Determinação Quantitativa da Concentração de Sódio em Pães Tipo Bisnaguinha Comercializados na Cidade do Rio de Janeiro

For the human body to work properly, it is estimated that 200-500 mg of sodium should be consumed per day. However, if consumed in excess, sodium causes an increase in blood pressure, which in turn increases the risk of cardiovascular diseases. Following guidelines established by the WHO, initiatives have been taken by several countries to reduce the consumption of foods containing high sodium concentrations. In Brazil, the Ministry of Health signed the Term of Commitment 004/2011 with entities representatives of the food industry to establish national targets for reducing the sodium content (mg/100 g) in various products, including bisnaguinha, a type of bread. Owing to the lack of studies about quantifying the concentration of sodium in bisnaguinha, this element was quantified in four brands (A, B, C, and D) of bisnaguinha by flame photometry. The concentrations of sodium found in mg/100 g of the product were as follows: A, 302.90; B, 419.60; C, 430.80; D, 308.22. The concentrations of sodium in all brands were below those declared on the product labels and in accordance with the Terms of Compromise established for the year 2014 (430 mg/100 g of the product).Para manter o organismo humano funcionando de modo adequado, estima-se que o consumo de sódio deve estar em torno de 200-500 mg por dia. Porém, se consumido em excesso, o sódio causa um aumento da pressão arterial, elevando o risco de ocorrência de doenças cardiovasculares. Vários países, seguindo orientações estabelecidas pela WHO, têm tomado iniciativas no sentido de diminuir o consumo de alimentos que contenham elevada concentração de sódio. No Brasil, o Ministério da Saúde firmou o Termo de Compromisso no 004/2011 com entidades representantes da indústria alimentícia, visando estabelecer metas nacionais para redução do teor de sódio em diversos produtos, inclusive pães do tipo bisnaguinha. Devido à falta de estudos que determinem a concentração de sódio em pães tipo bisnaguinha, esse elemento foi quantificado em quatro marcas (A, B, C e D) deste tipo de pão, através da fotometria de chama. As concentrações de sódio encontradas em mg 100g-1  de produto, foram as seguintes: A - 302,90; B – 419,60; C – 430,80; D – 308,22. As concentrações de sódio de todas as marcas apresentaram-se abaixo do declarado nos rótulos dos produtos e de acordo com o estabelecido no Termo de Compromisso firmado para o ano de 2014 (430 mg 100g-1  de produto)

Scientific research on food environments in Brazil: a scoping review

Abstract Objective: To map the scientific research on food environments in Brazil, based on the following questions: How many studies have addressed food environments?; What study designs and methodological approaches were applied?; What is the geographic scope of the studies?; What scenarios and dimensions of food environments were studied?; Which population groups were studied?; How were food environments conceptualised?; What are the main limitations of the studies? Design: Scoping review conducted in four databases, from January 2005 to December 2022, using different food environment-related terms to cover the main types and dimensions proposed in the literature. The studies were independently selected by two authors. A narrative synthesis was used to summarise the findings. Setting: Brazil. Participants: 130 articles. Results: Scientific research on Brazilian food environments has been increasing. The analytical quantitative approach and the cross-sectional design were the most frequently used. Most articles were published in English. The majority of studies evaluated the community food environment, addressed aspects of the physical dimension, sampled the adult population, had food consumption as an outcome, used primary data, and were carried out in capital cities in the Southeast region. Furthermore, in most articles, no conceptual model was explicitly adopted. Conclusions: Gaps in literature are related to the need for conducting studies in the Brazilian countryside, the support for the formulation of research questions based on conceptual models, the use of valid and reliable instruments to collect primary data, in addition to the need for a greater number of longitudinal, intervention and qualitative studies

Revisão bibliográfica: impactos em áreas nativas da caatinga causadas pelas atividades econômicas e as técnicas de reflorestamento / Bibliographic review: impacts on native areas the caatinga caused by economic activities and reforestation techniques

