Augmented Reality based monitoring of the remote-lab

© 2014 IEEE. Augmented Reality technology approach has been being adopted within the education sector. The advanced technology tools in many classes have the potential changed of users' attitudes toward the pedagogical and psychological objectives and goals. Moreover, augmented reality has not elicited so much attention within the corridors of education sector as it is now. In order to improve the interactive effectiveness in the smart classroom environment, there is a demand to tailor the innovation technology and align it with every changing requirements and capabilities of various users. Consequently, the educators are increasingly finding augmented reality suitable for deployment in education. In this paper, a project shows how Augmented Reality utilised with overlay Smart-Grid can support the learning process in attractive methods for monitoring events of captured scenes in remote-lab such as video stream, Web-link from smart devices' camera

Impact of Land Cover Change on Ecosystem Services in a Tropical Forested Landscape

Ecosystems provide a wide range of goods, services or ecosystem services (ES) to society. Estimating the impact of land use and land cover (LULC) changes on ES values (ESV) is an important tool to support decision making. This study used remote sensing and GIS tools to analyze LULC change and transitions from 2001 to 2016 and assess its impact on ESV in a tropical forested landscape in the southern plains of Nepal. The total ESV of the landscape for the year 2016 is estimated at USD 1264 million year−1. As forests are the dominant land cover class and have high ES value per hectare, they have the highest contribution in total ESV. However, as a result of LULC change (loss of forests, water bodies, and agricultural land), the total ESV of the landscape has declined by USD 11 million year−1. Major reductions come from the loss in values of climate regulation, water supply, provision of raw materials and food production. To halt the ongoing loss of ES and maintain the supply and balance of different ES in the landscape, it is important to properly monitor, manage and utilize ecosystems. We believe this study will inform policymakers, environmental managers, and the general public on the ongoing changes and contribute to developing effective land use policy in the region

Structural characterization of a novel GPVI-nanobody complex reveals a biologically active domain-swapped GPVI dimer

Glycoprotein VI (GPVI) is the major signaling receptor for collagen on platelets. We have raised 54 nanobodies (Nb), grouped into 33 structural classes based on their complementary determining region 3 loops, against recombinant GPVI-Fc (dimeric GPVI) and have characterized their ability to bind recombinant GPVI, resting and activated platelets, and to inhibit platelet activation by collagen. Nbs from 6 different binding classes showed the strongest binding to recombinant GPVI-Fc, suggesting that there was not a single dominant class. The most potent 3, Nb2, 21, and 35, inhibited collagen-induced platelet aggregation with nanomolar half maximal inhibitory concentration (IC50) values and inhibited platelet aggregation under flow. The binding KD of the most potent Nb, Nb2, against recombinant monomeric and dimeric GPVI was 0.6 and 0.7 nM, respectively. The crystal structure of monomeric GPVI in complex with Nb2 revealed a binding epitope adjacent to the collagen-related peptide (CRP) binding groove within the D1 domain. In addition, a novel conformation of GPVI involving a domain swap between the D2 domains was observed. The domain swap is facilitated by the outward extension of the C-C′ loop, which forms the domain swap hinge. The functional significance of this conformation was tested by truncating the hinge region so that the domain swap cannot occur. Nb2 was still able to displace collagen and CRP binding to the mutant, but signaling was abolished in a cell-based NFAT reporter assay. This demonstrates that the C-C′ loop region is important for GPVI signaling but not ligand binding and suggests the domain-swapped structure may represent an active GPVI conformation

14. Incidence, associated factors and patient outcomes of heart failure complicated by ventricular arrhythmia in saudi arabia: From heart function assessment registry trial in saudi arabia (hearts)

