10 research outputs found
History of Arab navigation in the Indian Ocean
- Author
- Publication venue
- The Marine Biological Association of India, Cochin
- Publication date
- 01/01/1973
- Field of study
The paper describes a brief history of the Arab navigation based on the original
Arabic sources from the 9th century onwards. The old literature indicates that the
Arabs had a good knowledge of the wind-directions, currents and tides. They also
knew the most favourable seasons for sailing from the different ports. The Arabs described the
reversing currents in the North Indian Ocean and made several interesting
observations on bioluminescence, discoloration of sea water, etc. They also made
references on the light houses at the entrance of Persian Gulf and on the eddies,
ascending currents and cyclonic winds.
Arab navigation in the Indian Ocean had deep connections with the Indian and
Persian nautical traditions. These probably dates back to the first century when the
Sanskrit " Jataka Mala " ( maritime code ) was written. The highly cultivated knowledge
of the Arabs on nautical matters could be attributed to their knowledge of the
stars, their eagerness to undertake extensive voyages and their desire to translate the
relevant works in other languages into Arabic. The impact of nautical traditions of the
Arabs on the Portuguese and Turkish navigations has been of considerable value
Influence of number of laser shots on laser induced microstructures on Ag and Cu targets
- Publication venue
- 'Cambridge University Press (CUP)'
- Publication date
- Field of study
Indications and determinants of caesarean section delivery: Evidence from a population-based study in Matlab, Bangladesh
- Author
- A Betran
- A Cockcroft
- A Dumont
- A Rahman
- A Rahman
- A TaĆpınar
- AB Caughey
- Al Fazal Khan
- AM Mansur
- Aminur Rahman
- AP BetrĂĄn
- AP BetrĂĄn
- C Ronsmans
- C Ronsmans
- C Stanton
- Cassandra Nichole Spracklen
- CL Roberts
- D Filmer
- Dewan Md. Emdadul Hoque
- DR Gwatkin
- F Althabe
- F Rebelo
- FA Huda
- FS Sanavi
- G Lewis
- GJ Hofmeyr
- H Abdel-Aleem
- H Ahmad
- H Bayrampour
- HC Lin
- Herfina Nababan
- I Anwar
- I Anwar
- I Anwar
- I Teguete
- Iqbal Anwar
- J Pervin
- JA Gamble
- JL Ecker
- LJ Heffner
- M Aminu
- M Gholitabar
- M Khawaja
- M Koblinsky
- MR Festin
- N Chaillet
- P Satyanarayana
- R Morris
- R Nazneen
- R Walker
- S Berendes
- SM Collin
- Tahmina Begum
- Taslim Ali
- TM Sakae
- Z Penn
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Design & thermal modeling of solar panel module with embedded reconfigurable Air-Coil for micro-satellites
- Author
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
The diagnostic value of arginase-1 immunostaining in differentiating hepatocellular carcinoma from metastatic carcinoma and cholangiocarcinoma as compared to HepPar-1
- Author
- AE Wennerberg
- AS Leong
- BC Yan
- DL Zynger
- DT Timek
- E Aleem
- H Hong
- H Iida
- H Multhaupt
- H Schmilovitz-Weiss
- L Wang
- LW Lamps
- M Fujiwara
- M Hishinuma
- MI Minervini
- MS Shiran
- Naglaa S Ahmed
- ND Theise
- Nehal A Radwan
- PG Chu
- PG Chu
- R McKnight
- S Aviel-Ronen
- S Choi
- S HajĂłsi-Kalcakosz
- S Kakar
- S Kakar
- S Sekine
- S Waly Raphael
- SK Lau
- SL Taylor
- W Cao
- WA Anwar
- X Guo
- X Guo
- Z Fan
- Publication venue
- BMC
- Publication date
- 01/01/2012
- Field of study
<p>Abstract</p> <p>Background</p> <p>The ability to distinguish hepatocellular carcinoma (HCC) from metastatic carcinoma (MC) involving the liver and cholangiocarcinoma (CC) by immunohistochemistry has been limited by the lack of a reliable positive marker for hepatocellular differentiation. Arginase-1 is a marker for HCC recently described in some literature.</p> <p>Aim</p> <p>To examine the immunohistochemical staining of arginase-1 in cases of HCC, MC involving the liver and CC as compared to hepatocyte paraffin antigen -1 (HepPar-1) in an attempt to further define the diagnostic utility of arginase-1 in differentiating these tumors.</p> <p>Materials and methods</p> <p>A comparative immunohistochemical study of arginase-1 and HepPar-1expression was performed in 50 HCC cases, 38 cases of MC to the liver from varying sites, 12 cases of CC and 10 specimens of normal liver tissues. The predictive capacity of arginase-1 and HepPar-1 staining was determined using sensitivity, specificity, positive predictive value, and negative predictive value calculations.</p> <p>Results</p> <p>All normal liver tissues (no=10), non- neoplastic cirrhotic liver tissues adjacent to HCC (no=42) as well as those adjacent to MC (no= 9) showed diffuse and strong immunostaining for both arginase-1 and HepPar-1. Arginase-1 demonstrated positive immunoreactivity in 42 of 50 (84%) cases of HCC compared with 35 of 50 (70%) for HepPar-1. Only one of 38 (2.6%) cases of MC and one of 12 (8.3%) cases of CC showed positive immunoreactivity for arginase-1. In contrast, HepPar-1 immunoreactivity was detected in 6 of 38 (15.8%) cases of MC and in 2 of 12 (16.7%) cases of CC. Arginase -1 showed a significantly higher sensitivity for HCC diagnosis (84%) compared to HepPar -1(70%) (p=0.016). The specificity of arginase-1 for HCC diagnosis was higher (96%) than that of HepPar -1 (84%); nevertheless, this was not statistically significant (p=0.109). Howerver, the combination of both immunomarkers for the diagnosis of HCC, raised the specificity to 100%.</p> <p>Conclusion</p> <p>Arginase-1 immunostaining has a higher sensitivity and specificity than HepPar-1 for HCC diagnosis. Furthermore, the combined use of arginase-1 and HepPar-1 can provide a potentially promising tool to improve the accuracy in distinguishing HCC from metastatic carcinoma and cholangiocarcinoma.</p> <p>Virtual slides</p> <p>The virtual slide(s) for this article can be found here: <url>http://www.diagnosticpathology.diagnomx.eu/vs/9991436558072434</url>.</p
