Avaliação do perfil da adolescente que procura anticoncepção na Maternidade Carmela Dutra.

Trabalho de Conclusão de Curso - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Departamento de Tocoginecologia, Curso de Medicina, Florianópolis, 200

Obesidade abdominal e consumo alimentar em portadores de HIV/Aids

OBJECTIVE: To assess the association between dietary intake and central obesity among people living with HIV/AIDS and receiving highly active antiretroviral therapy. METHODS: A cross-sectional study was conducted involving 223 adult individuals in the city of São Paulo city in 2002. The study population was classified according to central obesity, defined as waist-to-hip ratio >;0.95 for men and >;0.85 for women. The dietary variables studied were energy consumption (in calories and calories/kilo of body weight), macronutrients (in grams and % of energy intake), total fiber (grams) and fruit and vegetables intake (grams). The potential confounders examined were sex, skin color, age, schooling, income, body mass index, physical activity, smoking habits, peripheral CD4+ T lymphocyte count and length of protease inhibitor use. The multiple logistic regression model was performed in order to evaluate the association between central obesity and dietary intake. RESULTS: The prevalence of central obesity was 45.7% and it was associated with greater consumption of lipids: for every increase of 10g of lipid intake the odds of central obesity increased 1.28 times. Carbohydrate consumption showed negative association (OR=0.93) with central obesity after adjustment for control variables. CONCLUSIONS: The results suggest that the amount of carbohydrates and lipids in the diet, regardless of total energy intake, may modify the chance of developing central obesity in the studied population. Nutritional interventions may be beneficial for preventing central obesity among HIV/AIDS patients.OBJETIVO: Avaliar a associação entre consumo alimentar e presença de obesidade abdominal em indivíduos infectados pelo HIV/Aids, em uso de terapia antiretroviral de alta potência. MÉTODOS: Trata-se de estudo transversal envolvendo 223 indivíduos adultos, realizado no município de São Paulo, em 2002. A população de estudo foi classificada de acordo com a obesidade abdominal, definida pela razão das circunferências da cintura e quadril >;0,95 para os homens e >;0,85 para mulheres. As variáveis dietéticas estudadas foram consumo de energia (calorias e calorias/quilo de peso corporal), macronutrientes (em gramas e % da energia ingerida), fibra total (gramas) e consumo de frutas, verduras e legumes (gramas). Potenciais fatores de confusão examinados foram sexo, raça, idade, escolaridade, renda, índice de massa corporal, nível de atividade física, tabagismo, contagem de linfócitos T CD4+ e tempo de uso de inibidor de protease. Estimou-se modelo de regressão logística para avaliar a relação entre obesidade abdominal e consumo alimentar. RESULTADOS: A prevalência de obesidade abdominal foi de 45,7% e esteve associada ao maior consumo de lipídeos: para cada aumento de 10 g de lipídio na dieta a chance aumentou 1,28 vezes. O consumo de carboidratos mostrou-se negativamente associado (OR=0,93) com a presença de obesidade abdominal após ajuste pelas variáveis de controle. CONCLUSÕES: Os resultados sugerem que a quantidade de carboidratos e lipídeos na dieta, independente do consumo energético, pode modificar a chance de desenvolver obesidade abdominal na população estudada. Intervenções nutricionais podem ser benéficas na prevenção de obesidade abdominal entre pacientes vivendo com HIV/Aids

Determining of body mass index in adolescents from public schools in Piracicaba, São Paulo State

