PSA Decrease with Fulvestrant Acetate in a Hormone-Resistant Metastatic Prostate Cancer Patient: A Case Report

Metastatic prostate cancer is an incurable disease. After a period of hormone sensitivity that allows for the use of antiandrogens, the disease invariably progresses to a situation of androgen-independent growth, which deserves the consideration or the use of chemotherapy. As many of these patients are elderly and fragile, treatment with chemotherapy is challenging. Therefore, new drugs are required. Preclinical evidence supports the role of estrogen receptor (ER) signaling in prostate cancer. In this paper, we report the first published evidence of PSA control in a patient with metastatic prostate cancer treated with fulvestrant acetate

Análisis histórico y constructivo del Castillo de Planes

Este trabajo final de máster realiza un estudio sobre el Castillo de Planes de la Baronía en Alicante, con el fin de servir de referencia para otras investigaciones o para una futura intervención. Se intenta recabar toda la información relevante para entender y destacar este monumento, que actualmente se encuentra en estado de olvido y abandono. El objetivo del estudio es ser una fuente de información fidedigna ajustada a la realidad actual del recinto, dejando constancia de los elementos con los que cuenta el castillo, su estructura formal y estado de conservación. El trabajo realiza también una recopilación de información histórica y documental sobre el castillo y el pueblo de Planes, para dar a conocer su contexto social y resaltar su importancia como referente defensivo y de control del territorio.Alberola Quirant, JV. (2014). Análisis histórico y constructivo del Castillo de Planes. http://hdl.handle.net/10251/47962.Archivo delegad

"Intervenció terapèutica en usuaris TEA (Transtorn Espectre Autista). Intervenció en les àrees curriculars, Intervenció Logopèdica, Intervenció des de la musicoteràpia"

En aquest document es mostra el procés de reflexió i les conclusions del pràcticum II de psicopedagogia. En ell es mostra la intervenció en nens autistes des de la musicoteràpia. Un document que ajuda als lecotors a entendre millor aquests nens i a pensar que noves teràpies i respostes educatives són possibles

Multi-dimensional adaptation in MAS organizations

© 2013 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.Organization adaptation requires determining the consequences of applying changes not only in terms of the benefits provided but also measuring the adaptation costs as well as the impact that these changes have on all of the components of the organization. In this paper, we provide an approach for adaptation in multiagent systems based on a multidimensional transition deliberation mechanism (MTDM). This approach considers transitions in multiple dimensions and is aimed at obtaining the adaptation with the highest potential for improvement in utility based on the costs of adaptation. The approach provides an accurate measurement of the impact of the adaptation since it determines the organization that is to be transitioned to as well as the changes required to carry out this transition. We show an example of adaptation in a service provider network environment in order to demonstrate that the measurement of the adaptation consequences taken by the MTDM improves the organization performance more than the other approaches.Manuscript received January 2, 2012; revised July 26, 2012; accepted August 7, 2012. Date of publication August 31, 2012; date of current version April 16, 2013. This work was supported in part by projects TIN2008-04446 and TIN2009-13839-C03-01. J. M. Alberola received a Grant from Ministerio de Ciencia e Innovacion de Espana (AP2007-00289). This paper was recommended by Associate Editor J. Huang.Alberola Oltra, JM.; Julian Inglada, VJ.; García-Fornes, A. (2013). Multi-dimensional adaptation in MAS organizations. IEEE Transactions on Systems, Man, and Cybernetics, Part B: Cybernetics. 43(2):622-633. https://doi.org/10.1109/TSMCB.2012.2213592S62263343

Final Report of the First Refractory Germ Cell Tumor Treated with Sunitinib Malate

Patients with advanced germ cell tumors can be cured with cisplatin-based chemotherapy, but the outcome remains unsatisfactory for patients with relapsed disease, including those patients with refractory disease after bone marrow transplantation. Targeted therapies have changed the standard of care for many advanced solid tumors. We have identified, in the literature, potential targets for the treatment of refractory germ cell tumors, and applied to a patient with a refractory disease. We chose sunitinib for this purpose. To our knowledge, this is the first case to be treated with sunitinib, and we have found a promising activity