O desmatamento é um problema ambiental de destaque para países com grandes áreas de florestas tropicais, como o Brasil. Esse processo que começou de forma insignificante e hoje tomou proporções preocupante na medida em que as alterações na vegetação no ar atmosférico na absortividade na refletividade, na permeabilidade do solo e nas águas que compõem a superfície. O Bioma Caatinga apresenta um desmatamento acelerado ocasionado a redução das chuvas, e com isso vem as alterações nos fatores climáticos que poderão alcançar um ponto crítico de irreversibilidade causando empobrecimento da flora e da fauna por causa da exploração e ao consumo de lenha nativa de forma ilegal e insustentável para fins domésticos e industriais. Entretanto, o objetivo do presente trabalho foi avaliar os impactos causados pelas atividades econômicas: como o desmatamento de áreas nativas da Caatinga para a produção de lenha e carvão vegetal, bem como identificar as técnicas de reflorestamento. Uma das formas de recuperar as áreas degradadas é através da interferência das atividades humanas utilizando as espécies nativas lenhosas pioneiras que aparecem com mais frequência neste bioma com a Mimosa tenuiflora, o Croton sonderianus, a Caesalpinea bracteosa, a Bauhinia cheilantha e o Combretum leprosum, gerando atividades lucrativas e sustentáveis. As atividades econômicas realizadas no bioma Caatinga tem ocasionado impactos no meio ambiente que comprometem a fauna e a flora e as técnicas de reflorestamento são escassas e ineficientes para atender a economia de forma sustentável, prejudicando o equilíbrio do ecossistema e a perca da biodiversidade para as futuras gerações

The impact of surgical delay on resectability of colorectal cancer: An international prospective cohort study

AIM: The SARS-CoV-2 pandemic has provided a unique opportunity to explore the impact of surgical delays on cancer resectability. This study aimed to compare resectability for colorectal cancer patients undergoing delayed versus non-delayed surgery. METHODS: This was an international prospective cohort study of consecutive colorectal cancer patients with a decision for curative surgery (January-April 2020). Surgical delay was defined as an operation taking place more than 4 weeks after treatment decision, in a patient who did not receive neoadjuvant therapy. A subgroup analysis explored the effects of delay in elective patients only. The impact of longer delays was explored in a sensitivity analysis. The primary outcome was complete resection, defined as curative resection with an R0 margin. RESULTS: Overall, 5453 patients from 304 hospitals in 47 countries were included, of whom 6.6% (358/5453) did not receive their planned operation. Of the 4304 operated patients without neoadjuvant therapy, 40.5% (1744/4304) were delayed beyond 4 weeks. Delayed patients were more likely to be older, men, more comorbid, have higher body mass index and have rectal cancer and early stage disease. Delayed patients had higher unadjusted rates of complete resection (93.7% vs. 91.9%, P = 0.032) and lower rates of emergency surgery (4.5% vs. 22.5%, P < 0.001). After adjustment, delay was not associated with a lower rate of complete resection (OR 1.18, 95% CI 0.90-1.55, P = 0.224), which was consistent in elective patients only (OR 0.94, 95% CI 0.69-1.27, P = 0.672). Longer delays were not associated with poorer outcomes. CONCLUSION: One in 15 colorectal cancer patients did not receive their planned operation during the first wave of COVID-19. Surgical delay did not appear to compromise resectability, raising the hypothesis that any reduction in long-term survival attributable to delays is likely to be due to micro-metastatic disease

ATLANTIC EPIPHYTES: a data set of vascular and non-vascular epiphyte plants and lichens from the Atlantic Forest