Proteomics analysis of colon cancer progression
- Author
- A Cristobal
- A Inui
- Aamir Ali Syed
- AF Quest
- Aribah Atiq
- Asad Hayat Ahmad
- B Zhang
- C Le Tourneau
- CA Messick
- Chris Sutton
- D Chu
- D Kreutz
- DB Friedman
- E Kostova
- F Akhtar
- F Badar
- F Bozzi
- F Han
- F Liao
- FC Bender
- H Towbin
- Iffat Aleem
- J Lian
- JD Mancias
- JJ Wang
- K Ramkumar
- K Wiechen
- KK Wary
- KM McMahon
- LC Ngoka
- M Arnold
- M Deb
- M Masoudi
- M Shatz
- Mudassar Hussain
- Muhammad Abu Bakar
- Muhammad Tahseen
- Muhammed Aasim Yusuf
- N Anwar
- N Nohata
- NA Khan
- NG Hurst
- P Mishra
- P Ălvarez-Chaver
- PE Porporato
- PE Porporato
- Q Ye
- R Huxley
- RJ Honeywell
- S Boudjadi
- S Charrasse
- S Chevalier
- S Jamal
- S Nunez-Wehinger
- S Vyas
- S Wilson
- Sadia Hassan
- Sadr-ul Shaheed
- Sahrish Tariq
- Saira Saleem
- SC Ng
- Shahid Khattak
- UK Basu Roy
- WH Hartl
- Y Bhurgri
- Y Bhurgri
- Z Zhao
- Z Zhao
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Omics profiles in chronic venous ulcer wound fluid: innovative applications for translational medicine
- Author
- Ackerman Z
- Agren MS
- Agren MS
- Agren MS
- Allhorn M
- Amato B
- Anwar MA
- Anwar MA
- Barone EJ
- Barrick B
- bd-El-Aleem SA
- bd-El-Aleem SA
- Beebe-Dimmer JL
- Beidler SK
- Bergan J
- Bergan JJ
- Bergan JJ
- Bergan JJ
- Boyce DE
- Breslow R
- Breslow RA
- Brook I
- Bullen EC
- Caggiati A
- Campbell EJ
- Carroll C
- Chatterjee SS
- Childress B
- Cirino G
- Claudy AL
- Coccheri S
- Cooper DM
- Cornu-Thenard A
- Cowin AJ
- Cui C
- Cullen B
- Cullen B
- Daniela Ligi
- Delis KT
- Dodd H
- Dormandy A
- Eberhardt RT
- Escalante T
- Escandon J
- Ferdinando Mannello
- Fernandez ML
- Fernandez ML
- Fernandez ML
- Fivenson DP
- Gallo R
- Gartner MH
- Gemmati D
- Gemmati D
- Ghaderian SM
- Gillespie DL
- Gloviczki P
- Gohel MS
- Gohel MS
- Grayson LS
- Grinnell F
- Grinnell F
- Grinnell F
- Grzela T
- Hamdan A
- Harris IR
- Hasmann A
- Haukipuro K
- Haukipuro K
- Hermes O
- Herouy Y
- Herouy Y
- Herrick S
- Hoffman R
- Hoffman R
- Jagielska J
- James TJ
- James TJ
- Jones KR
- Joseph D Raffetto
- Kainulainen V
- Katz MH
- Kowalewski R
- Kowalewski R
- Kowalewski R
- Kowalewski R
- Krysa J
- Kucukguven A
- Labropoulos N
- Lantis JC
- Latijnhouwers MA
- Lauer G
- Le FL
- Lee S
- Lim CS
- Lim CS
- Lim M
- Loots MA
- Lopez-Otin C
- Lozano Sanchez FS
- Luk PP
- Lundqvist K
- Lundqvist K
- Lundqvist K
- Mannello F
- Mannello F
- Mannello F
- Mannello F
- Mannello F
- Markovic JN
- Matteo Canale
- McCarty SM
- McDaniel JC
- Meyer FJ
- Moali C
- Moor AN
- Moore K
- Moore K
- Moseley R
- Moseley R
- Moues CM
- Mwaura B
- Myers HL
- Neglen P
- Nicolaides AN
- Nicolaides AN
- Nwomeh BC
- Oklu R
- Ono T
- Overall CM
- Palolahti M
- Pannier F
- Pappas PJ
- Pappas PJ
- Pascual G
- Perrin M
- Peschen M
- Peschen M
- Peschen M
- Pukstad BS
- Rabe E
- Rabe E
- Raffetto JD
- Raffetto JD
- Raffetto JD
- Raffetto JD
- Raffetto JD
- Raffetto JD
- Raffetto JD
- Raffetto JD
- Raffetto JD
- Raffetto JD
- Raffetto JD and Mannello F
- Rasmussen LH
- Rayment EA
- Robnett AH
- Rogers AA
- Saharay M
- Sansilvestri-Morel P
- Schmidtchen A
- Schultz GS
- Schultz GS
- Seah CC
- Seidman C
- Seidman C
- Serra R
- Serra R
- Shoab SS
- Simka M
- Sola LR
- Staiano-Coico L
- Stechmiller JK
- Stotts NA
- Strlic M
- Subramanian SV
- Takase S
- Tarlton JF
- Tian YW
- Tisato V
- Tisato V
- Tognazzo S
- Toriseva M
- Trengove NJ
- Trengove NJ
- Trostrup H
- Vaalamo M
- Vasquez R
- Wenk J
- Weyl A
- Widgerow AD
- Widgerow AD
- Wipke-Tevis DD
- Wlaschek M
- Wolanska M
- Wyffels JT
- Wysocki AB
- Wysocki AB
- Xu HM
- Yager DR
- Yasim A
- Yeoh-Ellerton S
- Yin H
- Zamboni P
- Zamboni P
- Zamboni P
- Zamboni P
- Zamboni P
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Library literature in Pakistan
- Author
- Abdul Huq A. M.
- Ahmad Naqvi S. J.
- Ahmad Nazir
- Ahmad Rashiduddin
- Akhtar Khalida
- Akthar Abdul Hafiz
- Akthar Abdul Hafiz
- Akthar Abdul Hafiz
- Alam M.Khurshid
- Ali Syed Irshad
- Allana Ghulam A.
- Anwar Mumtaz A.
- Anwar Mumtaz A.
- Anwar Mumtaz A.
- Asghar Muhammad
- Aslam Muhammad
- Aslam Muhammad
- Bajwa Rashid Ahmad
- Choudhry Shafiqur Rehman
- Danish Usman Ahmad
- Dickinson Asa Don
- Dickinson Asa Don
- Dickinson Asa Don
- Donovan David G.
- Donovan David G.
- Donovan David G.
- East Pakistan Library Association
- Elahi Fazal
- Elahi Fazal
- Fatima Nasim
- Fatima Nasim
- Fatima Nasim
- Fatima Nasim
- Fatima Nasim
- Fatima Nasim
- Ghani A. R.
- Guha S. C.
- Haidcr Zia
- Haider Jalaluddin
- Haider Jalaluddin
- Haider Jalaluddin
- Haider Jalaluddin
- Haider Jalaluddin
- Haider Jalaluddin
- Haider Jalaluddin
- Haider Jalaluddin
- Haider Jalaluddin
- Haider Jalaluddin
- Haider Jalaluddin
- Hanif Akthar
- Hanif Akthar
- Hanif Akthar
- Hanif Shaikh Muhammad
- Hasan Mahmudul
- Hassan Khwaja Badrul
- Hassan Syed Akthar
- Hayat Khizr
- Henkle Herman H.
- Hitchler Theresa
- Husain Mahmud
- Husain Mahmud
- Husain Matloob
- Husain Matloob
- Hussain Ahmad
- Ibrahim Shaikh
- Integrated Rural Information System
- Izharul Hall Zia M.
- Jafari Owais M.
- Jehangir Muhammad
- Karachi University Department of Library Science
- Kazmi Maqsood
- Kesaven B. S.
- Key L. C.
