Comparación entre la irradiancia espectral UV medida experimentalmente en la estación de Izaña y simulada con los modelos de transferencia radiativa LibRadtran y UVA‐GOA

Financial supports from the Spanish MICIIN (projects CGL2008‐05939‐CO3‐00/CLI and CGL200909740) and from the GR‐220 Project of the “Junta de Castilla y León” are gratefully acknowledged

Comparison of measured and modelled UV spectral irradiance at the Izaña Station based on Libradtran and UVA-GOA models

Póster elaborado para el 37th Annual European Meeting on Atmospheric Studies by Optical Methods celebrado en Valladolid los días 23-26 de agosto de 2010Financial supports from the Spanish MICIIN (ref. CGL2008-05939-CO3-00/CLI and CGL 2009-09740) and from the GR-220 Project of the Junta de Castilla y León are gratefully acknowledge

Presentación de la base de datos y página web de la Red Antártica de Radiómetros NILU-UV

Póster elaborado para el VI Simposio Argentino y III Latinoamericano sobre Investigaciones Antárticas celebrado en Buenos Aires, Argentina los días 10-14 de septiembre de 2007Este trabajo ha sido realizado gracias a la beca de formación de postgraduados del Instituto Nacional de Meteorología dentro del proyecto POLAR-AOD y al proyecto MANA (“Measuring Antarctic Network Aerosols” ) financiado dentro del Plan Nacional I+D del Ministerio de Ciencia y Tecnología (GL2004-05419-CO2-02/ANT)

Myoinvasive pattern as a prognostic marker in low-grade, early-stage endometrioid endometrial carcinoma

Low-grade and early Federation for Gynecology and Obstetrics (FIGO) stage endometrioid endometrial carcinomas (EEC) have an excellent prognosis. However, approximately 10% of patients develop recurrence, which cannot be correctly predicted at diagnosis. We evaluated myoinvasive patterns as a prognostic factor of relapse in low-grade, early-stage EEC. Two-hundred and fifty-eight cases were selected according to the following inclusion criteria: (i) endometrioid endometrial carcinomas, (ii) grade 1 or 2 with (iii) FIGO stage I or II, and (iv) clinical follow-up. Slides were reviewed to annotate the myoinvasive pattern present in each case (infiltrative glands, microcystic, elongated and fragmented –MELF-, broad front, adenomyosis-like and adenoma malignum). Microsatellite instability was studied by immunoexpression of mismatch repair proteins (MLH1, PMS2, MSH2, and MSH6). There were 29 recurrences (11.2%) among the 258 cases analysed. A predominant broad front myoinvasive pattern was significantly associated with tumour relapse (p = 0.003). The presence of a pattern of infiltrative glands (p = 0.001) and microsatellite instability (p = 0.004) were associated with lower disease-free survival, without having an impact on overall survival. Our observations suggest the potential value of the pattern of myoinvasion as a prognostic factor in low-grade, early-stage endometrioid endometrial carcinomaThis research was funded by the Instituto de Salud Carlos III (ISCIII) (PI17/01723), co-financed by the European Development Regional Fund ‘A way to achieve Europe’ (FEDER)

Aplicación de la técnica de Campanelli para la calibración de los canales de vapor de agua de fotómetros CIMEL en el Observatorio Atmosférico de Izaña

Documento realizado por el personal del Centro de Investigación Atmosférica de IzañaEl objeto de esta nota técnica es presentar una aplicación práctica del método de Campanelli relacionado con la mejora de la metodología en el campo de la calibración "in situ" de los canales de vapor de agua de diferentes radiómetros. El método se aplica a los fotómetros CIMEL de la red AERONET que han medido en el Observatorio Atmosférico de Izaña durante 2009 y primer trimestre de 201

Análisis de la capacidad de los modelos de transferencia radiativa para la calibración de los radiómetros: aplicación al radiómetro NILU-UV

