The Low CO Content of the Extremely Metal Poor Galaxy I Zw 18

We present sensitive molecular line observations of the metal-poor blue compact dwarf I Zw 18 obtained with the IRAM Plateau de Bure interferometer. These data constrain the CO J=1-0 luminosity within our 300 pc (FWHM) beam to be L_CO < 1 \times 10^5 K km s^-1 pc^2 (I_CO < 1 K km s^-1), an order of magnitude lower than previous limits. Although I Zw 18 is starbursting, it has a CO luminosity similar to or less than nearby low-mass irregulars (e.g. NGC 1569, the SMC, and NGC 6822). There is less CO in I Zw 18 relative to its B-band luminosity, HI mass, or star formation rate than in spiral or dwarf starburst galaxies (including the nearby dwarf starburst IC 10). Comparing the star formation rate to our CO upper limit reveals that unless molecular gas forms stars much more efficiently in I Zw 18 than in our own galaxy, it must have a very low CO-to-H_2 ratio, \sim 10^-2 times the Galactic value. We detect 3mm continuum emission, presumably due to thermal dust and free-free emission, towards the radio peak.Comment: 5 pages in emulateapj style, accepted by the Astrophysical Journa

BAFF Index and CXCL13 levels in the cerebrospinal fluid associate respectively with intrathecal IgG synthesis and cortical atrophy in multiple sclerosis at clinical onset

Abstract Background B lymphocytes are thought to play a relevant role in multiple sclerosis (MS) pathology. The in vivo analysis of intrathecally produced B cell-related cytokines may help to clarify the mechanisms of B cell recruitment and immunoglobulin production within the central nervous system (CNS) in MS. Methods Paired cerebrospinal fluid (CSF) and serum specimens from 40 clinically isolated syndrome suggestive of MS or early-onset relapsing-remitting MS patients (CIS/eRRMS) and 17 healthy controls (HC) were analyzed for the intrathecal synthesis of IgG (quantitative formulae and IgG oligoclonal bands, IgGOB), CXCL13, BAFF, and IL-21. 3D-FLAIR, 3D-DIR, and 3D-T1 MRI sequences were applied to evaluate white matter (WM) and gray matter (GM) lesions and global cortical thickness (gCTh). Results Compared to HC, CIS/eRRMS having IgGOB (IgGOB+, 26 patients) had higher intrathecal IgG indexes ( p \u2009<\u20090.01), lower values of BAFF Index (11.9\u2009\ub1\u20096.1 vs 17.5\u2009\ub1\u20095.2, p \u2009<\u20090.01), and higher CSF CXCL13 levels (27.7\u2009\ub1\u200933.5 vs 0.9\u2009\ub1\u20091.5, p \u2009<\u20090.005). In these patients, BAFF Index but not CSF CXCL13 levels inversely correlated with the intrathecal IgG synthesis ( r \u2009>\u20090.5 and p \u2009<\u20090.05 for all correlations). CSF leukocyte counts were significantly higher in IgGOB+ compared to IgGOB\u2212 ( p \u2009<\u20090.05) and HC ( p \u2009<\u20090.01), and correlated to CSF CXCL13 concentrations ( r 0.77, p \u2009<\u20090.001). The gCTh was significantly lower in patients with higher CSF CXCL13 levels (2.41\u2009\ub1\u20090.1 vs 2.49\u2009\ub1\u20090.1\ua0mm, p \u2009<\u20090.05), while no difference in MRI parameters of WM and GM pathology was observed between IgGOB+ and IgGOB\u2212. Conclusions The intrathecal IgG synthesis inversely correlated with BAFF Index and showed no correlation with CSF CXCL13. These findings seem to indicate that intrathecally synthesized IgG are produced by long-term PCs that have entered the CNS from the peripheral blood, rather than produced by PCs developed in the meningeal follicle-like structures (FLS). In this study, CXCL13 identifies a subgroup of MS patients characterized by ..

