694 research outputs found

    Pharmacokinetics and oral bioavailability of metformin hydrochloride in healthy mixed-breed dogs

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    The Outstanding Decisions of the United States Supreme Court in 1954

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    We perform a kinematic and morphological analysis of 44 star-forming galaxies at z ̃ 2 in the COSMOS legacy field using near-infrared spectroscopy from Keck/MOSFIRE and F160W imaging from CANDELS/3D-HST as part of the ZFIRE survey. Our sample consists of cluster and field galaxies from 2.0 < z < 2.5 with K-band multi-object slit spectroscopic measurements of their Hα emission lines. Hα rotational velocities and gas velocity dispersions are measured using the Heidelberg Emission Line Algorithm (HELA), which compares directly to simulated 3D data cubes. Using a suite of simulated emission lines, we determine that HELA reliably recovers input S 0.5 and angular momentum at small offsets, but V 2.2/σ g values are offset and highly scattered. We examine the role of regular and irregular morphology in the stellar mass kinematic scaling relations, deriving the kinematic measurement S 0.5, and finding {log}({S}0.5)=(0.38+/- 0.07){log}(M/{M}☉ -10)+(2.04+/- 0.03) with no significant offset between morphological populations and similar levels of scatter (̃0.16 dex). Additionally, we identify a correlation between M ⋆ and V 2.2/σ g for the total sample, showing an increasing level of rotation dominance with increasing M ⋆, and a high level of scatter for both regular and irregular galaxies. We estimate the specific angular momenta (j disk) of these galaxies and find a slope of 0.36 ± 0.12, shallower than predicted without mass-dependent disk growth, but this result is possibly due to measurement uncertainty at M ⋆ < 9.5 However, through a Kolmogorov-Smirnov test we find irregular galaxies to have marginally higher j disk values than regular galaxies, and high scatter at low masses in both populations

    Generic Dynamic Modelling for Grid Integration of Ocean Energy Devices

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    International audienceAs ocean wave and tidal stream technologies approach commercial readiness, grid operators need to assess the impact a wave or tidal device will have on the electrical grid under both normal and fault conditions. In order to achieve this, it will be necessary for each device developer to supply dynamic models of their device to the grid operator. A generic modelling approach is proposed to facilitate the integration of ocean energy devices into the electrical grid, from the perspective of both device developers and grid operators. This paper outlines issues surrounding dynamic modelling for ocean energy devices, and proposes a generic model structure based on data obtained from a recent survey of device developers. The proposed model structure would simulate the power flow through a device using generic parameters which can be obtained from empirical test data and equipment specifications

    Towards a grapho-phonologically parsed corpus of medieval Scots:Database design and technical solutions

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    This paper presents a newly constructed corpus of sound-to-spelling mappings in medieval Scots, which stems from the work of the From Inglis to Scots (FITS) project. We have developed a systematic approach to the relationships between individual spellings and proposed sound values, and recorded these mutual links in a relational database. In this paper, we introduce the theoretical underpinnings of sound-to-spelling and spelling-to-sound mappings, and show how a Scots root morpheme undergoes grapho-phonological parsing, the analytical procedure that is employed to break down spelling sequences into sound units. We explain the data collection and annotation for the FITS Corpus (Alcorn et al., forthcoming), drawing attention to the extensive meta-data which accompany each analysed unit of spelling and sound. The database records grammatical and lexical information about the root, the positional arrangement of segments within the root, labels for the nuclei, vowels and consonants, the morphological context, and extra-linguistic detail of the text a given root was taken from (date, place and text type). With this wealth of information, the FITS corpus is capable of answering complex queries about the sound and spelling systems of medieval Scots. We also suggest how our methodology can be transferred to other non-standardised spelling systems

    Update of High Resolution (e,e'K^+) Hypernuclear Spectroscopy at Jefferson Lab's Hall A

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    Updated results of the experiment E94-107 hypernuclear spectroscopy in Hall A of the Thomas Jefferson National Accelerator Facility (Jefferson Lab), are presented. The experiment provides high resolution spectra of excitation energy for 12B_\Lambda, 16N_\Lambda, and 9Li_\Lambda hypernuclei obtained by electroproduction of strangeness. A new theoretical calculation for 12B_\Lambda, final results for 16N_\Lambda, and discussion of the preliminary results of 9Li_\Lambda are reported.Comment: 8 pages, 5 figures, submitted to the proceedings of Hyp-X Conferenc

    Measurement of the Condensation Coefficient of Water in the UMR Cloud Simulation Chamber

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    Measurements of the condensation coefficient of water under conditions closely approximating those in natural atmospheric cloud have been made in the cooled-wall UMR cloud simulation chamber. Current measurements disclose a value of condensation coefficient near unity at the outset of the experiment, generally decreasing to lower values (~ .01) as the experiment progresses. The significance of the magnitude of condensation coefficient in atmospheric cloud is briefly discussed

    Automatic Classification of Autistic Child Vocalisations: A Novel Database and Results

