Distinct magnetic signatures of fractional vortex configurations in multiband superconductors

Vortices carrying fractions of a flux quantum are predicted to exist in multiband superconductors, where vortex core can split between multiple band-specific components of the superconducting condensate. Using the two-component Ginzburg-Landau model, we examine such vortex configurations in a two-band superconducting slab in parallel magnetic field. The fractional vortices appear due to the band-selective vortex penetration caused by different thresholds for vortex entry within each band-condensate, and stabilize near the edges of the sample. We show that the resulting fractional vortex configurations leave distinct fingerprints in the static measurements of the magnetization, as well as in ac dynamic measurements of the magnetic susceptibility, both of which can be readily used for the detection of these fascinating vortex states in several existing multiband superconductors.Comment: 5 pages, 4 figure

The Application of Convolutional Neural Networks to Detect Slow, Sustained Deformation in InSAR Time Series

Automated systems for detecting deformation in satellite InSAR imagery could be used to develop a global monitoring system for volcanic and urban environments. Here we explore the limits of a CNN for detecting slow, sustained deformations in wrapped interferograms. Using synthetic data, we estimate a detection threshold of 3.9cm for deformation signals alone, and 6.3cm when atmospheric artefacts are considered. Over-wrapping reduces this to 1.8cm and 5.0cm respectively as more fringes are generated without altering SNR. We test the approach on timeseries of cumulative deformation from Campi Flegrei and Dallol, where over-wrapping improves classication performance by up to 15%. We propose a mean-filtering method for combining results of different wrap parameters to flag deformation. At Campi Flegrei, deformation of 8.5cm/yr was detected after 60days and at Dallol, deformation of 3.5cm/yr was detected after 310 days. This corresponds to cumulative displacements of 3 cm and 4 cm consistent with estimates based on synthetic data

Estudo preliminar sobre as formigas (Hymenoptera: Formicidae) associadas ao olival da Terra Quente Transmontana (Nordeste de Portugal).

Com o presente estudo pretendeu-se contribuir para identificar as principais espécies de formigas associadas ao olival da Terra Quente Transmontana (Nordeste de Portugal) e por outro lado, conhecer diferentes aspectos do seu comportamento, como os que se referem à época de maior ocorrência das diferentes espécies, ao período do dia em que apresentam maior actividade nas árvores e à sua importância na protecção contra espécies nocivas. As observações decorreram entre Abril e Junho de 1999, num olival de cerca de 50 anos de idade, isento de tratamentos fitossanitários há vários anos e conduzido em regime de sequeiro. Com periodicidade semanal seleccionaram-se ao acaso três árvores, cujo tronco se observou durante 10 minutos em quatro períodos distintos do dia - 9, 11, 15 e 17 horas -, para recolha de todas as formigas presentes. Estas identificaram-se como pertencentes a dez espécies: Crematogaster scutellaris Oliv., Tapinoma nigerrimwn Nyl., Tetramorium semilaeve André, Cataglyphis hispânica Emery, C. ibérica Emery, Camponotus piceus Leach, C. lateralis Oliv., C.foreli Emery, Leptothorax angustulus Nyl. e Plagiolepis pygmaea (Latr.). T. nigerrimum foi a espécie mais abundante, quer no conjunto dos exemplares identificados, com 89,4% destes exemplares, quer em cada uma das datas de amostragem e períodos do dia. A maior actividade registou-se nas amostragens correspondentes às 9 e 17 horas, quando se obtiveram 30,7% e 30,2% do total de exemplares. Nove dos indivíduos recolhidos transportavam presas visíveis, que eram, em seis casos, lagartas de Prays oleae (Bern.), num caso um adulto de Euphyllura olivina Costa e noutro, uma ninfa de Psocoptera e um indivíduo não identificado. Das formigas que transportavam presas, três pertenciam à espécie T. nigerrimum, três a C. piceus, duas a C. hispânica e uma a C. scutellaris

Identified hadron production at high transverse momenta in p+p collisions at sqrt(NN) = 200 GeV in STAR

We report the transverse momentum (pT) distributions for identified charged pions, protons and anti-protons using events triggered by high deposit energy in the Barrel Electro-Magnetic Calorimeter (BEMC) from p + p collisions at psNN = 200 GeV. The spectra are measured around mid-rapidity (|y|<0.5) over the range of 3<pT<15 GeV/c with particle identification (PID) by the relativistic ionization energy loss (rdE/dx) in the Time Projection Chamber (TPC) in the Solenoidal Tracker at RHIC (STAR). The charged pion, proton and anti-proton spectra at high pT are compared with published results from minimum bias triggered events and the Next-Leading-Order perturbative quantum chromodynamic (NLO pQCD) calculations (DSS, KKP and AKK 2008). In addition, we present the particle ratios of pi-/pi+, pbar/p, p/pi+ and pbar/pi- in p + p collisions.Comment: 4 pages, 4 figures, Hot Quark 2008 proceedin

Microstructure characterisation and mechanical properties of a functionally-graded NbC/high chromium white cast iron composite