- Khan Abdur Rahim
- Khan Abdur Rahim
- Khan Abdur Rahim
- Khan Abdur Rahim
- Khan Muhammad Siddiq
- Khan Muhammad Siddiq
- Khan Muhammad Siddiq
- Khan Muhammad Siddiq
- Khan Sadiq Ali
- Khan Sadiq Ali
- Khan Safia
- Khurshid Anis
- Khurshid Anis
- Khurshid Anis
- Khurshid Anis
- Khurshid Anis
- Khurshid Anis
- Khurshid Anis
- Khurshid Anis
- Khurshid Anis
- Khurshid Zahiruddin
- Khurshid Zahiruddin
- Khurshid Zahiruddin
- Kumar R. P.
- Kumar R. P.
- Kurshid Zahiruddin
- Library Promotion Bureau
- Library Science (English-Urdu)
- Library Science (English-Urdu)
- Library Science (English-Urdu)
- Library Standards
- Malik Sain Mohammad
- Mirza Qamar
- Moghul Muhammad Shafi
- Mohammadally Rafia
- Moid A.
- Moid A.
- Moid A.
- Moid A.
- Moid A.
- Moid A.
- Moreland Carroll C.
- Nawaz Iqbal Akthar
- Nur Elahi Khwaja
- Nur Elahi Khwaja
- Nur Elahi Khwaja
- Pakistan Bibliographical Working Group
- Pakistan Library Association
- Pakistan Library Association
- Pakistan Library Association
- Pakistan Library Association
- Pakistan Library Association
- Pakistan Library Association
- Pakistan Library Association
- Pakistan Library Association
- Pakistan Library Association
- Pakistan Library Association
- Pakistan Library Association
- Pakistan Library Association
- Pakistan Library Association
- Pakistan Library Association (Federal Branch)
- Pakistan Library Bulletin
- Pakistan Ministry of Education
- Pakistan Ministry of Education
- Pakistan Ministry of Education
- Pakistan Ministry of Education
- Pakistan Ministry of Education Directorate of Libraries. Technical Working Group
- Pakistan Ministry of Education Directorate of Libraries Technical Working Group
- Pakistan Ministry of Education: Department of Libraries
- Pakistan Ministry of Education: Department of Libraries
- Pakistan National Book Centre
- Pakistan National Scientific and Technical Documentation Centre
- Pakistan National Scientific and Technical Documentation Centre
- Pakistan Planning Commission
- Pakistan Planning Commission
- Public Libraries
- Punjab University
- Punjab University
- Qureshi Aleem
- Riaz Muhammad
- Riazuddin Syed
- Rustomji Behram S.H.J.
- Sabzwari G. A.
- Sabzwari G. A.
- Sabzwari G. A.
- Sabzwari G. A.
- Sabzwari Ghaniul Akram
- Saify Obaidullah
- Shafi Muhammad
- Shafi Muhammad
- Shafi Muhammad
- Shah Jamil Ahmad
- Shaikh Maratab Ali
- Sharify Nasser
- Shaukat Altaf
- Siddiqui Akthar H.
- Siddiqui Akthar H.
- Siddiqui Akthar H.
- Siddiqui Akthar H.
- Siddiqui Zainuddin
- Siddiqui Zainuddin
- Siddiqui Zainuddin
- Society for the Promotion and Improvement of Libraries
- Society for the Promotion and Improvement of Libraries
- Society for the Promotion and Improvement of Libraries
- Society for the Promotion and Improvement of Libraries
- Society for the Promotion and Improvement of Libraries
- Society for the Promotion and Improvement of Libraries Karachi
- Society for the Promotion and Improvement of Libraries Karachi
- Society for the Promotion and Improvement of Libraries Karachi
- Society for the Promotion and Improvement of Libraries. Karachi
- Tahir Azra
- The theses submitted at the University of the Punjab are listed in Zahiruddin Khurshid
- Usmani M. A.
- Usmani M. A.
- Usmani M. A.
- Usmani M. A.
- Usmani M. A.
- Zubair Muhammad
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
- Author
- Abdel-Aziz Amal Kamal
- Abdelfatah Sara
- Abdellatif Mahmoud
- Abdoli Asghar
- Abel Steffen
- Abeliovich Hagai
- Abildgaard Marie H
- Abudu Yakubu Princely
- Acevedo-Arozena Abraham
- Adamopoulos Iannis E
- Adeli Khosrow
- Adolph Timon E
- Adornetto Annagrazia
- Aflaki Elma
- Afshar Elham Ghasemipour
- Agam Galila
- Agarwal Anupam
- Aggarwal Bharat B
- Agnello Maria
- Agostinis Patrizia
- Agrewala Javed N
- Agrotis Alexander
- Aguilar Patricia V
- Ahmad S Tariq
- Ahmed Zubair M
- Ahumada-Castro Ulises
- Aits Sonja
- Aizawa Shu
- Akkoc Yunus
- Akoumianaki Tonia
- Akpinar Hafize Aysin
- Al-Abd Ahmed M
- Al-Akra Lina
- Al-Bari M Abdul Alim
- Al-Gharaibeh Abeer
- Alaoui-Jamali Moulay A
- Alberti Simon
- Alcocer-Gomez Elisabet
- Alcon Soledad Porte
- Alessandri Cristiano
- Ali Muhammad
- Aliwaini Saeb
- Alizadeh Javad
- Almacellas Eugenia
- Almasan Alexandru
- Alonso Alicia
- Alonso Guillermo D
- Altan-Bonnet Nihal
- Altieri Dario C
- Alvarez Elida MC
- Alves Sara
- Alzaharna Mazen M
- Amadio Marialaura
- Amantini Consuelo
- Amaral Cristina
- Ambrosio Susanna
- Amer Amal O
- Ammanathan Veena
- An Zhenyi
- Andersen Stig U
- Andrabi Shaida A
- Andrade-Silva Magaiver
- Andres Allen M
- Angelini Sabrina
- Ann David
- Anozie Uche C
- Ansari Mohammad Y
- Antas Pedro
- Antebi Adam
- Anton Zurine
- Anwar Tahira
- Apetoh Lionel
- Apostolova Nadezda
- Araki Toshiyuki
- Araki Yasuhiro
- Arasaki Kohei
- Araujo Thais Fenz
- Araujo Wagner L
- Araya Jun
- Arden Catherine
- Arevalo Maria-Angeles
- Arguelles Sandro
- Arias Esperanza
- Arikkath Jyothi
- Arimoto Hirokazu
- Ariosa Aileen R
- Armstrong-James Darius
- Arnaune-Pelloquin Laetitia
