece generated by the tools are used to evaluate their operational behaviour. Subsequently, the rock properties and the corresponding operational behaviour are used to assess the suitability of the rocks as cutting tool material. The results show that rock inserts can be used as cutting material for the turning of an aluminium alloy showing a width of wear marks between 83 and 1665 µm at the flank face after a cutting length of 500 m depending on the rock used. Furthermore, it is shown that rock tools are able to achieve surface roughness values which are comparable to those obtainable by using a conventional cemented carbide insert. The study shows that natural rocks can generally be used as alternative cutting material for the turning of aluminium. In addition a possible way for a systematic investigation and assessment of the suitability of natural rocks as cutting tool materials is presented, the relevance of the rock properties for the operational behaviour of the rock inserts is described and relevant future research topics concerning the use of rocks as cutting tool material are identified

Immunization with Single-Cycle SIV Significantly Reduces Viral Loads After an Intravenous Challenge with SIVmac239

Strains of simian immunodeficiency virus (SIV) that are limited to a single cycle of infection were evaluated for the ability to elicit protective immunity against wild-type SIVmac239 infection of rhesus macaques by two different vaccine regimens. Six animals were inoculated at 8-week intervals with 6 identical doses consisting of a mixture of three different envelope variants of single-cycle SIV (scSIV). Six additional animals were primed with a mixture of cytoplasmic domain-truncated envelope variants of scSIV and boosted with two doses of vesicular stomatitis virus glycoprotein (VSV G) trans-complemented scSIV. While both regimens elicited detectable virus-specific T cell responses, SIV-specific T cell frequencies were more than 10-fold higher after boosting with VSV G trans-complemented scSIV (VSV G scSIV). Broad T cell recognition of multiple viral antigens and Gag-specific CD4+ T cell responses were also observed after boosting with VSV G scSIV. With the exception of a single animal in the repeated immunization group, all of the animals became infected following an intravenous challenge with SIVmac239. However, significantly lower viral loads and higher memory CD4+ T cell counts were observed in both immunized groups relative to an unvaccinated control group. Indeed, both scSIV immunization regimens resulted in containment of SIVmac239 replication after challenge that was as good as, if not better than, what has been achieved by other non-persisting vaccine vectors that have been evaluated in this challenge model. Nevertheless, the extent of protection afforded by scSIV was not as good as typically conferred by persistent infection with live, attenuated SIV. These observations have potentially important implications to the design of an effective AIDS vaccine, since they suggest that ongoing stimulation of virus-specific immune responses may be essential to achieving the degree of protection afforded by live, attenuated SIV

Dynamic Coupling of Pattern Formation and Morphogenesis in the Developing Vertebrate Retina

In this Research Article, Picker et al. show how cells in the retina get their spatial coordinates