General RG Equations for Physical Neutrino Parameters and their Phenomenological Implications

The neutral leptonic sector of the Standard Model presumably consists of three neutrinos with non-zero Majorana masses with properties further determined by three mixing angles and three CP-violating phases. We derive the general renormalization group equations for these physical parameters and apply them to study the impact of radiative effects on neutrino physics. In particular, we examine the existing solutions to the solar and atmospheric neutrino problems, derive conclusions on their theoretical naturalness, and show how some of the measured neutrino parameters could be determined by purely radiative effects. For example, the mass splitting and mixing angle suggested by solar neutrino data could be entirely explained as a radiative effect if the small angle MSW solution is realized. On the other hand, the mass splitting required by atmospheric neutrino data is probably determined by unknown physics at a high energy scale. We also discuss the effect of non-zero CP-violating phases on radiative corrections

Desarrollo de un sistema de gestión para tareas de lubricación en planta Beneo Orafti Chile S.A.

88 p.La Planta Beneo Orafti Chile S.A. comienza con su producción el año 2005, es única en Sudamérica en la producción de inulina y oligofructosa en base de la raíz de la achicoria. Cada año su producción ha ido en aumento, es por este motivo que se hace imprescindible incrementar la disponibilidad y confiabilidad de sus equipos. Dentro de la mantención, la lubricación es una de las tareas más importantes y debe ser gestionada de forma eficiente para obtener resultados beneficiosos para la organización. Con el objetivo de aportar herramientas que ayuden a mejorar como empresa, y que sus equipos mejoren su disponibilidad, se ha desarrollado una serie de actividades en este trabajo que ayudaran en gran parte a gestionar el actual método utilizado en la lubricación, creando un sistema de información gerencial (SIG), el cual nos permitirá desarrollar procedimientos, diseñar documentos y controlar de forma eficiente las gestiones los trabajos de lubricación. Para desarrollar este trabajo se realizó un análisis de la efectividad de la lubricación a través de una auditoría interna. Mediante esta herramienta se obtuvieron las debilidades y las fortalezas del sistema actual. Con la información obtenida se crearon funciones de los puntos más débiles. Mediante los datos reunidos y las funciones creadas se creara un sistema de información gerencial que facilitara el procedimiento para creación o diseño de documentos, planificación, el control y la ejecución de las taras de lubricación. A través de este sistema se busca crear una base de datos que ayude administrar los trabajos de forma ordenada y eficiente, que contribuya a la hora de tomar decisiones, disminuyendo los costos en repuestos y las paradas no programadas./ABSTRACT Plant Beneo Orafti Chile SA production begins in 2005, is unique in South America in production units of inulin and oligofructose on the basis of chicory root. Every year its production has been increasing, that is why it is indispensable to increase the availability and reliability of their equipment. Within the maintenance, lubrication is one of the most important and must be managed efficiently to achieve results beneficial to the organization. With the aim of providing tools that help improve a company, and your staff improve their availability, has developed a series of activities in this work largely to help manage the current method used in lubrication, creating a system management information systems (GIS), which will allow us to develop procedures, design documents and efficiently control the work efforts of lubrication. To develop this work we studied the effectiveness of lubrication through an internal audit. With this tool were the weaknesses and strengths of the current system. With the information obtained functions were created weakest points. Using the data collected and the functions created the establishment of a management information system to facilitate the procedure for creation and document design, planning, monitoring and enforcement of the defects of lubrication. Through this system seeks to create a database that helps manage jobs in an orderly and efficient, which contributes to making decisions, reducing replacement costs and unscheduled downtime