- Aroca Angeles
- Arroyo Daniela S
- Arsov Ivica
- Artero Ruben
- Asaro Dalia Maria Lucia
- Aschner Michael
- Ashrafizadeh Milad
- Ashur-Fabian Osnat
- Atanasov Atanas G
- Au Alicia K
- Auberger Patrick
- Auner Holger W
- Aurelian Laure
- Autelli Riccardo
- Avagliano Laura
- Avalos Yenniffer
- Aveic Sanja
- Aveleira Celia Alexandra
- AvinWittenberg Tamar
- Aydin Yucel
- Ayton Scott
- Ayyadevara Srinivas
- Azzopardi Maria
- Baba Misuzu
- Backer Jonathan M
- Backues Steven K
- Bae Dong-Hun
- Bae Ok-Nam
- Bae Soo Han
- Baehrecke Eric H
- Baek Ahruem
- Baek Seung-Hoon
- Baek Sung Hee
- Bagetta Giacinto
- Bagniewska-Zadworna Agnieszka
- Bai Hua
- Bai Jie
- Bai Xiyuan
- Bai Yidong
- Bairagi Nandadulal
- Baksi Shounak
- Balazadeh Salma
- Balbi Teresa
- Baldari Cosima T
- Balduini Walter
- Ballabio Andrea
- Ballester Maria
- Balzan Rena
- Bandopadhyay Rina
- Banerjee Sreeparna
- Banerjee Sulagna
- Bao Yan
- Baptista Mauricio S
- Baracca Alessandra
- Barbati Cristiana
- Bargiela Ariadna
- Barila Daniela
- Barlow Peter G
- Barmada Sami J
- Barreiro Esther
- Barrera Miguel Calvo-Rubio
- Barreto George E
- Bartek Jiri
- Bartel Bonnie
- Bartolome Alberto
- Barve Gaurav R
- Basagoudanavar Suresh H
- Bassham Diane C
- Basu Alakananda
- Batoko Henri
- Batten Isabella
- Baulieu Etienne E
- Baumgarner Bradley L
- Bayry Jagadeesh
- Beale Rupert
- Beau Isabelle
- Beaumatin Florian
- Bechara Luiz RG
- Beck George R Jr
- Beers Michael F
- Begun Jakob
- Behl Christian
- Behrends Christian
- Behrens Georg MN
- Bei Roberto
- Bejarano Eloy
- Bel Shai
- Belaid Amine
- Belgareh-Touze Naima
- Bellarosa Cristina
- Belleudi Francesca
- Bello Perez Melissa
- Bello-Morales Raquel
- Beltran Sebastian
- Benbrook Doris Mangiaracina
- Bendorius Mykolas
- Benitez Bruno A
- Benito-Cuesta Irene
- Bensalem Julien
- Berchtold Martin W
- Berezowska Sabina
- Bergamaschi Daniele
- Bergami Matteo
- Bergmann Andreas
- Berliocchi Laura
- Berlioz-Torrent Clarisse
- Bernard Amelie
- Berthoux Lionel
- Besirli Cagri G
- Besteiro Sebastien
- Betin Virginie M
- Beyaert Rudi
- Bezbradica Jelena S
- Bharath MM Srinivas
- Bhaskar Kiran
- Bhatia-Kissova Ingrid
- Bhattacharya Resham
- Bhattacharya Sujoy
- Bhattacharyya Shalmoli
- Bhuiyan Md Shenuarin
- Bhutia Sujit Kumar
- Bi Lanrong
- Bi Xiaolin
- Biden Trevor J
- Bijian Krikor
- Billes Viktor A
- Binart Nadine
- Bincoletto Claudia
- Birgisdottir Asa B
- Bjorkoy Geir
- Blanco Gonzalo
- Blas-Garcia Ana
- Blasiak Janusz
- Blomgran Robert
- Blomgren Klas
- Blum Janice S
- Boada-Romero Emilio
- Boban Mirta
- BoeszeBattaglia Kathleen
- Boeuf Philippe
- Boland Barry
- Bomont Pascale
- Bonaldo Paolo
- Bonam Srinivasa Reddy
- Bonfili Laura
- Bonifacino Juan S
- Boone Brian A
- Bootman Martin D
- Bordi Matteo
- Borner Christoph
- Bornhauser Beat C
- Borthakur Gautam
- Bosch Jurgen
- Bose Santanu
- Botana Luis M
- Botas Juan
- Boulanger Chantal M
- Boulton Michael E
- Bourdenx Mathieu
- Bourgeois Benjamin
- Bourke Nollaig M
- Bousquet Guilhem
- Boya Patricia
- Bozhkov Peter V
- Bozi Luiz HM
- Bozkurt Tolga O
- Brackney Doug E
- Brand-Saberi Beate
- Brandts Christian H
- Braun Ralf J
- Braus Gerhard H
- Bravo-Sagua Roberto
- Bravo-San Pedro Jose M
- Brest Patrick
- Bringer Marie-Agnes
- Briones-Herrera Alfredo
- Broaddus V Courtney
- Brodersen Peter
- Brodsky Jeffrey L
- Brody Steven L
- Bronson Paola G
- Bronstein Jeff M
- Brown Carolyn N
- Brown Rhoderick E
- Brum Patricia C
- Brumell John H
- Brunetti-Pierri Nicola
- Bruno Daniele
- Bryson-Richardson Robert J
- Bucci Cecilia
- Buch Shilpa
- Buchan J Ross
- Buchrieser Carmen
- Buckingham Erin M
- Budak Hikmet
- Budini Mauricio
- Bueno Marta
- Buitrago-Molina Laura Elisa
- Bultynck Geert
- Burada Florin
- Buraschi Simone
- Burgoyne Joseph R
- Buron M Isabel
- Bustos Victor
- Buttner Sabrina
- Butturini Elena
- Byrd Aaron
- Cabas Isabel
- Cabrera-Benitez Sandra
- Cadwell Ken
- Cai Jingjing
- Cai Lu
- Cai Qian
- Cairo Montserrat
- Calbet Jose A
- Caldwell Guy A
- Caldwell Kim A
- Call Jarrod A
- Calvani Riccardo
- Calvo Ana C
- Camara Niels Os
- Camonis Jacques H
- Camougrand Nadine
- Campanella Michelangelo
- Campbell Edward M
- Campbell-Valois Francois-Xavier
- Campello Silvia
- Campesi Ilaria
- Campos Juliane C
- Camuzard Olivier
- Cancino Jorge
- Canesi Laura
- Caniggia Isabella
- Canonico Barbara
- Canti Carles
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- Sun Meng-xiang
- Sun Qiming
- Sun Yi
- Sun Zhongjie
- Sunahara Karen KS
- Sundberg Eva
- Susztak Katalin
- Sutovsky Peter
- Suzuki Hidekazu
- Sweeney Gary
- Symons J David
- Sze Stephen Cho Wing
- Szewczyk Nathaniel J
- Tabolacci Claudio
- Tacke Frank
- Taegtmeyer Heinrich
- Tafani Marco
- Tagaya Mitsuo
- Tai Haoran
- Tait Stephen WG
- Takahashi Yoshinori
- Takats Szabolcs
- Talwar Priti
- Tam Chit
- Tam Shing Yau
- Tampellini Davide
- Tamura Atsushi
- Tan Chong Teik
- Tan Eng-King
- Tan Ya-Qin
- Tanaka Masaki
- Tanaka Motomasa
- Tang Daolin
- Tang Jingfeng
- Tang Tie-Shan
- Tanida Isei
- Tao Zhipeng
