30 research outputs found
Maybe We Should Look at Other Countries
Affordable health care is becoming more and more of a problem in the United States. This article summarizes how three less developed countries have used acupuncture to improve their citizens' health without significant capital outlay or great cost to consumers
Pancreatic Adenocarcinoma in a Pregnant Patient with Situs Inversus: a Case Report
This is a report on the case of pancreatic adenocarcinoma in 29-year-old pregnant woman with situs inversus. The main consideration was whether pregnancy should be preserved. Patient underwent pancreatoduodenectomy following pregnancy, abortion, and mastectomy for breast adenoma. Whipple pancreatoduodenectomy with open pancreaticogastrostomy was performed. Microscopy revealed clear cell adenocarcinoma with low-grade differentiation, which was confirmed by an immunohistochemical study. Patient feels good, without any signs of pain or decrease in life quality, four years after the operation. We think that such complex cases require the application of every available diagnostic method and that surgery should be performed by the most experienced surgeon
Cooperation of RAD51 and RAD54 in regression of a model replication fork
DNA lesions cause stalling of DNA replication forks, which can be lethal for the cell. Homologous recombination (HR) plays an important role in DNA lesion bypass. It is thought that Rad51, a key protein of HR, contributes to the DNA lesion bypass through its DNA strand invasion activity. Here, using model stalled replication forks we found that RAD51 and RAD54 by acting together can promote DNA lesion bypass in vitro through the ‘template-strand switch’ mechanism. This mechanism involves replication fork regression into a Holliday junction (‘chicken foot structure’), DNA synthesis using the nascent lagging DNA strand as a template and fork restoration. Our results demonstrate that RAD54 can catalyze both regression and restoration of model replication forks through its branch migration activity, but shows strong bias toward fork restoration. We find that RAD51 modulates this reaction; by inhibiting fork restoration and stimulating fork regression it promotes accumulation of the chicken foot structure, which we show is essential for DNA lesion bypass by DNA polymerase in vitro. These results indicate that RAD51 in cooperation with RAD54 may have a new role in DNA lesion bypass that is distinct from DNA strand invasion
Modeling of GERDA Phase II data
The GERmanium Detector Array (GERDA) experiment at the Gran Sasso underground
laboratory (LNGS) of INFN is searching for neutrinoless double-beta
() decay of Ge. The technological challenge of GERDA is
to operate in a "background-free" regime in the region of interest (ROI) after
analysis cuts for the full 100kgyr target exposure of the
experiment. A careful modeling and decomposition of the full-range energy
spectrum is essential to predict the shape and composition of events in the ROI
around for the search, to extract a precise
measurement of the half-life of the double-beta decay mode with neutrinos
() and in order to identify the location of residual
impurities. The latter will permit future experiments to build strategies in
order to further lower the background and achieve even better sensitivities. In
this article the background decomposition prior to analysis cuts is presented
for GERDA Phase II. The background model fit yields a flat spectrum in the ROI
with a background index (BI) of cts/(kgkeVyr) for the enriched BEGe data set and
cts/(kgkeVyr) for the
enriched coaxial data set. These values are similar to the one of Gerda Phase I
despite a much larger number of detectors and hence radioactive hardware
components
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Modeling of GERDA Phase II data
The GERmanium Detector Array (Gerda) experiment at the Gran Sasso underground laboratory (LNGS) of INFN is searching for neutrinoless double-beta (0νββ) decay of 76Ge. The technological challenge of Gerda is to operate in a “background-free” regime in the region of interest (ROI) after analysis cuts for the full 100 kg·yr target exposure of the experiment. A careful modeling and decomposition of the full-range energy spectrum is essential to predict the shape and composition of events in the ROI around Qββ for the 0νββ search, to extract a precise measurement of the half-life of the double-beta decay mode with neutrinos (2νββ) and in order to identify the location of residual impurities. The latter will permit future experiments to build strategies in order to further lower the background and achieve even better sensitivities. In this article the background decomposition prior to analysis cuts is presented for Gerda Phase II. The background model fit yields a flat spectrum in the ROI with a background index (BI) of 16.04+0.78−0.85⋅10−3 cts/(keV·kg·yr) for the enriched BEGe data set and 14.68+0.47−0.52⋅10−3 cts/(keV·kg·yr) for the enriched coaxial data set. These values are similar to the one of Phase I despite a much larger number of detectors and hence radioactive hardware components
Liquid argon light collection and veto modeling in GERDA Phase II
The ability to detect liquid argon scintillation light from within a densely packed high-purity germanium detector array allowed the Gerda experiment to reach an exceptionally low background rate in the search for neutrinoless double beta decay of 76 Ge. Proper modeling of the light propagation throughout the experimental setup, from any origin in the liquid argon volume to its eventual detection by the novel light read-out system, provides insight into the rejection capability and is a necessary ingredient to obtain robust background predictions. In this paper, we present a model of the Gerda liquid argon veto, as obtained by Monte Carlo simulations and constrained by calibration data, and highlight its application for background decomposition
Search for tri-nucleon decays of ^{76}Ge in GERDA
We search for tri-nucleon decays of 76Ge in the dataset from the GERmanium Detector Array (GERDA) experiment. Decays that populate excited levels of the daughter nucleus above the threshold for particle emission lead to disintegration and are not considered. The ppp-, ppn-, and pnn-decays lead to 73Cu, 73Zn, and 73Ga nuclei, respectively. These nuclei are unstable and eventually proceed by the beta decay of 73Ga to 73Ge (stable). We search for the 73Ga decay exploiting the fact that it dominantly populates the 66.7 keV 73mGa state with half-life of 0.5 s. The nnn-decays of 76Ge that proceed via 73mGe are also included in our analysis. We find no signal candidate and place a limit on the sum of the decay widths of the inclusive tri-nucleon decays that corresponds to a lower lifetime limit of 1.2×1026 yr (90% credible interval). This result improves previous limits for tri-nucleon decays by one to three orders of magnitude
Search for exotic physics in double-β decays with GERDA Phase II
A search for Beyond the Standard Model double- decay modes ofGe has been performed with data collected during the Phase II of theGERmanium Detector Array (GERDA) experiment, located at Laboratori Nazionalidel Gran Sasso of INFN (Italy). Improved limits on the decays involvingMajorons have been obtained, compared to previous experiments with Ge,with half-life values on the order of 10 yr. For the first time withGe, limits on Lorentz invariance violation effects in double-decay have been obtained. The isotropic coefficient, which embeds Lorentz violation indouble- decay, has been constrained at the order of GeV. Wealso set the first experimental limits on the search for light exotic fermionsin double- decay, including sterile neutrinos.<br
Final Results of GERDA on the Two-Neutrino Double- Decay Half-Life of Ge
We present the measurement of the two-neutrino double- decay rate of
Ge performed with the GERDA Phase II experiment. With a subset of the
entire GERDA exposure, 11.8 kgyr, the half-life of the process has been
determined: yr. This is the most precise determination of the
Ge two-neutrino double- decay half-life and one of the most
precise measurements of a double- decay process. The relevant nuclear
matrix element can be extracted: Comment: 7 pages, 4 figures, 2 table