Does the Borexino experiment have enough resolution to detect the neutrino flavor day-night asymmetry?

The Earth's density distribution can be approximately considered piecewise continuous at the scale of two-flavor oscillations of neutrinos with energies about 1 MeV. This quite general assumption appears to be enough to analytically calculate the day-night asymmetry factor. Using the explicit time averaging procedure, we show that, within the leading-order approximation, this factor is determined by the electron density immediately before the detector, i.e. in the Earth's crust. Within the approximation chosen, the resulting asymmetry factor does not depend either on the properties of the inner Earth's layers or on the substance and the dimensions of the detector. For beryllium neutrinos, we arrive at the asymmetry factor estimation of about $-4 \times 10^{-4}$, which is at least one order of magnitude beyond the present experimental resolution, including that of the Borexino experiment.Comment: 16 pages, 3 figures; Talk given at the 17th International Seminar on High Energy Physics "QUARKS'2012" (Yaroslavl, Russia, June 4-10, 2012); to appear in the Proceedings volum

A Femtomol Range FRET Biosensor Reports Exceedingly Low Levels of Cell Surface Furin: Implications for the Processing of Anthrax Protective Antigen

Furin, a specialized endoproteinase, transforms proproteins into biologically active proteins. Furin function is important for normal cells and also in multiple pathologies including malignancy and anthrax. Furin is believed to cycle between the Golgi compartment and the cell surface. Processing of anthrax protective antigen-83 (PA83) by the cells is considered thus far as evidence for the presence of substantial levels of cell-surface furin. To monitor furin, we designed a cleavage-activated FRET biosensor in which the Enhanced Cyan and Yellow Fluorescent Proteins were linked by the peptide sequence SNSRKKR↓STSAGP derived from anthrax PA83. Both because of the sensitivity and selectivity of the anthrax sequence to furin proteolysis and the FRET-based detection, the biosensor recorded the femtomolar levels of furin in the in vitro reactions and cell-based assays. Using the biosensor that was cell-impermeable because of its size and also by other relevant methods, we determined that exceedingly low levels, if any, of cell-surface furin are present in the intact cells and in the cells with the enforced furin overexpression. This observation was in a sharp contrast with the existing concepts about the furin presentation on cell surfaces and anthrax disease mechanism. We next demonstrated using cell-based tests that PA83, in fact, was processed by furin in the extracellular milieu and that only then the resulting PA63 bound the anthrax toxin cell-surface receptors. We also determined that the biosensor, but not the conventional peptide substrates, allowed continuous monitoring of furin activity in cancer cell extracts. Our results suggest that there are no physiologically-relevant levels of cell-surface furin and, accordingly, that the mechanisms of anthrax should be re-investigated. In addition, the availability of the biosensor is a foundation for non-invasive monitoring of furin activity in cancer cells. Conceptually, the biosensor we developed may serve as a prototype for other proteinase-activated biosensors

Kombinasi Format Factory, U-lead dan Microsoft Office Powerpoint dalam Upaya Meningkatkan Kualitas Media Pembelajaran

Peserta didik mempunyai gaya belajar yang berbeda-beda. Gaya belajar tersebut meliputi auditori, visual dan kinestetik (VAK). Seorang guru harus mampu memenuhi kebutuhan masing-masing gaya belajar peserta didik tersebut. Salah satu cara yang dapat dilakukan adalah dengan menggunakan media pembelajaran berbasis VAK. Media pembelajaran berbasis VAK dapat dipenuhi dengan menyisipkan file video di dalamnya. Selain itu, penggunaan file video sebagai media pembelajaran mendukung implementasi pembelajaran saintifik pada kurikulum 2013. Namun, belum semua guru memiliki kemampuan untuk mengemas file video tersebut dalam bentuk media pembelajaran. Tujuan penelitian ini adalah untuk meningkatkan kemampuan guru-guru di SMA Negeri 1 Teras dan SMA Negeri 1 Boyolali dalam membuat media pembelajaran berbasis VAK dengan kombinasi software Format Factory, U-Lead dan PowerPoint. Hasil penelitian menunjukkan bahwa terjadi peningkatan kemampuan para guru di SMA Negeri 1 Teras dan SMA Negeri 1 Boyolali dalam membuat media pembelajaran. Peningkatan kemampuan guru-guru tersebut berada di atas target yang direncanakan. Rerata peningkatan kemampuan guru-guru di SMA Negeri 1 Teras 7,87% di atas target, sedangkan di SMA Negeri 1 Boyolali 9,58% di atas target. Kata kunci: Media Pembelajaran, Format Factory, U-Lead, PowerPoint Students have different learning styles. Learning styles include visual learners, auditory learners, and kinesthetic learners. A teacher must be able to fulfill the needs of individual students\u27 learning styles. One way that can be applied is using Visual, Audio and Kinesthetic (VAK) learning media based. VAK-learning media based can be created by inserting video files on it. In addition, using video file as a learning media can support the implementation of scientific learning on the 2013 curriculum. However, not all teachers have the ability to use video files into a learning media. The purpose of this study is to improve the teachers\u27 ability at SMA Negeri 1 Teras and SMAN 1 Boyolali on making VAK-learning media based with a combination of Format Factory, U-Lead and PowerPoint software. The results showed that the teachers\u27 ability on making VAK-learning media based was increased. Increased the teachers\u27 ability was above planned target score. The mean score of the teachers\u27 ability at SMA Negeri 1 Teras 7.87% above the target, while at SMAN 1 Boyolali 9.58% above the target

"Full-Core" VVER-1000 calculation benchmark

This work deals with the “Full-Core” VVER-1000 calculation benchmark which was proposed on the 26th Symposium of AER [1]. Recently, the calculation benchmarks “Full-Core” VVER-440 [2] and its extension [3] have been introduced in the AER community with positive response [4, 5]. Therefore we have decided to prepare a similar benchmark for VVER-1000. This benchmark is also a 2D calculation benchmark based on the VVER-1000 reactor core cold state geometry, explicitly taking into account the geometry of the radial reflector. The loading pattern for this core is very similar to the fresh fuel loading of cycle 9 at Unit 1 of the Temelin NPP (Czech Republic). This core is filled with six types of fuel assemblies with enrichment from 1.3%w 235U to 4.0%w 235U with up to 9 fuel pins with Gd burnable absorber per FA. The main task of this benchmark is to test the pin-by-pin power distribution in fuel assemblies predicted by macro-codes that are used for neutron-physics calculations especially for VVER reactors. In this contribution we present the overview of available macro-codes results