Epiphytes are hyper-diverse and one of the frequently undervalued life forms in plant surveys and biodiversity inventories. Epiphytes of the Atlantic Forest, one of the most endangered ecosystems in the world, have high endemism and radiated recently in the Pliocene. We aimed to (1) compile an extensive Atlantic Forest data set on vascular, non-vascular plants (including hemiepiphytes), and lichen epiphyte species occurrence and abundance; (2) describe the epiphyte distribution in the Atlantic Forest, in order to indicate future sampling efforts. Our work presents the first epiphyte data set with information on abundance and occurrence of epiphyte phorophyte species. All data compiled here come from three main sources provided by the authors: published sources (comprising peer-reviewed articles, books, and theses), unpublished data, and herbarium data. We compiled a data set composed of 2,095 species, from 89,270 holo/hemiepiphyte records, in the Atlantic Forest of Brazil, Argentina, Paraguay, and Uruguay, recorded from 1824 to early 2018. Most of the records were from qualitative data (occurrence only, 88%), well distributed throughout the Atlantic Forest. For quantitative records, the most common sampling method was individual trees (71%), followed by plot sampling (19%), and transect sampling (10%). Angiosperms (81%) were the most frequently registered group, and Bromeliaceae and Orchidaceae were the families with the greatest number of records (27,272 and 21,945, respectively). Ferns and Lycophytes presented fewer records than Angiosperms, and Polypodiaceae were the most recorded family, and more concentrated in the Southern and Southeastern regions. Data on non-vascular plants and lichens were scarce, with a few disjunct records concentrated in the Northeastern region of the Atlantic Forest. For all non-vascular plant records, Lejeuneaceae, a family of liverworts, was the most recorded family. We hope that our effort to organize scattered epiphyte data help advance the knowledge of epiphyte ecology, as well as our understanding of macroecological and biogeographical patterns in the Atlantic Forest. No copyright restrictions are associated with the data set. Please cite this Ecology Data Paper if the data are used in publication and teaching events. © 2019 The Authors. Ecology © 2019 The Ecological Society of Americ

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK.

BACKGROUND: A safe and efficacious vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), if deployed with high coverage, could contribute to the control of the COVID-19 pandemic. We evaluated the safety and efficacy of the ChAdOx1 nCoV-19 vaccine in a pooled interim analysis of four trials. METHODS: This analysis includes data from four ongoing blinded, randomised, controlled trials done across the UK, Brazil, and South Africa. Participants aged 18 years and older were randomly assigned (1:1) to ChAdOx1 nCoV-19 vaccine or control (meningococcal group A, C, W, and Y conjugate vaccine or saline). Participants in the ChAdOx1 nCoV-19 group received two doses containing 5 × 1010 viral particles (standard dose; SD/SD cohort); a subset in the UK trial received a half dose as their first dose (low dose) and a standard dose as their second dose (LD/SD cohort). The primary efficacy analysis included symptomatic COVID-19 in seronegative participants with a nucleic acid amplification test-positive swab more than 14 days after a second dose of vaccine. Participants were analysed according to treatment received, with data cutoff on Nov 4, 2020. Vaccine efficacy was calculated as 1 - relative risk derived from a robust Poisson regression model adjusted for age. Studies are registered at ISRCTN89951424 and ClinicalTrials.gov, NCT04324606, NCT04400838, and NCT04444674. FINDINGS: Between April 23 and Nov 4, 2020, 23 848 participants were enrolled and 11 636 participants (7548 in the UK, 4088 in Brazil) were included in the interim primary efficacy analysis. In participants who received two standard doses, vaccine efficacy was 62·1% (95% CI 41·0-75·7; 27 [0·6%] of 4440 in the ChAdOx1 nCoV-19 group vs71 [1·6%] of 4455 in the control group) and in participants who received a low dose followed by a standard dose, efficacy was 90·0% (67·4-97·0; three [0·2%] of 1367 vs 30 [2·2%] of 1374; pinteraction=0·010). Overall vaccine efficacy across both groups was 70·4% (95·8% CI 54·8-80·6; 30 [0·5%] of 5807 vs 101 [1·7%] of 5829). From 21 days after the first dose, there were ten cases hospitalised for COVID-19, all in the control arm; two were classified as severe COVID-19, including one death. There were 74 341 person-months of safety follow-up (median 3·4 months, IQR 1·3-4·8): 175 severe adverse events occurred in 168 participants, 84 events in the ChAdOx1 nCoV-19 group and 91 in the control group. Three events were classified as possibly related to a vaccine: one in the ChAdOx1 nCoV-19 group, one in the control group, and one in a participant who remains masked to group allocation. INTERPRETATION: ChAdOx1 nCoV-19 has an acceptable safety profile and has been found to be efficacious against symptomatic COVID-19 in this interim analysis of ongoing clinical trials. FUNDING: UK Research and Innovation, National Institutes for Health Research (NIHR), Coalition for Epidemic Preparedness Innovations, Bill & Melinda Gates Foundation, Lemann Foundation, Rede D'Or, Brava and Telles Foundation, NIHR Oxford Biomedical Research Centre, Thames Valley and South Midland's NIHR Clinical Research Network, and AstraZeneca

