Expectations Regarding Gastein Healing Gallery Treatment and Their Connection to Health-Related Quality of Life

The present study examines connections between patient expectations and health-related quality of life. We explore a key distinction between expectations about general health and expectations for functional improvement. Patients were 1444 individuals with multiple conditions experiencing chronic pain who were seeking treatment at the Gastein Healing Gallery in Böckstein, near Bad Gastein, Austria. In addition to measures of expectations, patients completed measures of pain, mental and physical health, life satisfaction, fatigue, and sleep problems. Structural equation models were used to fit a latent variable model where both expectation variables were used to predict health-related quality of life. Results showed that expectations regarding potential functional improvement resulting from treatments at the Gastein Healing Gallery were associated with improved health-related quality of life. Expectations about general health improvements related to treatment were not associated with health-related quality of life. To facilitate optimal healing, clinicians may decide to emphasize expectations about functional recovery when discussing treatment methods similar to those offered at the Gastein Healing Gallery, and in so doing, health-related quality of life may benefit

Toward Bioinspired Polymer Adhesives: Activation Assisted Via HOBt For Grafting of Dopamine Onto Poly(Acrylic Acid)

The design of bioinspired polymers has long been an area of intense study, however, applications to the design of concrete admixtures for improved materials performance have been relatively unexplored. In this work, we functionalized poly(acrylic acid) (PAA), a simple analogue to polycarboxylate ether admixtures in concrete, with dopamine to form a catechol-bearing polymer (PAA-g-DA). Synthetic routes using hydroxybenzotriazole (HOBt) as an activating agent were examined for their ability in grafting dopamine to the PAA backbone. Previous literature using the traditional coupling reagent 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDC) to graft dopamine to PAA were found to be inconsistent and the sensitivity of EDC coupling reactions necessitated a search for an alternative. Additionally, HOBt allowed for greater control over per cent functionalization of the backbone, is a simple, robust reaction, and showed potential for scalability. This finding also represents a novel synthetic pathway for amide bond formation between dopamine and PAA. Finally, we performed preliminary adhesion studies of our polymer on rose granite specimens and demonstrated a 56% improvement in the mean adhesion strength over unfunctionalized PAA. These results demonstrate an early study on the potential of PAA-g-DA to be used for improving the bonds within concrete

Oritavancin vs Standard of Care for Treatment of Nonendovascular Gram-Positive Bloodstream Infections

BACKGROUND: Data is limited comparing oritavancin (ORT) to the standard-of-care (SOC) for the treatment gram-positive blood stream infections (BSI). METHODS: This was a retrospective study of all patients in the Veteran\u27s Affairs Health Care System treated with at least 1 dose of oritavancin or at least 5 days of vancomycin, daptomycin, ceftaroline, ampicillin, ampicillin-sulbactam, nafcillin, oxacillin, or cefazolin for a documented gram-positive BSI from 1 January 2015 to 30 June 2021. Patients with polymicrobial blood cultures or positive cultures from other sites were included if the organisms were sensitive to the incident antimicrobial; no concomitant antimicrobials could be used once the incident agent was started. Individuals were also excluded if they were diagnosed with endocarditis, had a neutrophil count 96-hours of treatment before the incident antimicrobial was started.The primary composite outcome was clinical failure, defined as all-cause mortality within 30-days from the end of therapy, or blood cultures positive for the incident organisms ≥72 hours after administration of the first dose and ≤30 days after the administration of the final dose of the study antimicrobial, or any drug or line-related readmissions within 30-days of hospital discharge. RESULTS: Two hundred-forty patients were identified for screening with 96 meeting criteria (27 in ORT and 69 in SOC groups). Baseline characteristics were generally balanced between groups except more patients in the ORT group received \u3e96-hours of treatment before the incident antimicrobial was started (70.3% (19/27) vs 13.04% 9/69); CONCLUSIONS: ORT appears to be a safe and effective option when directly compared to the SOC for non-endocarditis BSIs

“I finally felt i had the tools to control these urges”: empowering students to achieve their device use goals with the reduce digital distraction workshop

Digital self-control tools (DSCTs) help people control their time and attention on digital devices, using interventions like distraction blocking or usage tracking. Most studies of DSCTs’ effectiveness have focused on whether a single intervention reduces time spent on a single device. In reality, people may require combinations of DSCTs to achieve more subjective goals across multiple devices. We studied how DSCTs can address individual needs of university students (n = 280), using a workshop where students reflect on their goals before exploring relevant tools. At 1-3 month follow-ups, 95% of respondents still used at least one type of DSCT, typically applied across multiple devices, and there was substantial variation in the tool combinations chosen. We observed a large increase in self reported digital self-control, suggesting that providing a space to articulate goals and self-select appropriate DSCTs is a powerful way to support people who struggle to self-regulate digital device use