- Taouis Mohammed
- Tatenhorst Lars
- Tavernarakis Nektarios
- Taylor Allen
- Taylor Gregory A
- Taylor Joan M
- Tchetina Elena
- Tee Andrew R
- Tegeder Irmgard
- Teis David
- Teixeira Natercia
- Teixeira-Clerc Fatima
- Tekirdag Kumsal A
- Tencomnao Tewin
- Tenreiro Sandra
- Tepikin Alexei V
- Testillano Pilar S
- Tettamanti Gianluca
- Tharaux PierreLouis
- Thedieck Kathrin
- Thekkinghat Arvind A
- Thellung Stefano
- Thinwa Josephine W
- Thirumalaikumar VP
- Thomas Sufi Mary
- Thomes Paul G
- Thorburn Andrew
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- Thum Thomas
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- Tian Ling
- Tichy Ales
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- Timmerman Vincent
- Titorenko Vladimir I
- Todi Sokol V
- Todorova Krassimira
- Toivonen Janne M
- Tomaipitinca Luana
- Tomar Dhanendra
- Tomas-Zapico Cristina
- Tong Benjamin Chun-Kit
- Tong Chao
- Tong Chun-Kit
- Tong Xin
- Tooze Sharon A
- Torgersen Maria L
- Torii Satoru
- Torres-Lopez Liliana
- Torriglia Alicia
- Towers Christina G
- Towns Roberto
- Toyokuni Shinya
- Trajkovic Vladimir
- Tramontano Donatella
- Tran QuynhGiao
- Travassos Leonardo H
- Trelford Charles B
- Tremel Shirley
- Trougakos Ioannis P
- Tsao Betty P
- Tschan Mario P
- Tse Hung-Fat
- Tse Tak Fu
- Tsugawa Hitoshi
- Tsvetkov Andrey S
- Tumbarello David A
- Tumtas Yasin
- Tunon Maria J
- Turcotte Sandra
- Turk Boris
- Turk Vito
- Turner Bradley J
- Tuxworth Richard I
- Tyler Jessica K
- Tyutereva Elena V
- Uchiyama Yasuo
- UgunKlusek Aslihan
- Uhlig Holm H
- Ulasov Ilya V
- Umekawa Midori
- Ungermann Christian
- Unno Rei
- Urbe Sylvie
- Uribe-Carretero Elisabet
- Ustun Suayib
- Uversky Vladimir N
- Vaccari Thomas
- Vaccaro Maria I
- Vahsen Bjorn F
- Vakifahmetoglu-Norberg Helin
- Valdor Rut
- Valente Maria J
- Valko Ayelen
- Vallee Richard B
- Valverde Angela M
- Van den Berghe Greet
- van Der Veen Stijn
- Van Kaer Luc
- van Loosdregt Jorg
- van Wijk Sjoerd JL
- Vandenberghe Wim
- Vanhorebeek Ilse
- Vannier-Santos Marcos A
- Vannini Nicola
- Vanrell M Cristina
- Vantaggiato Chiara
- Varano Gabriele
- Varela-Nieto Isabel
- Varga Mate
- Vasconcelos M Helena
- Vats Somya
- Vavvas Demetrios G
- Vega-Rubin-de-Celis Silvia
- VegaNaredo Ignacio
- Velasco Guillermo
- Velazquez Ariadna P
- Vellai Tibor
- Vellenga Edo
- Velotti Francesca
- Verdier Mireille
- Verginis Panayotis
- Vergne Isabelle
- Verkade Paul
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- Verstreken Patrik
- Vervliet Tim
- Vervoorts Jorg
- Vessoni Alexandre T
- Victor Victor M
- Vidal Michel
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- Vieira Otilia V
- Vierstra Richard D
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- Vilar Marcal
- Villalba Jose M
- Villalobo Antonio
- Villarejo-Zori Beatriz
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- Villarroya Joan
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- Vocadlo David J
- Voitsekhovskaja Olga V
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- Von Haefen Clarissa
- Vooijs Marc A
- Voos Wolfgang
- Vucicevic Ljubica
- Wade-Martins Richard
- Waguri Satoshi
- Waite Kenrick A
- Wakatsuki Shuji
- Walker David W
- Walker Mark J
- Walker Simon A
- Walter Jochen
- Wandosell Francisco G
- Wang Bo
- Wang Chao-Yung
- Wang Chen
- Wang Chenran
- Wang Chenwei
- Wang Cun-Yu
- Wang Dong
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- Wang Feng
- Wang Fengming
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- Wang Han
- Wang Hao
- Wang Hexiang
- Wang Hong-Gang
- Wang Jianrong
- Wang Jigang
- Wang Jiou
- Wang Jundong
- Wang Kui
- Wang Lianrong
- Wang Liming
- Wang Maggie Haitian
- Wang Meiqing
- Wang Nanbu
- Wang Peipei
- Wang Pengwei
- Wang Ping
- Wang Ping
- Wang Qing
- Wang Qing Jun
- Wang Qing Kenneth
- Wang Qiong A
- Wang Wen-Tao
- Wang Wuyang
- Wang Xinnan
- Wang Xuejun
- Wang Yan
- Wang Yanchang
- Wang Yanzhuang
- Wang YenYun
- Wang Yihua
- Wang Yipeng
- Wang Yu
- Wang Yuqi
- Wang Zhe
- Wang Zhenyu
- Wang Zhouguang
- Warnes Gary
- Warnsmann Verena
- Watada Hirotaka
- Watanabe Eizo
- Watchon Maxinne
- Weaver Timothy E
- Wegrzyn Grzegorz
- Wehman Ann M
- Wei Huafeng
- Wei Lei
- Wei Taotao
- Wei Yongjie
- Weiergraber Oliver H
- Weihl Conrad C
- Weindl Gunther
- Weiskirchen Ralf
- Wells Alan
- Wen Runxia H
- Wen Xin
- Werner Antonia
- Weykopf Beatrice
- Wheatley Sally P
- Whitton J Lindsay
- Whitworth Alexander J
- Wiktorska Katarzyna
- Wildenberg Manon E
- Wileman Tom
- Wilkinson Simon
- Willbold Dieter
- Williams Brett
- Williams Robin SB
- Williams Roger L
- Williamson Peter R
- Wilson Richard A
- Winner Beate
- Winsor Nathaniel J
- Witkin Steven S
- Wodrich Harald
- Woehlbier Ute
- Wollert Thomas
- Wong Esther
- Wong Jack Ho
- Wong Richard W
- Wong Vincent Kam Wai
- Wong W Wei-Lynn
- Wu An-Guo
- Wu Chengbiao
- Wu Jian
- Wu Junfang
- Wu Kenneth K
- Wu Min
- Wu Shan-Ying
- Wu Shengzhou
- Wu Shufang
- Wu ShuYan
- Wu William KK
- Wu Xiaohong
- Wu Xiaoqing
- Wu Yao-Wen
- Wu Yihua
- Xavier Ramnik J