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK

Background A safe and efficacious vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), if deployed with high coverage, could contribute to the control of the COVID-19 pandemic. We evaluated the safety and efficacy of the ChAdOx1 nCoV-19 vaccine in a pooled interim analysis of four trials. Methods This analysis includes data from four ongoing blinded, randomised, controlled trials done across the UK, Brazil, and South Africa. Participants aged 18 years and older were randomly assigned (1:1) to ChAdOx1 nCoV-19 vaccine or control (meningococcal group A, C, W, and Y conjugate vaccine or saline). Participants in the ChAdOx1 nCoV-19 group received two doses containing 5 × 1010 viral particles (standard dose; SD/SD cohort); a subset in the UK trial received a half dose as their first dose (low dose) and a standard dose as their second dose (LD/SD cohort). The primary efficacy analysis included symptomatic COVID-19 in seronegative participants with a nucleic acid amplification test-positive swab more than 14 days after a second dose of vaccine. Participants were analysed according to treatment received, with data cutoff on Nov 4, 2020. Vaccine efficacy was calculated as 1 - relative risk derived from a robust Poisson regression model adjusted for age. Studies are registered at ISRCTN89951424 and ClinicalTrials.gov, NCT04324606, NCT04400838, and NCT04444674. Findings Between April 23 and Nov 4, 2020, 23 848 participants were enrolled and 11 636 participants (7548 in the UK, 4088 in Brazil) were included in the interim primary efficacy analysis. In participants who received two standard doses, vaccine efficacy was 62·1% (95% CI 41·0–75·7; 27 [0·6%] of 4440 in the ChAdOx1 nCoV-19 group vs71 [1·6%] of 4455 in the control group) and in participants who received a low dose followed by a standard dose, efficacy was 90·0% (67·4–97·0; three [0·2%] of 1367 vs 30 [2·2%] of 1374; pinteraction=0·010). Overall vaccine efficacy across both groups was 70·4% (95·8% CI 54·8–80·6; 30 [0·5%] of 5807 vs 101 [1·7%] of 5829). From 21 days after the first dose, there were ten cases hospitalised for COVID-19, all in the control arm; two were classified as severe COVID-19, including one death. There were 74 341 person-months of safety follow-up (median 3·4 months, IQR 1·3–4·8): 175 severe adverse events occurred in 168 participants, 84 events in the ChAdOx1 nCoV-19 group and 91 in the control group. Three events were classified as possibly related to a vaccine: one in the ChAdOx1 nCoV-19 group, one in the control group, and one in a participant who remains masked to group allocation. Interpretation ChAdOx1 nCoV-19 has an acceptable safety profile and has been found to be efficacious against symptomatic COVID-19 in this interim analysis of ongoing clinical trials

