COMPLEXO INDUSTRIAL E PORTUÁRIO DE SUAPE, PERNAMBUCO: UMA PERSPECTIVA

Há uma multiplicidade de perspectivas e tipos de conhecimento sobre o espaço-sociedade, entretanto, optamos por abordá-lo a partir de sua diversidade e complexidade. Assim, a proposta deste artigo é entender o CIPS, não apenas do ponto de vista de sua funcionalidade econômica e produtiva, mas também suas significações sociais. Algumas questões metodológicas e instrumentos teóricos respaldam a análise. Fez-se pesquisa bibliográfica, para a investigação teórica e conceitual da abordagem institucional, destacando-se o pensamento de Veblen (1965) e Douglass North (1993), que resgata conceitos como o de instituições e organizações e sobre a sociologia das relações, com Gusmão (1970), Fernandes (1993) e Elias e Scotson (2000), bem como pesquisa de campo para bem conhecer a subjetividade da realidade. Conclui que, nesse espaço escolhido pelo capital, objetos, ações, instituições e políticas públicas estão direcionados a colaborar com a modernidade e com o grande capital, acompanhados da geração de emprego e do crescimento econômico, todavia o processo de inclusão social não vem sendo contemplado e os conflitos sociais estão presentes.Palavras-Chave: Espaço. Conflitos sociais. Funcionalidade econômica. Instituições. Complexidade

Anti-ganglioside antibodies in patients with Zika virus infection-associated Guillain-Barré Syndrome in Brazil.

Zika virus infection is associated with the development of Guillain-Barré syndrome (GBS), a neurological autoimmune disorder caused by immune recognition of gangliosides and other components at nerve membranes. Using a high-throughput ELISA, we have analyzed the anti-glycolipid antibody profile, including gangliosides, of plasma samples from patients with Zika infections associated or not with GBS in Salvador, Brazil. We have observed that Zika patients that develop GBS present higher levels of anti-ganglioside antibodies when compared to Zika patients without GBS. We also observed that a broad repertoire of gangliosides was targeted by both IgM and IgG anti-self antibodies in these patients. Since Zika virus infects neurons, which contain membrane gangliosides, antigen presentation of these infected cells may trigger the observed autoimmune anti-ganglioside antibodies suggesting direct infection-induced autoantibodies as a cause leading to GBS development. Collectively, our results establish a link between anti-ganglioside antibodies and Zika-associated GBS in patients

Mosquito-Borne Viral Diseases: Control and Prevention in the Genomics Era

Mosquito-borne viral diseases are infections transmitted by the bite of infected mosquitoes. The burden of these diseases is highest in tropical and subtropical areas and they disproportionately affect the poorest populations. Since 2014, major outbreaks of dengue, chikungunya, yellow fever and Zika have afflicted populations and overwhelmed health systems in many countries. Distribution of mosquito-borne diseases is determined by complex demographic, environmental and social factors, causing diseases to emerge in countries where they were previously unknown. Coupling genomic diagnostics and epidemiology to innovative digital disease detection platforms raises the possibility of an open, global, digital pathogen surveillance system. Considering pathogen surveillance in mind, real-time sequencing, bioinformatics tools and the combination of genomic and epidemiological data from viral infections can give essential information for understanding the past and the future of an epidemic, making possible to establish an effective surveillance framework on tracking the spread of infections to other geographic regions

Mortalidade e internação por doença hepática na Amazônia Ocidental entre 2008 a 2017

Introduction: As liver diseases (LDs) occur as liver damage takes place, their causes are variable and mostly caused by viruses and alcohol intake. The cases of LDs have increased significantly; they are also charged with mortality rates and hospitalizations. Objective: to analyze mortality and hospitalizations due to LDs in the Western Amazon. Methods: Ecological study with time series design using secondary data related to deaths and hospital admissions for LDs in the Western Amazon. Results: The number of cases of mortality due to male diseases is higher in men, considering the period from 2008 to 2017. The study results also show that the affected patients are mostly over 50 and under 20 years old, who are the least likely to die. Regarding hospitalization rates, male patients have the highest number of hospitalizations and are not different from mortality; patients over the age of 50 also represent the largest hospitalization cases. Conclusion: There is a tendency towards stability in cases of mortality and hospitalization due to liver diseases in the Western Amazonia.Introdução: As Doenças Hepáticas acontecem assim que ocorrem danificações no fígado, suas causas são variáveis e em sua maioria causada por vírus e ingesta de bebidas alcoólicas. Os números de casos dessa doença têm aumentado significativamente, aumentando também as taxas de mortalidade e as internações por conta da mesma. Objetivo: Avaliar a mortalidade e a internação por doença hepática na Amazônia Ocidental. Método: Estudo ecológico com delineamento de série temporal com utilização de dados de natureza secundária referentes aos óbitos e internações hospitalares por doença hepática na Amazônia Ocidental. Resultados: O número de casos de mortalidade por doenças do figado é maior no sexo masculino, considerando o periodo de 2008 a 2017 no estado da Amazônia Ocidental. Além disso, os resultados do estudo mostram que os pacientes afetados possuem em grande parte, idade superior a 50 anos e os menores de 20 anos, são os que menos vão ao óbito. Em relação a taxa de internação, os pacientes do sexo masculino são os responsáveis pelo maior número de internações relacionadas a essas doenças e não diferente da mortalidade, os pacientes com idade superior a 50 anos também representam os maiores casos de internação. Conclusão: Evidenciou que há uma tendência de estabilidade de casos de mortalidade e internação por doenças hepáticas no estado da Amazônia Ocidental