Este trabajo se centra en la modelización de la radiación ultravioleta en el Observatorio de Izaña, mediante el uso de dos modelos de transferencia radiativa, uno de alta gama de los denominados de "detallados o de múltiple scattering", el UVSpec/Libratran, y otro de los denominados "espectrales simples", el UVA-GOA, para posteriormente utilizar estos resultados para calibrar de forma absoluta el radiómetro NILU-UV

Clinicopathological features and prognostic significance of CTNNB1 mutation in low-grade, early-stage endometrial endometrioid carcinoma

Low-grade and early-stage endometrioid endometrial carcinomas (EECs) have an overall good prognosis but biomarkers identifying patients at risk of relapse are still lacking. Recently, CTNNB1 exon 3 mutation has been identified as a potential risk factor of recurrence in these patients. We evaluate the prognostic value of CTNNB1 mutation in a single-centre cohort of 218 low-grade, early-stage EECs, and the correlation with beta-catenin and LEF1 immunohistochemistry as candidate surrogate markers. CTNNB1 exon 3 hotspot mutations were evaluated by Sanger sequencing. Immunohistochemical staining of mismatch repair proteins (MLH1, PMS2, MSH2, and MSH6), p53, beta-catenin, and LEF1 was performed in representative tissue microarrays. Tumours were also reviewed for mucinous and squamous differentiation, and MELF pattern. Nineteen (8.7%) tumours harboured a mutation in CTNNB1 exon 3. Nuclear beta-catenin and LEF1 were significantly associated with CTNNB1 mutation, showing nuclear beta-catenin a better specificity and positive predictive value for CTNNB1 mutation. Tumours with CTNNB1 exon 3 mutation were associated with reduced disease-free survival (p = 0.010), but no impact on overall survival was found (p = 0.807). The risk of relapse in tumours with CTNNB1 exon 3 mutation was independent of FIGO stage, tumour grade, mismatch repair protein expression, or the presence of lymphovascular space invasion. CTNNB1 exon 3 mutation has a negative impact on disease-free survival in low-grade, early-stage EECs. Nuclear beta-catenin shows a higher positive predictive value than LEF1 for CTNNB1 exon 3 mutation in these tumoursThis research was funded by the Instituto de Salud Carlos III (ISCIII) (PI17/01723), co-financed by the European Development Regional Fund ‘A way to achieve Europe’ (FEDER

The MACC-II 2007-2008 reanalysis: atmospheric dust validation and characterization over northern Africa and Middle East

Presentación realizada en: MACC-II Open Science Conference celebrada en Bruselas del 27 al 30 de enero de 2014

Gaceta Sanitaria in 2013: changes, challenges and uncertainties

El año 2013 ha sido un año de cambios para GACETA SANITARIA, entre los que destaca su publicación exclusivamente on-line desde el pasado mes de noviembre. Ha sido también un año de intensa actividad, que resumimos en esta nota editorial como viene siendo habitual en los últimos tiempos y siguiendo las recomendaciones del Comité Internacional de Editores de Revistas Biomédicas

Long-term characterisation of the vertical structure of the Saharan Air Layer over the Canary Islands using lidar and radiosonde profiles: implications for radiative and cloud processes over the subtropical Atlantic Ocean

Every year, large-scale African dust outbreaks frequently pass over the Canary Islands (Spain). Here we describe the seasonal evolution of atmospheric aerosol extinction and meteorological vertical profiles on Tenerife over the period 2007–2018 using long-term micropulse lidar (MPL-3) and radiosonde observations. These measurements are used to categorise the different patterns of dust transport over the subtropical North Atlantic and, for the first time, to robustly describe the dust vertical distribution in the Saharan Air Layer (SAL) over this region. Three atmospheric scenarios dominate the aerosol climatology: dust-free (clean) conditions, the Saharan summer scenario (summer-SAL) and the Saharan winter scenario (winter-SAL).This research has received support from the Institute of Physics Belgrade, through the grant by the Ministry of Education, Science, and Technological Development of the Republic of Serbia