A note on a third order curvature invariant in static spacetimes

We consider here the third order curvature invariant $I=R_{\mu\nu\rho\sigma;\delta}R^{\mu\nu\rho\sigma;\delta}$ in static spacetimes ${\cal M}=R\times\Sigma$ for which $\Sigma$ is conformally flat. We evaluate explicitly the invariant for the $N$-dimensional Majumdar-Papapetrou multi black-holes solution, confirming that $I$ does indeed vanish on the event horizons of such black-holes. Our calculations show, however, that solely the vanishing of $I$ is not sufficient to locate an event horizon in non-spherically symmetric spacetimes. We discuss also some tidal effects associated to the invariant $I$.Comment: 5 pages, 3 figures. Extra material available at http://vigo.ime.unicamp.br/in

Phase transition in the Jarzynski estimator of free energy differences

The transition between a regime in which thermodynamic relations apply only to ensembles of small systems coupled to a large environment and a regime in which they can be used to characterize individual macroscopic systems is analyzed in terms of the change in behavior of the Jarzynski estimator of equilibrium free energy differences from nonequilibrium work measurements. Given a fixed number of measurements, the Jarzynski estimator is unbiased for sufficiently small systems. In these systems, the directionality of time is poorly defined and configurations that dominate the empirical average, but which are in fact typical of the reverse process, are sufficiently well sampled. As the system size increases the arrow of time becomes better defined. The dominant atypical fluctuations become rare and eventually cannot be sampled with the limited resources that are available. Asymptotically, only typical work values are measured. The Jarzynski estimator becomes maximally biased and approaches the exponential of minus the average work, which is the result that is expected from standard macroscopic thermodynamics. In the proper scaling limit, this regime change can be described in terms of a phase transition in variants of the random energy model (REM). This correspondence is explicitly demonstrated in several examples of physical interest: near-equilibrium processes in which the work distribution is Gaussian, the sudden compression of an ideal gas and adiabatic quasi-static volume changes in a dilute real gas.Comment: 29 pages, 5 figures, accepted for publication in Physical Review E (2012

A mid-IR survey of the L 1641-N region with ISOCAM

We present an analysis of the L 1641 outflow region using broad-band and narrow-band imaging data at mid-infrared wavelengths from ISOCAM. We detect a total of 34 sources in the $7.65^{\prime}$ x $8.40^{\prime}$ region covered by the broad-band filters. Four of these sources have no reported detection in previous studies of the region. We find that the source previously identified as the near-IR counter-part to the IRAS detected point-source (IRAS 05338-0624) is not the brightest source in the wavelength region of the IRAS 12 \micron\ filter. We find instead that a nearby object (within the beam of IRAS and not detected at near-IR wavelengths) outshines all others sources in the area by a factor of $\sim$2. We submit that this source is likely to be the IRAS detected point source. A comparison of the near-IR (J-H vs H-K) and mid-IR (J-K vs [6.7 um]-[14 um]) color-color plots shows only four sources with excess emission at near-IR wavelengths, but atleast 85% of all sources show excess emission at mid-IR wavelengths. The CVF spectra suggest a range of evolutionary status in the program stars ranging from embedded YSOs to the young disks. When combined with optical and near-IR age estimates, these results show active current star-formation in the region that has been on-going for at least 2 Myr.Comment: Submitted to ApJ. Abstracted edited for arXiv submission Replaced by version accepted by Ap

Topological BF Theories in 3 and 4 Dimensions

In this paper we discuss topological BF theories in 3 and 4 dimensions. Observables are associated to ordinary knots and links (in 3 dimensions) and to 2-knots (in 4 dimensions). The vacuum expectation values of such observables give a wide range of invariants. Here we consider mainly the 3-dimensional case, where these invariants include Alexander polynomials, HOMFLY polynomials and Kontsevich integrals.Comment: 25 pages, latex, no figures. Transmission problems have been solve

High Excitation Molecular Gas in the Magellanic Clouds

We present the first survey of submillimeter CO 4-3 emission in the Magellanic Clouds. The survey is comprised of 15 6'x6' maps obtained using the AST/RO telescope toward the molecular peaks of the Large and Small Magellanic Clouds. We have used these data to constrain the physical conditions in these objects, in particular their molecular gas density and temperature. We find that there are significant amounts of molecular gas associated with most of these molecular peaks, and that high molecular gas temperatures are pervasive throughout our sample. We discuss whether this may be due to the low metallicities and the associated dearth of gas coolants in the Clouds, and conclude that the present sample is insufficient to assert this effect.Comment: 18 pages, 3 figures, 5 tables. To appear in Ap

Renormalizability of Nonrenormalizable Field Theories

We give a simple and elegant proof of the Equivalence Theorem, stating that two field theories related by nonlinear field transformations have the same S matrix. We are thus able to identify a subclass of nonrenormalizable field theories which are actually physically equivalent to renormalizable ones. Our strategy is to show by means of the BRS formalism that the "nonrenormalizable" part of such fake nonrenormalizable theories, is a kind of gauge fixing, being confined in the cohomologically trivial sector of the theory.Comment: 3 pages, revtex, no figure