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    Humanoid robots have in recent years shown great promise for supporting the educational needs of children on the autism spectrum. To further improve the efficacy of such interactions, user-adaptation strategies based on the individual needs of a child are required. In this regard, the proposed study assesses the suitability of a range of speech-based classification approaches for automatic detection of autism severity according to the com- monly used Social Responsiveness Scale ™ second edition (SRS- 2). Autism is characterised by socialisation limitations including child language and communication ability. When compared to neurotypical children of the same age these can be a strong indi- cation of severity. This study introduces a novel dataset of 803 utterances recorded from 14 autistic children aged between 4 – 10 years, during Wizard-of-Oz interactions with a humanoid robot. Our results demonstrate the suitability of support vector machines (SVMs) which use acoustic feature sets from multiple Interspeech C OM P AR E challenges. We also evaluate deep spec- trum features, extracted via an image classification convolutional neural network (CNN) from the spectrogram of autistic speech instances. At best, by using SVMs on the acoustic feature sets, we achieved a UAR of 73.7 % for the proposed 3-class task

    GI Bleeding in the Elderly

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    Purpose: To determine the risk factors contributing to and etiologies of gastrointestinal bleeding in an elderly patient population seen by Southwest Gastroenterology (SWGA) providers. Methods: This study reviews charts of patients with GI bleeding from documented sources between 1/1999 and 3/2006. The cases are gathered retrospectively from the clinical records of SWGA, a 12-person private, single specialty gastroenterology group serving community hospitals. Etiology and risk factors for GI hemorrhages are recorded in an elderly population, defined as patients age 55 and older. Results: GI hemorrhages are identified in 105 patients. The majority (83, 79%) of hemorrhages are upper GI bleeds (UGIB) comparing to 22 (21%) lower GI bleeds (LGIB). In the UGIB group, the most common etiology of bleed is gastric ulcer (29%). We also found 72% of UGIB patients on prescribed anticoagulation medications, including anti-platelet agents or non-steroidal anti-inflammatory drugs (NSAIDs). 20% of these patients are also positive for H. Pylori. Thirty patients in the UGIB group smoke or consume alcohol heavily (consuming more than 3 drinks per day for men and two drinks per day for women) while 2 patients smoke or consume alcohol in the LGIB group. Previous bleeds are common in both groups with 39 (41%) in UGIB and 9 (47%) in LGIB. Co-morbidity is the most common risk factor with 20 (91%) in LGIB and 73 (88%) in UGIB. In the peptic ulcer disease (PUD) bleeds, the majority (77%) are taking NSAIDs, while in the non-PUD bleeds, only 38% are currently on NSAIDs. Overall, there are 2 mortalities resulting from cardiovascular complications of GI bleeding. Conclusion: The etiologies of GI bleeds in this population are comparable to other studies in the literature. The ratio of UGIB to LGIB in this elderly population is also similar to that reported in the literature. The risk factors shown to be most correlated to bleeding are co-morbidities, previous episodes of bleeding, anticoagulation, NSAID use, smoking and alcohol use. NSAID use is significant in PUD bleed patients. This study reinforces that increased knowledge of etiology, incidence and contributing factors of GI bleeding are necessary for physicians to efficiently treat GI bleeds in the elderly population

    MOSEL: Strong [OIII]5007 \AA\ Emitting Galaxies at (3<z<4) from the ZFOURGE Survey

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    To understand how strong emission line galaxies (ELGs) contribute to the overall growth of galaxies and star formation history of the universe, we target Strong ELGs (SELGs) from the ZFOURGE imaging survey that have blended (Hb+[OIII]) rest-frame equivalent widths of >230A and 2.5<zphot<4.0. Using Keck/MOSFIRE, we measure 49 redshifts for galaxies brighter than Ks=25 mag as part of our Multi-Object Spectroscopic Emission Line (MOSEL) survey. Our spectroscopic success rate is ~53% and zphot uncertainty is sigma_z= [Delta(z)/(1+z)]=0.0135. We confirm 31 ELGs at 3<zspec<3.8 and show that Strong ELGs have spectroscopic rest-frame [OIII]5007A equivalent widths of 100-500A and tend to be lower mass systems [log(Mstar/Msun)~8.2-9.6] compared to more typical star-forming galaxies. The Strong ELGs lie ~0.9 dex above the star-forming main-sequence at z~3.5 and have high inferred gas fractions of fgas~>60%, i.e. the inferred gas masses can easily fuel a starburst to double stellar masses within ~10-100 Myr. Combined with recent results using ZFOURGE, our analysis indicates that 1) strong [OIII]5007A emission signals an early episode of intense stellar growth in low mass (Mstar<0.1M*) galaxies and 2) many, if not most, galaxies at z>3 go through this starburst phase. If true, low-mass galaxies with strong [OIII]5007A emission (EW_rest>200A) may be an increasingly important source of ionizing UV radiation at z>3.Comment: Astrophysical Journal, in pres
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