A functionally graded NbC – high chromium white cast iron composite was successfully fabricated by centrifugal casting for high wear applications. The migration of primary NbC particles to the outer periphery, as predicted by Stokes’ law, resulted in an extremely hard outer layer at the surface of a softer bulk material. Microstructural characterisation showed that both the volume fraction and the morphology of the carbides varies along the thickness of the specimen. At the outer surface, the NbC was present as primary carbides while Chinese-script NbC was found in the bulk of the material. Hardness, sliding wear and three-point bending tests confirmed that the outer layer was harder and more wear resistant than the rest of the material, which was correspondingly tougher. The study of the fracture surface of the specimens showed that there is a strong bond between NbC and the matrix such that delamination between the reinforcements and the matrix did not occur during fracture. If Chinese-script NbC can be reduced or prevented in the bulk material, further improvements to toughness could be achieved.ARC LP130100111, ARC DE150101703, FEDER POCI-01-0145-FEDER-00763

The ETS factor ESE3/EHF represses IL-6 preventing STAT3 activation and expansion of the prostate cancer stem-like compartment.

Metastatic prostate cancer represents a yet unsolved clinical problem due to the high frequency of relapse and treatment resistance. Understanding the pathways that lead to prostate cancer progression is an important task to prevent this deadly disease. The ETS transcription factor ESE3/EHF has an important role in differentiation of human prostate epithelial cells. Loss of ESE3/EHF in prostate epithelial cells determines transformation, epithelial-to-mesenchymal transition (EMT) and acquisition of stem-like properties. In this study we identify IL-6 as a direct target of ESE3/EHF that is activated in prostate epithelial cells upon loss of ESE3/EHF. ESE3/EHF and IL-6 were significantly inversely correlated in prostate tumors. Chromatin immunoprecipitation confirmed binding of ESE3/EHF to a novel ETS binding site in the IL-6 gene promoter. Inhibition of IL-6 reverted transformation and stem-like phenotype in tumorigenic ESE3/EHF knockdown prostate epithelial cell models. Conversely, IL-6 stimulation induced malignant phenotypes, stem-like behavior and STAT3 activation. Increased level of IL-6 was observed in prostatospheres compared with adherent bulk cancer cells and this was associated with stronger activation of STAT3. Human prostate tumors with IL-6 elevation and loss of ESE3/EHF were associated with STAT3 activation and displayed upregulation of genes related to cell adhesion, cancer stem-like and metastatic spread. Pharmacological inhibition of IL-6/STAT3 activation by a JAK inhibitor restrained cancer stem cell growth in vitro and inhibited self-renewal in vivo. This study identifies a novel connection between the transcription factor ESE3/EHF and the IL-6/JAK/STAT3 pathway and suggests that targeting this axis might be preferentially beneficial in tumors with loss of ESE3/EHF

The pro-resolving lipid mediator Maresin 1 ameliorates pain responses and neuroinflammation in the spared nerve injury-induced neuropathic pain: A study in male and female mice

Specialized pro-resolving mediators (SPMs) have recently emerged as promising therapeutic approaches for neuropathic pain (NP). We evaluated the effects of oral treatment with the SPM Maresin 1 (MaR1) on behavioral pain responses and spinal neuroinflammation in male and female C57BL/6J mice with spared nerve injury (SNI)-induced NP. MaR1, or vehicle, was administered once daily, on post-surgical days 3 to 5, by voluntary oral intake. Sensory-discriminative and affective-motivational components of pain were evaluated with von Frey and place escape/avoidance paradigm (PEAP) tests, respectively. Spinal microglial and astrocytic activation were assessed by immunofluorescence, and the spinal concentration of cytokines IL-1 & beta;, IL-6, IL-10, and macrophage colony-stimulating factor (M-CSF) were evaluated by multiplex immunoassay. MaR1 treatment reduced SNI-induced mechanical hypersensitivity on days 7 and 11 in both male and female mice, and appeared to ameliorate the affective component of pain in males on day 11. No definitive conclusions could be drawn about the impact of MaR1 on the affective-motivational aspects of pain in female mice, since repeated suprathreshold mechanical stimulation of the affected paw in the dark compartment did not increase the preference of vehicle-treated SNI females for the light side, during the PEAP test session (a fundamental assumption for PAEP's validity). MaR1 treatment also reduced ipsilateral spinal microglial and astrocytic activation in both sexes and marginally increased M-CSF in males, while not affecting cytokines IL-1 & beta;, IL-6 and IL-10 in either sex. In summary, our study has shown that oral treatment with MaR1 (i) produces antinociception even in an already installed peripheral NP mouse model, and (ii) this antinociception may extend for several days beyond the treatment time-frame. These therapeutic effects are associated with attenuated microglial and astrocytic activation in both sexes, and possibly involve modulation of M-CSF action in males.& nbsp;This work was supported by University of Porto/Faculty of Medicine (https://sigarra.up.pt/fmup) and ESF - European Social Fund (https://ec. europa.eu/esf/home.jsp), through NORTE2020 - North Portugal Regional Operational Programme [NORTE-08-5369-FSE-000011-Doctoral Programmes - LTS' PhD fellowship], and by Fundacao Grunenthal Portugal (https://www. fundacaogrunenthal.pt), Bolsa Jovens Investigadores em Dor 2018 - LTS). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript