IMPLICAÇÕES DO ISOLAMENTO SOCIAL DURANTE A PANDEMIA DO COVID-19 NA COMUNICAÇÃO DE CRIANÇAS

Introduction: With the COVID-19 pandemic, several countries adopted social distancing as a preventive measure, which caused the social isolation of families, consequently, children who were in the course of communication and language development had these processes delayed or not started. Objective: To analyze the impacts of social isolation during the COVID-19 pandemic on children's communication in São Luís - MA. Methods: A retrospective longitudinal observational study was adopted, evaluating the speech-language pathology records, on the communicative behavior, of 15 children treated at a speech-language pathology clinic, considering the last and the first assessment before and after social isolation, respectively. The answers were analyzed in percentage and for statistical analysis, a non- parametric chi-square test was used. Results: It is observed that there were significant differences (P < 0.05) in the results obtained by the evaluations of the medical records regarding the language aspects of the children assisted after social isolation, the children began not to obey orders and auditory and visual commands after isolation. , where an increase of 14% is observed and it differed significantly (P < 0.05) before social isolation. There was a significant change (P < 0.05) in the ratio of children who were sometimes able to communicate by forming sentences of 2 or 3 words correctly in order not to communicate after social isolation, with a   decrease from 36% to 14% of children who were able to communicate and an increase from 14% to 36% in the number of children who cannot. Conclusion: Social isolation during the COVID-19 pandemic negatively influenced the communication of children in São Luís - MA.Introdução: Com a pandemia da COVID-19 vários países adotaram o distanciamento social como medida preventiva, que ocasionou no isolamento social das famílias, consequentemente, as crianças que estavam em curso do desenvolvimento da comunicação e linguagem tiveram esses processos retardados ou não iniciados. Objetivo: analisar os impactos do isolamento social durante a pandemia da COVID-19 na comunicação de crianças em São Luís - MA. Métodos: Adotou-se estudo observacional do tipo longitudinal de caráter retrospectivo avaliando prontuários fonoaudiológicos, sobre o comportamento comunicativo, de 15 crianças atendidas numa clínica fonoaudiológica, considerando-se a última e a primeira avaliação antes e após o isolamento social, respectivamente. As respostas foram analisadas em porcentagem e para análise estatística adotou-se teste não paramétrico quadrado. Resultados: Observa-se que houve diferenças significativa (P < 0,05) nos resultados obtidos pelas avaliações dos prontuários quanto aos aspectos de linguagem das crianças atendidas depois do isolamento social, as crianças passaram a não obedecer a ordens e comandos auditivos e visuais depois do isolamento, onde se observa aumento de 14% e diferiu significativamente (P < 0,05) antes do isolamento social. Ocorreu mudança significativa (P < 0,05) na relação das crianças que conseguiam às vezes se comunicar formando frases de 2 ou 3 palavras corretamente para não se comunicar depois do isolamento social, com diminuição de 36% para 14% das crianças que conseguiam às vezes se comunicar e aumento de 14% para 36% no quantitativo de crianças que não conseguem. Conclusão: O isolamento social durante a pandemia do COVID-19 influenciou negativamente na comunicação de crianças em São Luís – MA

Cardiac Impairment Evaluated by Transesophageal Echocardiography and Invasive Measurements in Rats Undergoing Sinoaortic Denervation