Speciation in the Emerald Toucanet (*Aulacorhynchus prasinus*) complex

We analyzed genetic variation in the Emerald Toucanet (Aulacorhynchus prasinus), a species complex that ranges primarily along the montane forests of southern and eastern Mexico south to Bolivia. Segments of three mitochondrial DNA genes (cytochrome b, ND2, and ND3) were sequenced for a total of 1,159 base pairs. Using maximum parsimony, maximum likelihood, and Bayesian analysis,we found a set of seven differentiated populations that correspond to clear geographic breaks throughout the highlands of the Neotropics. These genetically distinct populations also correspond with the geographic breaks found in previous analyses of morphological data. Molecular evidence suggests species treatment for four of the Central American clades and three South American clades. Received 19 June 2006, accepted 28 January 2007

Uso de pulsos de metilprednisolona de repetición en adultos hospitalizados por neumonía y síndrome de distrés respiratorio agudo por COVID-19: un estudio preliminar de tipo antes-después (estudio CortiCOVID)

[EN] Introduction: The use of systemic corticosteroids in severely ill patients with coronavirus disease 2019 (COVID-19) is controversial. We aimed to evaluate the efficacy and safety of corticosteroid pulses in patients with COVID-19 pneumonia. Methods: A quasi-experimental study, before and after, was performed in a tertiary referral hospital, including admitted patients showing COVID-19-associated pneumonia. The standard treatment protocol included targeted COVID-19 antiviral therapy from 23rd March 2020, and additionally pulses of methylprednisolone from 30th March 2020. The primary outcome was a composite endpoint combining oro-tracheal intubation (OTI) and death within 7 days. Results: A total of 24 patients were included. Standard of care (SOC) (before intervention) was prescribed in 14 patients, while 10 received SOC plus pulses of methylprednisolone (after intervention). The median age of patients was 64.5 years and 83.3% of the patients were men. The primary composite endpoint occurred in 13 patients (92.9%) who received SOC vs. 2 patients (20%) that received pulses of methylprednisolone (odds ratio, 0.02; 95% confidence interval, 0.001 to 0.25; p = 0.019). Length of hospitalization in survivors was shorter in the corticosteroids group (median, 14.5 [8.5–21.8] days vs. 29 [23–31] days, p = 0.003). There were no differences in the development of infections between both groups. There were 3 deaths, none of them in the corticosteroids group. Conclusions: In patients with severe pneumonia due to COVID-19, the administration of methylprednisolone pulses was associated with a lower rate of OTI and/or death and a shorter hospitalization episode.[ES] Introducción: El uso de corticosteroides sistémicos en pacientes gravemente enfermos por enfermedad coronavírica de 2019 (covid-19) es controvertido. Nuestro objetivo fue evaluar la eficacia y la seguridad de los pulsos de corticoesteroides en los pacientes con neumonía por covid-19. Métodos: Se realizó un ensayo cuasiexperimental, tipo antes y después, en un hospital terciario de referencia que incluyó a pacientes ingresados por neumonía asociada a covid-19. El protocolo de tratamiento estándar incluía un tratamiento antiviral dirigido contra el virus de la covid-19 desde el 23 de marzo de 2020 y añadió pulsos de metilprednisolona desde el 30 de marzo de 2020. El resultado primario fue un criterio combinado compuesto por la intubación orotraqueal y el fallecimiento durante los siguientes siete días. Resultados: Se incluyó un total de 24 pacientes. El protocolo de tratamiento (antes de la intervención) se prescribió en 14 pacientes, mientras que 10 recibieron el protocolo de tratamiento además de los pulsos de metilprednisolona (después de la intervención). La edad media de los pacientes fue de 64,5 años y el 83,3% de los pacientes eran hombres. El resultado combinado primario tuvo lugar en 13 pacientes (92,9%) que recibieron el protocolo de tratamiento frente a 2 pacientes (20%) que recibieron los pulsos de metilprednisolona (odds ratio = 0,02; intervalo de confianza del 95% = 0,001-0,25; p = 0,019). La duración de la hospitalización en los supervivientes fue más corta en el grupo que recibió corticoesteroides (media = 14,5 [8,5-21,8] días frente a 29 [23-31] días, p = 0,003). No hubo diferencias en el desarrollo de infecciones entre ambos grupos. Hubo tres fallecimientos, ninguno de ellos en el grupo que recibió corticoesteroides. Conclusiones: En los pacientes con neumonía grave por covid-19, la administración de pulsos de metilprednisolona se asoció a unas tasas menores de intubación orotraqueal y/o muerte y a episodios de hospitalización más cortos