In vivo selectivity and localization of reactive oxygen species (ROS) induction by osmium anticancer complexes that circumvent platinum resistance

YesPlatinum drugs are widely used for cancer treatment. Other precious metals are promising, but their clinical progress depends on achieving different mechanisms of action to overcome Pt-resistance. Here, we evaluate 13 organo-Os complexes: 16-electron sulfonyl-diamine catalysts [(η6-arene)Os(N,N′)], and 18-electron phenylazopyridine complexes [(η6-arene)Os(N,N’)Cl/I]+ (arene = p-cymene, biphenyl, or terphenyl). Their antiproliferative activity does not depend on p21 or p53 status, unlike cisplatin, and their selective potency toward cancer cells involves the generation of reactive oxygen species. Evidence of such a mechanism of action has been found both in vitro and in vivo. This work appears to provide the first study of osmium complexes in the zebrafish model, which has been shown to closely model toxicity in humans. A fluorescent osmium complex, derived from a lead compound, was employed to confirm internalization of the complex, visualize in vivo distribution, and confirm colocalization with reactive oxygen species generated in zebrafish.Wellcome Trust (grant no. 107691/Z/15/Z), ERC (grant nos. 247450, 324594), Science City (AWM and ERDF), WCPRS and Bruker Daltonics (Studentship for JPCC), Mike and Enfys Bagguley, and EPSRC (Studentship for HEB, and grant no. EP/F034210/1)

JADES: Resolving the Stellar Component and Filamentary Overdense Environment of HST-Dark Submillimeter Galaxy HDF850.1 at z=5.18z=5.18

HDF850.1 is the brightest submillimeter galaxy (SMG) in the Hubble Deep Field. It is known as a heavily dust-obscured star-forming galaxy embedded in an overdense environment at $z = 5.18$. With nine-band NIRCam images at 0.8-5.0 $\mu$m obtained through the JWST Advanced Deep Extragalactic Survey (JADES), we detect and resolve the rest-frame UV-optical counterpart of HDF850.1, which splits into two components because of heavy dust obscuration in the center. The southern component leaks UV and H$\alpha$ photons, bringing the galaxy $\sim$100 times above the empirical relation between infrared excess and UV continuum slope (IRX-$\beta_\mathrm{UV}$). The northern component is higher in dust attenuation and thus fainter in UV and H$\alpha$ surface brightness. We construct a spatially resolved dust attenuation map from the NIRCam images, well matched with the dust continuum emission obtained through millimeter interferometry. The whole system hosts a stellar mass of $10^{11.0\pm0.1}\,\mathrm{M}_\odot$ and star-formation rate of $10^{3.0\pm0.2}\,\mathrm{M}_\odot\,\mathrm{yr}^{-1}$, placing the galaxy at the massive end of the star-forming main sequence at this epoch. We further confirm that HDF850.1 resides in a complex overdense environment at $z=5.17-5.30$, which hosts another luminous SMG at $z=5.30$ (GN10). The filamentary structures of the overdensity are characterized by 109 H$\alpha$-emitting galaxies confirmed through NIRCam slitless spectroscopy at 3.9-5 $\mu$m, of which only eight were known before the JWST observations. Given the existence of a similar galaxy overdensity in the GOODS-S field, our results suggest that $50\pm20$% of the cosmic star formation at $z=5.1-5.5$ occur in protocluster environments.Comment: 44 pages, 16 figures, 2 tables. Resubmitted to ApJ after including the first-round referee's comment

JADES: Resolving the Stellar Component and Filamentary Overdense Environment of Hubble Space Telescope (HST)-dark Submillimeter Galaxy HDF850.1 at z = 5.18

© 2024 The Author(s). Published by the American Astronomical Society. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY), https://creativecommons.org/licenses/by/4.0/HDF850.1 is the brightest submillimeter galaxy (SMG) in the Hubble Deep Field. It is known as a heavily dust-obscured star-forming galaxy embedded in an overdense environment at z = 5.18. With nine-band NIRCam images at 0.8–5.0 μm obtained through the JWST Advanced Deep Extragalactic Survey, we detect and resolve the rest-frame UV–optical counterpart of HDF850.1, which splits into two components because of heavy dust obscuration in the center. The southern component leaks UV and Hα photons, bringing the galaxy ∼100 times above the empirical relation between infrared excess and UV continuum slope (IRX–β UV). The northern component is higher in dust attenuation and thus fainter in UV and Hα surface brightness. We construct a spatially resolved dust-attenuation map from the NIRCam images, well matched with the dust continuum emission obtained through millimeter interferometry. The whole system hosts a stellar mass of 1010.8±0.1 M ⊙ and star formation rate (SFR) of 102.8±0.2 M ⊙ yr−1, placing the galaxy at the massive end of the star-forming main sequence at this epoch. We further confirm that HDF850.1 resides in a complex overdense environment at z = 5.17–5.30, which hosts another luminous SMG at z = 5.30 (GN10). The filamentary structures of the overdensity are characterized by 109 Hα-emitting galaxies confirmed through NIRCam slitless spectroscopy at 3.9–5 μm, of which only eight were known before the JWST observations. Given the existence of a similar galaxy overdensity in the GOODS-S field, our results suggest that 50% ± 20% of the cosmic star formation at z = 5.1–5.5 occur in protocluster environments.Peer reviewe

