Molecular Mechanisms Responsible for the Antiinflammatory and Protective Effect of HDL on the Endothelium

In addition to their role in reverse cholesterol transport, high-density lipoproteins (HDL) exert several beneficial effects, including the prevention and correction of endothelial dysfunction. HDL promote endothelium proliferation and diminish endothelial apoptosis; they play a key role in vasorelaxation by increasing the release of nitric oxide and prostacyclin through the induction of the expression and the activity of endothelial nitric oxide synthase and the coupling of cyclooxygenase 2 and prostacyclin synthase. In addition, HDL affect coagulation, fibrynolisis, platelet adhesion, adhesion molecules, and protease expression, and they exert antioxidant activity. These effects are achieved at the gene expression level and are dependent on the activation of several intracellular signaling pathways, including PI3K/Akt, ERK1/2, PKC, and p38MAPK. The complexity of the signaling pathways modulated by HDL reflects the different effects of the components of this class of lipoproteins such as apolipoproteins or lipids on endothelial cell gene expression and the subsequent modulation of endothelial function observed. The in vivo relevance of these findings to endothelial recovery during physiological or pathological conditions remains to be addressed; nevertheless, the results of clinical studies with synthetic HDL, ApoA-I mimetics, and drugs that are becoming available that selectively affect HDL plasma levels and biological functions support the importance of the correction of endothelial function by HDL

Influence of second-order corrections to the energy-dependence of neutrino flavor conversion formulae

We discuss the {\em intermediate} wave-packet formalism for analytically quantifying the energy dependence of the two-flavor conversion formula that is usually considered for analyzing neutrino oscillations and adjusting the focusing horn, target position and/or detector location of some flavor conversion experiments. Following a sequence of analytical approximations where we consider the second-order corrections in a power series expansion of the energy, we point out a {\em residual} time-dependent phase which, in addition to some well known wave-packet effects, can subtly modify the oscillation parameters and limits. In the present precision era of neutrino oscillation experiments where higher precision measurements are required, we quantify some small corrections in neutrino flavor conversion formulae which lead to a modified energy-dependence for $\nu_{\mu}\leftrightarrow\nu_{e}$ oscillations.Comment: 13 pages, 3 figure

Inclusive versus Exclusive EM Processes in Relativistic Nuclear Systems

Connections are explored between exclusive and inclusive electron scattering within the framework of the relativistic plane-wave impulse approximation, beginning with an analysis of the model-independent kinematical constraints to be found in the missing energy--missing momentum plane. From the interplay between these constraints and the spectral function basic features of the exclusive and inclusive nuclear responses are seen to arise. In particular, the responses of the relativistic Fermi gas and of a specific hybrid model with confined nucleons in the initial state are compared in this work. As expected, the exclusive responses are significantly different in the two models, whereas the inclusive ones are rather similar. By extending previous work on the relativistic Fermi gas, a reduced response is introduced for the hybrid model such that it fulfills the Coulomb and the higher-power energy-weighted sum rules. While incorporating specific classes of off-shellness for the struck nucleons, it is found that the reducing factor required is largely model-independent and, as such, yields a reduced response that is useful for extracting the Coulomb sum rule from experimental data. Finally, guided by the difference between the energy-weighted sum rules of the two models, a version of the relativistic Fermi gas is devised which has the 0$^{\rm th}$, 1$^{\rm st}$ and 2$^{\rm nd}$ moments of the charge response which agree rather well with those of the hybrid model: this version thus incorporates {\em a priori} the binding and confinement effects of the stuck nucleons while retaining the simplicity of the original Fermi gas.Comment: LaTex file with 15 .ps figure

Neutrino Oscillations in the Early Universe: A Real Time Formulation

Neutrino oscillations in the early Universe prior to the epoch of primordial nucleosynthesis is studied by implementing real time non-equilibrium field theory methods. We focus on two flavors of Dirac neutrinos, however, the formulation is general. We obtain the equations of motion for neutrino wavepackets of either chirality and helicity in the plasma allowing for CP asymmetry. Contributions non-local in space-time to the self-energy dominate over the asymmetry for $T \gtrsim 3-5 \mathrm{MeV}$ if the lepton and neutrino asymmetries are of the same order as the baryon asymmetry. We find a new contribution which cannot be interpreted as the usual effective potential. The mixing angles and dispersion relations in the medium depend on \emph{helicity}. We find that resonant transitions are possible in the temperature range $10 \lesssim T \ll 100 \mathrm{MeV}$. Near a resonance in the mixing angle, the oscillation time scale in the medium as compared to the vacuum is \emph{slowed-down} substantially for small vacuum mixing angle. The time scale of oscillations \emph{speeds-up} for off resonance high energy neutrinos for which the mixing angle becomes vanishingly small. The equations of motion reduce to the familiar oscillation formulae for negative helicity ultrarelativistic neutrinos, but include consistently both the \emph{mixing angle and the oscillation frequencies in the medium}. These equations of motion also allow to study the dynamics of right handed as well as positive helicity neutrinos.Comment: 31 pages 2 figures. Version to appear in Phys. Rev.

