La tumba romana de Orippo, Sevilla

En este articulo se desarrolla la metodología antropológica sobre dos incineraciones procedentes de una tumba romana de Orippo (Sevilla), excavada en 1988 y datada en el siglo I DC. La tumba fue construida para albergar los huesos quemados de una joven de edad comprendida entre 13 y 15 años, como se deduce de la fusión epifisaria de algunos huesos y del desarrollo de la dentición. La tumba fue reutilizada, probablemente algún tiempo después, para depositar dos urnas de cristal que contenían los huesos quemados de una mujer de edad comprendida entre 40 y 50 años, que padecía artrosis vertebral y coxofemoral, así como hiperóstosis interna del frontal.In this paper we present the anthropological study of two incinerations. They were found in a roman tomb excavated in 1988 in Orippo (Sevilla), and dated in the I century AC. The tomb was built to contain the burnt bones of a young woman betwen 13 and 15 years of age, as it is concluded of the epiphyseal union of some bones and of the dental development. The tomb was used again, probably sometime later, in orden to deposit two glass ums that contained the burnt bones of a woman, 40 o 50 years old, with a vertebral and coxofemoral arthropathy, and also internal hyperostosis of the frontal bone

Aspectos docentes sobre enfermedades raras en las universidades españolas

Trabajo presentado al VI Congreso Internacional de Medicamentos Huérfanos y Enfermedades Raras: IV Mesa Redonda y Coloquio: Acciones institucionales enrelación con lasEnfermedades Raras, celebrado en Sevilla (España) del 14 al 16 de febrero de 2013 y organizado por el Real e Ilustre Colegio Oficial de Farmacéuticos de Sevilla, la Federación Española de Enfermedades Raras (FEDER), la Fundación MEHUER y la Fundación FEDER.Mesa patrocinada por AMGEN.Peer Reviewe

Plant polyamines in stress and development: an emerging area of research in plant sciences.

Compelling evidence indicates the participation of polyamines in abiotic and biotic stress responses in plants. Indeed, genetic engineering of polyamine levels in plants has successfully improved biotic and abiotic stress resistance in model plants and crops. We anticipate that many of the current challenges in agriculture to cope with climate change and maintain nutritional quality of fruits and vegetables can be approached by considering the polyamine pathway..

Bifurcation of closed orbits from equilibria of Newtonian systems with Coriolis forces

We consider autonomous Newtonian systems with Coriolis forces in two and three dimensions and study the existence of branches of periodic orbits emanating from equilibria. We investigate both degenerate and nondegenerate situations. While Lyapunov’s center theorem applies locally in the nondegen- erate, nonresonant context, equivariant degree theory provides a global answer which is significant also in some degenerate cases. We apply our abstract results to a problem from Celestial Mechanics. More precisely, in the three-dimensional version of the Restricted Triangular Four- Body Problem with possibly different primaries our results show the existence of at least seven branches of periodic orbits emanating from the stationary points

Characterization and Drugs Screening in Human Dermal Fibroblasts Derived From Patient With Amiotrophic Lateral Sclerosis

Motivation: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease caused by the loss of motor neurons. Though currently we unknow its etiology, there are several alterations related to its physiopathology, such as mutation in Superoxide dismutase-1 (SOD-1), an enzyme which prevents free radical production, and intracellular non-avaliable iron accumulation, both alterations have been observed in the patient. The mutated form of this enzyme tends to form fibrillar aggregates on the cytoplasm. In this way, the research line have two parts: the molecular characterization of the disease, and the elimination or reduction of  intracellular iron accumulation and the reestablishment of modified protein levels. Treatments screening allows to increase patient's survival due to we use commercialized compounds, with this approximation we can skip long proccess of drugs commercialization.Methods: Human Dermal Fibroblast (HDF) primary cultures with and without pathological background are used. Iron accumulation in this cultures is observed by Prussian Blue technique. Expression protein levels are measured by Western Blotting, TransferBlot, InmmunoBlot and ChemicDoc developing. Quantifications were calculated with ImageJ software.Preliminar Results: We observed differences in the expression protein levels involved in autophagy proccess (P62, LC3B), antioxidative activity (GPX, SOD1), lipid peroxidation (PLA2G6) and lisosomal dynamic (LAMP1). Drugs screening allowed to select several drugs which reduced intracellular iron levels. With this technique we did another screening combining that drugs to select the best combination

Magnetic properties of Fe0.9-qMn0.1Alq disordered alloys: Theory

ABSTRACT: By using the free-energy variational method based on the Bogoliubov inequality and a diluted and randombond Ising model with nearest-neighbors interactions, we investigate the magnetic phase diagram and some of the magnetic properties of the disordered Fe0.92qMn0.1Alq alloys system. Thus the mean magnetization per site, and hence the average hyperfine magnetic field, are computed. The so-obtained results are compared with room-temperature experimental data obtained by 57Fe Mo¨ssbauer spectroscopy and vibrating sample magnetometry, from which a very good agreement is achieved. Here, the occurrence of a ‘‘critical concentration’’ at 40.0 at.% Al, for which the system passes from a ferromagnetically ordered state to a paramagnetic one, is evidenced. The model allows obtaining an estimate of the exchange energy between Fe-Fe pairs. How this energy depends on the Al concentration and the role of the manganese atoms is also presented and discussed