JADES: Rest-frame UV-to-NIR Size Evolution of Massive Quiescent Galaxies from Redshift z=5 to z=0.5

We present the UV-to-NIR size evolution of a sample of 161 quiescent galaxies (QGs) with $M_*>10^{10}M_\odot$ over $0.5<z<5$. With deep multi-band NIRCam images in GOODS-South from JADES, we measure the effective radii ($R_e$) of the galaxies at rest-frame 0.3, 0.5 and 1$\mu m$. On average, QGs are 45% (15%) more compact at rest-frame 1$\mu m$ than they are at 0.3$\mu m$ (0.5$\mu m$). Regardless of wavelengths, the $R_e$ of QGs strongly evolves with redshift, and this evolution depends on stellar mass. For lower-mass QGs with $M_*=10^{10}-10^{10.6}M_\odot$, the evolution follows $R_e\sim(1+z)^{-1.1}$, whereas it becomes steeper, following $R_e\sim(1+z)^{-1.7}$, for higher-mass QGs with $M_*>10^{10.6}M_\odot$. To constrain the physical mechanisms driving the apparent size evolution, we study the relationship between $R_e$ and the formation redshift ($z_{form}$) of QGs. For lower-mass QGs, this relationship is broadly consistent with $R_e\sim(1+z_{form})^{-1}$, in line with the expectation of the progenitor effect. For higher-mass QGs, the relationship between $R_e$ and $z_{form}$ depends on stellar age. Older QGs have a steeper relationship between $R_e$ and $z_{form}$ than that expected from the progenitor effect alone, suggesting that mergers and/or post-quenching continuous gas accretion drive additional size growth in very massive systems. We find that the $z>3$ QGs in our sample are very compact, with mass surface densities $\Sigma_e\gtrsim10^{10} M_\odot/\rm{kpc}^2$, and their $R_e$ are possibly even smaller than anticipated from the size evolution measured for lower-redshift QGs. Finally, we take a close look at the structure of GS-9209, one of the earliest confirmed massive QGs at $z_{spec}\sim4.7$. From UV to NIR, GS-9209 becomes increasingly compact, and its light profile becomes more spheroidal, showing that the color gradient is already present in this earliest massive QG.Comment: 28 pages, 19 figures, submitted to Ap

A recently quenched galaxy 700 million years after the Big Bang

© 2024 The Author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY), https://creativecommons.org/licenses/by/4.0/Local and low-redshift ($z$10^{10}~M_{\odot}$) and relatively old. Here we report a (mini-)quenched galaxy at z$=$7.3, when the Universe was only 700~Myr old. The JWST/NIRSpec spectrum is very blue ($U$-$V$$=$0.16$\pm0.03$~mag), but exhibits a Balmer break and no nebular emission lines. The galaxy experienced a short starburst followed by rapid quenching; its stellar mass (4-6$\times 10^8~M_\odot$) falls in a range that is sensitive to various feedback mechanisms, which can result in perhaps only temporary quenching.Peer reviewe

Spectroscopic confirmation of two luminous galaxies at a redshift of 14

© 2024 The Author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY), https://creativecommons.org/licenses/by/4.0/The first observations of the James Webb Space Telescope (JWST) have revolutionized our understanding of the Universe by identifying galaxies at redshift z ≈ 13 (refs. 1–3). In addition, the discovery of many luminous galaxies at Cosmic Dawn (z > 10) has suggested that galaxies developed rapidly, in apparent tension with many standard models4–8. However, most of these galaxies lack spectroscopic confirmation, so their distances and properties are uncertain. Here we present JWST Advanced Deep Extragalactic Survey–Near-Infrared Spectrograph spectroscopic confirmation of two luminous galaxies at z=14.32−0.20+0.08 and z = 13.90 ± 0.17. The spectra reveal ultraviolet continua with prominent Lyman-α breaks but no detected emission lines. This discovery proves that luminous galaxies were already in place 300 million years after the Big Bang and are more common than what was expected before JWST. The most distant of the two galaxies is unexpectedly luminous and is spatially resolved with a radius of 260 parsecs. Considering also the very steep ultraviolet slope of the second galaxy, we conclude that both are dominated by stellar continuum emission, showing that the excess of luminous galaxies in the early Universe cannot be entirely explained by accretion onto black holes. Galaxy formation models will need to address the existence of such large and luminous galaxies so early in cosmic history.Peer reviewe