O objetivo do presente estudo foi verificar os fatores determinantes do índice de massa corporal (IMC) de adolescentes matriculados nas escolas públicas de Piracicaba, São Paulo. A amostra foi constituída por 328 adolescentes de ambos os sexos, com idade mínima de dez anos. Verificou-se peso, estatura, maturação sexual, atividade física e consumo alimentar. Foi usado um modelo de regressão linear múltipla para verificar a associação entre as variáveis independentes e o IMC. Enquanto as meninas consideradas fisicamente ativas apresentaram maior média de IMC do que as insuficientemente ativas, a média do IMC dos meninos não apresentou diferença estatística quando comparada entre meninos ativos e insuficientemente ativos. A maturação sexual foi determinante do IMC, para ambos os sexos, reforçando a ideia de que é fundamental levar em consideração essa variável em estudos que avaliam o estado nutricional em adolescentes. Acredita-se que os métodos utilizados no presente estudo, os quais são normalmente utilizados em pesquisas semelhantes, apresentaram importantes limitações para avaliar a influência do nível de atividade física e do consumo alimentar sobre o IMC dos adolescentes. Dessa forma, ressalta-se a necessidade de aprimoramento desses métodos para adoção em futuros estudos.The objective of this study was to assess determining factors of body mass index (BMI) in adolescents enrolled in public schools in Piracicaba, São Paulo. The sample had 328 adolescents from both genders; minimum age was 10 years old. We have assessed weight, height, sexual maturity, physical activity, and diet. A multiple linear regression model was used to assess the association between independent variables and BMI. While girls considered physically active presented greater mean BMI than those insufficiently active, boys did not present statistical difference between mean BMI among those active and those insufficiently active. Sexual maturity was a determinant for BMI, for both genders, reinforcing the idea that it is essential to take this variable into account in studies that assess the nutritional situation in adolescents. We believe that the methods used in the present study, which are normally used in similar surveys, have important limitations to assess the influence of variables such as the level of physical activity and food intake on the BMI of adolescents. Thus, it is important to improve these methods and adopt them in further studies

Determinação Quantitativa da Concentração de Sódio em Pães Tipo Bisnaguinha Comercializados na Cidade do Rio de Janeiro

For the human body to work properly, it is estimated that 200-500 mg of sodium should be consumed per day. However, if consumed in excess, sodium causes an increase in blood pressure, which in turn increases the risk of cardiovascular diseases. Following guidelines established by the WHO, initiatives have been taken by several countries to reduce the consumption of foods containing high sodium concentrations. In Brazil, the Ministry of Health signed the Term of Commitment 004/2011 with entities representatives of the food industry to establish national targets for reducing the sodium content (mg/100 g) in various products, including bisnaguinha, a type of bread. Owing to the lack of studies about quantifying the concentration of sodium in bisnaguinha, this element was quantified in four brands (A, B, C, and D) of bisnaguinha by flame photometry. The concentrations of sodium found in mg/100 g of the product were as follows: A, 302.90; B, 419.60; C, 430.80; D, 308.22. The concentrations of sodium in all brands were below those declared on the product labels and in accordance with the Terms of Compromise established for the year 2014 (430 mg/100 g of the product).Para manter o organismo humano funcionando de modo adequado, estima-se que o consumo de sódio deve estar em torno de 200-500 mg por dia. Porém, se consumido em excesso, o sódio causa um aumento da pressão arterial, elevando o risco de ocorrência de doenças cardiovasculares. Vários países, seguindo orientações estabelecidas pela WHO, têm tomado iniciativas no sentido de diminuir o consumo de alimentos que contenham elevada concentração de sódio. No Brasil, o Ministério da Saúde firmou o Termo de Compromisso no 004/2011 com entidades representantes da indústria alimentícia, visando estabelecer metas nacionais para redução do teor de sódio em diversos produtos, inclusive pães do tipo bisnaguinha. Devido à falta de estudos que determinem a concentração de sódio em pães tipo bisnaguinha, esse elemento foi quantificado em quatro marcas (A, B, C e D) deste tipo de pão, através da fotometria de chama. As concentrações de sódio encontradas em mg 100g-1  de produto, foram as seguintes: A - 302,90; B – 419,60; C – 430,80; D – 308,22. As concentrações de sódio de todas as marcas apresentaram-se abaixo do declarado nos rótulos dos produtos e de acordo com o estabelecido no Termo de Compromisso firmado para o ano de 2014 (430 mg 100g-1  de produto)

Avaliação da efetividade de intervenções de promoção da atividade física no Sistema Único de Saúde