KNOWLEDGE OF HEALTH SCIENCES UNDERGRADUATE STUDENTS IN OBJECTIVE TESTS ON BASIC LIFE SUPPORT

Introduction: Sudden Cardiac Arrest (SCA) is a serious public health problem and represents one of the leading causes of death in the world. In emergency situations the assessment of the victim and care must be effective, to reduce negative outcomes and to increase the survival rate. Objective: To analyze graduation students in the Health Sciences through objective testing on Basic Life Support (BLS). Methods: This is a descriptive, observational and cross sectional study, performed in the State of São Paulo, Brazil. The study population consisted of 664 graduation students in Medicine, Nursing, Physiotherapy, Pharmacy, Nutrition and Occupational Therapy. Data collection occurred through an instrument in the form of objective tests based on the guidelines for Basic Life Support from the American Heart Association. For analysis the Shapiro-Wilk, Chi-square, Mann-Whitney and Kruskal-Wallis tests were used. The adopted confidence level was 95%. The statistical program used was Stata 11.0. Result: There was found to be a prevalence of students who were female (82.23%), single (77.56%), on the physiotherapy course (53.16%), in the freshmen year (32.2%) with previous training (54.45%) and with a median age of 22 years old. When the association between the scores was analyzed according to sex, marital status, previous training, course and year of study, the relation between the number of correct answers and previous training, course and year of study showed statistically significant differences (p < 0.001). Conclusion: 99.9% of subjects had lower score than the minimum score of 84% of Americam Heart Association, which characterizes insufficient knowledge about the basic support of life theme. Thus, there is need for continued training of health sciences students on the subject, at the undergraduate level

Lipidomic Analysis Reveals Serum Alteration of Plasmalogens in Patients Infected With ZIKA Virus

Zika virus (ZIKV) is an arthropod-borne virus (arbovirus) in the Flavivirus genus of the Flaviviridae family. Since the large outbreaks in French Polynesia in 2013–2014 and in Brazil in 2015, ZIKV has been considered a new public health threat. Similar to other related flavivirus, ZIKV is associated with mild and self-limiting symptoms such as rash, pruritus, prostration, headache, arthralgia, myalgia, conjunctivitis, lower back pain and, when present, a short-term low grade fever. In addition, ZIKV has been implicated in neurological complications such as neonatal microcephaly and Guillain–Barré syndrome in adults. Herein, serum lipidomic analysis was used to identify possible alterations in lipid metabolism triggered by ZIKV infection. Patients who presented virus-like symptoms such as fever, arthralgia, headache, exanthema, myalgia and pruritus were selected as the control group. Our study reveals increased levels of several phosphatidylethanolamine (PE) lipid species in the serum of ZIKV patients, the majority of them plasmenyl-phosphatidylethanolamine (pPE) (or plasmalogens) linked to polyunsaturated fatty acids. Constituting up to 20% of total phospholipids in humans, plasmalogens linked to polyunsaturated fatty acids are particularly enriched in neural membranes of the brain. The biosynthesis of plasmalogens requires functional peroxisomes, which are important sites for viral replication, including ZIKV. Thus, increased levels of plasmalogens in serum of ZIKV infected subjects suggest a link between ZIKV life cycle and peroxisomes. Our data provide important insights into specific host cellular lipids that are likely associated with ZIKV replication and may serve as platform for antiviral strategy against ZIKV

Mapping the molecular characteristics of Brazilian human T-cell lymphotropic virus type 1 Env (gp46) and Pol amino acid sequences for vaccine design

Agradecimentos a Elisabeth Deliège pela assistência técnica.This study was carried out to evaluate the molecular pattern of all available Brazilian human T-cell lymphotropic virus type 1 Env (n = 15) and Pol (n = 43) nucleotide sequences via epitope prediction, physicochemical analysis, and protein potential sites identification, giving support to the Brazilian AIDS vaccine program. In 12 previously described peptides of the Env sequences we found 12 epitopes, while in 4 peptides of the Pol sequences we found 4 epitopes. The total variation on the amino acid composition was 9 and 17% for human leukocyte antigen (HLA) class I and class II Env epitopes, respectively. After analyzing the Pol sequences, results revealed a total amino acid variation of 0.75% for HLA-I and HLA-II epitopes. In 5 of the 12 Env epitopes the physico-chemical analysis demonstrated that the mutations magnified the antigenicity profile. The potential protein domain analysis of Env sequences showed the loss of a CK-2 phosphorylation site caused by D197N mutation in one epitope, and a N-glycosylation site caused by S246Y and V247I mutations in another epitope. Besides, the analysis of selection pressure have found 8 positive selected sites (w = 9.59) using the codon-based substitution models and maximum-likelihood methods. These studies underscore the importance of this Env region for the virus fitness, for the host immune response and, therefore, for the development of vaccine candidates

