Notes on the systematic value of the tongue morphology in different genera and species groups of lacertid lizards (Reptilia: Lacertidae)

The tongue shape and its epidermal structure was examined in a stock of palearctic and paleotropical lizards from Europe, Africa, the Middle East and south eastern Asia. The results of this preliminary report clearly point out the systematic importance of this morphological feature in providing valuable generic and specific characters. The fundamental pattern described for the genera Podarcis, Lacerta sensu stricto and Gallotia, e. g., is very distinctive despite several features in common, likely due to ancient phyletic relationships. A number of similar morphological trends stress the reciprocal affinities between Lacerta (Archaeolacerta) and the widely spread genus Podarcis which is still undergoing speciation. Another case is the minor but significant affinities linking the genera Lacerta sensu stricto and Gallotia, the latter also undergoing more complicated speciation due to its insular isolation. The interspecific differences in the taxa belonging to the so-called “species groups” such as Podarcis, are scanty or insignificant. Instead there are striking differences in the generic patterns of the tongue morphology in Afro-Asian lacertid lizards. However, a similar pattern was found in the African genera Adolfus and Holaspis or Centromastix (= Gastropholis according to Arnold, 1989) and Ichnotropis.Material digitalizado en SEDICI gracias a la colaboración del Dr. Jorge Williams (FCNM-UNLP).Facultad de Ciencias Naturales y Muse

Notes on the systematic value of the tongue morphology in different genera and species groups of lacertid lizards (Reptilia: Lacertidae)

The tongue shape and its epidermal structure was examined in a stock of palearctic and paleotropical lizards from Europe, Africa, the Middle East and south eastern Asia. The results of this preliminary report clearly point out the systematic importance of this morphological feature in providing valuable generic and specific characters. The fundamental pattern described for the genera Podarcis, Lacerta sensu stricto and Gallotia, e. g., is very distinctive despite several features in common, likely due to ancient phyletic relationships. A number of similar morphological trends stress the reciprocal affinities between Lacerta (Archaeolacerta) and the widely spread genus Podarcis which is still undergoing speciation. Another case is the minor but significant affinities linking the genera Lacerta sensu stricto and Gallotia, the latter also undergoing more complicated speciation due to its insular isolation. The interspecific differences in the taxa belonging to the so-called “species groups” such as Podarcis, are scanty or insignificant. Instead there are striking differences in the generic patterns of the tongue morphology in Afro-Asian lacertid lizards. However, a similar pattern was found in the African genera Adolfus and Holaspis or Centromastix (= Gastropholis according to Arnold, 1989) and Ichnotropis.Material digitalizado en SEDICI gracias a la colaboración del Dr. Jorge Williams (FCNM-UNLP).Facultad de Ciencias Naturales y Muse

A case of pulmonary edema: The critical role of lung-heart integrated ultrasound examination.

Cardiogenic pulmonary edema is a common presentation of acute heart failure normally treated with continuous positive airway pressure (CPAP), diuretics and nitrates. This therapy is contraindicated in case of cardiac tamponade. We describe a case of pulmonary edema due to cardiac tamponade in which integrated lung-heart ultrasound examination allowed prompt diagnosis and pericardiocentesis before administration of CPAP thus avoiding circulatory collapse