Neuromonitoring depth of anesthesia and its association with postoperative delirium

Delirium after surgery or Postoperative delirium (POD) is an underdiagnosed entity, despite its severity and high incidence. Patients with delirium require a longer hospital stay and present more postoperative complications, which also increases hospital costs. Given its importance and the lack of specific treatment, multifactorial preventive strategies are evidenced based. Our hypothesis is that using general anaesthesia and avoiding the maximum time in excessively deep anaesthetic planes through BIS neuromonitoring device will reduce the incidence of postoperative delirium in patients over the age of 65 and their hospitalization stay. Patients were randomly assigned to two groups: The visible BIS group and the hidden BIS neuromonitoring group. In the visible BIS group, the depth of anaesthesia was sustained between 40 and 60, while in the other group the depth of anaesthesia was guided by hemodynamic parameters and the Minimum Alveolar Concentration value. Patients were assessed three times a day by research staff fully trained during the 72 h after the surgery to determine the presence of POD, and there was follow-up at 30 days. Patients who developed delirium (n = 69) was significantly lower in the visible BIS group (n = 27; 39.1%) than in the hidden BIS group (n = 42, 60.9%; p = 0.043). There were no differences between the subtypes of delirium in the two groups. Patients in the hidden BIS group were kept for 26.6 ± 14.0 min in BIS values < 40 versus 11.6 ± 10.9 min (p < 0.001) for the patients in the visible BIS group. The hospital stay was lower in the visible BIS group 6.56 ± 6.14 days versus the 9.30 ± 7.11 days (p < 0.001) for the hidden BIS group, as well as mortality; hidden BIS 5.80% versus visible BIS 0% (p = 0.01). A BIS-guided depth of anaesthesia is associated with a lower incidence of delirium. Patients with intraoperative neuromonitoring stayed for a shorter time in excessively deep anaesthetic planes and presented a reduction in hospital stay and mortality

16 derivas hipermínimas

Postprint (published version

Galectin-3 Deletion Reduces LPS and Acute Colitis-Induced Pro-Inflammatory Microglial Activation in the Ventral Mesencephalon

Parkinson’s disease is a highly prevalent neurological disorder for which there is currently no cure. Therefore, the knowledge of risk factors as well as the development of new putative molecular targets is mandatory. In this sense, peripheral inflammation, especially the originated in the colon, is emerging as a predisposing factor for suffering this disease. We have largely studied the pleiotropic roles of galectin-3 in driving microglia-associated immune responses. However, studies aimed at elucidating the role of galectin-3 in peripheral inflammation in terms of microglia polarization are lacking. To achieve this, we have evaluated the effect of galectin-3 deletion in two different models of acute peripheral inflammation: intraperitoneal injection of lipopolysaccharide or gut inflammation induced by oral administration of dextran sodium sulfate. We found that under peripheral inflammation the number of microglial cells and the expression levels of pro-inflammatory mediators take place specifically in the dopaminergic system, thus supporting causative links between Parkinson’s disease and peripheral inflammation. Absence of galectin-3 highly reduced neuroinflammation in both models, suggesting an important central regulatory role of galectin-3 in driving microglial activation provoked by the peripheral inflammation. Thus, modulation of galectin-3 function emerges as a promising strategy to minimize undesired microglia polarization states.This work was supported by grants from the Spanish Ministerio de Ciencia, Innovación y Universidades (RTI 2018-098830-B-I00), from the Consejería de Economía y Conocimiento of Junta de Andalucía (P18-RT-1372 and US-1264806). MJP, MDVC and PGM were supported by a grant from the Junta de Andalucía (CTS 5884) and AEC by an associated post-doctoral grant