56 research outputs found
ImplementaciĂłn de estrategias financieras para la generaciĂłn de valor de la compañĂa Lukas Editores SAS
EXTRACCIĂN DE PIGMENTOS APARTIR DE CULTIVO IN VITRO DE MICROALGAS: ALTERNATIVA A LA SĂNTESIS QUĂMICA DE COLORANTES
La sĂntesis quĂmica de colorantes del sector textil genera residuos tĂłxicos que afectan al entorno que rodea a estas industrias, causando contaminaciĂłn hĂdrica, del suelo y atmosfĂ©rica, con mĂșltiples afectaciones en la salud humana y de los ecosistemas, siendo la alternativa a este problema: los pigmentos obtenidos a partir de microalgas. El objetivo de esta investigaciĂłn es extraer pigmentos partiendo del cultivo in vitro de las microalgas Chlorella spp y Scenedesmus spp con medio F/2. La extracciĂłn de los pigmentos es asistida por ultrasonido y un peso seco
EXTRACCIĂN DE PIGMENTOS APARTIR DE CULTIVO IN VITRO DE MICROALGAS: ALTERNATIVA A LA SĂNTESIS QUĂMICA DE COLORANTES
La sĂntesis quĂmica de colorantes del sector textil genera residuos tĂłxicos que afectan al entorno que rodea a estas industrias, causando contaminaciĂłn hĂdrica, del suelo y atmosfĂ©rica, con mĂșltiples afectaciones en la salud humana y de los ecosistemas, siendo la alternativa a este problema: los pigmentos obtenidos a partir de microalgas. El objetivo de esta investigaciĂłn es extraer pigmentos partiendo del cultivo in vitro de las microalgas Chlorella spp y Scenedesmus spp con medio F/2. La extracciĂłn de los pigmentos es asistida por ultrasonido y un peso seco
Violencias basadas en género: la otra tragedia de Colombia
This book, a product of academic and discursive activity, develops five chapters of scientific dissemination in which it presents an interdisciplinary analysis of the phenomena that extend in gender violence against women. The first chapter deals with the factual circumstances for the imputation of femicide in Colombia; the second chapter constructs a clinical psychological approach to the aggressor; the third chapter establishes an analysis of femicide from the logics of evolutionary and developmental psychology; the fourth chapter refers to the warp and woof of the brand of violence against women; the fifth chapter analyzes the cultural, social and educational elements of hegemonic machismo as a precipitating, maintaining and creating factor of violence against women.
This publication seeks to contribute to the social, academic and scientific expansion of gender-based violence as another of Colombia's most atrocious tragedies that require a refined view on the part of divergent and critically grounded thinking.PublishedEste libro, producto de la actividad acadĂ©mica y discursiva, desarrolla cinco capĂtulos de divulgaciĂłn cientĂfica en los cuales presenta un anĂĄlisis interdisciplinario de los fenĂłmenos que se extienden en las violencias basadas en gĂ©nero en contra de la mujer. El primer capĂtulo trabaja las circunstancias fĂĄcticas para la imputaciĂłn del feminicidio en Colombia; el segundo construye una aproximaciĂłn clĂnica psicolĂłgica del feminicida, el tercero establece un anĂĄlisis del feminicidio desde las lĂłgicas de la psicologĂa evolutiva y del desarrollo, el cuarto refiere las urdimbres a propĂłsito de la marca de violencia en contra de la mujer; el quinto capĂtulo analiza los elementos culturales, sociales y educativos del machismo hegemĂłnico como factor precipitador, mantenedor y creador de las violencias en contra de la mujer.
Con esta publicaciĂłn se busca contribuir a la expansiĂłn social, acadĂ©mica y cientĂfica de las violencias basadas en gĂ©nero como otra de las tragedias mĂĄs atroces de Colombia que requieren de miradas afinadas por parte del pensamiento divergente y crĂtico fundamentado
A Conceptual Framework Based on Maturanaâs Ontology of the Observer to Explore the Checklandâs Soft Systems Methodology
© 2019, Springer Science+Business Media, LLC, part of Springer Nature. This paper explores Checklandâs Soft Systems Methodology (SSM) through the lenses of a theoretical framework that incorporates key concepts from Maturanaâs Ontology of the Observer (OoO) with the view of complementing Checklandâs SSM application process. We outline and examine paradigmatic compatibility between: Checklandâs ontological position (reality is problematic/chaotic) together with his interpretivist epistemology (multiple perceptions enrich the ever-changing reality); and Maturanaâs OoO (we are immersed in the praxis of living in an ontological multi-universe). We argue that OoO resonates with key SSM theoretical underpinnings. After establishing compatibility between these two influential systems thinkers, we advance a conceptual framework in which Checklandâs SSM learning process is re-visited through a the framework grounded on Maturanaâs OoO. The proposed framework illustrates how key ideas drawn from Maturanaâs OoO can shed light into the way in which some of the main SSM devices (i.e.: Root definitions, Conceptual model) are used in the SSM process. By doing that, SSM is enriched and becomes more flexible as the stakeholders involved are placed within the domain of constitutive ontologies from which, a deeper dialogue can be promoted in a domain of coexistence in mutual acceptance. We argue that this is a suitable way to have more flexible and holistic views for a SSM intervention in particular to promote the learning process and debating proposed changes amongst the stakeholders involved. The proposed framework, when applied, may enhance the power of SSM learning process and when adopted can have substantial implications to complement the SSM process
Long-Term Real-World Effectiveness and Safety of Ustekinumab in Crohnâs Disease Patients: The SUSTAIN Study
Background
Large real-world-evidence studies are required to confirm the durability of response, effectiveness, and safety of ustekinumab in Crohnâs disease (CD) patients in real-world clinical practice.