ANÁLISE EPIDEMIOLÓGICA DOS CASOS NOTIFICADOS DE SÍFILIS CONGÊNITA NO ESTADO DO AMAPÁ DE 2020 A 2022

Introdução: A sífilis congênita é uma infecção resultante da transmissão da sífilis materna, causa pela bactéria Treponema pallidum para o feto e tende a cursar com complicações como abortamentos, surdez, cegueira, más formações fetais e morte do feto. No amapá, ainda há poucos estudos sobre essa condição e entendendo a importância de conhecer a distribuição destes casos, se faz necessário conhecer o perfil epidemiológico envolvido nessa patologia. Métodos: Estudo epidemiológico observacional do tipo análise de série temporal, realizado por meio da análise de dados extraídos do Departamento de HIV/Aids, Tuberculose, Hepatites Virais e Infecções Sexualmente Transmissíveis (DVIAHV) e os selecionados foram as gestantes, independente da faixa etária, com sorologia positiva para sífilis das quais também houve o exame positivo no neonato. As variáveis analisadas foram: faixa etária, escolaridade, realização de pré-natal, momento do diagnóstico, esquema de tratamento da gestante, evolução, e óbitos por meio de estatística descritiva. Resultados: Observaram-se 1.142 casos de sífilis diagnosticada em gestantes no período analisado, sendo que 520 (45,53%) culminaram na infecção do feto pela sífilis. Dentre essas, houve predomínio da faixa etária entre 20-29 anos com 289 casos (55,57%) com maiores taxas em pardas 453 (87,11%) e com ensino médio incompleto 106 (20,38%) sendo que 354 gestantes (68,07%) realizaram o pré-natal e o momento de maior diagnóstico da sífilis materna foi no parto/curetagem 264 (50,76%) e o esquema de tratamento materno em 439 pacientes (84,42%) foi inadequado. Ademais, 57 dos casos (10,96%) evoluíram com natimorto por sífilis. Conclusão: Os resultados reforçam a relação do contato com as Infeções Sexualmente Transmissíveis (IST) com a baixa escolaridade, ao passo que a desinformação da saúde sexual entra como um fator que corrobora para o contato com as IST antes ou durante a gestação. Não só isso, como também, as políticas de diagnóstico e tratamento realizadas no pré-natal apresentam fragilidades haja visto que, em grande parte das pacientes, o diagnóstico da sífilis materna foi tardio mesmo com o pré-natal. Condição está, sobretudo por um possível tratamento ineficaz que por vezes deixa de englobar a parceria da gestante, o que cursa com a possibilidade de reinfecção e permanência da bactéria para transmissão. Desse modo, é de suma importância uma maior ênfase na saúde sexual da gestante desde a atenção primária de saúde

ATLANTIC BIRD TRAITS: a data set of bird morphological traits from the Atlantic forests of South America

Scientists have long been trying to understand why the Neotropical region holds the highest diversity of birds on Earth. Recently, there has been increased interest in morphological variation between and within species, and in how climate, topography, and anthropogenic pressures may explain and affect phenotypic variation. Because morphological data are not always available for many species at the local or regional scale, we are limited in our understanding of intra- and interspecies spatial morphological variation. Here, we present the ATLANTIC BIRD TRAITS, a data set that includes measurements of up to 44 morphological traits in 67,197 bird records from 2,790 populations distributed throughout the Atlantic forests of South America. This data set comprises information, compiled over two centuries (1820–2018), for 711 bird species, which represent 80% of all known bird diversity in the Atlantic Forest. Among the most commonly reported traits are sex (n = 65,717), age (n = 63,852), body mass (n = 58,768), flight molt presence (n = 44,941), molt presence (n = 44,847), body molt presence (n = 44,606), tail length (n = 43,005), reproductive stage (n = 42,588), bill length (n = 37,409), body length (n = 28,394), right wing length (n = 21,950), tarsus length (n = 20,342), and wing length (n = 18,071). The most frequently recorded species are Chiroxiphia caudata (n = 1,837), Turdus albicollis (n = 1,658), Trichothraupis melanops (n = 1,468), Turdus leucomelas (n = 1,436), and Basileuterus culicivorus (n = 1,384). The species recorded in the greatest number of sampling localities are Basileuterus culicivorus (n = 243), Trichothraupis melanops (n = 242), Chiroxiphia caudata (n = 210), Platyrinchus mystaceus (n = 208), and Turdus rufiventris (n = 191). ATLANTIC BIRD TRAITS (ABT) is the most comprehensive data set on measurements of bird morphological traits found in a biodiversity hotspot; it provides data for basic and applied research at multiple scales, from individual to community, and from the local to the macroecological perspectives. No copyright or proprietary restrictions are associated with the use of this data set. Please cite this data paper when the data are used in publications or teaching and educational activities. © 2019 The Authors. Ecology © 2019 The Ecological Society of Americ