Encuentro del XV Aniversario de la Revista ESPACIOS EN BLANCO: Educación, investigación y difusión

En este largo pero fructífero camino hacia la construcción y difusión del conocimiento, la Revista de Educación Espacios en Blanco cumplió quince años ininterrumpidos de labor desde su propósito fundacional de generar y consolidar ese espacio para compartir experiencias, problematizar e indagar la cuestión educativa. Para su celebración se organizaron –entre otras actividades– cuatro paneles en los que convergieron miembros del Consejo Asesor Externo de la Revista, del Núcleo de Educacionales y Sociales (NEES) y referentes de ámbitos escolares y educativos de la ciudad sede –Tandil–, con el objetivo de brindar sus conocimientos a alumnos, graduados, docentes y a la sociedad en general; como así también seguir poniendo al servicio de la comunidad académica y educativa la producción de saberes, preocupaciones, debates y proyectos futuros. Y más aún: lograr que de ese diálogo y aprendizaje colaborativo podamos seguir orientando nuestra actividad docente e investigativa

PERCEPÇÕES E ENFRENTAMENTOS DE MULHERES QUE VIVENCIARAM DIAGNÓSTICO DE CÂNCER DE MAMA

Objetivou-se conhecer as percepções e enfrentamentos de mulheres que vivenciaram o diagnóstico de câncer de mama. Trata-se de uma pesquisa descritiva com caráter qualitativo, desenvolvida no decorrer do segundo semestre de 2010 e primeiro semestre de 2011, com mulheres diagnosticadas com câncer de mama nos últimos cinco anos, residentes em um município na Região Norte do estado do Rio Grande do Sul. Os resultados permitiram agrupar informações acerca da obtenção e negação do diagnóstico, bem como, o apoio da família. Evidenciou-se a importância de desenvolver trabalhos junto a este público, a fim de traçar estratégias para a atuação da enfermagem neste contexto.-PERCEPTIONS AND COPING OF WOMEN WHO HAVE EXPERIENCED BREAST CANCER DIAGNOSISABSTRACT: It was aimed knowing the perceptions and coping of women who have experienced breast cancer diagnosis. It is a descriptive research with qualitative character, developed during the second half of 2010 and the first half of 2011, with women diagnosed with breast cancer in the last five years, residents in a municipality in the northern region of Rio Grande do Sul. The results enabled grouping information about receiving the diagnosis and its negation, as well as the family support. It was highlighted the importance of developing works along this public, in order to consider strategies for nursing practice in this context.Keywords: Women's health. Breast câncer. Perception

Atividade antineoplásica e tripanocida de Hovenia dulcis Thunb. cultivada in vivo e in vitro

Muitas são as substâncias do metabolismo vegetal que têm despertado grande interesse, principalmente no setor de fármacos. No presente estudo, foram avaliadas as atividades antineoplásica e tripanocida de extratos vegetais de Hovenia dulcis (Rhamnaceae) cultivada sob condições in vivo e in vitro. Extratos metanólicos das folhas de material jovem desenvolvido in vivo e in vitro, exibiram altas porcentagens na inibição do crescimento de todas as linhagens de células tumorais testadas, enquanto extratos etanólicos do pseudofruto mostraram seletividade com elevado percentual de inibição do crescimento celular nas linhagens SP2/0 e BW. Quanto à atividade tripanocida, os extratos aquoso do pseudofruto e metanólico das folhas das plantas germinadas in vivo, apresentaram percentual de inibição em 48 h, de 95% e 100%, respectivamente

Incidence of severe critical events in paediatric anaesthesia (APRICOT): a prospective multicentre observational study in 261 hospitals in Europe