A computer-based support system for cooperative tasks in nursing homes

Different studies have shown the benefits of a cooperative activities programme for the elderly. Members of a group with similar abilities or disabilities are often encouraged by having the opportunity to share their experiences, knowledge, or opinions. Nevertheless, when caregivers try to plan specific cooperative activities, different aspects, as the individual needs of each person, should be taken into account, which notably increases the complexity of that planification. This paper proposes a computer-based support tool for recreational therapists which facilitates the management task of grouping elderly people into cooperative groups for existing activities. To do this, an iterative learning process is proposed allowing the formation of proper distributions of elderly people into activities. (c) 2019 The Authors. Published by Atlantis Press SARL.This work has been supported by COMPETE: POCI-01-0145-FEDER-007043 and FCT -Fundacao para a Ciencia e Tecnologia within the Project Scope: UID/CEC/00319/2013. A. Costa thanks the Fundacao para a Ciencia e a Tecnologia (FCT) the Post-Doc scholarship with the Ref. SFRH/BPD/102696/2014. This work is also partially supported by the MINECO/FEDER TIN2015-655-15C4-1-R

Problemas resueltos de análisis de riesgos en instalaciones

Enginyeria Industrial. 369: Seguretat i Anàlisi de RiscosBeing able to define which products are creative and which are not in a totally objective way with just one rater is of great importance. Accordingly, this study was conducted with the aim of identifying which methods of evaluating product creativity respond best to the requirements established for a method, namely, it must be useful, objective and simple to apply in enterprises. Likewise, this work also seeks to determine their shortcomings and the possible modifications or adaptations needed to correct them. To accomplish this goal, three known methods of evaluating creativity were analysed and applied to five products in order to determine their creative value, by means of a single rater. The findings are validated by evaluating creativity through questionnaires answered by experts in order to obtain a set of reference values for each parameter that creativity depends on. The analysis of the results, both graphically and numerically, reveals a tendency of the different metrics to display similar results, although they do not coincide in absolute terms due to the different scales and formats used for each metric. The conclusions show the most common shortcomings when it comes to evaluating creativity and, therefore, being able to propose global improvements that should be implemented in order to create a metric for objective creativity

An intelligent self-configurable mechanism for distributed energy storage systems