The effects of nonextensive statistics on fluctuations investigated in event-by-event analysis of data

We investigate the effect of nonextensive statistics as applied to the chemical fluctuations in high-energy nuclear collisions discussed recently using the event-by-event analysis of data. It turns out that very minuite nonextensitivity changes drastically the expected experimental output for the fluctuation measure. This results is in agreement with similar studies of nonextensity performed recently for the transverse momentum fluctuations in the same reactions.Comment: Revised version, to be published in J. Phys. G (2000

Meson-exchange currents and quasielastic predictions for charged-current neutrino-12C scattering in the superscaling approach

We evaluate and discuss the impact of meson-exchange currents (MECs) on charged-current quasielastic neutrino cross sections. We consider the nuclear transverse response arising from two-particle two-hole states excited by the action of electromagnetic, purely isovector meson-exchange currents in a fully relativistic framework based on the work by the Torino Collaboration [A. D. Pace, M. Nardi, W. M. Alberico, T. W. Donnelly, and A. Molinari, Nucl. Phys. A726, 303 (2003)]. An accurate parametrization of this MEC response as a function of the momentum and energy transfers involved is presented. Results of neutrino-nucleus cross sections using this MEC parametrization together with a recent scaling approach for the one-particle one-hole contributions (named SuSAv2) are compared with experimental data (MiniBooNE, MINERvA, NOMAD and T2K Collaborations).Comment: 16 pages, 19 figure

Distorted wave impulse approximation analysis for spin observables in nucleon quasi-elastic scattering and enhancement of the spin-longitudinal response

We present a formalism of distorted wave impulse approximation (DWIA) for analyzing spin observables in nucleon inelastic and charge exchange reactions leading to the continuum. It utilizes response functions calculated by the continuum random phase approximation (RPA), which include the effective mass, the spreading widths and the \Delta degrees of freedom. The Fermi motion is treated by the optimal factorization, and the non-locality of the nucleon-nucleon t-matrix by an averaged reaction plane approximation. By using the formalism we calculated the spin-longitudinal and the spin-transverse cross sections, ID_q and ID_p, of 12C, 40Ca (\vec{p},\vec{n}) at 494 and 346 MeV. The calculation reasonably reproduced the observed ID_q, which is consistent with the predicted enhancement of the spin-longitudinal response function R_L. However, the observed ID_p is much larger than the calculated one, which was consistent with neither the predicted quenching nor the spin-transverse response function R_T obtained by the (e,e') scattering. The Landau-Migdal parameter g'_N\Delta for the N\Delta transition interaction and the effective mass at the nuclear center m^*(r=0) are treated as adjustable parameters. The present analysis indicates that the smaller g'_{N\Delta}(\approx 0.3) and m^*(0) \approx 0.7 m are preferable. We also investigate the validity of the plane wave impulse approximation (PWIA) with the effective nucleon number approximation for the absorption, by means of which R_L and R_T have conventionally been extracted.Comment: RevTex 3, 29 pages, 2 tables, 8 figure

Quasielastic K-nucleus scattering

Quasielastic K^+ - nucleus scattering data at q=290, 390 and 480 MeV/c are analyzed in a finite nucleus continuum random phase approximation framework, using a density-dependent particle-hole interaction. The reaction mechanism is consistently treated according to Glauber theory, keeping up to two-step inelastic processes. A good description of the data is achieved, also providing a useful constraint on the strength of the effective particle-hole interaction in the scalar-isoscalar channel at intermediate momentum transfers. We find no evidence for the increase in the effective number of nucleons participating in the reaction which has been reported in the literature.Comment: 21 pages, uses REVTeX and epsfig, 9 postscript figures; replaced version corrects a few minor errors in the tex

Nuclear model effects in Charged Current neutrino--nucleus quasielastic scattering

The quasielastic scattering of muon neutrinos on oxygen 16 is studied for neutrino energies between 200 MeV and 1 GeV using a relativistic shell model. Final state interactions are included within the distorted wave impulse approximation, by means of a relativistic optical potential, with and without imaginary part, and of a relativistic mean field potential. For comparison with experimental data the inclusive charged--current quasielastic cross section for $\nu_\mu$--$^{12}C$ scattering in the kinematical conditions of the LSND experiment at Los Alamos is also presented and briefly discussed.Comment: 4 pages, 5 figures, two-column format. Accepted as brief report in Phys. Rev.