Mobile real-time surveillance of Zika virus in Brazil

Submitted by Ana Maria Fiscina Sampaio ([email protected]) on 2016-11-29T17:59:25Z No. of bitstreams: 1 Faria N R Mobil real....pdf: 357343 bytes, checksum: 5e7279515aa41c01d0c75ed09a95c5b2 (MD5)Approved for entry into archive by Ana Maria Fiscina Sampaio ([email protected]) on 2016-11-29T18:43:34Z (GMT) No. of bitstreams: 1 Faria N R Mobil real....pdf: 357343 bytes, checksum: 5e7279515aa41c01d0c75ed09a95c5b2 (MD5)Made available in DSpace on 2016-11-29T18:43:34Z (GMT). No. of bitstreams: 1 Faria N R Mobil real....pdf: 357343 bytes, checksum: 5e7279515aa41c01d0c75ed09a95c5b2 (MD5) Previous issue date: 2016-09-29University of Oxford. Department of Zoology. South Parks Road. Oxford, UK.University of Sao Paulo. Department of Infectious Diseases and Institute of Tropical Medicine. São Paulo, BrasilMinistry of Health. Evandro Chagas Institute. Center for Technological Innovation. Ananindeua, PA, Brasil / University of Texas Medical Branch. Department of Pathology. Galveston, USAFundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversity of Birmingham. Institute of Microbiology and Infection. Birmingham, UK.The World Health Organization has declared Zika virus an international public health emergency. Knowledge of Zika virus genomic epidemiology is currently limited due to challenges in obtaining and processing samples for sequencing. The ZiBRA project is a United Kingdom-Brazil collaboration that aims to improve this situation using new sequencing technologies

Opsoclonus-myoclonus-ataxia syndrome associated with chikungunya and dengue virus co-infection

Submitted by Ana Maria Fiscina Sampaio ([email protected]) on 2018-09-19T16:55:58Z No. of bitstreams: 1 Rosario MS Opsoclonus-Myoclonus-Ataxia Syndrome....pdf: 514736 bytes, checksum: 2d645cdbe4121ce8c8d637e1a2c7ed2d (MD5) Approved for entry into archive by Ana Maria Fiscina Sampaio ([email protected]) on 2018-09-19T17:27:26Z (GMT) No. of bitstreams: 1 Rosario MS Opsoclonus-Myoclonus-Ataxia Syndrome....pdf: 514736 bytes, checksum: 2d645cdbe4121ce8c8d637e1a2c7ed2d (MD5) Made available in DSpace on 2018-09-19T17:27:26Z (GMT). No. of bitstreams: 1 Rosario MS Opsoclonus-Myoclonus-Ataxia Syndrome....pdf: 514736 bytes, checksum: 2d645cdbe4121ce8c8d637e1a2c7ed2d (MD5) Previous issue date: 2018 CNPq-National Council for Scientific and Technological Development (302584/2015-3) and MCTI-Ministry of Science, Technology, Innovation/FINEP–Funding Authority for Studies and Projects/FNDCT–National Fund for the Development of Science and Technology (04160060-00/2016) Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Secretaria Estadual da Saúde da Bahia. Hospital Geral Roberto Santos. Salvador, BA, Brasil Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / University of Rome Tor Vergata. Rome, Italy Secretaria Estadual da Saúde da Bahia. Hospital Geral Roberto Santos. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil Secretaria Estadual da Saúde da Bahia. Hospital Geral Roberto Santos. Salvador, BA, Brasil University of Oxford. Department of Zoology. Oxford, UK Instituto Evandro Chagas. Centro de Tecnologia e Inovação. Ananindeua, PA, Brasil Instituto Evandro Chagas. Centro de Tecnologia e Inovação. Ananindeua, PA, Brasil Instituto Evandro Chagas. Centro de Tecnologia e Inovação. Ananindeua, PA, Brasil Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil Opsoclonus-myoclonus-ataxia syndrome (OMAS) is a rare neurological disorder characterized by irregular multidirectional eye movements, myoclonus, cerebellar ataxia, sleep disturbances, and cognitive dysfunction. Although most commonly related to paraneoplastic syndrome, this condition has occasionally been described following infectious illnesses. This article reports the first case of OMAS in association with chikungunya and dengue virus co-infection. The genetic analysis identified chikungunya virus of East/Central/South African genotype and dengue serotype 4 virus of genotype II. This report represents an unusual clinical syndrome associated with viral co-infection and reinforces the need for clinical vigilance with regard to neurological syndromes in the context of emergent arboviruses