Simulation of the spatial structure and cellular organization evolution of cell aggregates arranged in various simple geometries, using a kinetic monte carlo method applied to a lattice model

ilustraciones, graficasEsta tesis trata los modelos de morfogénesis, en particular los modelos de evolución guiada por contacto que son coherentes con la hipótesis de la adhesión diferencial. Se presenta una revisión de algunos modelos, sus principios biológicos subyacentes, la relevancia y aplicaciones en el marco de la bioimpresión, la ingeniería de tejidos y la bioconvergencia. Luego, se presentan los detalles de los modelos basados en métodos de Monte Carlo para profundizar más adelante en el modelo basados en algoritmos Kinetic Monte Carlo (KMC) , más específicamente, se describe en detalle un modelo KMC de autoaprendizaje (SL-KMC). Se presenta y explica la estructura algorítmica del código implementado, se evalúa el rendimiento del modelo y se compara con un modelo KMC tradicional. Finalmente, se realizan los procesos de calibración y validación, se observó que el modelo es capaz de replicar la evolución del sistema multicelular cuando las condiciones de energía interfacial del sistema simulado son similares a las del sistema de calibraciones. (Texto tomado de la fuente)This thesis treats the models for morphogenesis, in particular the contact-guided evolution models that are coherent with the differential adhesion hypothesis. A review of some models, their biological underpinning principles, the relevance and applications in the framework of bioprinting, tissue engineering and bioconvergence are presented. Then the details for the Monte Carlo methods-based models are presented to later deep dive into the Kinetic Monte Carlo (KMC) based model, and more specifically a Self-Learning KMC (SL-KMC) model is described to detail. The algorithmic structure of the implemented code is presented and explained, the model performance is assessed and compared with a traditional KMC model. Finally, the calibration and validation processes have been carried out, it was observed that the model is able to replicate the multicellular system evolution when the interfacial energy conditions of the simulated system are similar to those of the calibrations system.MaestríaMagíster en Ingeniería - Ingeniería Químic

Nonequilibrium Phase Transitions in Directed Small-World Networks

Many social, biological, and economic systems can be approached by complex networks of interacting units. The behaviour of several models on small-world networks has recently been studied. These models are expected to capture the essential features of the complex processes taking place on real networks like disease spreading, formation of public opinion, distribution of wealth, etc. In many of these systems relations are directed, in the sense that links only act in one direction (outwards or inwards). We investigate the effect of directed links on the behaviour of a simple spin-like model evolving on a small-world network. We show that directed networks may lead to a highly nontrivial phase diagram including first and second-order phase transitions out of equilibrium.Comment: 4 pages, RevTeX format, 4 postscript figs, uses eps

Propuesta de mejora del módulo de inventarios del sistema Open Orange para soportar la atención de pedidos en los almacenes de la empresa Continental S.A.C

RESUMEN La presente investigación tuvo como objetivo determinar la usabilidad actual del sistema Open Orange en el módulo de inventario para la atención de pedidos en el subproceso picking de mercadería, el cual es un subproceso Core de la empresaContinental S.A.C que cuenta con varias deficiencias a nivel de actividades como de las herramientas tecnológicas que lo soportan. Se sabe por la investigación realizada que en los antecedentes y bases teóricas que una solución tecnológica especializada puede ayudar al rendimiento de los procesos en una organización, un ejemplo fue el de la empresa RANSA que implemento un Warehouse Management System (WMS) y con ello consiguió mejorar su inventario en un 20%. y la atención de pedidos en un 5%. El enfoque dado a la investigación fue cuantitativo que fue desde la concepción de la idea hasta la elaboración de una propuesta rediseñada tomando en cuenta los resultados obtenidos. Como resultado principal de la investigación se pudo comprobar que existe una baja usabilidad del sistema que es insuficiente para satisfacer al usuario. Adicionalmente se comprobó que existen pantallas y controles por mejorar, así como nuevas funcionalidades por incorporar, en tanto se concluyó fundamentalmente que el sistema debe ser rediseñado o muy probablemente reemplazado. PALABRAS CLAVES: Usabilidad, WMS, gestión de almacenes, picking, mercadería

Implementación de Lean Six Sigma para mejorar el proceso de picking de mercadería en la empresa Continental S.A.C., Lima 2018

RESUMEN CONTINENTAL fue fundada en 1951, ubicándose su primer local en el antiguo barrio chino, atravesando desde esos años diversas etapas de desarrollo. En sus inicios su rubro de negocio era la de un bazar que cambiaba de mercadería de acuerdo con la estacionalidad de venta. Luego viendo la alta demanda en útiles escolares y de oficina decidieron crear la empresa STANDFORD, marca 100% peruana creada el año 1995 y desde un principio se ubicó en la preferencia del público estudiantil pues se caracterizó por su altísima calidad. Luego en años posteriores nace Utilex en febrero de 2011, como división Minorista y Venta Corporativa del grupo Continental SAC. Ahora contamos con una impresionante infraestructura, estamos presentes en 3 provincias del Perú (Arequipa, Trujillo y Chiclayo) y en Lima contamos con 8 tiendas Mayoristas (Continental) y 11 tiendas minoristas (Utilex)

Effects of different post-activation potentiation warm-ups on repeated sprint ability in soccer players from different competitive levels