Arrhythmia is a common finding in heart failure patients. It has a greater impact on prognosis in those patients, especially ventricular arrhythmia type. Although there are some studies about PVCs and NSVT in heart failure, few data are available regarding sustained VT/VF in heart failure. In this study, our aim was to investigate the incidence of sustained VT/VF, the factors associated with its occurrence and prognosis in hospitalized heart failure patients.We hypothesized that heart failure patients are prone to develop ventricular arrhythmia which can adversely affect the prognosis.Prospective study of 2610 patients admitted in 18 government hospitals with HF between October 2009 and December 2010. Patients were categorized as having ventricular arrhythmia (VA) if they experienced either sustained ventricular tachycardia (VT) or ventricular fibrillation (VF) or both during hospitalization.Of 2610 patients with HF enrolled in the HEARTS registry, 110 (4.2%) were diagnosed with VA. The vast majority (97%) occurred in patients with heart failure with reduced ejection fraction (HFrEF). Factors associated with an increased risk of developing VA during hospitalization for HF are arrhythmia (OR 8.2; 95% CI 3.3-20.4), STEMI (OR 2.6; 95% CI 1.1–6.3) as precipitating factors for HF, and systolic blood pressure <90 mm Hg at presentation (OR 3.1; 95% CI 1.3–7.4). Adverse in-hospital outcomes including recurrent HF, hemodialysis, shock, sepsis, major bleeding, intra-aortic balloon pump (IABP) and pacing were higher for patients with VA (P ⩽ .001 for all comparisons) and signified a poor prognosis. The in-hospital, 30-days, 1-year, 2-year, and 3-year mortality rates were significantly higher in VA patients compared with non-VA patients (P ⩽ .001 for all comparisons). VA was found in a small percentage of hospitalized heart failure patients. However, it was associated with remarkably high rates of adverse events and increased mortality rate. Information from patient’s medical history and clinical presentation parameters can predict VA development in HF patients. Evaluating those associated factors would help isn identifying patients at high risk for VA

Thematic Roles in Somali: A Principles and Parameters Approach

This study describes the thematic roles of Somali; a language that manifests unorthodox grammatical structures due to the use of the focus particle. A mapping of some language features related to the semantic-syntactic interface is carried out. The effect of the meaning of the lexical items is tested to whether it affects the syntactic structures of the sentences. It was found that the word order of Somali is determined by pragmatic and sociolinguistics factors. The focus particle of Somali plays a key-role in the Surface structure of the sentences. However; the thematic roles of the language appear not to be influenced by the grammatical manifestation of the language at the surface structure. Rather, they are determined at the deep structure level. Somali, being a pro-drop language, shows that predicates require obligatory external arguments while internal arguments are determined by the verb class and kind. Some structures show that certain verbs require PPs as obligatory arguments.       Keywords: Somali, Theta Theory, Thematic Role

Possible use of calcifying nanoparticles in immature root apex treatment

Introduction: There are reports in the literature, which describe different techniques and materials in the challenging management of thin dentin walls and immature root apex. It has been suggested that calcifying nanoparticles (CNPs) could be used in the management of these conditions. The Hypothesis: Compositionally modified CNPs made into a paste could become efficacious in managing thin dentin walls and immature root apex. Calcium and phosphate ions when mixed with CNPs could form a synthetic nanopaste that clinicians could use to manage thin dentin walls and to get a biological seal for immature root apex. Evaluation of the Hypothesis: CNPs can replicate and could facilitate the aggregations of calcium hydroxyapatite to produce a self-surrounding shell. These characteristics of CNPs could be used through their biomineralization process as initial nidus of calcification for further calcification progression to achieve total biological apical seal. If the hypothesis could be supported by biomineralization behavior of the paste (CNPs, Ca2 + , and PO4− ), a new therapeutic agent would have been added to the armamentarium of endodontists. There is need for more in vivo and in vitro investigations of modified nanopaste to manage these conditions

Thematic Roles in Somali: A Principles and Parameters Approach

This study describes the thematic roles of Somali; a language that manifests unorthodox grammatical structures due to the use of the focus particle. A mapping of some language features related to the semantic-syntactic interface is carried out. The effect of the meaning of the lexical items is tested to whether it affects the syntactic structures of the sentences. It was found that the word order of Somali is determined by pragmatic and sociolinguistics factors. The focus particle of Somali plays a key-role in the Surface structure of the sentences. However; the thematic roles of the language appear not to be influenced by the grammatical manifestation of the language at the surface structure. Rather, they are determined at the deep structure level. Somali, being a pro-drop language, shows that predicates require obligatory external arguments while internal arguments are determined by the verb class and kind. Some structures show that certain verbs require PPs as obligatory arguments.       Keywords: Somali, Theta Theory, Thematic Role