Methods
A retrospective, multicentre study was conducted in Spain in patients with active CD who had received â„1 intravenous dose of ustekinumab for â„6 months. Primary outcome was ustekinumab retention rate; secondary outcomes were to identify predictive factors for drug retention, short-term remission (week 16), loss of response and predictive factors for short-term efficacy and loss of response, and ustekinumab safety.
Results
A total of 463 patients were included. Mean baseline Harvey-Bradshaw Index was 8.4. A total of 447 (96.5%) patients had received prior biologic therapy, 141 (30.5%) of whom had received â„3 agents. In addition, 35.2% received concomitant immunosuppressants, and 47.1% had â„1 abdominal surgery. At week 16, 56% had remission, 70% had response, and 26.1% required dose escalation or intensification; of these, 24.8% did not subsequently reduce dose. After a median follow-up of 15 months, 356 (77%) patients continued treatment. The incidence rate of ustekinumab discontinuation was 18% per patient-year of follow-up. Previous intestinal surgery and concomitant steroid treatment were associated with higher risk of ustekinumab discontinuation, while a maintenance schedule every 12 weeks had a lower risk; neither concomitant immunosuppressants nor the number of previous biologics were associated with ustekinumab discontinuation risk. Fifty adverse events were reported in 39 (8.4%) patients; 4 of them were severe (2 infections, 1 malignancy, and 1 fever).
Conclusions
Ustekinumab is effective and safe as short- and long-term treatment in a refractory cohort of CD patients in real-world clinical practice
Using Interpretable Machine Learning to Identify Baseline Predictive Factors of Remission and Drug Durability in Crohnâs Disease Patients on Ustekinumab
Ustekinumab has shown efficacy in Crohn's Disease (CD) patients. To identify patient profiles of those who benefit the most from this treatment would help to position this drug in the therapeutic paradigm of CD and generate hypotheses for future trials. The objective of this analysis was to determine whether baseline patient characteristics are predictive of remission and the drug durability of ustekinumab, and whether its positioning with respect to prior use of biologics has a significant effect after correcting for disease severity and phenotype at baseline using interpretable machine learning. Patients' data from SUSTAIN, a retrospective multicenter single-arm cohort study, were used. Disease phenotype, baseline laboratory data, and prior treatment characteristics were documented. Clinical remission was defined as the Harvey Bradshaw Index <= 4 and was tracked longitudinally. Drug durability was defined as the time until a patient discontinued treatment. A total of 439 participants from 60 centers were included and a total of 20 baseline covariates considered. Less exposure to previous biologics had a positive effect on remission, even after controlling for baseline disease severity using a non-linear, additive, multivariable model. Additionally, age, body mass index, and fecal calprotectin at baseline were found to be statistically significant as independent negative risk factors for both remission and drug survival, with further risk factors identified for remission
Aprendizajes y prĂĄcticas educativas en las actuales condiciones de Ă©poca: COVID-19
âEsta obra colectiva es el resultado de una convocatoria a docentes, investigadores y profesionales del campo pedagĂłgico a visibilizar procesos investigativos y prĂĄcticas educativas situadas en el marco de COVI-19. La misma se inscribe en el trabajo llevado a cabo por el equipo de InvestigaciĂłn responsable del Proyecto âSentidos y significados acerca de aprender en las actuales condiciones de Ă©poca: un estudio con docentes y estudiantes de la educaciĂłn secundarias en la ciudad de CĂłrdobaâ de la Facultad de FilosofĂa y Humanidades. Universidad Nacional de CĂłrdoba.
El momento excepcional que estamos atravesando, pero que tambiĂ©n nos atraviesa, ha modificado la percepciĂłn temporal a punto tal que habitamos un tiempo acelerado y angustiante que nos exige la producciĂłn de conocimiento provisorio. La presente publicaciĂłn surge como un espacio para detenernos a documentar lo que nos acontece y, a su vez, como oportunidad para atesorar y resguardar las experiencias educativas que hemos construido, inventado y reinventando en este contexto. En ella encontrarĂĄn pluralidad de voces acerca de enseñar y aprender durante la pandemia. Este texto es una pausa para reflexionar sobre el hacer y las prĂĄcticas educativas por venirâ.Fil: Beltramino, Lucia (comp.). Universidad Nacional de CĂłrdoba. Facultad de FilosofĂa y Humanidades. Escuela de ArchivologĂa; Argentina
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Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study
Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9â27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6â16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2â1.8), stage II (OR 1.6; 95% CI 1.4â1.9), and stage III or worse (OR 2.8; 95% CI 2.3â3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat
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Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study
The original version of this article unfortunately contained a mistake
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