Background: Sympathetic hyperactivity may be related to left ventricular (LV) dysfunction and baro- and chemoreflex impairment in hypertension. However, cardiac function, regarding the association of hypertension and baroreflex dysfunction, has not been previously evaluated by transesophageal echocardiography (TEE) using intracardiac echocardiographic catheter.Methods and Results: We evaluated exercise tests, baroreflex sensitivity and cardiovascular autonomic control, cardiac function, and biventricular invasive pressures in rats 10 weeks after sinoaortic denervation (SAD). the rats (n = 32) were divided into 4 groups: 16 Wistar (W) with (n = 8) or without SAD (n = 8) and 16 spontaneously hypertensive rats (SHR) with (n = 8) or without SAD (SHRSAD) (n = 8). Blood pressure (BP) and heart rate (HR) did not change between the groups with or without SAD; however, compared to W, SHR groups had higher BP levels and BP variability was increased. Exercise testing showed that SHR had better functional capacity compared to SAD and SHRSAD. Echocardiography showed left ventricular (LV) concentric hypertrophy; segmental systolic and diastolic biventricular dysfunction; indirect signals of pulmonary arterial hypertension, mostly evident in SHRSAD. the end-diastolic right ventricular (RV) pressure increased in all groups compared to W, and the end-diastolic LV pressure increased in SHR and SHRSAD groups compared to W, and in SHRSAD compared to SAD.Conclusions: Our results suggest that baroreflex dysfunction impairs cardiac function, and increases pulmonary artery pressure, supporting a role for baroreflex dysfunction in the pathogenesis of hypertensive cardiac disease. Moreover, TEE is a useful and feasible noninvasive technique that allows the assessment of cardiac function, particularly RV indices in this model of cardiac disease.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Univ São Paulo, Fac Med, Cardiomyopathy Unit, Heart Inst InCor,Hosp Clin, São Paulo, BrazilUniv São Paulo, Fac Med, Hypertens Unit, Heart Inst InCor,Hosp Clin, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Biosci, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Biosci, São Paulo, BrazilWeb of Scienc

Effect of exercise training in heart rate variability, anxiety, depression, and sleep quality in kidney recipients : a preliminary study

The aim of this study was to compare the sleep quality, depression, anxiety, and autonomic function of a group of kidney-transplanted recipients who joined a combined exercise program (KTRt) or remained sedentary (KTRs). A total of 20 kidney-transplanted recipients, split into two groups (10 KTRt and 10 KTRs), joined the study. Heart rate variability, cardiorespiratory capacity, depression, and sleep questionnaires were evaluated. KTRt presented lower Pittsburgh Sleep Quality Index and greater entropy, and increased parasympathetic and decreased sympathetic modulation than KTRs. Anxiety level was minimal and depression was absent in both groups. KTRt group presented better sleep quality and better autonomic modulation than KTRs243299308CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQNão temWe would like to thank Federal University of Maranhão’s Presidente Dutra Hospital and the Centro de Prevenção de Doenças Renais (CPDR) for its wonderful contribution to the kidney-transplanted patients. R.B. and A.C.S.-F. contributed equally to this work. Also, we would like to thank Fundação de Amparo à Pesquisa (FAPEMA) and Conselho Nacional de Pesquisa e Desenvolvimento Cientifico (CNPq) for suppor

A system to improve the physical ergonomics in Human-Robot Collaboration

In the industry 4.0 era, pursuing social sustainability also means implementing a synergic collaboration between workers and robots. Indeed, robot behavior does not affect only worker safety, but it also influences his health and comfort. In this context, an important topic to be enhanced is the operator's physical monitoring aimed at reducing the risk of musculoskeletal disorders. Some research studies deal with the improvement of the worker's posture during human-robot collaboration; however, non-intrusive methods applicable in real industrial scenarios are lacking. To this ending, this paper proposes a system to avoid uncomfortable and unsafe postures based on workers' anthropometric characteristics, posture monitoring by inertial and visual systems, task requirements, and a real-time risk assessment by standard methodology. The system allows the optimization of the robot behavior in order to improve worker's well-being. Finally, the virtual simulation of a real case study is presented. (C) 2022 The Authors. Published by Elsevier B.V

Representative results of <i>SERPINA1</i> gene expression in different ovine tissues.

<p>A) Expression of <i>SERPINA1</i> transcript variants (indicated by arrows on right) and B) expression of ATPB5 control gene in various tissues. Lanes represent molecular weight marker (M) spleen (1), <i>semitendinosus</i> muscle (2), longissimus dorsi muscle (3), mammary gland (4), brain (5), cerebellum (6), rumen (7), bladder (8), adrenal (9), uterus (10) and liver (11)..</p

Alignment of the reactive center loop (RCL) region (25 aa) for AAT protein in different mammalian.

<p>RCL region is dotted underlined. The two amino acids important for the inhibitory AAT function are highlighted with a box.</p

Gel electrophoresis of ovine <i>SERPINA1</i> cDNA transcript variants.

<p>Molecular weight markers on the left (lane M), cDNA from mammary gland Sarda (lane 1) and Gentile di Puglia (lane 2) breeds, and cDNA from milk cells of Sarda (lane 3) and Gentile di Puglia (lane 4) breeds. The three identified splicing variants are indicated by arrows on right side of pictograph.</p