SerpinB3 promotes pro-fibrogenic responses in activated hepatic stellate cells

SerpinB3 is a hypoxia- and hypoxia-inducible factor-2\u3b1-dependent cystein protease inhibitor that is up-regulated in hepatocellular carcinoma and in parenchymal cells during chronic liver diseases (CLD). SerpinB3 up-regulation in CLD patients has been reported to correlate with the extent of liver fibrosis and the production of transforming growth factor-\u3b21, but the actual role of SerpinB3 in hepatic fibrogenesis is still poorly characterized. In the present study we analyzed the pro-fibrogenic action of SerpinB3 in cell cultures and in two different murine models of liver fibrosis. "In vitro" experiments revealed that SerpinB3 addition to either primary cultures of human activated myofibroblast-like hepatic stellate cells (HSC/MFs) or human stellate cell line (LX2 cells) strongly up-regulated the expression of genes involved in fibrogenesis and promoted oriented migration, but not cell proliferation. Chronic liver injury by CCl4 administration or by feeding a methionine/choline deficient diet to transgenic mice over-expressing human SerpinB3 in hepatocytes confirmed that SerpinB3 over-expression significantly increased the mRNA levels of pro-fibrogenic genes, collagen deposition and \u3b1SMA-positive HSC/MFs as compared to wild-type mice, without affecting parenchymal damage. The present study provides for the first time evidence that hepatocyte release of SerpinB3 during CLD can contribute to liver fibrogenesis by acting on HSC/MFs

Outcome of Allogeneic Peripheral Blood Stem Cell Transplantation by Donor Graft CD3+/Tregs Ratio: A Single-Center Experience

n/

Laboratorio de Innovación educativa EDUKLAB: Una experiencia que promueve la creatividad docente

The text presents the teaching experience of the EDUKLAB Educational Innovation Laboratory in the city of Ibagué, Tolima, Colombia in 2019, at the Mariano Melendro Educational Institution. This proposal is linked to national projects for the inclusion of technologies in classrooms such as Computers to Educate and is installed in the context of educational policies and technological appropriation plans of the ministries of technology, communication, culture and education from a critical stance in its updating processes, since it presents an encouraging panorama and an opportunity for educational innovation thought from the context. At the same time, it is invited to recognize the importance of technology in schools based on the reflections aroused by the field of communication-education, accounting for the transformations of a current situation mitigated by new ways of being a teacher and student, the social and cultural configurations, the tensions between uses, rituals and knowledge that are in permanent tension with the daily use of digital technologies.En el siguiente proceso investigativo se presenta una experiencia docente desde el laboratorio de Innovación Educativa EDUKLAB en la ciudad de Ibagué Tolima (Colombia) durante el año 2019 en la Institución Educativa Mariano Melendro. Esta propuesta se encuentra vinculada a los proyectos nacionales de inclusión tecnológica en las aulas de clase como Computadores para Educar y se instala en el contexto de las políticas educativas y los planes de apropiación tecnológica de los ministerios de tecnologías, comunicación, cultura y educación desde una postura crítica en sus procesos de actualización, ya que presenta un panorama alentador y una oportunidad de innovación educativa pensada desde el contexto. Al mismo tiempo se invita a reconocer la importancia de la tecnología en las escuelas a partir de las reflexiones que suscita el campo la comunicación-educación, exponiendo las transformaciones de un escenario de actualidad mitigado por nuevas formas de ejercer el rol docente y estudiante, las configuraciones sociales y culturales, las tensiones entre usos, ritualidades y saberes que están en tensión permanente con el uso cotidiano de las tecnologías digitales

Laboratorio de Innovación educativa EDUKLAB: Una experiencia que promueve la creatividad docente