OBJECTIVE To assess the effect of interventions on the levels of physical activity of healthy adults, users of the Brazilian Unified Health System and attended by the Family Health Strategy. METHODS Non-randomized experimental study with 157 adults allocated in three groups: 1) physical exercise classes (n = 54), 2) health education (n = 54), 3) control (n = 49). The study lasted for18 months, with 12 months of interventions and six months of follow-up after intervention. Assessments took place at the beginning, in the 12 months, and in the 18 months of study. Physical activity has been assessed by questionnaires and accelerometry. For the analyses, we have used the intention-to-treat principle and generalized estimating equations. RESULTS After 12 months, both intervention groups have increased the minutes of weekly leisure time physical activity and annual scores of physical exercise, leisure and transport-related physical activity. The exercise class group has obtained the highest average annual physical exercises score when compared to the other groups (p < 0.001). In the follow-up period, the exercise class group reduced its annual score (average: -0.3; 95%CI -0.5–-0.1), while the health education group increased this score (average: 0.2; 95%CI 0.1–0.4). There have been no differences in the levels of physical activity measured by accelerometry. CONCLUSIONS The interventions have been effective in increasing the practice of physical activity. However, we have observed that the health education intervention was more effective for maintaining the practice of physical activity in the period after intervention. We recommend the use of both interventions to promote physical activity in the Brazilian Unified Health System, according to the local reality of professionals, facilities, and team objectives.OBJETIVO Avaliar o efeito de intervenções nos níveis de atividade física de adultos saudáveis, usuários do Sistema Único de Saúde e atendidos pela Estratégia de Saúde da Família. MÉTODOS Estudo experimental, não randomizado, com 157 adultos alocados em três grupos: 1) classes de exercícios físicos (n = 54); 2) educação em saúde (n = 54); 3) controle (n = 49). O estudo teve duração de 18 meses, sendo 12 meses de intervenções e seis meses de acompanhamento pós-intervenção. As avaliações ocorreram no início, nos 12 e nos 18 meses de estudo. A atividade física foi avaliada por questionários e por acelerometria. Para as análises, utilizaram-se o princípio de intenção de tratar e equações de estimativas generalizadas. RESULTADOS Após 12 meses, ambos os grupos de intervenção aumentaram os minutos semanais de atividade física no lazer e os escores anuais de exercícios físicos, de lazer e de deslocamento. O grupo das classes de exercícios físicos obteve maior média de escore anual de exercícios físicos em comparação com os outros grupos (p < 0,001). No período pós-intervenção, o grupo de classes de exercícios físicos reduziu o escore anual de exercícios físicos (média: -0,3; IC95% -0,5–-0,1), enquanto o grupo de educação em saúde aumentou este escore (média: 0,2; IC95% 0,1–0,4). Não houve diferenças nos níveis de atividade física mensurados por acelerometria. CONCLUSÕES As intervenções foram efetivas para aumentar a prática de atividade física. No entanto, observou-se que a intervenção de educação em saúde foi mais efetiva para a manutenção da prática de atividade física no período pós-intervenção. Recomenda-se a utilização de ambas as intervenções para a promoção da atividade física no Sistema Único de Saúde, de acordo com as realidades locais de profissionais, instalações e objetivos das equipes

Voluntary project “For Others” provides recreation and social interaction by implementing the activity assisted by animals / Projeto voluntário “Pelos Outros” proporciona recreação e interação social mediante implantação da atividade assistida por animais

Animal-assisted activity is characterized by informal visits to schools, daycare centers, nursing homes and hospitals with the presence of animals, trained or not, for recreation with educational, social and motivational purposes. This activity can be applied in isolation or in association with other complementary ones such as therapy and animal-assisted education. In this context, in the activity assisted by animals several species are used, but the one of choice is the canine, due to indole and dressage facility. It is essential that the participating animals have an updated health certificate so that they do not transmit infectious diseases, in addition to the importance for their own health. Scientifically, it has been proven that human-animal interaction provides social reintegration, reduction of anxiety, loneliness, depression and psychological disorders, in addition to improving self-esteem, reasoning and concentration. Thus, the association of these adjuvant factors with conventional therapies favors the quality of life and longevity of the participating individuals. In view of the promising results attributed to the activity assisted by animals, the objective of the present work is to describe the performance of the social project “For Others” in the implementation of this modality with the help of trained dogs, helping the elderly, children, disabled, sick and homeless people in the city of Franca (SP) and region. The results of this voluntary category demonstrate satisfaction not only from participants in the activity assisted by animals, but also from their families and caregivers.