Next generation of smart grid technologies demand intel- ligent capabilities for communication, interaction, monitoring, storage, and energy transmission. Multiagent systems are envisioned to provide autonomic and adaptability features to these systems in order to gain advantage in their current environments. In this paper we present a mechanism for providing distributed energy storage systems (DESSs) with intelligent capabilities. In more detail, we propose a self-con gurable mechanism which allows a DESS to adapt itself according to the future environmental requirements. This mechanism is aimed at reducing the costs at which energy is purchased from the market.This work has been partially supported by projects TIN2012-36586-C03-01 and TIN2011-27652-C03-01.Alberola Oltra, JM.; Julian Inglada, VJ.; García-Fornes, A. (2014). An intelligent self-configurable mechanism for distributed energy storage systems. Cybernetics and Systems. 45(3):292-305. https://doi.org/10.1080/01969722.2014.894859S292305453Abbey , C. and G. Joos . “Coordination of Distributed Storage with Wind Energy in a Rural Distribution System.” Paper presented at Industry Applications Conference, 42nd IAS Annual Meeting, September 23–27, 2007, New Orleans, USA .Alberola , J. M. , V. Julian , and A. Garcia-Fornes . “Multi-Dimensional Transition Deliberation for Organization Adaptation in Multiagent Systems.” Paper presented at the 11th International Conference on Aut. Agents and MAS (AAMAS12), June 4–8, 2012, Valencia, Spain .Chouhan , N. S. and M. Ferdowsi . “Review of Energy Storage Systems.” Paper presented at North American Power Symposium (NAPS), October 4–6, 2009, Mississippi, USA.Conejo, A. J., Plazas, M. A., Espinola, R., & Molina, A. B. (2005). Day-Ahead Electricity Price Forecasting Using the Wavelet Transform and ARIMA Models. IEEE Transactions on Power Systems, 20(2), 1035-1042. doi:10.1109/tpwrs.2005.846054Costa , L. , F. Bourry , J. Juban , and G. Kariniotakis . “Management of Energy Storage Coordinated with Wind Power under Electricity Market Conditions.” Paper presented at 10th International Conference on Probabilistic Methods Applied to Power Systems, May 25–29, 2008, Rincón, Puerto Rico .Eyer , J. and G. Corey . “Energy Storage for the Electricity Grid: Benefits and Market Potential Assessment Guide.” Sandia National Laboratories, 2010. Technical Report .Jiang , Z. “Agent-Based Control Framework for Distributed Energy Resources Microgrids.” Paper presented at International Conference on Intelligent Agent Technology, December 18–22, 2006, Hong Kong .Karnouskos , S. and T. N. De Holanda . “Simulation of a Smart Grid City with Software Agents.” Paper presented at Third UKSim European Symposium on Computer Modeling and Simulation, November 25–27, 2009, Athens, Greece .Ketter, W., Collins, J., & Reddy, P. (2013). Power TAC: A competitive economic simulation of the smart grid. Energy Economics, 39, 262-270. doi:10.1016/j.eneco.2013.04.015Lakshman, A., & Malik, P. (2010). Cassandra. ACM SIGOPS Operating Systems Review, 44(2), 35. doi:10.1145/1773912.1773922Logenthiran, T., Srinivasan, D., Khambadkone, A. M., & Aung, H. N. (2012). Multiagent System for Real-Time Operation of a Microgrid in Real-Time Digital Simulator. IEEE Transactions on Smart Grid, 3(2), 925-933. doi:10.1109/tsg.2012.2189028Maly, D. K., & Kwan, K. S. (1995). Optimal battery energy storage system (BESS) charge scheduling with dynamic programming. IEE Proceedings - Science, Measurement and Technology, 142(6), 453-458. doi:10.1049/ip-smt:19951929Mihailescu , R. C. , M. Vasirani , and S. Ossowski . “Dynamic Coalition Formation and Adaptation for Virtual Power Stations in Smart Grids.” Paper presented at 2nd International Workshop on Agent Technologies for Energy Systems, May 2, 2011, Taipei, Taiwan .Mohd , A. , E. Ortjohann , A. Schmelter , N. Hamsic , and D. Morton . “Challenges in Integrating Distributed Energy Storage Systems into Future Smart Grid.” Paper presented at IEEE International Symposium on Industrial Electronics, June 30–July 2, 2008, Cambridge, UK .Mohsenian-Rad, A.-H., & Leon-Garcia, A. (2010). Optimal Residential Load Control With Price Prediction in Real-Time Electricity Pricing Environments. IEEE Transactions on Smart Grid, 1(2), 120-133. doi:10.1109/tsg.2010.2055903Momoh , J. A. “Smart Grid Design for Efficient and Flexible Power Networks Operation and Control.” Paper presented at IEEE PES Power Systems Conference and Exposition, March 15–18, 2009, Seattle, USA .Nguyen, C. P., & Flueck, A. J. (2012). Agent Based Restoration With Distributed Energy Storage Support in Smart Grids. IEEE Transactions on Smart Grid, 3(2), 1029-1038. doi:10.1109/tsg.2012.2186833Nourai , A. “Installation of the First Distributed Energy Storage System (DESS) At American Electric Power.” Sandia National Laboratories, 2007. Technical Report.Oyarzabal , J. , J. Jimeno , J. Ruela , A. Engler , and C. Hardt . “Agent Based Micro Grid Management System.” Paper presented at International Conference on Future Power Systems, November 16–18, 2005, Amsterdam, Netherlands .Pinson, P., Chevallier, C., & Kariniotakis, G. N. (2007). Trading Wind Generation From Short-Term Probabilistic Forecasts of Wind Power. IEEE Transactions on Power Systems, 22(3), 1148-1156. doi:10.1109/tpwrs.2007.901117Pipattanasomporn , M. , H. Feroze , and S. Rahman . “Multi-agent Systems in a Distributed Smart Grid: Design and Implementation.” Paper presented at IEEE/PES Power Systems Conference and Exposition, March 15–18, 2009, Seattle, USA .Reddy , P. P. and M. M. Veloso . “Factored Models for Multiscale Decision Making in Smart Grid Customers.” Paper presented at the Twenty-sixth AAAI Conference on Artificial Intelligence, July 22–26, 2012, Toronto, Canada .Ribeiro, P. F., Johnson, B. K., Crow, M. L., Arsoy, A., & Liu, Y. (2001). Energy storage systems for advanced power applications. Proceedings of the IEEE, 89(12), 1744-1756. doi:10.1109/5.975900Schutte , S. and M. Sonnenschein . “Mosaik-Scalable Smart Grid Scenario Specification.” Paper presented at Proceedings of the 2012 Winter Simulation Conference (WSC), December 9–12, 2012, Berlin, Germany .Sioshansi, R., Denholm, P., Jenkin, T., & Weiss, J. (2009). Estimating the value of electricity storage in PJM: Arbitrage and some welfare effects. Energy Economics, 31(2), 269-277. doi:10.1016/j.eneco.2008.10.005Szkuta, B. R., Sanabria, L. A., & Dillon, T. S. (1999). Electricity price short-term forecasting using artificial neural networks. IEEE Transactions on Power Systems, 14(3), 851-857. doi:10.1109/59.780895Van Dam, K. H., Houwing, M., Lukszo, Z., & Bouwmans, I. (2008). Agent-based control of distributed electricity generation with micro combined heat and power—Cross-sectoral learning for process and infrastructure engineers. Computers & Chemical Engineering, 32(1-2), 205-217. doi:10.1016/j.compchemeng.2007.07.012Vosen, S. (1999). Hybrid energy storage systems for stand-alone electric power systems: optimization of system performance and cost through control strategies. International Journal of Hydrogen Energy, 24(12), 1139-1156. doi:10.1016/s0360-3199(98)00175-xVytelingum , P. , T. D. Voice , S. Ramchurn , A. Rogers , and N. R. Jennings . “Agent-Based Micro-Storage Management for the Smart Grid.” Paper presented at Proceedings of the 9th International Conference on Autonomous Agents and Multiagent Systems, May 10–14, 2010a, Toronto, Canada .Vytelingum , P. , T. D. Voice , S. Ramchurn , A. Rogers , and N. R. Jennings . “Intelligent Agents for the Smart Grid.” Paper presented at the 9th International Conference on Autonomous Agents and Multiagent Systems, May 10–14, 2010b, Toronto, Canada