The text presents the teaching experience of the EDUKLAB Educational Innovation Laboratory in the city of Ibagué, Tolima, Colombia in 2019, at the Mariano Melendro Educational Institution. This proposal is linked to national projects for the inclusion of technologies in classrooms such as Computers to Educate and is installed in the context of educational policies and technological appropriation plans of the ministries of technology, communication, culture and education from a critical stance in its updating processes, since it presents an encouraging panorama and an opportunity for educational innovation thought from the context. At the same time, it is invited to recognize the importance of technology in schools based on the reflections aroused by the field of communication-education, accounting for the transformations of a current situation mitigated by new ways of being a teacher and student, the social and cultural configurations, the tensions between uses, rituals and knowledge that are in permanent tension with the daily use of digital technologies.En el siguiente proceso investigativo se presenta una experiencia docente desde el laboratorio de Innovación Educativa EDUKLAB en la ciudad de Ibagué Tolima (Colombia) durante el año 2019 en la Institución Educativa Mariano Melendro. Esta propuesta se encuentra vinculada a los proyectos nacionales de inclusión tecnológica en las aulas de clase como Computadores para Educar y se instala en el contexto de las políticas educativas y los planes de apropiación tecnológica de los ministerios de tecnologías, comunicación, cultura y educación desde una postura crítica en sus procesos de actualización, ya que presenta un panorama alentador y una oportunidad de innovación educativa pensada desde el contexto. Al mismo tiempo se invita a reconocer la importancia de la tecnología en las escuelas a partir de las reflexiones que suscita el campo la comunicación-educación, exponiendo las transformaciones de un escenario de actualidad mitigado por nuevas formas de ejercer el rol docente y estudiante, las configuraciones sociales y culturales, las tensiones entre usos, ritualidades y saberes que están en tensión permanente con el uso cotidiano de las tecnologías digitales

What Is New in the Treatment of Smoldering Multiple Myeloma?

Smoldering multiple myeloma (SMM), an asymptomatic plasma cell neoplasm, is currently diagnosed according to the updated IMWG criteria, which reflect an intermediate tumor mass between monoclonal gammopathy of undetermined significance (MGUS) and active MM. However, SMM is a heterogeneous entity and individual case may go from an “MGUS-like” behavior to “early MM” with rapid transformation into symptomatic disease. This wide range of clinical outcomes poses challenges for prognostication and management of individual patients. However, initial studies showed a benefit in terms of progression or even survival for early treatment of high-risk SMM patients. While outside of clinical trials the conventional approach to SMM generally remains that of close observation, these studies raised the question of whether early treatment should be offered in high-risk patients, prompting evaluation of several different therapeutic approaches with different goals. While delay of progression to MM with a non-toxic treatment is clearly achievable by early treatment, a convincing survival benefit still needs to be proven by independent studies. Furthermore, if SMM is to be considered less biologically complex than MM, early treatment may offer the chance of cure that is currently not within reach of any active MM treatment. In this paper, we present updated results of completed or ongoing clinical trials in SMM treatment, highlighting areas of uncertainty and critical issues that will need to be addressed in the near future before the “watch and wait” paradigm in SMM is abandoned in favor of early treatmen

Codiseño de Laboratorios Vivos para la paz: estrategias virtuales para el agenciamiento y la transición hacia las paces

Este artículo es el resultado de uno de los procesos de investigación-creación desarrollados en el proyecto Hilando Capacidades Políticas para la Transición en los Territorios, que pertenece al programa de Colombia Científica, y se ocupa particularmente de presentar una ruta metodológica para la implementación de estrategias de codiseño de Laboratorios Vivos Comunitarios para fortalecer las iniciativas de paz en los territorios, el agenciamiento de las comunidades y el desarrollo de políticas públicas. Las estrategias de codiseño de los Laboratorios Vivos proponen una metodología donde se relacionan los siguientes aspectos fundamentales para el abordaje del trabajo social durante 2020: a) La definición de las caracterizaciones de los municipios afectados por el conflicto armado colombiano: Riosucio y Bojayá en Chocó, Riosucio y Samaná en Caldas y Ovejas y Chalán en Sucre, b) La sensibilización a las comunidades a través de la metodología del Laboratorio, c) Las mediaciones y traducciones en los laboratorios ciudadanos y d) Los procesos de trasmisión a partir de la materialización con tecnologías en un Laboratorio de Medios. Finalmente, se expone cómo la situación generada por la Covid-19 es mediada por herramientas digitales sincrónicas y asincrónicas para llevar a cabo procesos de cocreación, experimentación y producción conjunta de diversas narrativas que son evidencia de las iniciativas de paz creadas por las comunidades desde la comunicación a través de diversos medios expresivos