Whole-body MRI in pediatric patients with cancer

Cancer is the leading cause of natural death in the pediatric populations of developed countries, yet cure rates are greater than 70% when a cancer is diagnosed in its early stages. Recent advances in magnetic resonance imaging methods have markedly improved diagnostic and therapeutic approaches, while avoiding the risks of ionizing radiation that are associated with most conventional radiological methods, such as computed tomography and positron emission tomography/computed tomography. The advent of whole-body magnetic resonance imaging in association with the development of metabolic- and function-based techniques has led to the use of whole-body magnetic resonance imaging for the screening, diagnosis, staging, response assessment, and post-therapeutic follow-up of children with solid sporadic tumours or those with related genetic syndromes. Here, the advantages, techniques, indications, and limitations of whole-body magnetic resonance imaging in the management of pediatric oncology patients are presented.AC Camargo Canc Ctr, Dept Imaging, Rua Prof Antonio Prudente 211, BR-01509010 Sao Paulo, SP, BrazilUniv Fed Vale Sao Francisco UNIVASF, Av Jose Sa Manicoba, BR-56304917 Petrolina, PE, BrazilAC Camargo Canc Ctr, Dept Imaging, Rua Prof Antonio Prudente 211, BR-01509010 Sao Paulo, SP, BrazilUniv Sao Paulo, Ribeirao Preto Med Sch, Div Radiol, Dept Internal Med, Av Bandeirantes 3900, BR-14049090 Ribeirao Preto, SP, BrazilUniv Fed Sao Paulo, Dept Diagnost Imagem, Disciplina Diagnost Imagem Pediat, Rua Napoleao de Barros 800, BR-04024002 Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Ctr Diagnost Imagem, Inst Oncol Pediat & Med Radiol, Inst Oncol Pediat, Rua Napoleao Barros 800, BR-04024002 Sao Paulo, SP, BrazilUniv Texas MD Anderson Canc Ctr, Dept Diagnost Radiol, 1515 Holcombe Blvd, Houston, TX 77030 USAUniv Fed Ciencias Saude Porto Alegre, Dept Radiol, Ctr Hist, Rua Prof Anes Dias 285, BR-90020090 Porto Alegre, RS, BrazilUniv Fed Rio de Janeiro, Dept Radiol, Rua Thomaz Cameron 438, BR-25685129 Petropolis, RJ, BrazilUniv Fed Sao Paulo, Dept Diagnost Imagem, Disciplina Diagnost Imagem Pediat, Rua Napoleao de Barros 800, BR-04024002 Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Ctr Diagnost Imagem, Inst Oncol Pediat & Med Radiol, Inst Oncol Pediat, Rua Napoleao Barros 800, BR-04024002 Sao Paulo, SP, BrazilWeb of Scienc

Assessment of the effectiveness of physical activity interventions in the Brazilian Unified Health System.