- Xia Hongguang
- Xia Lixin
- Xia Zhengyuan
- Xiang Ge
- Xiang Jin
- Xiang Mingliang
- Xiang Wei
- Xiao Bin
- Xiao Guozhi
- Xiao Hengyi
- Xiao Hong-tao
- Xiao Jian
- Xiao Lan
- Xiao Shi
- Xiao Yin
- Xie Baoming
- Xie Chuan-Ming
- Xie Min
- Xie Yuxiang
- Xie Zhiping
- Xie Zhonglin
- Xilouri Maria
- Xu Congfeng
- Xu En
- Xu Haoxing
- Xu Jing
- Xu JinRong
- Xu Liang
- Xu Wen Wen
- Xu Xiulong
- Xue Yu
- Yakhine-Diop Sokhna MS
- Yamaguchi Masamitsu
- Yamaguchi Osamu
- Yamamoto Ai
- Yamashina Shunhei
- Yan Shengmin
- Yan Shian-Jang
- Yan Zhen
- Yanagi Yasuo
- Yang Chuanbin
- Yang Dun-Sheng
- Yang Huan
- Yang Huang-Tian
- Yang Hui
- Yang Jin-Ming
- Yang Jing
- Yang Jingyu
- Yang Ling
- Yang Liu
- Yang Ming
- Yang Pei-Ming
- Yang Qian
- Yang Seungwon
- Yang Shu
- Yang Shun-Fa
- Yang Wannian
- Yang Wei Yuan
- Yang Xiaoyong
- Yang Xuesong
- Yang Yi
- Yang Ying
- Yao Honghong
- Yao Shenggen
- Yao Xiaoqiang
- Yao Yong-Gang
- Yao Yong-Ming
- Yasui Takahiro
- Yazdankhah Meysam
- Yen Paul M
- Yi Cong
- Yin Xiao-Ming
- Yin Yanhai
- Yin Zhangyuan
- Yin Ziyi
- Ying Meidan
- Ying Zheng
- Yip Calvin K
- Yiu Stephanie Pei Tung
- Yoo Young H
- Yoshida Kiyotsugu
- Yoshii Saori R
- Yoshimori Tamotsu
- Yousefi Bahman
- Yu Boxuan
- Yu Haiyang
- Yu Jun
- Yu Jun
- Yu Li
- Yu Ming-Lung
- Yu Seong-Woon
- Yu Victor C
- Yu W Haung
- Yu Zhengping
- Yu Zhou
- Yuan Junying
- Yuan Ling-Qing
- Yuan Shilin
- Yuan Shyng-Shiou F
- Yuan Yanggang
- Yuan Zengqiang
- Yue Jianbo
- Yue Zhenyu
- Yun Jeanho
- Yung Raymond L
- Zacks David N
- Zaffagnini Gabriele
- Zambelli Vanessa O
- Zanella Isabella
- Zang Qun S
- Zanivan Sara
- Zappavigna Silvia
- Zaragoza Pilar
- Zarbalis Konstantinos S
- Zarebkohan Amir
- Zarrouk Amira
- Zeitlin Scott O
- Zeng Jialiu
- Zeng Ju-deng
- Zerovnik Eva
- Zhan Lixuan
- Zhang Bin
- Zhang Donna D
- Zhang Hanlin
- Zhang Hong
- Zhang Hong
- Zhang Honghe
- Zhang Huafeng
- Zhang Huaye
- Zhang Hui
- Zhang Hui-Ling
- Zhang Jianbin
- Zhang Jianhua
- Zhang Jing-Pu
- Zhang Kalin YB
- Zhang Leshuai W
- Zhang Lin
- Zhang Lisheng
- Zhang Lu
- Zhang Luoying
- Zhang Menghuan
- Zhang Peng
- Zhang Sheng
- Zhang Wei
- Zhang Xiangnan
- Zhang Xiao-Wei
- Zhang Xiaolei
- Zhang Xiaoyan
- Zhang Xin
- Zhang Xinxin
- Zhang Xu Dong
- Zhang Yang
- Zhang Yanjin
- Zhang Yi
- Zhang Ying-Dong
- Zhang Yingmei
- Zhang Yuan-Yuan
- Zhang Yuchen
- Zhang Zhe
- Zhang Zhengguang
- Zhang Zhibing
- Zhang Zhihai
- Zhang Zhiyong
- Zhang Zili
- Zhao Haobin
- Zhao Lei
- Zhao Shuang
- Zhao Tongbiao
- Zhao Xiao-Fan
- Zhao Ying
- Zhao Yongchao
- Zhao Yongliang
- Zhao Yuting
- Zheng Guoping
- Zheng Kai
- Zheng Ling
- Zheng Shizhong
- Zheng Xi-Long
- Zheng Yi
- Zheng Zu-Guo
- Zhivotovsky Boris
- Zhong Qing
- Zhou Ao
- Zhou Ben
- Zhou Cefan
- Zhou Gang
- Zhou Hao
- Zhou Hong
- Zhou Hongbo
- Zhou Jie
- Zhou Jing
- Zhou Jing
- Zhou Jiyong
- Zhou Kailiang
- Zhou Rongjia
- Zhou Xu-Jie
- Zhou Yanshuang
- Zhou Yinghong
- Zhou Yubin
- Zhou Zheng-Yu
- Zhou Zhou
- Zhu Binglin
- Zhu Changlian
- Zhu Guo-Qing
- Zhu Haining
- Zhu Hongxin
- Zhu Hua
- Zhu WeiGuo
- Zhu Yanping
- Zhu Yushan
- Zhuang Haixia
- Zhuang Xiaohong
- Zientara-Rytter Katarzyna
- Zimmermann Christine M
- Ziviani Elena
- Zoladek Teresa
- Zong Wei-Xing
- Zorov Dmitry B
- Zorzano Antonio
- Zou Weiping
- Zou Zhen
- Zou Zhengzhi
- Zuryn Steven
- Zwerschke Werner
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
Evaluation of a quality improvement intervention to reduce anastomotic leak following right colectomy (EAGLE): pragmatic, batched stepped-wedge, cluster-randomized trial in 64 countries
- Author
- Aarts Frits
- Ababneh Hazim
- Abad-Motos Ane
- Abaidalla Ahmed
- Abbakar Malaz
- Abd El Aal Ahmed
- Abd-Errazik Mohammad Ahmad
- Abdalradiy Abdalrahmman G
- Abdelkhalek Mohamed
- Abdelkhalek Mostafa
- Abdellatif Ahmed
- Abdellatif Mohamed
- Abdelsaid Kirolas
- Abdou Khaled
- Abdulfatah Mustapha
- Abdullah Mohammad Amer
- Abdullahi Mustapha Miko Mohammed
- AbellĂĄn Antonio Melero
- Abeysinghe Nayana
- Abiyere Henry
- Achimas-Cadariu Patriciu Andrei
- Adakaya Sıla
- Adam Nicolas
- Adams Benita
- Adams Ferdinand
- Adegboye Kazeem
- Adeyeye Ademola
- Adra Lama
- Adu-Poku Patricia
- Afuwape Oludolapo
- Afzal Ameer
- Afzal Muhammad Farooq
- Agapov Mihail
- Agara Daniel
- Aggarwal Manisha
- Agger Erika
- Aghadi Ifeanyi Kene
- Ahmed Amjed Yassir
- Ahmed Haleemasahdia
- Ahmed Khalil
- Ahmed Manar
- Ahmed Masood
- Ahmed Safia
- Ahn Hong Min
- Aibe Raquel
- Aigner Felix
- Aissat Abdenour
- Aitbaeva Arai
- Akay Omer
- Akbar Ali
- Akbas Ahmet
- Akere Abidemi
- Akesen Selcan
- Akgun Erhan
- Akhtar Naseem
- Akın Emrah
- Akova Elif
- Aktas Serhat
- Akçay Ăzlem
- Al Masri Mahmoud
- Al-Alnsi Ahmed
- Al-Hutheifi Roqia'A
- Al-Jarrah Amar
- Al-Naggar Hamza
- Al-Shehari Mohammed
- Alamin Nadeen
- Alawi Raneen
- Alawlaqi Dina
- Alawneh Fade
- Alberola Maria José
- Albers Michael
- Alcolea Natalia GonzĂĄlez
- Aleem Muhammad
- Alegre InĂȘs
- Alegre Javier Martinez
- Alexandre Flavia
- Alexandrescu Corina
- Alexnder Abelevich