Análisis termohidraulico de piscinas de combustible gastado PWR

Dentro del estudio de Seguridad en Parada de centrales nucleares se ha analizado el comportamiento del reactor bajo diferentes secuencias accidentales utilizando códigos de estimación óptima. Además, en dicha configuración de planta (en parada) las piscinas de combustible gastado están conectadas mediante el canal de transferencia con la cavidad de recarga para realizar la recarga de elementos combustibles. En estas condiciones, un determinado iniciador puede tener consecuencias tanto en el núcleo del reactor como en las piscinas de combustible gastado. Con el objetivo de analizar el comportamiento termohidráulico de las piscinas, y tomando como planta de referencia la central nuclear de Ascó, se ha construido un modelo de TRACE para la piscina haciendo uso de una componente Vessel-3D en coordenadas cartesianas. Dicho modelo ha sido utilizado para la simulación de dos escenarios transitorios: uno de ellos supone la pérdida del sistema de refrigeración de la piscina, mientras que en el segundo se postula la pérdida del sistema de refrigeración junto con una pérdida de refrigerante a través del canal de transferencia, ya que es muy importante conocer los tiempos disponibles de actuación que logren mantener la integridad de los elementos de combustible gastado frente a una pérdida de refrigerante. Ambos escenarios se han simulado suponiendo que la piscina se encuentra completamente llena de elementos combustibles, con lo que la generación de calor residual es la máxima posible.Sánchez Sáez, F.; Serradell García, VJ.; Carlos Alberola, S. (2011). Análisis termohidraulico de piscinas de combustible gastado PWR. Sociedad Nuclear Española. http://hdl.handle.net/10251/71500

Infant gut microbiota modulation by human milk disaccharides in humanized microbiome mice

Human milk glycans present a unique diversity of structures that suggest different mechanisms by which they may affect the infant microbiome development. A humanized mouse model generated by infant fecal transplantation was utilized here to evaluate the impact of fucosyl-α1,3-GlcNAc (3FN), fucosyl-α1,6-GlcNAc, lacto-N-biose (LNB) and galacto-N-biose on the fecal microbiota and host-microbiota interactions. 16S rRNA amplicon sequencing showed that certain bacterial genera significantly increased (Ruminococcus and Oscillospira) or decreased (Eubacterium and Clostridium) in all disaccharide-supplemented groups. Interestingly, cluster analysis differentiates the consumption of fucosyl-oligosaccharides from galactosyl-oligosaccharides, highlighting the disappearance of Akkermansia genus in both fucosyl-oligosaccharides. An increment of the relative abundance of Coprococcus genus was only observed with 3FN. As well, LNB significantly increased the relative abundance of Bifidobacterium, whereas the absolute levels of this genus, as measured by quantitative real-time PCR, did not significantly increase. OTUs corresponding to the species Bifidobacterium longum, Bifidobacterium adolescentis and Ruminococcus gnavus were not present in the control after the 3-week intervention, but were shared among the donor and specific disaccharide groups, indicating that their survival is dependent on disaccharide supplementation. The 3FN-feeding group showed increased levels of butyrate and acetate in the colon, and decreased levels of serum HDL-cholesterol. 3FN also down-regulated the pro-inflammatory cytokine TNF-α and up-regulated the anti-inflammatory cytokines IL-10 and IL-13, and the Toll-like receptor 2 in the large intestine tissue. The present study revealed that the four disaccharides show efficacy in producing beneficial compositional shifts of the gut microbiota and in addition, the 3FN demonstrated physiological and immunomodulatory roles