Anaphylaxis in the 21st century: phenotypes, endotypes, and biomarkers

Anaphylaxis is the most serious of all allergic reactions and can be fatal. The diagnosis is frequently delayed, and misdiagnosis often occurs with asthma or urticaria. Biomarkers such as tryptase are not routinely checked, and appropriate treatment with epinephrine is not administered in a majority of cases, increasing the risk of poor outcomes. The objective of this review is to provide a better understanding of the pathophysiology of anaphylaxis with a description of phenotypes, endotypes, and biomarkers available in both the clinical and research settings. Expanding knowledge with regard to the presentation, causes, and triggers for anaphylaxis among health care providers will improve its diagnosis and management, increase patient safety, and decrease morbidity and mortality

Drug Hypersensitivity and Desensitizations: Mechanisms and New Approaches

Drug hypersensitivity reactions (HSRs) are increasing in the 21st Century with the ever expanding availability of new therapeutic agents. Patients with cancer, chronic inflammatory diseases, cystic fibrosis, or diabetes can become allergic to their first line therapy after repeated exposures or through cross reactivity with environmental allergens. Avoidance of the offending allergenic drug may impact disease management, quality of life, and life expectancy. Precision medicine provides new tools for the understanding and management of hypersensitivity reactions (HSRs), as well as a personalized treatment approach for IgE (Immunoglobuline E) and non-IgE mediated HSRs with drug desensitization (DS). DS induces a temporary hyporesponsive state by incremental escalation of sub-optimal doses of the offending drug. In vitro models have shown evidence that IgE desensitization is an antigen-specific process which blocks calcium flux, impacts antigen/IgE/FcεRI complex internalization and prevents the acute and late phase reactions as well as mast cell mediator release. Through a “bench to bedside” approach, in vitro desensitization models help elucidate the molecular pathways involved in DS, providing new insights to improved desensitization protocols for all patients. The aim of this review is to summarize up to date information on the drug HSRs, the IgE mediated mechanisms of desensitization, and their clinical applications

Glycogenic Hepatopathy: A Rare Hepatic Complication of Poorly Controlled Type 1 DM

Glycogen hepatopathy (GH) is a rare complication of type 1 diabetes mellitus that leads to an abnormal accumulation of glycogen in the hepatocytes. The exact mechanism of GH remains unknown, but fluctuations in blood glucose and insulin levels play important roles in promoting glycogen accumulation. We report a case of a 16-year-old female diagnosed with poorly controlled type 1 diabetes mellitus with hepatomegaly and elevated liver enzymes. The patient experienced multiple admissions for diabetic ketoacidosis, and she also had celiac disease diagnosed 2 years previously based on serology and a duodenal biopsy. The laboratory analyses results were compatible with acute hepatitis, and the celiac serology was positive. Other investigations ruled out viral hepatitis and autoimmune and metabolic liver diseases. Ultrasound and computerized tomography (CT) scans of the abdomen revealed liver enlargement with diffuse fatty infiltration. A liver biopsy revealed the presence of abundant glycogen in the cytoplasm of the hepatocytes. PAS staining was strongly positive, which confirmed the diagnosis of GH. There were no features of autoimmune hepatitis or significant fibrosis. Duodenal biopsy results were consistent with celiac disease. Despite our efforts, which are supported by a multidisciplinary team approach that included a hepatologist, a diabetic educator, a dietitian, and an endocrinologist, we have encountered difficulties in controlling the patient’s diabetes, and she persistently maintains symptomatic hepatomegaly and abnormal liver biochemistry. Given the patient’s age, we assumed that these abnormalities were related to patient noncompliance. In conclusion, GH remains an under-recognized complication of type 1 DM that is potentially reversible with adequate glycemic control. The awareness of GH should prevent diagnostic delay and its implications for management and the outcome