- Alexopoulou Kalliopi
- Alfonso Beatriz AmorĂłs
- Ali Ahmed
- Ali Che Saniati Che
- Ali Danish
- Ali Madeeha
- Ali Mahmoud Abdelwahab
- Ali Manhal Hashim
- Ali Noura Al
- Alikhanli Jhale
- Aliyeva Zumrud
- Aliyu Mohammed
- Aljawder Hasan
- Allen Kate
- Almahmeed Ebrahim
- Alonso Alfredo
- Alonso Javier Etreros
- Alsamneh Muneer
- Alsayadi Ramzi
- Altinel Yuksel
- Altintoprak Fatih
- Altomare Donato F
- Alvarenga Isabella
- Alvarez Laura Jimenez
- Alvarez-Bautista Francisco Emmanuel
- Alvarez-DĂez Marcos
- Alves Brenda Chayanny
- Amadigwe Rita
- Amado Andreia
- Amado FabĂola
- Amador Cristina GarcĂa
- Amanullah Nazli
- Amaral HĂ©lida Aline Tomacheski
- Amaral Luis
- Amin-Tai Hizami
- Aminu Bashiru
- Amir Ahmad Suhaimi
- Ammar Ahmed Siddique
- Ammar Mona Ahmed
- Ammendola Michele
- Ammerata Giorgio
- Amorim Edgar
- Ancans Guntis
- Anderson Tom
- Andrade Diogo
- Andrejevic Predrag
- AndrĂ©s Beatriz DĂaz San
- Anestiadou Elissavet
- Ang Chin Wee
- Angelo Franceschi
- Anokhin Evgeny
- Anoldo Pietro
- Antakia Ramez
- Anton Majd
- Antonelli Serena
- Antropoli Carmine
- Anula Rocio
- Anwar Jamal
- Anyadike Florence
- Apostolakidou Magda
- Apostolidi Eirini
- Aprea Giovanni
- Arabadzhiev Angel
- Arakawa Satoshi
- Arauz Jazmin
- Aravindan U
- Aremu Abdurrahman
- Aremu Isiaka
- Argawy Osama
- Arican Can
- Arida Zahed Abu
- Armellin Claudia
- Arnaoutoglou Eleni
- Arreguy-Borges Kanthya
- Artigot Mariano
- Arturi Alessandro
- Arulappan Nirupama
- Arya Shobhit
- Arynov Ardak
- Asaad Peter
- Asano Yukio
- Ascari Francesca
- Asgarov Mohsum
- Ashmawy Soad
- Aslam Muhammad Imran
- Assimakopoulou Elena
- Assis Ana
- Astilleta Romina
- Atanasov Boyko
- Atendido Tiffany
- Athanasakis Elias
- Atici Semra Demirli
- Avellaneda Nicholas
- Avellaneda Nicolas
- Avseren Goksu
- Awead Marwa
- Ayandipo Omobolaji
- Aybar Engin
- Aydin Funda
- Aydin Gaye
- Ayoub Kusay
- Aytac Erman
- Aytaç Erman
- Azevedo Jose
- Azevedo Patricia
- Azhar Najia
- Aziz Gowhar
- Azman Zairul Azwan Mohd
- AĆkar Ahmet
- Babatunde Olanrewaju
- Badawi Marwa
- Baek Jeong-Heum
- Baez Noelia FernĂĄndez
- Baeza-Murcia Melody
- Bagnardi Francesco
- Baharom Salahudin
- Baik Seung Hyuk
- Baimakhanov Abylai
- Bains Lovenish
- Baker Aleksandra
- Bakmaz Bernarda
- Bala Abubakar Muhammad
- Balaban Vladimir
- Balalis Dimitrios
- Balasubramaniam Dinesh
- Balathayalan Yathev
- Baldi Claudio
- Balestri Riccardo
- Balfour James
- Ballah Abubakar
- Ballian Nikiforos
- Balooshi Iman Al
- Baloyiannis Ioannis
- Bamford Richard
- Bandar Mahdi Al
- Banham Gail
- Bannoud Mohammad Hassan
- Baptista Victor
- Baral Jörg
- Barbalace Nicolas
- Barbato Giuseppe
- Barbosa Anderson
- Bareka Metaxia
- Baris Baver
- Barradas Renato
- Barreda Sara Castillo
- Barrena-Blazquez Silvestra
- Barton Jess
- Bartosiak Katarzyna
- Bashilkina Olga
- Bashir Mohammed
- Basile Raffaele
- Basnyat Pradeep
- Batool Sana
- Bautista Wilson Manuel SĂĄnchez
- Bayhan ZĂŒlfĂŒ
- Bayo José Manuel Muros
- BayĂłn Raquel Ălvaro
- Baños Pedro Antonio Parra
- Beard David
- Bedzhanyan Arkady
- Behilil Chakib
- Bekele Kebebe
- Belarmino Armin
- Belay Million
- Belev Nikolay
- Bellato Vittoria
- BeltrĂĄn de Heredia Juan
- Belvedere Angela
- Benetti Emilio
- Benetti Sara
- Bengueddach Aicha
- Benjelloun El Bachir
- Benkabbou Amine
- Bennett James
- Bensafir Salim
- Bergamini Carlo
- Bernotaite Vlada
- Beron Reinaldo Isaacs
- Bethune Robert
- Bezede Cosmin
- Beznosenko Andriy
- Bhangu Aneel
- Bhargava Aman
- Bhat Rama Rani Krishna
- Bianchi Romina
- Bianco Francesco
- Bigoni Irene
- Binetti Margherita
- Bintintan Vasile
- Biondi Alberto
- Biondo Santino Antonio
- Bisgin Tayfun
- Bisheet George
- Bissett Ian
- Biswas Jyotirmoy
- Blackwell Sue
- Blanco Pablo
- Blanco Raquel RĂos
- Blanco-Colino Ruth
- Blasco Laura Fraile
- Blazquez-Martin Alma
- Bobadilla Billy Jimenez
- Bocancia Raluca
- Boccia Giuseppe
- Bogatikov Alexander
- Bolanle Olajide Edward
- Bomfa-Barbosa Alysson
- Bompou Effrosyni
- Bonardello Michela
- Bonci Eduard-Alexandru
- Bordom Daniel Osei
- Borges Filipe
- Borghi Felice
- Boschiero Matheus Negri
- Bose Bodhisattva
- Bouchagier Konstantinos
- Boudjenan-Serradj Nabil
- Boudoux Sabrina
- Bourazani Maria
- Boyce Stephen
- Bozbiyik Osman
- Bracale Umberto
- Brachini Gioia
- Bradulskis Saulius
- Brainsa Eneida
- Brandström Gustav
- Braumille Markus
- Bravo Ana Minaya
- Bravo Raquel
- Bredikhin Mikhail
- Brito Noelia
- Bruni Andrea
- Buccianti Piero
- Buchs Nicolas
- Buchwald Pamela
- Budnikova Ina
- BudrikienÄ Rima
- Buey Lourdes
- Buijs Louis
- Buleje Jorge Alejandro Benavides
- Burlov Nikita
- Butt Anam
- Byshetty Rajendar
- Bywater Edward
- Bzikha Ilham
- BĂĄnky BalĂĄzs
- BĂŠlum Jens Kristian
- Caballero-Delgado Javier
- Cabrera Claudia
- Cafranga EstĂbaliz GutiĂ©rrez
- Cagnazzo Federica
- Calabria Mariangela
- Calabro' Marcello
- Caliendo Domenico
- Calin Camelia
- Caliskan Cemil
- Callan Rory
- Callari Cosimo
- Caltea Mihaela
- Calvo Almudena Castro
- Camacho Amparo
- Cammarata Francesco
- Campanati Renato