Background Little is known about the incidence of severe critical events in children undergoing general anaesthesia in Europe. We aimed to identify the incidence, nature, and outcome of severe critical events in children undergoing anaesthesia, and the associated potential risk factors. Methods The APRICOT study was a prospective observational multicentre cohort study of children from birth to 15 years of age undergoing elective or urgent anaesthesia for diagnostic or surgical procedures. Children were eligible for inclusion during a 2-week period determined prospectively by each centre. There were 261 participating centres across 33 European countries. The primary endpoint was the occurence of perioperative severe critical events requiring immediate intervention. A severe critical event was defined as the occurrence of respiratory, cardiac, allergic, or neurological complications requiring immediate intervention and that led (or could have led) to major disability or death. This study is registered with ClinicalTrials.gov, number NCT01878760. Findings Between April 1, 2014, and Jan 31, 2015, 31â127 anaesthetic procedures in 30â874 children with a mean age of 6·35 years (SD 4·50) were included. The incidence of perioperative severe critical events was 5·2% (95% CI 5·0â5·5) with an incidence of respiratory critical events of 3·1% (2·9â3·3). Cardiovascular instability occurred in 1·9% (1·7â2·1), with an immediate poor outcome in 5·4% (3·7â7·5) of these cases. The all-cause 30-day in-hospital mortality rate was 10 in 10â000. This was independent of type of anaesthesia. Age (relative risk 0·88, 95% CI 0·86â0·90; p<0·0001), medical history, and physical condition (1·60, 1·40â1·82; p<0·0001) were the major risk factors for a serious critical event. Multivariate analysis revealed evidence for the beneficial effect of years of experience of the most senior anaesthesia team member (0·99, 0·981â0·997; p<0·0048 for respiratory critical events, and 0·98, 0·97â0·99; p=0·0039 for cardiovascular critical events), rather than the type of health institution or providers. Interpretation This study highlights a relatively high rate of severe critical events during the anaesthesia management of children for surgical or diagnostic procedures in Europe, and a large variability in the practice of paediatric anaesthesia. These findings are substantial enough to warrant attention from national, regional, and specialist societies to target education of anaesthesiologists and their teams and implement strategies for quality improvement in paediatric anaesthesia. Funding European Society of Anaesthesiology

Incidence of severe critical events in paediatric anaesthesia (APRICOT): a prospective multicentre observational study in 261 hospitals in Europe

Background Little is known about the incidence of severe critical events in children undergoing general anaesthesia in Europe. We aimed to identify the incidence, nature, and outcome of severe critical events in children undergoing anaesthesia, and the associated potential risk factors. Methods The APRICOT study was a prospective observational multicentre cohort study of children from birth to 15 years of age undergoing elective or urgent anaesthesia for diagnostic or surgical procedures. Children were eligible for inclusion during a 2-week period determined prospectively by each centre. There were 261 participating centres across 33 European countries. The primary endpoint was the occurence of perioperative severe critical events requiring immediate intervention. A severe critical event was defined as the occurrence of respiratory, cardiac, allergic, or neurological complications requiring immediate intervention and that led (or could have led) to major disability or death. This study is registered with ClinicalTrials.gov, number NCT01878760. Findings Between April 1, 2014, and Jan 31, 2015, 31 127 anaesthetic procedures in 30 874 children with a mean age of 6.35 years (SD 4.50) were included. The incidence of perioperative severe critical events was 5.2% (95% CI 5.0-5.5) with an incidence of respiratory critical events of 3.1% (2.9-3.3). Cardiovascular instability occurred in 1.9% (1.7-2.1), with an immediate poor outcome in 5.4% (3.7-7.5) of these cases. The all-cause 30-day in-hospital mortality rate was 10 in 10 000. This was independent of type of anaesthesia. Age (relative risk 0.88, 95% CI 0.86-0.90; p<0.0001), medical history, and physical condition (1.60, 1.40-1.82; p<0.0001) were the major risk factors for a serious critical event. Multivariate analysis revealed evidence for the beneficial effect of years of experience of the most senior anaesthesia team member (0.99, 0.981-0.997; p<0.0048 for respiratory critical events, and 0.98, 0.97-0.99; p=0.0039 for cardiovascular critical events), rather than the type of health institution or providers. Interpretation This study highlights a relatively high rate of severe critical events during the anaesthesia management of children for surgical or diagnostic procedures in Europe, and a large variability in the practice of paediatric anaesthesia. These findings are substantial enough to warrant attention from national, regional, and specialist societies to target education of anaesthesiologists and their teams and implement strategies for quality improvement in paediatric anaesthesia