AdS3_3 solutions with exceptional supersymmetry

Among the possible superalgebras that contain the AdS$_3$ isometries, two interesting possibilities are the exceptional $F(4)$ and $G(3)$. Their R-symmetry is respectively SO(7) and $G_2$, and the amount of supersymmetry ${\cal N}=8$ and ${\cal N}=7$. We find that there exist two (locally) unique solutions in type IIA supergravity that realize these superalgebras, and we provide their analytic expressions. In both cases, the internal space is obtained by a round six-sphere fibred over an interval, with an O8-plane at one end. The R-symmetry is the symmetry group of the sphere; in the $G(3)$ case, it is broken to $G_2$ by fluxes. We also find several numerical ${\cal N}=1$ solutions with $G_2$ flavor symmetry, with various localized sources, including O2-planes and O8-planes.Comment: 30 pages, 4 figures; v3: revised appendix, minor correction

Holographic duals of 6d RG flows

A notable class of superconformal theories (SCFTs) in six dimensions is parameterized by an integer $N$, an ADE group $G$, and two nilpotent elements $\mu_\mathrm{L,R}$ in $G$. Nilpotent elements have a natural partial ordering, which has been conjectured to coincide with the hierarchy of renormalization-group flows among the SCFTs. In this paper we test this conjecture for $G=\mathrm{SU}(k)$, where AdS$_7$ duals exist in IIA. We work with a seven-dimensional gauged supergravity, consisting of the gravity multiplet and two $\mathrm{SU}(k)$ non-Abelian vector multiplets. We show that this theory has many supersymmetric AdS$_7$ vacua, determined by two nilpotent elements, which are naturally interpreted as IIA AdS$_7$ solutions. The BPS equations for domain walls connecting two such vacua can be solved analytically, up to a Nahm equation with certain boundary conditions. The latter admit a solution connecting two vacua if and only if the corresponding nilpotent elements are related by the natural partial ordering, in agreement with the field theory conjecture.Comment: 33 pages, 2 figure

Multi-agent quality of experience control

In the framework of the Future Internet, the aim of the Quality of Experience (QoE) Control functionalities is to track the personalized desired QoE level of the applications. The paper proposes to perform such a task by dynamically selecting the most appropriate Classes of Service (among the ones supported by the network), this selection being driven by a novel heuristic Multi-Agent Reinforcement Learning (MARL) algorithm. The paper shows that such an approach offers the opportunity to cope with some practical implementation problems: in particular, it allows to face the so-called “curse of dimensionality” of MARL algorithms, thus achieving satisfactory performance results even in the presence of several hundreds of Agents

Chemical evolution of disc galaxies from cosmological simulations

We perform a suite of cosmological hydrodynamical simulations of disc galaxies, with zoomedin initial conditions leading to the formation of a halo of mass M-halo, DM similar or equal to 2 x 10(12) M-circle dot at redshift z = 0. These simulations aim at investigating the chemical evolution and the distribution of metals in a disc galaxy, and at quantifying the effect of (i) the assumed IMF, (ii) the adopted stellar yields, and (iii) the impact of binary systems originating SNe Ia on the process of chemical enrichment. We consider either a Kroupa, Tout & Gilmore (1993) or a more top-heavy Kroupa (2001) IMF, two sets of stellar yields and different values for the fraction of binary systems suitable to give rise to SNe Ia. We investigate stellar ages, SN rates, stellar and gas metallicity gradients, and stellar alpha-enhancement in simulations, and compare predictions with observations. We find that a Kroupa et al. (1993) IMF has to be preferred when modelling late-type galaxies in the local Universe. On the other hand, the comparison of stellar metallicity profiles and alpha-enhancement trends with observations of Milky Way stars shows a better agreement when a Kroupa (2001) IMF is assumed. Comparing the predicted SN rates and stellar alpha-enhancement with observations supports a value for the fraction of binary systems producing SNe Ia of 0.03, at least for late-type galaxies and for the considered IMFs. Adopted stellar yields are crucial in regulating cooling and star formation, and in determining patterns of chemical enrichment for stars, especially for those located in the galaxy bulge

A multi-factorial genetic model for prognostic assessment of high risk melanoma patients receiving adjuvant interferon

Purpose: IFNa was the first cytokine to demonstrate anti-tumor activity in advanced melanoma. Despite the ability of high-dose IFNa reducing relapse and mortality by up to 33%, large majority of patients experience side effects and toxicity which outweigh the benefits. The current study attempts to identify genetic markers likely to be associated with benefit from IFN-a2b treatment and predictive for survival. Experimental design: We tested the association of variants in FOXP3 microsatellites, CTLA4 SNPs and HLA genotype in 284 melanoma patients and their association with prognosis and survival of melanoma patients who received IFNa adjuvant therapy. Results: Univariate survival analysis suggested that patients bearing either the DRB1*15 or HLA-Cw7 allele suffered worse OS while patients bearing either HLA-Cw6 or HLA-B44 enjoyed better OS. DRB1*15 positive patients suffered also worse RFS and conversely HLA-Cw6 positive patients had better RFS. Multivariate analysis revealed that a five-marker genotyping signature was prognostic of OS independent of disease stage. In the multivariate Cox regression model, HLA-B38 (p = 0.021), HLA-C15 (p = 0.025), HLA-C3 (p = 0.014), DRB1*15 (p = 0.005) and CT60*G/G (0.081) were significantly associated with OS with risk ratio of 0.097 (95% CI, 0.013-0.709), 0.387 (95% CI, 0.169-0.889), 0.449 (95% CI, 0.237-0.851), 1.948 (95% CI, 1.221-3.109) and 1.484 (95% IC, 0.953-2.312) respectively. Conclusion: These results suggest that gene polymorphisms relevant to a biological occurrence are more likely to be informative when studied in concert to address potential redundant or conflicting functions that may limit each gene individual contribution. The five markers identified here exemplify this concept though prospective validation in independent cohorts is needed

Osservatorio giurisprudenziale dell'Istituto di Diritto penale

[Abstract non disponibile

Integrated care for the management of ageing-related non-communicable diseases: current gaps and future directions

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On the effect of galactic outflows in cosmological simulations of disc galaxies

We investigate the impact of galactic outflow modelling on the formation and evolution of a disc galaxy, by performing a suite of cosmological simulations with zoomed-in initial conditions of a Milky Way-sized halo. We verify how sensitive the general properties of the simulated galaxy are to the way in which stellar feedback triggered outflows are implemented, keeping initial conditions, simulation code and star formation (SF) model all fixed. We present simulations that are based on a version of the GADGET3 code where our sub-resolution model is coupled with an advanced implementation of Smoothed Particle Hydrodynamics that ensures a more accurate fluid sampling and an improved description of gas mixing and hydrodynamical instabilities. We quantify the strong interplay between the adopted hydrodynamic scheme and the sub-resolution model describing SF and feedback. We consider four different galactic outflow models, including the one introduced by Dalla Vecchia and Schaye (2012) and a scheme that is inspired by the Springel and Hernquist (2003) model. We find that the sub-resolution prescriptions adopted to generate galactic outflows are the main shaping factor of the stellar disc component at low redshift. The key requirement that a feedback model must have to be successful in producing a disc-dominated galaxy is the ability to regulate the high-redshift SF (responsible for the formation of the bulge component), the cosmological infall of gas from the large-scale environment, and gas fall-back within the galactic radius at low redshift, in order to avoid a too high SF rate at z=0