- Campanelli Michela
- Campbell Marion
- Canals LucĂa Otazu
- Canda Aras Emre
- Cano-Matias Auxiliadora
- Cao Victor Hugo Bruno
- Capolupo Gabriella Teresa
- Cappiello Antonio
- Capuano Marianna
- Capusan Alina
- Carannante Filippo
- Carbone Ludovico
- Cardelli Stefano
- Carden Claire
- Cardoso Diogo
- Caricato Marco
- Carlin Patricia Saez
- Carlini Massimo
- Carlos Sandra
- Carneros Virginia Jimenez
- Carosso Fabio
- Caroço Teresa Vieira
- Carpelan Anu
- Carpenter Holly
- Carrascosa-Morales Irene
- Carrie Augusto
- Carrizo Claudia
- Carta Giuseppina
- Carvalho Alexandre
- Carvello Michele
- Casanova Daniel
- Cascais Raquel
- Cassia Gabriela
- Castaldi Antonio
- Castaño Renata
- Castiglioni Simone
- Castillo Enrique Roca
- Castro Marta Cuartero
- Catalano Pablo
- Cato Liam
- Caz Esra
- Cebolla Elena Sagarra
- Cecchini Ilaria
- CeldrĂĄn Rebeca GonzĂĄlez
- Celik Hale Kefeli
- Ceretti Andrea Pisani
- Ceron Silvia Ferrer
- Cervellera Maurizio
- Cervone Carmela
- Chacko Anil
- Chandrasinghe Pramodh
- Charakopoulou Alexandra
- Chardalias Leonidas
- Chaturvedi Arun
- Chatzikomnitsa Paraskevi
- Chaudhari Abhishek
- Chaudhry Sanjay
- Chawla Tabish
- Chee Corissa
- Chen Nevin
- Cheng Kuang I
- Chiarugi Massimo
- Chisthi Meer
- Chitnis Abhishek
- Chitul Andrei
- Chmielewski Gaspard
- Cholewa Hanna
- Chornet Marta RosellĂł
- Chowdhary Manish
- Chowdhury Sharfuddin
- Chowdhury Sharfuddin M
- Chowdri Nisar
- Christensen Peter
- Christodoulidis Grigorios
- Chrysos Emmanuel
- Chua Lorna
- Chubukova Natlia
- Chung Jun Seong
- Church Robert
- Chwat Carina
- Ciabattari Paula
- Cianchi Fabio
- Cianci Pasquale
- Ciccarese Angelo Antonio
- Ciftci Ahmet Burak
- Cigagna Luca
- Cini Charles
- Ciotarla Danut Constantin
- Cirocchi Nicholas
- Ciubotaru Cezar
- Ciulli Cristina
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- Yew Chor Kuan
- Yılmaz GĂŒlseren
- Yilmazlar Tuncay
- YiÄit Direnç
- Yoldas Tayfun
- Yonekura Hiroshi
- Yorkmui Liu
- Yoshino Kenji
- Younes Lina
- Young Trudi
- Yule Michael
- Yusoff Zakiah Mohd
- Zaari Fatimazahraa
- Zabiyaka Mikhail
- ZadroĆŒna Monika
- Zafar Madiha
- Zagaynov Eugeny
- Zaidi Syed-Nadeem
- Zaimis Tilemachos
- Zain Wan Zainira Wan
- Zainy Rhendra Hardy Mohamad
- Zakaria Andee Dzulkarnaen
- Zakaria Maheen
- Zakaria Zaidi
- Zamudio-Bautista Jorge Luis
- Zanc Loredana
- Zanoni Andrea
- Zanus Giacomo
- Zapparoli Alessandro
- Zappone Anna
- Zarzava Eirini
- Zatari Dirar
- Zawadzki Marek
- Zayakov Georgi
- Zaycev Andrey
- Zazo Aya
- Zazo Rama
- Zdravkovic Maja
- Zengin Abdullah KaÄan
- Zeringa Georgia
- Zimmerman David D E
- Zuhdy Mohammad
- Zvirych Vitalii
- Zywicka Ewa
- Ălvarez-Llano Laura
- Ăngelo Miguel Duarte
- ĂSullivan Sara Nuñez
- Ăzçelik Mehmet Faik
- Äoza Ivo
- Ćanlı Ahmet Necati
- Publication venue
- Publication date
- 01/01/2023
- Field of study
Background
Anastomotic leak affects 8 per cent of patients after right colectomy with a 10-fold increased risk of postoperative death. The EAGLE study aimed to develop and test whether an international, standardized quality improvement intervention could reduce anastomotic leaks.
Methods
The internationally intended protocol, iteratively co-developed by a multistage Delphi process, comprised an online educational module introducing risk stratification, an intraoperative checklist, and harmonized surgical techniques. Clusters (hospital teams) were randomized to one of three arms with varied sequences of intervention/data collection by a derived stepped-wedge batch design (at least 18 hospital teams per batch). Patients were blinded to the study allocation. Low- and middle-income country enrolment was encouraged. The primary outcome (assessed by intention to treat) was anastomotic leak rate, and subgroup analyses by module completion (at least 80 per cent of surgeons, high engagement; less than 50 per cent, low engagement) were preplanned.
Results
A total 355 hospital teams registered, with 332 from 64 countries (39.2 per cent low and middle income) included in the final analysis. The online modules were completed by half of the surgeons (2143 of 4411). The primary analysis included 3039 of the 3268 patients recruited (206 patients had no anastomosis and 23 were lost to follow-up), with anastomotic leaks arising before and after the intervention in 10.1 and 9.6 per cent respectively (adjusted OR 0.87, 95 per cent c.i. 0.59 to 1.30; P = 0.498). The proportion of surgeons completing the educational modules was an influence: the leak rate decreased from 12.2 per cent (61 of 500) before intervention to 5.1 per cent (24 of 473) after intervention in high-engagement centres (adjusted OR 0.36, 0.20 to 0.64; P < 0.001), but this was not observed in low-engagement hospitals (8.3 per cent (59 of 714) and 13.8 per cent (61 of 443) respectively; adjusted OR 2.09, 1.31 to 3.31).
Conclusion
Completion of globally available digital training by engaged teams can alter anastomotic leak rates. Registration number: NCT04270721 (http://www.clinicaltrials.gov)