OBJECTIVE: To assess the effect of interventions on the levels of physical activity of healthy adults, users of the Brazilian Unified Health System and attended by the Family Health Strategy. METHODS: Non-randomized experimental study with 157 adults allocated in three groups: 1) physical exercise classes (n = 54), 2) health education (n = 54), 3) control (n = 49). The study lasted for18 months, with 12 months of interventions and six months of follow-up after intervention. Assessments took place at the beginning, in the 12 months, and in the 18 months of study. Physical activity has been assessed by questionnaires and accelerometry. For the analyses, we have used the intention-to-treat principle and generalized estimating equations. RESULTS: After 12 months, both intervention groups have increased the minutes of weekly leisure time physical activity and annual scores of physical exercise, leisure and transport-related physical activity. The exercise class group has obtained the highest average annual physical exercises score when compared to the other groups (p < 0.001). In the follow-up period, the exercise class group reduced its annual score (average: -0.3; 95%CI -0.5--0.1), while the health education group increased this score (average: 0.2; 95%CI 0.1-0.4). There have been no differences in the levels of physical activity measured by accelerometry. CONCLUSIONS: The interventions have been effective in increasing the practice of physical activity. However, we have observed that the health education intervention was more effective for maintaining the practice of physical activity in the period after intervention. We recommend the use of both interventions to promote physical activity in the Brazilian Unified Health System, according to the local reality of professionals, facilities, and team objectives. OBJETIVO: Avaliar o efeito de intervenções nos níveis de atividade física de adultos saudáveis, usuários do Sistema Único de Saúde e atendidos pela Estratégia de Saúde da Família. MÉTODOS: Estudo experimental, não randomizado, com 157 adultos alocados em três grupos: 1) classes de exercícios físicos (n = 54); 2) educação em saúde (n = 54); 3) controle (n = 49). O estudo teve duração de 18 meses, sendo 12 meses de intervenções e seis meses de acompanhamento pós-intervenção. As avaliações ocorreram no início, nos 12 e nos 18 meses de estudo. A atividade física foi avaliada por questionários e por acelerometria. Para as análises, utilizaram-se o princípio de intenção de tratar e equações de estimativas generalizadas. RESULTADOS: Após 12 meses, ambos os grupos de intervenção aumentaram os minutos semanais de atividade física no lazer e os escores anuais de exercícios físicos, de lazer e de deslocamento. O grupo das classes de exercícios físicos obteve maior média de escore anual de exercícios físicos em comparação com os outros grupos (p < 0,001). No período pós-intervenção, o grupo de classes de exercícios físicos reduziu o escore anual de exercícios físicos (média: -0,3; IC95% -0,5--0,1), enquanto o grupo de educação em saúde aumentou este escore (média: 0,2; IC95% 0,1-0,4). Não houve diferenças nos níveis de atividade física mensurados por acelerometria. CONCLUSÕES: As intervenções foram efetivas para aumentar a prática de atividade física. No entanto, observou-se que a intervenção de educação em saúde foi mais efetiva para a manutenção da prática de atividade física no período pós-intervenção. Recomenda-se a utilização de ambas as intervenções para a promoção da atividade física no Sistema Único de Saúde, de acordo com as realidades locais de profissionais, instalações e objetivos das equipes

“Rural Extension - Dairy Cattle” of the Professional Improvement Program in Veterinary Medicine at University of Franca provides veterinary assistance to small rural properties of region / “Extensão Rural - Gado de Leite” do Programa de Aprimoramento Profissional em Medicina Veterinária da Universidade de Franca proporciona assistência veterinária a pequenas propriedades rurais da região

The rural extension is a technical activity that aims at an educational and instructive character in assisted properties, especially for small and medium rural dairy farmers. In this way, among other factors, it aims to maintain the welfare and health of the animals involved and also to produce subsistence with the activity. Given the importance of dairy farming in Brazil and the various difficulties encountered in this sector, this work aims to report the performance and importance of the “Rural Extension - Dairy Cattle” Project of the Professional Improvement Program in Veterinary Medicine at the University of Franca (UNIFRAN). This extension project, created in 2012, in addition to improving the knowledge of recently graduated academics, provides veterinary technical assistance to small rural dairy farmers in the city of Franca (SP) and region, especially in relation to the processes that involve the handling, welfare, nutrition, production, reproduction and health of the animals. Each selected student develops these activities for two consecutive years, under the constant supervision and guidance of the institution's faculty, in addition to the assistance of interns. Thus, using the rural extension methodology recommended by the “Rural Extension – Dairy Cattle” Project, It is admitted that it provides the intensive improvement of the veterinarian for being directly inserted in the current job market, in addition to offering instructions to rural producers followed by animal care, which favors the productivity and quality of the product obtained.

A multivalent chimeric vaccine composed of Schistosoma mansoni SmTSP-2 and Sm29 was able to induce protection against infection in mice

Schistosoma mansoni is a blood fluke parasite responsible for schistosomiasis. The best long-term strategy to control schistosomiasis is through immunization combined with drug treatment. In this study, we cloned, expressed and purified SmTSP-2 fused to the N- and C-terminal halves of Sm29 and tested these chimeras as vaccine candidates using an adjuvant approved to be used in humans. The results demonstrated that vaccination with SmTSP-2 fused to N- or C-terminus of Sm29-induced reduction in worm burden and liver pathology when compared to control animals. Additionally, we detected high levels of mouse-specific IgG, IgG1 and IgG2a against both chimeras and significant amounts of IFN-γ and TNF-α and no IL-4. Finally, studies with sera from patients resistant to infection and living in schistosomiasis endemic areas revealed high levels of specific IgG to both chimeras when compared to healthy individuals. In conclusion, SmTSP-2/Sm29 chimeras tested here induced partial protection against infection and might be a potential vaccine candidate