Polyamines: Small Amines with Large Effects on Plant Abiotic Stress Tolerance

In recent years, climate change has altered many ecosystems due to a combination of frequent droughts, irregular precipitation, increasingly salinized areas and high temperatures. These environmental changes have also caused a decline in crop yield worldwide. Therefore, there is an urgent need to fully understand the plant responses to abiotic stress and to apply the acquired knowledge to improve stress tolerance in crop plants. The accumulation of polyamines (PAs) in response to many abiotic stresses is one of the most remarkable plant metabolic responses. In this review, we provide an update about the most significant achievements improving plant tolerance to drought, salinity, low and high temperature stresses by exogenous application of PAs or genetic manipulation of endogenous PA levels. We also provide some clues about possible mechanisms underlying PA functions, as well as known cross-talks with other stress signaling pathways. Finally, we discuss about the possible use of PAs for seed priming to induce abiotic stress tolerance in agricultural valuable crop plants

Is Inflammation a Mitochondrial Dysfunction-Dependent Event in Fibromyalgia?

Fibromyalgia (FM) is a complex disorder that affects up to 5% of the general population worldwide. Both mitochondrial dysfunction and inflammation have been implicated in the pathophysiology of FM. We have investigated the possible relationship between mitochondrial dysfunction, oxidative stress, and inflammation in FM. We studied 30 women diagnosed with FM and 20 healthy women. Blood mononuclear cells (BMCs) from FM patients showed reduced level of coenzyme Q10 (CoQ10) and mtDNA contents and high level of mitochondrial reactive oxygen species (ROS) and serum tumor necrosis factor (TNF)-alpha and transcript levels. A significant negative correlation between CoQ10 and TNF-alpha levels (r= -0.588; p < 0.01), and a positive correlation between ROS and TNF-alpha levels (r = 0.791; p < 0.001) were observed accompanied by a significant correlation of visual analogical scale with serum TNF-alpha and transcript levels (r = 0.4507; p < 0.05 and r = 0.7089; p < 0.001, respectively). TNF-alpha release was observed in an in vitro (BMCs) and in vivo (mice) CoQ10 deficiency model. Oral CoQ10 supplementation restored biochemical parameters and induced a significant improvement in clinical symptoms ( p < 0.001). These results lead to the hypothesis that inflammation could be a mitochondrial dysfunction-dependent event implicated in the pathophysiology of FM in several patients indicating at mitochondria as a possible new therapeutic target.Unión Europea FIS PI10/00543Servicio Andaluz de Salud Junta de Andalucía SAS 111242Junta de Andalucía CTS-572

Estudio energético de un motor de encendido por compresión y arquitectura 2-tiempos operando con el concepto de combustión parcialmente premezclada

[ES] Dicho proyecto se encuentra dentro de un proyecto de colaboración “Powertrain of future lightduty vehicles (POWERFUL)” cuyo fin es la investigación y desarrollo de futuros motores de vehículos ligeros para transporte terrestre. Está compuesto por los siguientes sub-proyectos: V1. Motor de 4T MEP caracterizado por bajas emisiones y bajo coste. V2. Motor de 4TMEC con combustible a medida e integrando el modo LTC (Low Temperature Combustion) al sistema de encendido por compresión. V3. Concepto de motor 2T funcionando con combustible diésel e integrando el modo LTHC (Low Termal Homogeneous Combustion) al sistema de encendido por compresión. El presente trabajo se enmarca en este sub-proyecto. El sub-proyecto V3 se parte de la base de los resultados obtenidos por el proyecto NICE de la Unión Europea; cuyo fin era el desarrollo de una combustión pura en modo HCCI (Homogeneous Charge CompressionlIgnition) cumpliendo los límites de la norma Euro6 sin necesidad de caros sistemas de post-tratamiento. Por contra, el consumo de combustible sufrió un aumento de entre el 2% y el 5%, además de un rango de par y potencia reducido. El modo HCCI era aceptable para un rango de 3 a 8 bares de presión efectiva media indicada (IMEP); por debajo de 3 bares de IMEP, las inestabilidades en la combustión obligaban a utilizar el modo LTC. Otro aspecto era poder obtener un tipo de combustión mixto buscando una reducción de los óxidos de nitrógeno (NOx), obteniendo el nuevo concepto LTHC, combustión homogénea con baja carga térmica. Las bajas temperaturas se consiguen a través de la recirculación interna de gases (IGR), que a su vez dan lugar a una reducción significante de emisiones de hidrocarburos sin quemar (HC) y monóxido de carbono (CO), uno de los mayores inconvenientes del modo HCCI puro.Alcázar López, A. (2016). Estudio energético de un motor de encendido por compresión y arquitectura 2-tiempos operando con el concepto de combustión parcialmente premezclada. http://hdl.handle.net/10251/73185.TFG