This study aimed to compare the effects of a traditional warm-up with two post-activation potentiation (PAP) warm-up strategies on the repeated sprint ability (RSA) of soccer players from national (NL) and regional (RL) competitive levels. Sixteen young players (NL, n = 8, age = 20.7 +/- 1.4 y, body mass = 68.5 +/- 7.0 kg, body height = 177.4 +/- 5.2 cm; RL, n = 8, age = 20.8 +/- 1.0 y, body mass = 68.7 +/- 4.0 kg, body height = 176.6 +/- 5.6 cm) were recruited to complete a traditional warm-up (CONTROL), a PAP warm-up incorporating squats with a load (similar to 60% 1RM) that allowed a high speed (1 m/s) of movement and a high number of repetitions (PAP-1), and a PAP warm-up with a load (similar to 90% 1RM) that allowed a moderate speed (0.5 m/s) of movement and a reduced number of repetitions (PAP-0.5). A RSA test (six 20-m sprints with 20 s of recovery) was performed 5 min after the PAP warm-up to assess the effects of the different protocols on the fastest sprint (RSAb) and the mean time of all sprints (RSAm). A meaningful improvement of RSA performance was observed with PAP-0.5, attaining a large effect on NL (RSAb, ES = -1.5; RSAm, ES = -1.3) and only a small effect on RL athletes (RSAb and RSAm, ES = -0.2). Moreover, when each RSA sprint performance was compared between NL and RL players, after PAP-0.5 greater performance for all sprints was observed in the NL players. Therefore, adding a heavy strength-based conditioning exercise during the warm-up prior to a RSA test may induce significant performance improvements in NL, but only small effects in RL players

The Gut Microbiota and Its Implication in the Development of Atherosclerosis and Related Cardiovascular Diseases

Julio Plaza-Díaz is part of the “UGR Plan Propio de Investigación 2016” and the “Excellence actions: Unit of Excellence on Exercise and Health (UCEES), University of Granada”. We are grateful to Belen Vazquez-Gonzalez for assistance with the illustration service.The importance of gut microbiota in health and disease is being highlighted by numerous research groups worldwide. Atherosclerosis, the leading cause of heart disease and stroke, is responsible for about 50% of all cardiovascular deaths. Recently, gut dysbiosis has been identified as a remarkable factor to be considered in the pathogenesis of cardiovascular diseases (CVDs). In this review, we briefly discuss how external factors such as dietary and physical activity habits influence host-microbiota and atherogenesis, the potential mechanisms of the influence of gut microbiota in host blood pressure and the alterations in the prevalence of those bacterial genera affecting vascular tone and the development of hypertension. We will also be examining the microbiota as a therapeutic target in the prevention of CVDs and the beneficial mechanisms of probiotic administration related to cardiovascular risks. All these new insights might lead to novel analysis and CVD therapeutics based on the microbiota

New Approaches in Tourism Management: The Innovative Business Group Programme in Spain

Este estudio se enmarca en el análisis de las nuevas políticas de innovación aplicadas al turismo en España. El objetivo fundamental es evaluar la política reciente de apoyo a la creación y consolidación de Agrupaciones Empresariales Innovadoras en el ámbito del turismo, el Programa AEIs, atendiendo a su singularidad, las características de las AEIs resultantes y la valoración de sus responsables. El análisis ofrece luces y sombras y concluye con argumentos para repensar este tipo de políticas, así como con elementos de discusión interesantes en torno a la innovación derivada de los procesos de colaboración en turismo.This study aims to evaluate recent tourism innovation policies in Spain, specifically those that support the creation and consolidation of the Innovative Business Group (AEI, for its initials in Spanish) Programme in Tourism, its singularity, the characteristics of the resulting AEIs and the evaluation made by managers. The analysis shows the lights and shadows of the Programme and also suggests the need to reformulate these types of policies. It also highlights interesting discussion points about the innovation derived from collaborative processes in tourism.El presente trabajo se enmarca en el proyecto de investigación «Metodología, criterios y aplicaciones para la configuración de clusters en áreas turísticas consolidadas: innovación, complementariedad y competitividad territorial» (CSO2011-26396), financiado por el Plan Nacional de I+D+i del Ministerio de Economía y Competitividad

Stellar energy loss rates beyond the standard model

It is known that the dipolemoments of the neutrino lead to important astrophysical and cosmological effects. In this regard, within the context of a U(1)B−L model, we develop and present novel analytical formulas to assess the effects of the anomalous magnetic moment and electric dipole moment of the neutrino on the stellar energy loss rates through some common physical process of pair-annihilation e+e− → (γ, Z, Z ) → ν¯ν. Our results show that the stellar energy loss rates strongly depend on the effective magnetic moment of the neutrino, but also on the parameters which characterize the adopted U(1)B−L mode

Characterization of Landfill Leachate for Enhanced Metal Recovery

Landfills contain a trove of valuable materials, such as critical, precious, and rare earth metals, that are integral to the United State’s economy and national security. The leachate that filters through landfills picks up these materials, which allows for the possibility of recovery. For this research, samples will be analyzed from landfills throughout the Midwestern United States to provide a baseline on water quality constituents, elements present, and microbial activity. Preliminary data for this study was acquired by analyzing samples of landfill leachate from a landfill in northern Indiana. pH readings indicate that the leachate is slightly basic. It also contains around 1-2% total solids. Inductively coupled plasma optical emission spectrometry (ICP-OES) was also used to identify elements present in the samples. Of the 66 elements considered in the analysis, 35 were detectable in quantifiable amounts. The most common elements present were sodium, potassium, magnesium, calcium, boron, and sulfur. Critical elements such as lithium and chromium were also found in the leachate. Future research will develop an integrated method applying microbial bioleaching, physico-chemical processes, and membrane filtration to recover critical elements from landfill leachate

No evidence that selection for egg production persistency causes loss of bone quality in laying hens

ERANET grant BBSRC BB/M028291/1Swedish Research Council Formas 2014-01840ARN (Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria) 291815European Cooperation in Science and Technology (COST) CA15224UK Research & Innovation (UKRI) Biotechnology and Biological Sciences Research Council (BBSRC) BB/P013759/